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Entry version 147 (08 May 2019)
Sequence version 3 (14 Apr 2009)
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Protein

Tetratricopeptide repeat protein 7B

Gene

TTC7B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns4P) synthesis. In the complex, plays a central role in bridging PI4KA to EFR3B and FAM126A, via direct interactions (PubMed:26571211).2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tetratricopeptide repeat protein 7B
Short name:
TPR repeat protein 7B
Alternative name(s):
Tetratricopeptide repeat protein 7-like-1
Short name:
TPR repeat protein 7-like-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TTC7B
Synonyms:TTC7L1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:19858 TTC7B

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q86TV6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
145567

Open Targets

More...
OpenTargetsi
ENSG00000165914

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134947112

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TTC7B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
226693616

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001063871 – 843Tetratricopeptide repeat protein 7BAdd BLAST843

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei160PhosphoserineCombined sources1
Modified residuei202PhosphoserineBy similarity1
Modified residuei625PhosphoserineBy similarity1
Modified residuei629PhosphoserineBy similarity1
Modified residuei630PhosphoserineBy similarity1
Modified residuei673PhosphoserineCombined sources1
Modified residuei677PhosphoserineCombined sources1
Modified residuei678PhosphoserineCombined sources1
Modified residuei681PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q86TV6

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q86TV6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q86TV6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q86TV6

PeptideAtlas

More...
PeptideAtlasi
Q86TV6

PRoteomics IDEntifications database

More...
PRIDEi
Q86TV6

ProteomicsDB human proteome resource

More...
ProteomicsDBi
69737
69738 [Q86TV6-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q86TV6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q86TV6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000165914 Expressed in 198 organ(s), highest expression level in cerebellum

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q86TV6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q86TV6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA058363
HPA059577

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of a phosphatidylinositol 4-kinase (PI4K) complex, composed of PI4KA, EFR3 (EFR3A or EFR3B), TTC7 (TTC7A or TTC7B) and FAM126 (FAM126A or FAM126B) (PubMed:23229899). Interacts with PI4KA, interaction is direct (PubMed:26571211). Interacts with EFR3 (EFR3A or EFR3B), interaction is direct (PubMed:26571211). Interacts with FAM126 (FAM126A or FAM126B), interaction is direct (PubMed:26571211). Association with the PI4K complex is strongly reduced by TMEM150A (PubMed:25608530).3 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
126922, 5 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q86TV6

Protein interaction database and analysis system

More...
IntActi
Q86TV6, 5 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000336127

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1843
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q86TV6

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati97 – 131TPR 1Add BLAST35
Repeati219 – 252TPR 2Add BLAST34
Repeati363 – 396TPR 3Add BLAST34
Repeati397 – 430TPR 4Add BLAST34
Repeati479 – 514TPR 5Add BLAST36
Repeati516 – 548TPR 6Add BLAST33
Repeati549 – 582TPR 7Add BLAST34
Repeati696 – 729TPR 8Add BLAST34
Repeati730 – 763TPR 9Add BLAST34
Repeati765 – 797TPR 10Add BLAST33
Repeati798 – 831TPR 11Add BLAST34

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi329 – 333Poly-Leu5

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4162 Eukaryota
ENOG410XQ09 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158474

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000045494

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q86TV6

KEGG Orthology (KO)

More...
KOi
K21843

Identification of Orthologs from Complete Genome Data

More...
OMAi
VNRRMGA

Database of Orthologous Groups

More...
OrthoDBi
167932at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q86TV6

TreeFam database of animal gene trees

More...
TreeFami
TF313783

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13181 TPR_8, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00028 TPR, 7 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452 SSF48452, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50005 TPR, 7 hits
PS50293 TPR_REGION, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86TV6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATKKAGSRL ETEIERCRSE CQWERIPELV KQLSAKLIAN DDMAELLLGE
60 70 80 90 100
SKLEQYLKEH PLRQGASPRG PKPQLTEVRK HLTAALDRGN LKSEFLQESN
110 120 130 140 150
LIMAKLNYVE GDYKEALNIY ARVGLDDLPL TAVPPYRLRV IAEAYATKGL
160 170 180 190 200
CLEKLPISSS TSNLHVDREQ DVITCYEKAG DIALLYLQEI ERVILSNIQN
210 220 230 240 250
RSPKPGPAPH DQELGFFLET GLQRAHVLYF KNGNLTRGVG RFRELLRAVE
260 270 280 290 300
TRTTQNLRMT IARQLAEILL RGMCEQSYWN PLEDPPCQSP LDDPLRKGAN
310 320 330 340 350
TKTYTLTRRA RVYSGENIFC PQENTEEALL LLLISESMAN RDAVLSRIPE
360 370 380 390 400
HKSDRLISLQ SASVVYDLLT IALGRRGQYE MLSECLERAM KFAFEEFHLW
410 420 430 440 450
YQFALSLMAA GKSARAVKVL KECIRLKPDD ATIPLLAAKL CMGSLHWLEE
460 470 480 490 500
AEKFAKTVVD VGEKTSEFKA KGYLALGLTY SLQATDASLR GMQEVLQRKA
510 520 530 540 550
LLAFQRAHSL SPTDHQAAFY LALQLAISRQ IPEALGYVRQ ALQLQGDDAN
560 570 580 590 600
SLHLLALLLS AQKHYHDALN IIDMALSEYP ENFILLFSKV KLQSLCRGPD
610 620 630 640 650
EALLTCKHML QIWKSCYNLT NPSDSGRGSS LLDRTIADRR QLNTITLPDF
660 670 680 690 700
SDPETGSVHA TSVAASRVEQ ALSEVASSLQ SSAPKQGPLH PWMTLAQIWL
710 720 730 740 750
HAAEVYIGIG KPAEATACTQ EAANLFPMSH NVLYMRGQIA ELRGSMDEAR
760 770 780 790 800
RWYEEALAIS PTHVKSMQRL ALILHQLGRY SLAEKILRDA VQVNSTAHEV
810 820 830 840
WNGLGEVLQA QGNDAAATEC FLTALELEAS SPAVPFTIIP RVL
Note: No experimental confirmation available. Derived from EST data.
Length:843
Mass (Da):94,179
Last modified:April 14, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iADAB8B36878AABDA
GO
Isoform 2 (identifier: Q86TV6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     656-656: G → GNSPEAYFHGFPSLFSVS

Note: No experimental confirmation available.
Show »
Length:860
Mass (Da):96,047
Checksum:i23F1D3C39CB9D77B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YJS2H0YJS2_HUMAN
Tetratricopeptide repeat protein 7B
TTC7B
271Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YIZ4H0YIZ4_HUMAN
Tetratricopeptide repeat protein 7B
TTC7B
105Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q6PIF1Q6PIF1_HUMAN
TTC7B protein
TTC7B
417Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YJP9H0YJP9_HUMAN
Tetratricopeptide repeat protein 7B
TTC7B
175Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0C4DGK5A0A0C4DGK5_HUMAN
Tetratricopeptide repeat protein 7B
TTC7B
330Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YK02H0YK02_HUMAN
Tetratricopeptide repeat protein 7B
TTC7B
213Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V3E4G3V3E4_HUMAN
Tetratricopeptide repeat protein 7B
TTC7B
48Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V3H1G3V3H1_HUMAN
Tetratricopeptide repeat protein 7B
TTC7B
204Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAI46128 differs from that shown. Reason: Frameshift at position 718.Curated
The sequence CAI46128 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_008061656G → GNSPEAYFHGFPSLFSVS in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL096869 Genomic DNA No translation available.
AL122020 Genomic DNA No translation available.
AL139193 Genomic DNA No translation available.
AL832848 mRNA Translation: CAI46128.1 Sequence problems.
BX247966 mRNA Translation: CAD62305.1
BX248275 mRNA Translation: CAD62603.1
BC048270 mRNA Translation: AAH48270.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS32140.1 [Q86TV6-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001010854.1, NM_001010854.1 [Q86TV6-1]
NP_001307350.1, NM_001320421.1
XP_016876534.1, XM_017021045.1 [Q86TV6-2]
XP_016876535.1, XM_017021046.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000328459; ENSP00000336127; ENSG00000165914 [Q86TV6-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
145567

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:145567

UCSC genome browser

More...
UCSCi
uc001xyp.4 human [Q86TV6-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL096869 Genomic DNA No translation available.
AL122020 Genomic DNA No translation available.
AL139193 Genomic DNA No translation available.
AL832848 mRNA Translation: CAI46128.1 Sequence problems.
BX247966 mRNA Translation: CAD62305.1
BX248275 mRNA Translation: CAD62603.1
BC048270 mRNA Translation: AAH48270.2
CCDSiCCDS32140.1 [Q86TV6-1]
RefSeqiNP_001010854.1, NM_001010854.1 [Q86TV6-1]
NP_001307350.1, NM_001320421.1
XP_016876534.1, XM_017021045.1 [Q86TV6-2]
XP_016876535.1, XM_017021046.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5DSEX-ray2.90A/C7-843[»]
6BQ1electron microscopy3.60B/F1-843[»]
SMRiQ86TV6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126922, 5 interactors
CORUMiQ86TV6
IntActiQ86TV6, 5 interactors
STRINGi9606.ENSP00000336127

PTM databases

iPTMnetiQ86TV6
PhosphoSitePlusiQ86TV6

Polymorphism and mutation databases

BioMutaiTTC7B
DMDMi226693616

Proteomic databases

EPDiQ86TV6
jPOSTiQ86TV6
MaxQBiQ86TV6
PaxDbiQ86TV6
PeptideAtlasiQ86TV6
PRIDEiQ86TV6
ProteomicsDBi69737
69738 [Q86TV6-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
145567
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000328459; ENSP00000336127; ENSG00000165914 [Q86TV6-1]
GeneIDi145567
KEGGihsa:145567
UCSCiuc001xyp.4 human [Q86TV6-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
145567
DisGeNETi145567

GeneCards: human genes, protein and diseases

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GeneCardsi
TTC7B

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0011885
HGNCiHGNC:19858 TTC7B
HPAiHPA058363
HPA059577
neXtProtiNX_Q86TV6
OpenTargetsiENSG00000165914
PharmGKBiPA134947112

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG4162 Eukaryota
ENOG410XQ09 LUCA
GeneTreeiENSGT00940000158474
HOGENOMiHOG000045494
InParanoidiQ86TV6
KOiK21843
OMAiVNRRMGA
OrthoDBi167932at2759
PhylomeDBiQ86TV6
TreeFamiTF313783

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TTC7B human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
145567

Protein Ontology

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PROi
PR:Q86TV6

Gene expression databases

BgeeiENSG00000165914 Expressed in 198 organ(s), highest expression level in cerebellum
ExpressionAtlasiQ86TV6 baseline and differential
GenevisibleiQ86TV6 HS

Family and domain databases

Gene3Di1.25.40.10, 2 hits
InterProiView protein in InterPro
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PfamiView protein in Pfam
PF13181 TPR_8, 2 hits
SMARTiView protein in SMART
SM00028 TPR, 7 hits
SUPFAMiSSF48452 SSF48452, 2 hits
PROSITEiView protein in PROSITE
PS50005 TPR, 7 hits
PS50293 TPR_REGION, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTTC7B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86TV6
Secondary accession number(s): Q86U24, Q86VT3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: April 14, 2009
Last modified: May 8, 2019
This is version 147 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
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