UniProtKB - Q86U06 (RBM23_HUMAN)
Protein
Probable RNA-binding protein 23
Gene
RBM23
Organism
Homo sapiens (Human)
Status
Functioni
RNA-binding protein that acts both as a transcription coactivator and pre-mRNA splicing factor (PubMed:15694343). Regulates steroid hormone receptor-mediated transcription, independently of the pre-mRNA splicing factor activity (PubMed:15694343).1 Publication
GO - Molecular functioni
- RNA binding Source: UniProtKB-KW
GO - Biological processi
- mRNA processing Source: UniProtKB-KW
- positive regulation of transcription, DNA-templated Source: UniProtKB
- regulation of mRNA splicing, via spliceosome Source: UniProtKB
- RNA splicing Source: UniProtKB-KW
Keywordsi
Molecular function | RNA-binding |
Biological process | mRNA processing, mRNA splicing, Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q86U06 |
Names & Taxonomyi
Protein namesi | Recommended name: Probable RNA-binding protein 231 PublicationAlternative name(s): CAPER beta1 Publication Short name: CAPERbeta1 Publication RNA-binding motif protein 23 RNA-binding region-containing protein 4 Splicing factor SF2 |
Gene namesi | ORF Names:PP239 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000100461.17 |
HGNCi | HGNC:20155, RBM23 |
neXtProti | NX_Q86U06 |
Pathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 169 – 173 | FCMQL → ACMQA in M1; abolished ability to regulate steroid hormone receptor-mediated transcription, without affecting the pre-mRNA splicing factor activity. 1 Publication | 5 | |
Mutagenesisi | 266 – 270 | YVGSL → AVGSA in M2; reduced pre-mRNA splicing factor activity without affecting steroid hormone receptor-mediated transcription. 1 Publication | 5 | |
Mutagenesisi | 369 – 373 | LMAKL → AMAKA in M3; reduced pre-mRNA splicing factor activity without affecting steroid hormone receptor-mediated transcription. 1 Publication | 5 |
Organism-specific databases
DisGeNETi | 55147 |
OpenTargetsi | ENSG00000100461 |
PharmGKBi | PA134974852 |
Miscellaneous databases
Pharosi | Q86U06, Tbio |
Polymorphism and mutation databases
BioMutai | RBM23 |
DMDMi | 34925229 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000081783 | 1 – 439 | Probable RNA-binding protein 23Add BLAST | 439 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 128 | PhosphoserineCombined sources | 1 | |
Modified residuei | 149 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Aryl sulfonamide anticancer drugs, such as indisulam (E7070) or E7820, promote ubiquitination and subsequent degradation by the DCX(DCAF15) complex (PubMed:31693891, PubMed:31686031, PubMed:31819272). Aryl sulfonamide anticancer drugs change the substrate specificity of DCAF15 by acting as a molecular glue that promotes binding between DCAF15 and weak affinity interactor RBM23 (PubMed:31686031, PubMed:31819272).3 Publications
Keywords - PTMi
Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q86U06 |
jPOSTi | Q86U06 |
MassIVEi | Q86U06 |
MaxQBi | Q86U06 |
PaxDbi | Q86U06 |
PeptideAtlasi | Q86U06 |
PRIDEi | Q86U06 |
ProteomicsDBi | 69751 [Q86U06-1] 69752 [Q86U06-2] 69753 [Q86U06-3] 69754 [Q86U06-4] 69755 [Q86U06-5] |
PTM databases
iPTMneti | Q86U06 |
PhosphoSitePlusi | Q86U06 |
SwissPalmi | Q86U06 |
Expressioni
Tissue specificityi
Highly expressed in placenta, liver, skeletal muscle, heart and kidney (PubMed:15694343). Expressed at lower levels in the colon, thymus, spleen, small intestine and lung (PubMed:15694343).1 Publication
Gene expression databases
Bgeei | ENSG00000100461, Expressed in calcaneal tendon and 234 other tissues |
ExpressionAtlasi | Q86U06, baseline and differential |
Genevisiblei | Q86U06, HS |
Organism-specific databases
HPAi | ENSG00000100461, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ86U06
Isoform 2 [Q86U06-2]
With | #Exp. | IntAct |
---|---|---|
BHLHE40 [O14503] | 3 | EBI-10258579,EBI-711810 |
MAGEA11 - isoform 2 [P43364-2] | 3 | EBI-10258579,EBI-10178634 |
Protein-protein interaction databases
BioGRIDi | 120450, 63 interactors |
IntActi | Q86U06, 38 interactors |
MINTi | Q86U06 |
STRINGi | 9606.ENSP00000352956 |
Miscellaneous databases
RNActi | Q86U06, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q86U06 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q86U06 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 166 – 243 | RRM 1PROSITE-ProRule annotationAdd BLAST | 78 | |
Domaini | 263 – 341 | RRM 2PROSITE-ProRule annotationAdd BLAST | 79 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 63 – 127 | Arg-richAdd BLAST | 65 | |
Compositional biasi | 371 – 424 | Ala-richAdd BLAST | 54 |
Sequence similaritiesi
Belongs to the splicing factor SR family.Curated
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0147, Eukaryota |
GeneTreei | ENSGT00940000162546 |
HOGENOMi | CLU_020551_2_0_1 |
InParanoidi | Q86U06 |
OMAi | CNITEDM |
OrthoDBi | 873705at2759 |
PhylomeDBi | Q86U06 |
TreeFami | TF320448 |
Family and domain databases
Gene3Di | 3.30.70.330, 2 hits |
InterProi | View protein in InterPro IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR029123, RBM39_linker IPR006509, RBM39_SF IPR000504, RRM_dom |
Pfami | View protein in Pfam PF15519, RBM39linker, 1 hit PF00076, RRM_1, 2 hits |
SMARTi | View protein in SMART SM00360, RRM, 2 hits |
SUPFAMi | SSF54928, SSF54928, 2 hits |
TIGRFAMsi | TIGR01622, SF-CC1, 1 hit |
PROSITEi | View protein in PROSITE PS50102, RRM, 2 hits |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 16 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q86U06-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MASDDFDIVI EAMLEAPYKK EEDEQQRKEV KKDYPSNTTS STSNSGNETS
60 70 80 90 100
GSSTIGETSK KKRSRSHNKS RDRKRSRSRD RDRYRRRNSR SRSPGRQCRH
110 120 130 140 150
RSRSWDRRHG SESRSRDHRR EDRVHYRSPP LATGYRYGHS KSPHFREKSP
160 170 180 190 200
VREPVDNLSP EERDARTVFC MQLAARIRPR DLEDFFSAVG KVRDVRIISD
210 220 230 240 250
RNSRRSKGIA YVEFCEIQSV PLAIGLTGQR LLGVPIIVQA SQAEKNRLAA
260 270 280 290 300
MANNLQKGNG GPMRLYVGSL HFNITEDMLR GIFEPFGKID NIVLMKDSDT
310 320 330 340 350
GRSKGYGFIT FSDSECARRA LEQLNGFELA GRPMRVGHVT ERLDGGTDIT
360 370 380 390 400
FPDGDQELDL GSAGGRFQLM AKLAEGAGIQ LPSTAAAAAA AAAQAAALQL
410 420 430
NGAVPLGALN PAALTALSPA LNLASQCFQL SSLFTPQTM
Computationally mapped potential isoform sequencesi
There are 16 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketG3XAP0 | G3XAP0_HUMAN | Probable RNA-binding protein 23 | RBM23 hCG_41980 | 269 | Annotation score: | ||
G3V3S8 | G3V3S8_HUMAN | Probable RNA-binding protein 23 | RBM23 | 66 | Annotation score: | ||
G3V2B6 | G3V2B6_HUMAN | Probable RNA-binding protein 23 | RBM23 | 101 | Annotation score: | ||
G3V5W6 | G3V5W6_HUMAN | Probable RNA-binding protein 23 | RBM23 | 92 | Annotation score: | ||
G3V5Y2 | G3V5Y2_HUMAN | Probable RNA-binding protein 23 | RBM23 | 144 | Annotation score: | ||
G3V3V3 | G3V3V3_HUMAN | Probable RNA-binding protein 23 | RBM23 | 75 | Annotation score: | ||
G3V5J5 | G3V5J5_HUMAN | Probable RNA-binding protein 23 | RBM23 | 91 | Annotation score: | ||
G3V5V1 | G3V5V1_HUMAN | Probable RNA-binding protein 23 | RBM23 | 57 | Annotation score: | ||
G3V2H9 | G3V2H9_HUMAN | Probable RNA-binding protein 23 | RBM23 | 59 | Annotation score: | ||
A0A0B4J267 | A0A0B4J267_HUMAN | Probable RNA-binding protein 23 | RBM23 | 100 | Annotation score: | ||
There are more potential isoformsShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 132 | A → T in AAG24388 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 321 – 330 | LEQLNGFELA → CGTVEWGLSLL in AAP97203 (Ref. 1) Curated | 10 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_052221 | 184 | D → N. Corresponds to variant dbSNP:rs34246954Ensembl. | 1 | |
Natural variantiVAR_016841 | 393 | A → AA4 Publications | 1 | |
Natural variantiVAR_052222 | 428 | F → L. Corresponds to variant dbSNP:rs1127066Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_008311 | 1 – 100 | MASDD…RQCRH → MSNKGKKLKRIILAIPPAAP ATVAMRPVEAAPSGRQARRR GVGAIIKAGIESAVVVEIGI GIDGEIVGAEVQVGSVVT in isoform 5. 1 PublicationAdd BLAST | 100 | |
Alternative sequenceiVSP_008312 | 60 – 76 | KKKRS…DRKRS → N in isoform 2 and isoform 4. 3 PublicationsAdd BLAST | 17 | |
Alternative sequenceiVSP_008313 | 135 – 152 | Missing in isoform 4. 1 PublicationAdd BLAST | 18 | |
Alternative sequenceiVSP_008314 | 311 – 319 | FSDSECARR → LHPPPLGTV in isoform 3. 1 Publication | 9 | |
Alternative sequenceiVSP_008315 | 320 – 439 | Missing in isoform 3. 1 PublicationAdd BLAST | 120 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF087905 mRNA Translation: AAP97203.1 AF275678 mRNA Translation: AAG24388.1 AK001344 mRNA Translation: BAA91638.1 AL834198 mRNA Translation: CAD38887.1 BX161440 mRNA Translation: CAD61910.1 AL132780 Genomic DNA No translation available. AL135998 Genomic DNA No translation available. CH471078 Genomic DNA Translation: EAW66223.1 CH471078 Genomic DNA Translation: EAW66229.1 BC002566 mRNA Translation: AAH02566.1 BC024208 mRNA Translation: AAH24208.1 |
CCDSi | CCDS41919.1 [Q86U06-4] CCDS41920.1 [Q86U06-2] CCDS41921.1 [Q86U06-1] |
RefSeqi | NP_001070819.1, NM_001077351.1 [Q86U06-1] NP_001070820.1, NM_001077352.1 [Q86U06-4] NP_001294973.1, NM_001308044.1 NP_060577.3, NM_018107.4 [Q86U06-2] XP_016876896.1, XM_017021407.1 XP_016876902.1, XM_017021413.1 |
Genome annotation databases
Ensembli | ENST00000346528; ENSP00000339220; ENSG00000100461 [Q86U06-4] ENST00000359890; ENSP00000352956; ENSG00000100461 [Q86U06-1] ENST00000399922; ENSP00000382806; ENSG00000100461 [Q86U06-2] |
GeneIDi | 55147 |
KEGGi | hsa:55147 |
UCSCi | uc001whg.4, human [Q86U06-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF087905 mRNA Translation: AAP97203.1 AF275678 mRNA Translation: AAG24388.1 AK001344 mRNA Translation: BAA91638.1 AL834198 mRNA Translation: CAD38887.1 BX161440 mRNA Translation: CAD61910.1 AL132780 Genomic DNA No translation available. AL135998 Genomic DNA No translation available. CH471078 Genomic DNA Translation: EAW66223.1 CH471078 Genomic DNA Translation: EAW66229.1 BC002566 mRNA Translation: AAH02566.1 BC024208 mRNA Translation: AAH24208.1 |
CCDSi | CCDS41919.1 [Q86U06-4] CCDS41920.1 [Q86U06-2] CCDS41921.1 [Q86U06-1] |
RefSeqi | NP_001070819.1, NM_001077351.1 [Q86U06-1] NP_001070820.1, NM_001077352.1 [Q86U06-4] NP_001294973.1, NM_001308044.1 NP_060577.3, NM_018107.4 [Q86U06-2] XP_016876896.1, XM_017021407.1 XP_016876902.1, XM_017021413.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2CQ4 | NMR | - | A | 148-248 | [»] | |
2DNZ | NMR | - | A | 265-346 | [»] | |
SMRi | Q86U06 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 120450, 63 interactors |
IntActi | Q86U06, 38 interactors |
MINTi | Q86U06 |
STRINGi | 9606.ENSP00000352956 |
PTM databases
iPTMneti | Q86U06 |
PhosphoSitePlusi | Q86U06 |
SwissPalmi | Q86U06 |
Polymorphism and mutation databases
BioMutai | RBM23 |
DMDMi | 34925229 |
Proteomic databases
EPDi | Q86U06 |
jPOSTi | Q86U06 |
MassIVEi | Q86U06 |
MaxQBi | Q86U06 |
PaxDbi | Q86U06 |
PeptideAtlasi | Q86U06 |
PRIDEi | Q86U06 |
ProteomicsDBi | 69751 [Q86U06-1] 69752 [Q86U06-2] 69753 [Q86U06-3] 69754 [Q86U06-4] 69755 [Q86U06-5] |
Protocols and materials databases
Antibodypediai | 114, 74 antibodies |
DNASUi | 55147 |
Genome annotation databases
Ensembli | ENST00000346528; ENSP00000339220; ENSG00000100461 [Q86U06-4] ENST00000359890; ENSP00000352956; ENSG00000100461 [Q86U06-1] ENST00000399922; ENSP00000382806; ENSG00000100461 [Q86U06-2] |
GeneIDi | 55147 |
KEGGi | hsa:55147 |
UCSCi | uc001whg.4, human [Q86U06-1] |
Organism-specific databases
CTDi | 55147 |
DisGeNETi | 55147 |
EuPathDBi | HostDB:ENSG00000100461.17 |
GeneCardsi | RBM23 |
HGNCi | HGNC:20155, RBM23 |
HPAi | ENSG00000100461, Low tissue specificity |
neXtProti | NX_Q86U06 |
OpenTargetsi | ENSG00000100461 |
PharmGKBi | PA134974852 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0147, Eukaryota |
GeneTreei | ENSGT00940000162546 |
HOGENOMi | CLU_020551_2_0_1 |
InParanoidi | Q86U06 |
OMAi | CNITEDM |
OrthoDBi | 873705at2759 |
PhylomeDBi | Q86U06 |
TreeFami | TF320448 |
Enzyme and pathway databases
PathwayCommonsi | Q86U06 |
Miscellaneous databases
BioGRID-ORCSi | 55147, 25 hits in 847 CRISPR screens |
ChiTaRSi | RBM23, human |
EvolutionaryTracei | Q86U06 |
GeneWikii | RBM23 |
GenomeRNAii | 55147 |
Pharosi | Q86U06, Tbio |
PROi | PR:Q86U06 |
RNActi | Q86U06, protein |
Gene expression databases
Bgeei | ENSG00000100461, Expressed in calcaneal tendon and 234 other tissues |
ExpressionAtlasi | Q86U06, baseline and differential |
Genevisiblei | Q86U06, HS |
Family and domain databases
Gene3Di | 3.30.70.330, 2 hits |
InterProi | View protein in InterPro IPR012677, Nucleotide-bd_a/b_plait_sf IPR035979, RBD_domain_sf IPR029123, RBM39_linker IPR006509, RBM39_SF IPR000504, RRM_dom |
Pfami | View protein in Pfam PF15519, RBM39linker, 1 hit PF00076, RRM_1, 2 hits |
SMARTi | View protein in SMART SM00360, RRM, 2 hits |
SUPFAMi | SSF54928, SSF54928, 2 hits |
TIGRFAMsi | TIGR01622, SF-CC1, 1 hit |
PROSITEi | View protein in PROSITE PS50102, RRM, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RBM23_HUMAN | |
Accessioni | Q86U06Primary (citable) accession number: Q86U06 Secondary accession number(s): D3DS32 Q9NVV7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 19, 2003 |
Last sequence update: | June 1, 2003 | |
Last modified: | December 2, 2020 | |
This is version 171 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations