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UniProtKB - Q86U10 (LPP60_HUMAN)

Entry version 138 (02 Dec 2020)
Sequence version 3 (11 Jan 2011)
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Protein

60 kDa lysophospholipase

Gene

ASPG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Exhibits lysophospholipase, transacylase, PAF acetylhydrolase and asparaginase activities (By similarity). Can catalyze three types of transacylation reactions: (1) acyl transfer from 1-acyl-sn-glycero-3-phosphocholine (1-acyl-GPC) to the sn-13 positions of glycerol and 2-acylglycerol (sn-1 to -13 transfer), (2) acyl transfer from 1-acyl-GPC to the sn-2 positions of 1-acyl-GPC, 1-acyl-sn-glycero-3-phosphoethanolamine (1-acyl-GPE), and other lysophospholipids (sn-1 to -2 transfer) and (3) acyl transfer from 2-acyl-GPC to the sn-1 position of 2-acyl-GPC and 2-acyl-GPE (sn-2 to -1 transfer) (By similarity). Mediates the synthesis of 1-arachidonoyl species of phospholipids by transferring the arachidonoyl residue from 2-arachidonoyl lysophospholipid to the sn-1 position of 2-acyl lysophospholipid (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei19Acyl-ester intermediatePROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAcyltransferase, Hydrolase, Transferase
Biological processLipid degradation, Lipid metabolism

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MetaCyc:HS15413-MONOMER

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q86U10

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-8963693, Aspartate and asparagine metabolism

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
60 kDa lysophospholipase (EC:3.1.1.5By similarity)
Short name:
LysoLP
Alternative name(s):
Lysophospholipase-transacylaseBy similarity
Including the following 2 domains:
L-asparaginase (EC:3.5.1.1By similarity)
Alternative name(s):
L-asparagine amidohydrolase
1-alkyl-2-acetylglycerophosphocholine esterase (EC:3.1.1.47By similarity)
Alternative name(s):
Platelet-activating factor acetylhydrolase
Short name:
PAF acetylhydrolase
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ASPG
Synonyms:C14orf76
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000166183.15

Human Gene Nomenclature Database

More...HGNCi		HGNC:20123, ASPG

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		618472, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q86U10

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		374569

Open Targets

More...OpenTargetsi		ENSG00000166183

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q86U10, Tbio

Chemistry databases

Drug and drug target database

More...DrugBanki		DB00721, Procaine

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ASPG

Domain mapping of disease mutations (DMDM)

More...DMDMi		317373428

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003241631 – 57360 kDa lysophospholipaseAdd BLAST573

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q86U10

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q86U10

PeptideAtlas

More...PeptideAtlasi		Q86U10

PRoteomics IDEntifications database

More...PRIDEi		Q86U10

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		69756 [Q86U10-1]
69757 [Q86U10-3]

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q86U10

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000166183, Expressed in right lobe of liver and 103 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q86U10, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q86U10, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000166183, Group enriched (heart muscle, liver)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		131909, 13 interactors

Protein interaction database and analysis system

More...IntActi		Q86U10, 11 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000450040

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q86U10, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q86U10

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini9 – 355Asparaginase/glutaminasePROSITE-ProRule annotationAdd BLAST347
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati141 – 170ANK 1Add BLAST30
Repeati399 – 429ANK 2Add BLAST31
Repeati433 – 462ANK 3Add BLAST30
Repeati466 – 495ANK 4Add BLAST30
Repeati533 – 562ANK 5Add BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni41 – 350AsparaginaseAdd BLAST310
Regioni84 – 86Substrate bindingBy similarity3
Regioni116 – 117Substrate bindingBy similarity2

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the N-terminal section; belongs to the asparaginase 1 family.Curated

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0503, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000001610

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_019134_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q86U10

Identification of Orthologs from Complete Genome Data

More...OMAi		QYGADLC

Database of Orthologous Groups

More...OrthoDBi		886725at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q86U10

TreeFam database of animal gene trees

More...TreeFami		TF315247

Family and domain databases

Conserved Domains Database

More...CDDi		cd08963, L-asparaginase_I, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.40.20, 2 hits
3.40.50.1170, 1 hit
3.40.50.40, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR006033, AsnA_fam
IPR036152, Asp/glu_Ase-like_sf
IPR006034, Asparaginase/glutaminase-like
IPR027475, Asparaginase/glutaminase_AS2
IPR040919, Asparaginase_C
IPR027473, L-asparaginase_C
IPR041725, L-asparaginase_I
IPR027474, L-asparaginase_N
IPR037152, L-asparaginase_N_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12796, Ank_2, 1 hit
PF00710, Asparaginase, 1 hit
PF17763, Asparaginase_C, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF001220, L-ASNase_gatD, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01415, ANKYRIN
PR00139, ASNGLNASE

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00248, ANK, 4 hits
SM00870, Asparaginase, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48403, SSF48403, 1 hit
SSF53774, SSF53774, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00519, asnASE_I, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 2 hits
PS00917, ASN_GLN_ASE_2, 1 hit
PS51732, ASN_GLN_ASE_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86U10-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MARAVGPERR LLAVYTGGTI GMRSELGVLV PGTGLAAILR TLPMFHDEEH 
        60         70         80         90        100
ARARGLSEDT LVLPPASRNQ RILYTVLECQ PLFDSSDMTI AEWVCLAQTI 
       110        120        130        140        150
KRHYEQYHGF VVIHGTDTMA FAASMLSFML ENLQKTVILT GAQVPIHALW 
       160        170        180        190        200
SDGRENLLGA LLMAGQYVIP EVCLFFQNQL FRGNRATKVD ARRFAAFCSP 
       210        220        230        240        250
NLLPLATVGA DITINRELVR KVDGKAGLVV HSSMEQDVGL LRLYPGIPAA 
       260        270        280        290        300
LVRAFLQPPL KGVVMETFGS GNGPTKPDLL QELRVATERG LVIVNCTHCL 
       310        320        330        340        350
QGAVTTDYAA GMAMAGAGVI SGFDMTSEAA LAKLSYVLGQ PGLSLDVRKE 
       360        370        380        390        400
LLTKDLRGEM TPPSVEERRP SLQGNTLGGG VSWLLSLSGS QEADALRNAL 
       410        420        430        440        450
VPSLACAAAH AGDVEALQAL VELGSDLGLV DFNGQTPLHA AARGGHTEAV 
       460        470        480        490        500
TMLLQRGVDV NTRDTDGFSP LLLAVRGRHP GVIGLLREAG ASLSTQELEE 
       510        520        530        540        550
AGTELCRLAY RADLEGLQVW WQAGADLGQP GYDGHSALHV AEAAGNLAVV 
       560        570 
AFLQSLEGAV GAQAPCPEVL PGV
Length:573
Mass (Da):60,883
Last modified:January 11, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i62DBC583FF9C3AD7
GO
Isoform 3 (identifier: Q86U10-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     568-568: E → EPSCFQE

Note: May be due to a competing acceptor splice site.Curated
Show »
Length:579
Mass (Da):61,575
Checksum:i23E583A1518006CA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V1Y8G3V1Y8_HUMAN
Asparaginase
ASPG hCG_23215
555Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YHG5H0YHG5_HUMAN
Asparaginase
ASPG
126Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YHD3H0YHD3_HUMAN
60 kDa lysophospholipase
ASPG
140Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAD62331 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05913195C → R. Corresponds to variant dbSNP:rs1770984Ensembl.1
Natural variantiVAR_05913296L → V. Corresponds to variant dbSNP:rs1744284Ensembl.1
Natural variantiVAR_059133344S → R1 PublicationCorresponds to variant dbSNP:rs8012505Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_040740568E → EPSCFQE in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AL136001 Genomic DNA No translation available.
CH471061 Genomic DNA Translation: EAW81858.1
CH471061 Genomic DNA Translation: EAW81859.1
BC035836 mRNA Translation: AAH35836.1
BC136637 mRNA Translation: AAI36638.1
BX247999 mRNA Translation: CAD62331.1 Sequence problems.
AI373537 mRNA No translation available.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS45170.2 [Q86U10-1]

NCBI Reference Sequences

More...RefSeqi		NP_001073933.2, NM_001080464.2 [Q86U10-1]
XP_005267647.1, XM_005267590.4 [Q86U10-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000551177; ENSP00000450040; ENSG00000166183 [Q86U10-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		374569

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:374569

UCSC genome browser

More...UCSCi		uc001yoq.3, human [Q86U10-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136001 Genomic DNA No translation available.
CH471061 Genomic DNA Translation: EAW81858.1
CH471061 Genomic DNA Translation: EAW81859.1
BC035836 mRNA Translation: AAH35836.1
BC136637 mRNA Translation: AAI36638.1
BX247999 mRNA Translation: CAD62331.1 Sequence problems.
AI373537 mRNA No translation available.
CCDSiCCDS45170.2 [Q86U10-1]
RefSeqiNP_001073933.2, NM_001080464.2 [Q86U10-1]
XP_005267647.1, XM_005267590.4 [Q86U10-3]

3D structure databases

SMRiQ86U10
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi131909, 13 interactors
IntActiQ86U10, 11 interactors
STRINGi9606.ENSP00000450040

Chemistry databases

DrugBankiDB00721, Procaine

PTM databases

PhosphoSitePlusiQ86U10

Polymorphism and mutation databases

BioMutaiASPG
DMDMi317373428

Proteomic databases

MassIVEiQ86U10
PaxDbiQ86U10
PeptideAtlasiQ86U10
PRIDEiQ86U10
ProteomicsDBi69756 [Q86U10-1]
69757 [Q86U10-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		59083, 58 antibodies

Genome annotation databases

EnsembliENST00000551177; ENSP00000450040; ENSG00000166183 [Q86U10-1]
GeneIDi374569
KEGGihsa:374569
UCSCiuc001yoq.3, human [Q86U10-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		374569
DisGeNETi374569
EuPathDBiHostDB:ENSG00000166183.15

GeneCards: human genes, protein and diseases

More...GeneCardsi		ASPG
HGNCiHGNC:20123, ASPG
HPAiENSG00000166183, Group enriched (heart muscle, liver)
MIMi618472, gene
neXtProtiNX_Q86U10
OpenTargetsiENSG00000166183

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0503, Eukaryota
GeneTreeiENSGT00390000001610
HOGENOMiCLU_019134_3_0_1
InParanoidiQ86U10
OMAiQYGADLC
OrthoDBi886725at2759
PhylomeDBiQ86U10
TreeFamiTF315247

Enzyme and pathway databases

BioCyciMetaCyc:HS15413-MONOMER
PathwayCommonsiQ86U10
ReactomeiR-HSA-8963693, Aspartate and asparagine metabolism

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		374569, 2 hits in 837 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		374569
PharosiQ86U10, Tbio

Protein Ontology

More...PROi		PR:Q86U10
RNActiQ86U10, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000166183, Expressed in right lobe of liver and 103 other tissues
ExpressionAtlasiQ86U10, baseline and differential
GenevisibleiQ86U10, HS

Family and domain databases

CDDicd08963, L-asparaginase_I, 1 hit
Gene3Di1.25.40.20, 2 hits
3.40.50.1170, 1 hit
3.40.50.40, 1 hit
InterProiView protein in InterPro
IPR002110, Ankyrin_rpt
IPR020683, Ankyrin_rpt-contain_dom
IPR036770, Ankyrin_rpt-contain_sf
IPR006033, AsnA_fam
IPR036152, Asp/glu_Ase-like_sf
IPR006034, Asparaginase/glutaminase-like
IPR027475, Asparaginase/glutaminase_AS2
IPR040919, Asparaginase_C
IPR027473, L-asparaginase_C
IPR041725, L-asparaginase_I
IPR027474, L-asparaginase_N
IPR037152, L-asparaginase_N_sf
PfamiView protein in Pfam
PF12796, Ank_2, 1 hit
PF00710, Asparaginase, 1 hit
PF17763, Asparaginase_C, 1 hit
PIRSFiPIRSF001220, L-ASNase_gatD, 1 hit
PRINTSiPR01415, ANKYRIN
PR00139, ASNGLNASE
SMARTiView protein in SMART
SM00248, ANK, 4 hits
SM00870, Asparaginase, 1 hit
SUPFAMiSSF48403, SSF48403, 1 hit
SSF53774, SSF53774, 1 hit
TIGRFAMsiTIGR00519, asnASE_I, 1 hit
PROSITEiView protein in PROSITE
PS50297, ANK_REP_REGION, 1 hit
PS50088, ANK_REPEAT, 2 hits
PS00917, ASN_GLN_ASE_2, 1 hit
PS51732, ASN_GLN_ASE_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLPP60_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86U10
Secondary accession number(s): B9EGQ2, Q8IV80
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: January 11, 2011
Last modified: December 2, 2020
This is version 138 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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