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Protein

Tetratricopeptide repeat protein 6

Gene

TTC6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Tetratricopeptide repeat protein 6
Short name:
TPR repeat protein 6
Gene namesi
Name:TTC6Imported
Synonyms:C14orf25Imported, NCRNA00291Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000139865.16
HGNCiHGNC:19739 TTC6
neXtProtiNX_Q86TZ1

Pathology & Biotechi

Organism-specific databases

DisGeNETi319089
OpenTargetsiENSG00000139865

Polymorphism and mutation databases

DMDMi37088302

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001063841 – 520Tetratricopeptide repeat protein 6Add BLAST520

Proteomic databases

PaxDbiQ86TZ1
PeptideAtlasiQ86TZ1
PRIDEiQ86TZ1
ProteomicsDBi69747

PTM databases

iPTMnetiQ86TZ1
PhosphoSitePlusiQ86TZ1

Expressioni

Gene expression databases

BgeeiENSG00000139865 Expressed in 82 organ(s), highest expression level in prostate gland
CleanExiHS_TTC6
ExpressionAtlasiQ86TZ1 baseline and differential
GenevisibleiQ86TZ1 HS

Organism-specific databases

HPAiHPA069293

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000451131

Structurei

3D structure databases

ProteinModelPortaliQ86TZ1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati57 – 90TPR 1Add BLAST34
Repeati101 – 138TPR 2Add BLAST38
Repeati139 – 172TPR 3Add BLAST34
Repeati176 – 209TPR 4Add BLAST34
Repeati210 – 243TPR 5Add BLAST34
Repeati245 – 280TPR 6Add BLAST36
Repeati281 – 314TPR 7Add BLAST34
Repeati320 – 347TPR 8Add BLAST28
Repeati348 – 381TPR 9Add BLAST34
Repeati382 – 415TPR 10Add BLAST34
Repeati416 – 449TPR 11Add BLAST34
Repeati450 – 483TPR 12Add BLAST34
Repeati484 – 517TPR 13Add BLAST34

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG1124 Eukaryota
COG0457 LUCA
GeneTreeiENSGT00730000110941
HOGENOMiHOG000132920
HOVERGENiHBG047666
InParanoidiQ86TZ1
PhylomeDBiQ86TZ1

Family and domain databases

Gene3Di1.25.40.10, 6 hits
InterProiView protein in InterPro
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR001440 TPR_1
IPR019734 TPR_repeat
PfamiView protein in Pfam
PF00515 TPR_1, 2 hits
PF13181 TPR_8, 2 hits
SMARTiView protein in SMART
SM00028 TPR, 12 hits
SUPFAMiSSF48452 SSF48452, 3 hits
PROSITEiView protein in PROSITE
PS50005 TPR, 10 hits
PS50293 TPR_REGION, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86TZ1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMKYYDLAKF TIYQIAEMDK GLSELSPMQQ ALIYSFCENH DKAIEVLDGI
60 70 80 90 100
SWNRAEMTMC ALLAKVQMKA KRTKEAVEVL KKALDAISHS DKGPDATAIS
110 120 130 140 150
ADCLYNLGLC YMEEGNLQMT YKLAITDLTT AISMDKNSYT AFYNRALCYT
160 170 180 190 200
KIRELQMALT DYGIVLLLDA TETVKLNTFL NRGLIYVELG QYGFALEDFK
210 220 230 240 250
QAALISRTNG SLCHATAMCH HRINEFEEAV NFFTWALKIN PCFLDAYVGR
260 270 280 290 300
GNSYMEYGHD EATKQAQKDF LKALHINPAY IKARISFGYN LQAQGKFQKA
310 320 330 340 350
WNHFTIAIDT DPKNYLAYEG RAVVCLQMGN NFAAMQDINA AMKISTTAEF
360 370 380 390 400
LTNRGVIHEF MGHKQNAMKD YQDAITLNPK YSLAYFNAGN IYFHHRQFSQ
410 420 430 440 450
ASDYFSKALK FDPENEYVLM NRAITNTILK KYEEAKEDFA NVIESCPFWA
460 470 480 490 500
AVYFNRAHFY YCLKQYELAE EDLNKALSLK PNDALVYNFR AKVRGKIGLI
510 520
EEAMADYNQA LDLEDYASVI
Length:520
Mass (Da):59,379
Last modified:June 1, 2003 - v1
Checksum:i4F253FF28B54845E
GO
Isoform 2 (identifier: Q86TZ1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: Missing.
     119-119: M → MAFDSFTKAV...YRGVLKYYNK
     401-456: ASDYFSKALK...PFWAAVYFNR → EESLGLAWSL...CPRDEMDFTS
     457-520: Missing.

Note: No experimental confirmation available.
Show »
Length:536
Mass (Da):60,701
Checksum:iEFCDAD2E1767CCED
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V3A5G3V3A5_HUMAN
Tetratricopeptide repeat protein 6
TTC6
1,886Annotation score:
G5E9W5G5E9W5_HUMAN
Tetratricopeptide repeat protein 6
TTC6
553Annotation score:
Q3SY87Q3SY87_HUMAN
TTC6 protein
TTC6
600Annotation score:
H0YJ01H0YJ01_HUMAN
Tetratricopeptide repeat protein 6
TTC6
78Annotation score:
G3V435G3V435_HUMAN
Tetratricopeptide repeat protein 6
TTC6
440Annotation score:
G3V2C3G3V2C3_HUMAN
Tetratricopeptide repeat protein 6
TTC6
38Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03413287I → S. Corresponds to variant dbSNP:rs12896790Ensembl.1
Natural variantiVAR_03413398A → T. Corresponds to variant dbSNP:rs17768654Ensembl.1
Natural variantiVAR_024677140T → I. Corresponds to variant dbSNP:rs4901284Ensembl.1
Natural variantiVAR_034134376T → S. Corresponds to variant dbSNP:rs17107176Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0563211 – 17Missing in isoform 2. 1 PublicationAdd BLAST17
Alternative sequenceiVSP_056322119M → MAFDSFTKAVKANPDFAESF YQRGLCKVKLHKDSSILDFN RAITLNPKHYQAYLSRVAFY GLKGRYSKAILNCNKAIKIY PESVRAYLYRGVLKYYNK in isoform 2. 1 Publication1
Alternative sequenceiVSP_056323401 – 456ASDYF…VYFNR → EESLGLAWSLSLDSFLRTGG ATFSSGVNPLQTLHRRMSIL SPLPPTCPRDEMDFTS in isoform 2. 1 PublicationAdd BLAST56
Alternative sequenceiVSP_056324457 – 520Missing in isoform 2. 1 PublicationAdd BLAST64

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX161415 mRNA Translation: CAD61890.1
AL121790 Genomic DNA No translation available.
AL136296 Genomic DNA No translation available.
AL163151 Genomic DNA No translation available.
AL359233 Genomic DNA No translation available.
BC014342 mRNA Translation: AAH14342.2
BC103914 mRNA Translation: AAI03915.1
UniGeneiHs.659936

Genome annotation databases

EnsembliENST00000267368; ENSP00000267368; ENSG00000139865 [Q86TZ1-1]
ENST00000476979; ENSP00000417788; ENSG00000139865 [Q86TZ1-1]
UCSCiuc001wuh.4 human [Q86TZ1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX161415 mRNA Translation: CAD61890.1
AL121790 Genomic DNA No translation available.
AL136296 Genomic DNA No translation available.
AL163151 Genomic DNA No translation available.
AL359233 Genomic DNA No translation available.
BC014342 mRNA Translation: AAH14342.2
BC103914 mRNA Translation: AAI03915.1
UniGeneiHs.659936

3D structure databases

ProteinModelPortaliQ86TZ1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000451131

PTM databases

iPTMnetiQ86TZ1
PhosphoSitePlusiQ86TZ1

Polymorphism and mutation databases

DMDMi37088302

Proteomic databases

PaxDbiQ86TZ1
PeptideAtlasiQ86TZ1
PRIDEiQ86TZ1
ProteomicsDBi69747

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000267368; ENSP00000267368; ENSG00000139865 [Q86TZ1-1]
ENST00000476979; ENSP00000417788; ENSG00000139865 [Q86TZ1-1]
UCSCiuc001wuh.4 human [Q86TZ1-1]

Organism-specific databases

DisGeNETi319089
EuPathDBiHostDB:ENSG00000139865.16
GeneCardsiTTC6
HGNCiHGNC:19739 TTC6
HPAiHPA069293
neXtProtiNX_Q86TZ1
OpenTargetsiENSG00000139865
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1124 Eukaryota
COG0457 LUCA
GeneTreeiENSGT00730000110941
HOGENOMiHOG000132920
HOVERGENiHBG047666
InParanoidiQ86TZ1
PhylomeDBiQ86TZ1

Miscellaneous databases

ChiTaRSiTTC6 human
PROiPR:Q86TZ1

Gene expression databases

BgeeiENSG00000139865 Expressed in 82 organ(s), highest expression level in prostate gland
CleanExiHS_TTC6
ExpressionAtlasiQ86TZ1 baseline and differential
GenevisibleiQ86TZ1 HS

Family and domain databases

Gene3Di1.25.40.10, 6 hits
InterProiView protein in InterPro
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR001440 TPR_1
IPR019734 TPR_repeat
PfamiView protein in Pfam
PF00515 TPR_1, 2 hits
PF13181 TPR_8, 2 hits
SMARTiView protein in SMART
SM00028 TPR, 12 hits
SUPFAMiSSF48452 SSF48452, 3 hits
PROSITEiView protein in PROSITE
PS50005 TPR, 10 hits
PS50293 TPR_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTTC6_HUMAN
AccessioniPrimary (citable) accession number: Q86TZ1
Secondary accession number(s): Q3SY88, Q96CE6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: June 1, 2003
Last modified: October 10, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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