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UniProtKB - Q86U06 (RBM23_HUMAN)

Entry version 171 (02 Dec 2020)
Sequence version 1 (01 Jun 2003)
Previous versions | rss
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Protein

Probable RNA-binding protein 23

Gene

RBM23

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

RNA-binding protein that acts both as a transcription coactivator and pre-mRNA splicing factor (PubMed:15694343). Regulates steroid hormone receptor-mediated transcription, independently of the pre-mRNA splicing factor activity (PubMed:15694343).1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processmRNA processing, mRNA splicing, Transcription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q86U06

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable RNA-binding protein 231 Publication
Alternative name(s):
CAPER beta1 Publication
Short name:
CAPERbeta1 Publication
RNA-binding motif protein 23
RNA-binding region-containing protein 4
Splicing factor SF2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RBM231 PublicationImported
Synonyms:RNPC4
ORF Names:PP239
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000100461.17

Human Gene Nomenclature Database

More...HGNCi		HGNC:20155, RBM23

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q86U06

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi169 – 173FCMQL → ACMQA in M1; abolished ability to regulate steroid hormone receptor-mediated transcription, without affecting the pre-mRNA splicing factor activity. 1 Publication5
Mutagenesisi266 – 270YVGSL → AVGSA in M2; reduced pre-mRNA splicing factor activity without affecting steroid hormone receptor-mediated transcription. 1 Publication5
Mutagenesisi369 – 373LMAKL → AMAKA in M3; reduced pre-mRNA splicing factor activity without affecting steroid hormone receptor-mediated transcription. 1 Publication5

Organism-specific databases

DisGeNET

More...DisGeNETi		55147

Open Targets

More...OpenTargetsi		ENSG00000100461

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134974852

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q86U06, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		RBM23

Domain mapping of disease mutations (DMDM)

More...DMDMi		34925229

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000817831 – 439Probable RNA-binding protein 23Add BLAST439

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei128PhosphoserineCombined sources1
Modified residuei149PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Aryl sulfonamide anticancer drugs, such as indisulam (E7070) or E7820, promote ubiquitination and subsequent degradation by the DCX(DCAF15) complex (PubMed:31693891, PubMed:31686031, PubMed:31819272). Aryl sulfonamide anticancer drugs change the substrate specificity of DCAF15 by acting as a molecular glue that promotes binding between DCAF15 and weak affinity interactor RBM23 (PubMed:31686031, PubMed:31819272).3 Publications

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q86U06

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q86U06

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q86U06

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q86U06

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q86U06

PeptideAtlas

More...PeptideAtlasi		Q86U06

PRoteomics IDEntifications database

More...PRIDEi		Q86U06

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		69751 [Q86U06-1]
69752 [Q86U06-2]
69753 [Q86U06-3]
69754 [Q86U06-4]
69755 [Q86U06-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q86U06

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q86U06

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q86U06

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in placenta, liver, skeletal muscle, heart and kidney (PubMed:15694343). Expressed at lower levels in the colon, thymus, spleen, small intestine and lung (PubMed:15694343).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000100461, Expressed in calcaneal tendon and 234 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q86U06, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q86U06, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000100461, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		120450, 63 interactors

Protein interaction database and analysis system

More...IntActi		Q86U06, 38 interactors

Molecular INTeraction database

More...MINTi		Q86U06

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000352956

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q86U06, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1439
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q86U06

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q86U06

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini166 – 243RRM 1PROSITE-ProRule annotationAdd BLAST78
Domaini263 – 341RRM 2PROSITE-ProRule annotationAdd BLAST79

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi63 – 127Arg-richAdd BLAST65
Compositional biasi371 – 424Ala-richAdd BLAST54

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the splicing factor SR family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0147, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000162546

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_020551_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q86U06

Identification of Orthologs from Complete Genome Data

More...OMAi		CNITEDM

Database of Orthologous Groups

More...OrthoDBi		873705at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q86U06

TreeFam database of animal gene trees

More...TreeFami		TF320448

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.70.330, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR029123, RBM39_linker
IPR006509, RBM39_SF
IPR000504, RRM_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF15519, RBM39linker, 1 hit
PF00076, RRM_1, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00360, RRM, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54928, SSF54928, 2 hits

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR01622, SF-CC1, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50102, RRM, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 16 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86U06-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASDDFDIVI EAMLEAPYKK EEDEQQRKEV KKDYPSNTTS STSNSGNETS 
        60         70         80         90        100
GSSTIGETSK KKRSRSHNKS RDRKRSRSRD RDRYRRRNSR SRSPGRQCRH 
       110        120        130        140        150
RSRSWDRRHG SESRSRDHRR EDRVHYRSPP LATGYRYGHS KSPHFREKSP 
       160        170        180        190        200
VREPVDNLSP EERDARTVFC MQLAARIRPR DLEDFFSAVG KVRDVRIISD 
       210        220        230        240        250
RNSRRSKGIA YVEFCEIQSV PLAIGLTGQR LLGVPIIVQA SQAEKNRLAA 
       260        270        280        290        300
MANNLQKGNG GPMRLYVGSL HFNITEDMLR GIFEPFGKID NIVLMKDSDT 
       310        320        330        340        350
GRSKGYGFIT FSDSECARRA LEQLNGFELA GRPMRVGHVT ERLDGGTDIT 
       360        370        380        390        400
FPDGDQELDL GSAGGRFQLM AKLAEGAGIQ LPSTAAAAAA AAAQAAALQL 
       410        420        430 
NGAVPLGALN PAALTALSPA LNLASQCFQL SSLFTPQTM
Length:439
Mass (Da):48,731
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCFF3E56F7EA12D0B
GO
Isoform 2 (identifier: Q86U06-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     60-76: KKKRSRSHNKSRDRKRS → N

Show »
Length:423
Mass (Da):46,708
Checksum:i0DD858657398EC9C
GO
Isoform 3 (identifier: Q86U06-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     311-319: FSDSECARR → LHPPPLGTV
     320-439: Missing.

Show »
Length:319
Mass (Da):36,535
Checksum:i3983D6B0494B7EC8
GO
Isoform 4 (identifier: Q86U06-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     60-76: KKKRSRSHNKSRDRKRS → N
     135-152: Missing.

Show »
Length:405
Mass (Da):44,495
Checksum:i1344E0827F28B86D
GO
Isoform 5 (identifier: Q86U06-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-100: MASDDFDIVI...SRSPGRQCRH → MSNKGKKLKR...AEVQVGSVVT

Show »
Length:417
Mass (Da):44,930
Checksum:i88EB17EF60E117CB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 16 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3XAP0G3XAP0_HUMAN
Probable RNA-binding protein 23
RBM23 hCG_41980
269Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V3S8G3V3S8_HUMAN
Probable RNA-binding protein 23
RBM23
66Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V2B6G3V2B6_HUMAN
Probable RNA-binding protein 23
RBM23
101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V5W6G3V5W6_HUMAN
Probable RNA-binding protein 23
RBM23
92Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V5Y2G3V5Y2_HUMAN
Probable RNA-binding protein 23
RBM23
144Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V3V3G3V3V3_HUMAN
Probable RNA-binding protein 23
RBM23
75Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V5J5G3V5J5_HUMAN
Probable RNA-binding protein 23
RBM23
91Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V5V1G3V5V1_HUMAN
Probable RNA-binding protein 23
RBM23
57Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V2H9G3V2H9_HUMAN
Probable RNA-binding protein 23
RBM23
59Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4J267A0A0B4J267_HUMAN
Probable RNA-binding protein 23
RBM23
100Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti132A → T in AAG24388 (PubMed:14702039).Curated1
Sequence conflicti321 – 330LEQLNGFELA → CGTVEWGLSLL in AAP97203 (Ref. 1) Curated10

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_052221184D → N. Corresponds to variant dbSNP:rs34246954Ensembl.1
Natural variantiVAR_016841393A → AA4 Publications1
Natural variantiVAR_052222428F → L. Corresponds to variant dbSNP:rs1127066Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0083111 – 100MASDD…RQCRH → MSNKGKKLKRIILAIPPAAP ATVAMRPVEAAPSGRQARRR GVGAIIKAGIESAVVVEIGI GIDGEIVGAEVQVGSVVT in isoform 5. 1 PublicationAdd BLAST100
Alternative sequenceiVSP_00831260 – 76KKKRS…DRKRS → N in isoform 2 and isoform 4. 3 PublicationsAdd BLAST17
Alternative sequenceiVSP_008313135 – 152Missing in isoform 4. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_008314311 – 319FSDSECARR → LHPPPLGTV in isoform 3. 1 Publication9
Alternative sequenceiVSP_008315320 – 439Missing in isoform 3. 1 PublicationAdd BLAST120

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF087905 mRNA Translation: AAP97203.1
AF275678 mRNA Translation: AAG24388.1
AK001344 mRNA Translation: BAA91638.1
AL834198 mRNA Translation: CAD38887.1
BX161440 mRNA Translation: CAD61910.1
AL132780 Genomic DNA No translation available.
AL135998 Genomic DNA No translation available.
CH471078 Genomic DNA Translation: EAW66223.1
CH471078 Genomic DNA Translation: EAW66229.1
BC002566 mRNA Translation: AAH02566.1
BC024208 mRNA Translation: AAH24208.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS41919.1 [Q86U06-4]
CCDS41920.1 [Q86U06-2]
CCDS41921.1 [Q86U06-1]

NCBI Reference Sequences

More...RefSeqi		NP_001070819.1, NM_001077351.1 [Q86U06-1]
NP_001070820.1, NM_001077352.1 [Q86U06-4]
NP_001294973.1, NM_001308044.1
NP_060577.3, NM_018107.4 [Q86U06-2]
XP_016876896.1, XM_017021407.1
XP_016876902.1, XM_017021413.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000346528; ENSP00000339220; ENSG00000100461 [Q86U06-4]
ENST00000359890; ENSP00000352956; ENSG00000100461 [Q86U06-1]
ENST00000399922; ENSP00000382806; ENSG00000100461 [Q86U06-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		55147

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:55147

UCSC genome browser

More...UCSCi		uc001whg.4, human [Q86U06-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF087905 mRNA Translation: AAP97203.1
AF275678 mRNA Translation: AAG24388.1
AK001344 mRNA Translation: BAA91638.1
AL834198 mRNA Translation: CAD38887.1
BX161440 mRNA Translation: CAD61910.1
AL132780 Genomic DNA No translation available.
AL135998 Genomic DNA No translation available.
CH471078 Genomic DNA Translation: EAW66223.1
CH471078 Genomic DNA Translation: EAW66229.1
BC002566 mRNA Translation: AAH02566.1
BC024208 mRNA Translation: AAH24208.1
CCDSiCCDS41919.1 [Q86U06-4]
CCDS41920.1 [Q86U06-2]
CCDS41921.1 [Q86U06-1]
RefSeqiNP_001070819.1, NM_001077351.1 [Q86U06-1]
NP_001070820.1, NM_001077352.1 [Q86U06-4]
NP_001294973.1, NM_001308044.1
NP_060577.3, NM_018107.4 [Q86U06-2]
XP_016876896.1, XM_017021407.1
XP_016876902.1, XM_017021413.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CQ4NMR-A148-248[»]
2DNZNMR-A265-346[»]
SMRiQ86U06
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi120450, 63 interactors
IntActiQ86U06, 38 interactors
MINTiQ86U06
STRINGi9606.ENSP00000352956

PTM databases

iPTMnetiQ86U06
PhosphoSitePlusiQ86U06
SwissPalmiQ86U06

Polymorphism and mutation databases

BioMutaiRBM23
DMDMi34925229

Proteomic databases

EPDiQ86U06
jPOSTiQ86U06
MassIVEiQ86U06
MaxQBiQ86U06
PaxDbiQ86U06
PeptideAtlasiQ86U06
PRIDEiQ86U06
ProteomicsDBi69751 [Q86U06-1]
69752 [Q86U06-2]
69753 [Q86U06-3]
69754 [Q86U06-4]
69755 [Q86U06-5]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		114, 74 antibodies

The DNASU plasmid repository

More...DNASUi		55147

Genome annotation databases

EnsembliENST00000346528; ENSP00000339220; ENSG00000100461 [Q86U06-4]
ENST00000359890; ENSP00000352956; ENSG00000100461 [Q86U06-1]
ENST00000399922; ENSP00000382806; ENSG00000100461 [Q86U06-2]
GeneIDi55147
KEGGihsa:55147
UCSCiuc001whg.4, human [Q86U06-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		55147
DisGeNETi55147
EuPathDBiHostDB:ENSG00000100461.17

GeneCards: human genes, protein and diseases

More...GeneCardsi		RBM23
HGNCiHGNC:20155, RBM23
HPAiENSG00000100461, Low tissue specificity
neXtProtiNX_Q86U06
OpenTargetsiENSG00000100461
PharmGKBiPA134974852

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0147, Eukaryota
GeneTreeiENSGT00940000162546
HOGENOMiCLU_020551_2_0_1
InParanoidiQ86U06
OMAiCNITEDM
OrthoDBi873705at2759
PhylomeDBiQ86U06
TreeFamiTF320448

Enzyme and pathway databases

PathwayCommonsiQ86U06

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		55147, 25 hits in 847 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		RBM23, human
EvolutionaryTraceiQ86U06

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		RBM23

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		55147
PharosiQ86U06, Tbio

Protein Ontology

More...PROi		PR:Q86U06
RNActiQ86U06, protein

Gene expression databases

BgeeiENSG00000100461, Expressed in calcaneal tendon and 234 other tissues
ExpressionAtlasiQ86U06, baseline and differential
GenevisibleiQ86U06, HS

Family and domain databases

Gene3Di3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR029123, RBM39_linker
IPR006509, RBM39_SF
IPR000504, RRM_dom
PfamiView protein in Pfam
PF15519, RBM39linker, 1 hit
PF00076, RRM_1, 2 hits
SMARTiView protein in SMART
SM00360, RRM, 2 hits
SUPFAMiSSF54928, SSF54928, 2 hits
TIGRFAMsiTIGR01622, SF-CC1, 1 hit
PROSITEiView protein in PROSITE
PS50102, RRM, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRBM23_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86U06
Secondary accession number(s): D3DS32
, Q8ND16, Q8TB88, Q8WY40, Q9BUJ1, Q9NVV7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: June 1, 2003
Last modified: December 2, 2020
This is version 171 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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