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Protein

Acyl-coenzyme A thioesterase 1

Gene

ACOT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Active towards fatty acyl-CoA with chain-lengths of C12-C16 (By similarity).By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=35.8 µM for C10-acyl-CoA1 Publication
  2. KM=3.6 µM for C12-acyl-CoA1 Publication
  3. KM=2.8 µM for C14-acyl-CoA1 Publication
  4. KM=3.6 µM for C16-acyl-CoA1 Publication
  5. KM=2.4 µM for C18-acyl-CoA1 Publication
  6. KM=2 µM for C20-acyl-CoA1 Publication
  7. KM=2.4 µM for C16:1-acyl-CoA1 Publication
  8. KM=4.1 µM for C18:1-acyl-CoA1 Publication
  9. KM=2.1 µM for C18:1-trans-acyl-CoA1 Publication
  1. Vmax=224 nmol/min/mg enzyme toward C10-acyl-CoA1 Publication
  2. Vmax=700 nmol/min/mg enzyme toward C12-acyl-CoA1 Publication
  3. Vmax=912 nmol/min/mg enzyme toward C14-acyl-CoA1 Publication
  4. Vmax=691 nmol/min/mg enzyme toward C16-acyl-CoA1 Publication
  5. Vmax=597 nmol/min/mg enzyme toward C18-acyl-CoA1 Publication
  6. Vmax=520 nmol/min/mg enzyme toward C20-acyl-CoA1 Publication
  7. Vmax=577 nmol/min/mg enzyme toward C16:1-acyl-CoA1 Publication
  8. Vmax=258 nmol/min/mg enzyme toward C18:1-acyl-CoA1 Publication
  9. Vmax=309 nmol/min/mg enzyme toward C18:1-trans-acyl-CoA1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei232Charge relay systemBy similarity1
Active sitei326Charge relay systemBy similarity1
Active sitei360Charge relay systemBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Serine esterase

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:MONOMER-14105

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.1.2.2 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-77289 Mitochondrial Fatty Acid Beta-Oxidation

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
Q86TX2

Protein family/group databases

ESTHER database of the Alpha/Beta-hydrolase fold superfamily of proteins

More...
ESTHERi
human-ACOT1 Acyl-CoA_Thioesterase

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000000613

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Acyl-coenzyme A thioesterase 1 (EC:3.1.2.2)
Short name:
Acyl-CoA thioesterase 1
Alternative name(s):
CTE-I
CTE-Ib
Inducible cytosolic acyl-coenzyme A thioester hydrolase
Long chain acyl-CoA thioester hydrolase
Short name:
Long chain acyl-CoA hydrolase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ACOT1
Synonyms:CTE1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000184227.7

Human Gene Nomenclature Database

More...
HGNCi
HGNC:33128 ACOT1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
614313 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q86TX2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
641371

Open Targets

More...
OpenTargetsi
ENSG00000184227

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162375318

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2189136

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ACOT1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
50428913

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002021552 – 421Acyl-coenzyme A thioesterase 1Add BLAST420

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q86TX2

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q86TX2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q86TX2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q86TX2

PeptideAtlas

More...
PeptideAtlasi
Q86TX2

PRoteomics IDEntifications database

More...
PRIDEi
Q86TX2

ProteomicsDB human proteome resource

More...
ProteomicsDBi
69743

2D gel databases

University College Dublin 2-DE Proteome Database

More...
UCD-2DPAGEi
Q86TX2

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q86TX2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q86TX2

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q86TX2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000184227 Expressed in 93 organ(s), highest expression level in right lobe of liver

CleanEx database of gene expression profiles

More...
CleanExi
HS_ACOT1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q86TX2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q86TX2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA043705

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
534965, 10 interactors

Protein interaction database and analysis system

More...
IntActi
Q86TX2, 13 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000311224

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q86TX2

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q86TX2

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the C/M/P thioester hydrolase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410II3X Eukaryota
COG1073 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153226

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000116219

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG000331

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q86TX2

KEGG Orthology (KO)

More...
KOi
K01068

Identification of Orthologs from Complete Genome Data

More...
OMAi
EDDHNWN

Database of Orthologous Groups

More...
OrthoDBi
991383at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q86TX2

TreeFam database of animal gene trees

More...
TreeFami
TF314911

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.1820, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029058 AB_hydrolase
IPR016662 Acyl-CoA_thioEstase_long-chain
IPR014940 BAAT_C
IPR006862 Thio_Ohase/aa_AcTrfase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08840 BAAT_C, 1 hit
PF04775 Bile_Hydr_Trans, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF016521 Acyl-CoA_hydro, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53474 SSF53474, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q86TX2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAATLILEPA GRCCWDEPVR IAVRGLAPEQ PVTLRASLRD EKGALFQAHA
60 70 80 90 100
RYRADTLGEL DLERAPALGG SFAGLEPMGL LWALEPEKPL VRLVKRDVRT
110 120 130 140 150
PLAVELEVLD GHDPDPGRLL CRVRHERYFL PPGVRREPVR AGRVRGTLFL
160 170 180 190 200
PPEPGPFPGI VDMFGTGGGL LEYRASLLAG KGFAVMALAY YNYEDLPKTM
210 220 230 240 250
ETLHLEYFEE AVNYLLSHPE VKGPGVGLLG ISKGGELCLS MASFLKGITA
260 270 280 290 300
AVVINGSVAN VGGTLRYKGE TLPPVGVNRN RIKVTKDGYA DIVDVLNSPL
310 320 330 340 350
EGPDQKSFIP VERAESTFLF LVGQDDHNWK SEFYANEACK RLQAHGRRKP
360 370 380 390 400
QIICYPETGH YIEPPYFPLC RASLHALVGS PIIWGGEPRA HAMAQVDAWK
410 420
QLQTFFHKHL GGHEGTIPSK V
Length:421
Mass (Da):46,277
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i04675F28D9D53B97
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V4F2G3V4F2_HUMAN
Acyl-coenzyme A thioesterase 1
ACOT1
395Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_059830266R → H. Corresponds to variant dbSNP:rs1049568Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DQ082754 mRNA Translation: AAZ31236.1
BX161396 mRNA Translation: CAD61883.1
BC127748 mRNA Translation: AAI27749.1
BC132889 mRNA Translation: AAI32890.1
BC132891 mRNA Translation: AAI32892.1
BC143042 mRNA Translation: AAI43043.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS32117.1

NCBI Reference Sequences

More...
RefSeqi
NP_001032238.1, NM_001037161.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.446685
Hs.568046

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000311148; ENSP00000311224; ENSG00000184227

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
641371

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:641371

UCSC genome browser

More...
UCSCi
uc001xol.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ082754 mRNA Translation: AAZ31236.1
BX161396 mRNA Translation: CAD61883.1
BC127748 mRNA Translation: AAI27749.1
BC132889 mRNA Translation: AAI32890.1
BC132891 mRNA Translation: AAI32892.1
BC143042 mRNA Translation: AAI43043.1
CCDSiCCDS32117.1
RefSeqiNP_001032238.1, NM_001037161.1
UniGeneiHs.446685
Hs.568046

3D structure databases

ProteinModelPortaliQ86TX2
SMRiQ86TX2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi534965, 10 interactors
IntActiQ86TX2, 13 interactors
STRINGi9606.ENSP00000311224

Chemistry databases

ChEMBLiCHEMBL2189136
SwissLipidsiSLP:000000613

Protein family/group databases

ESTHERihuman-ACOT1 Acyl-CoA_Thioesterase

PTM databases

iPTMnetiQ86TX2
PhosphoSitePlusiQ86TX2
SwissPalmiQ86TX2

Polymorphism and mutation databases

BioMutaiACOT1
DMDMi50428913

2D gel databases

UCD-2DPAGEiQ86TX2

Proteomic databases

EPDiQ86TX2
jPOSTiQ86TX2
MaxQBiQ86TX2
PaxDbiQ86TX2
PeptideAtlasiQ86TX2
PRIDEiQ86TX2
ProteomicsDBi69743

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
641371
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311148; ENSP00000311224; ENSG00000184227
GeneIDi641371
KEGGihsa:641371
UCSCiuc001xol.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
641371
DisGeNETi641371
EuPathDBiHostDB:ENSG00000184227.7

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ACOT1
HGNCiHGNC:33128 ACOT1
HPAiHPA043705
MIMi614313 gene
neXtProtiNX_Q86TX2
OpenTargetsiENSG00000184227
PharmGKBiPA162375318

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410II3X Eukaryota
COG1073 LUCA
GeneTreeiENSGT00940000153226
HOGENOMiHOG000116219
HOVERGENiHBG000331
InParanoidiQ86TX2
KOiK01068
OMAiEDDHNWN
OrthoDBi991383at2759
PhylomeDBiQ86TX2
TreeFamiTF314911

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-14105
BRENDAi3.1.2.2 2681
ReactomeiR-HSA-77289 Mitochondrial Fatty Acid Beta-Oxidation
SABIO-RKiQ86TX2

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ACOT1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
641371

Protein Ontology

More...
PROi
PR:Q86TX2

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000184227 Expressed in 93 organ(s), highest expression level in right lobe of liver
CleanExiHS_ACOT1
ExpressionAtlasiQ86TX2 baseline and differential
GenevisibleiQ86TX2 HS

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR016662 Acyl-CoA_thioEstase_long-chain
IPR014940 BAAT_C
IPR006862 Thio_Ohase/aa_AcTrfase
PfamiView protein in Pfam
PF08840 BAAT_C, 1 hit
PF04775 Bile_Hydr_Trans, 1 hit
PIRSFiPIRSF016521 Acyl-CoA_hydro, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiACOT1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86TX2
Secondary accession number(s): A1L173, Q3I5F9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: June 1, 2003
Last modified: January 16, 2019
This is version 131 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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