SYVN1

Functionⁱ

Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation (PubMed:12459480, PubMed:12646171, PubMed:12975321, PubMed:14593114, PubMed:16289116, PubMed:16847254, PubMed:17059562, PubMed:17141218, PubMed:17170702, PubMed:22607976, PubMed:26471130). Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:12459480, PubMed:12646171, PubMed:12975321, PubMed:14593114, PubMed:16289116, PubMed:16847254, PubMed:17059562, PubMed:17141218, PubMed:17170702, PubMed:22607976, PubMed:26471130). Also promotes the degradation of normal but naturally short-lived proteins such as SGK. Protects cells from ER stress-induced apoptosis. Protects neurons from apoptosis induced by polyglutamine-expanded huntingtin (HTT) or unfolded GPR37 by promoting their degradation (PubMed:17141218). Sequesters p53/TP53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis (PubMed:17170702). Mediates the ubiquitination and subsequent degradation of cytoplasmic NFE2L1 (By similarity).By similarity11 Publications

Catalytic activityⁱ

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N₆-ubiquitinyl-[acceptor protein]-L-lysine.

Pathwayⁱ: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.6 Publications
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	291 – 330	RING-type; atypicalPROSITE-ProRule annotationAdd BLAST		40

GO - Molecular functionⁱ

ATPase binding
Source: ParkinsonsUK-UCL
Inferred from physical interactionⁱ
- 16186510
- 22590560
chaperone binding
Source: ParkinsonsUK-UCL
Inferred from physical interactionⁱ
- 21636303
metal ion binding Source: UniProtKB-KW
ubiquitin protein ligase activity
Source: ParkinsonsUK-UCL
Inferred from direct assayⁱ
ubiquitin-specific protease binding
Source: ParkinsonsUK-UCL
Inferred from physical interactionⁱ
- 22590560
- 24068323
unfolded protein binding
Source: ParkinsonsUK-UCL
Inferred from physical interactionⁱ
- 17059562

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

endoplasmic reticulum mannose trimming Source: Reactome
endoplasmic reticulum unfolded protein response Source: GO_Central
ERAD pathway
Source: ParkinsonsUK-UCL
Inferred from direct assayⁱ
- 22590560
IRE1-mediated unfolded protein response Source: Reactome
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
Source: ParkinsonsUK-UCL
Inferred from direct assayⁱ
- 12459480
- 17059562
protein K48-linked ubiquitination
Source: ParkinsonsUK-UCL
Inferred from direct assayⁱ
- 14593114
protein N-linked glycosylation via asparagine
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 22607976
protein stabilization
Source: ParkinsonsUK-UCL
Inferred from mutant phenotypeⁱ
- 21454652
protein ubiquitination
Source: ParkinsonsUK-UCL
Inferred from direct assayⁱ
- 12459480
- 22590560
retrograde protein transport, ER to cytosol
Source: ParkinsonsUK-UCL
Inferred from mutant phenotypeⁱ
- 25660456
ubiquitin-dependent ERAD pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 12459480
ubiquitin-dependent protein catabolic process
Source: ParkinsonsUK-UCL
Inferred from direct assayⁱ
- 14593114
- 17059562

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Transferase
Biological process	Stress response, Ubl conjugation pathway
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-HSA-381038 XBP1(S) activates chaperone genes R-HSA-5358346 Hedgehog ligand biogenesis R-HSA-5362768 Hh mutants that don't undergo autocatalytic processing are degraded by ERAD R-HSA-901032 ER Quality Control Compartment (ERQC)
UniPathwayⁱ	UPA00143

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: E3 ubiquitin-protein ligase synoviolin (EC:2.3.2.27) Alternative name(s): RING-type E3 ubiquitin transferase synoviolinCurated Synovial apoptosis inhibitor 1
Gene namesⁱ	Name:SYVN1 Synonyms:HRD1, KIAA1810
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000162298.16
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:20738 SYVN1
MIMⁱ	608046 gene
neXtProtⁱ	NX_Q86TM6

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	23 – 41	LumenalSequence analysisAdd BLAST	19
Transmembraneⁱ	42 – 62	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	63 – 98	CytoplasmicSequence analysisAdd BLAST	36
Transmembraneⁱ	99 – 119	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	120 – 140	LumenalSequence analysisAdd BLAST	21
Transmembraneⁱ	141 – 161	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	162 – 169	CytoplasmicSequence analysis	8
Transmembraneⁱ	170 – 190	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	191 – 224	LumenalSequence analysisAdd BLAST	34
Transmembraneⁱ	225 – 245	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	246 – 617	CytoplasmicSequence analysisAdd BLAST	372

Keywords - Cellular componentⁱ

Endoplasmic reticulum, Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	329	C → S: Abolishes E3 ligase activity. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	84447
Open Targets More...OpenTargetsⁱ	ENSG00000162298
PharmGKBⁱ	PA128394735

Polymorphism and mutation databases

BioMutaⁱ	SYVN1
DMDMⁱ	134035039

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 22	Sequence analysisAdd BLAST		22
ChainⁱPRO_0000280548	23 – 617	E3 ubiquitin-protein ligase synoviolinAdd BLAST		595

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	613	PhosphoserineCombined sources		1

Post-translational modificationⁱ

Not N-glycosylated.

Auto-ubiquitinated.3 Publications

Keywords - PTMⁱ

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q86TM6
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q86TM6
PaxDbⁱ	Q86TM6
PeptideAtlas More...PeptideAtlasⁱ	Q86TM6
PRIDEⁱ	Q86TM6
ProteomicsDBⁱ	69713 69714 [Q86TM6-2] 69715 [Q86TM6-3]

PTM databases

iPTMnetⁱ	Q86TM6
PhosphoSitePlusⁱ	Q86TM6

Expressionⁱ

Tissue specificityⁱ

Ubiquitously expressed, with highest levels in liver and kidney (at protein level). Up-regulated in synovial tissues from patients with rheumatoid arthritis (at protein level).3 Publications

Inductionⁱ

By endoplasmic reticulum stress-inducing agents such as thapsigargin, tunicamycin or brefeldin A, but not by heat shock.2 Publications

Gene expression databases

Bgeeⁱ	ENSG00000162298 Expressed in 193 organ(s), highest expression level in right lobe of liver
CleanExⁱ	HS_SYVN1
ExpressionAtlasⁱ	Q86TM6 baseline and differential
Genevisibleⁱ	Q86TM6 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB037030 HPA005480 HPA024300

HPAⁱ

CAB037030
HPA005480
HPA024300

Interactionⁱ

Subunit structureⁱ

Homodimer. Interacts with p53/TP53 and HTT. Interacts with VCP, HERPUD1 and DERL1. Part of a complex containing SYVN1, HERPUD1, VIMP and DERL1; which probably transfer misfolded proteins from the ER to VCP. Part of a complex containing SYVN1, SEL1L and DERL2. Interacts with UBXN6. Interacts (via N-terminal loop) with SEL1L; recruits ERLEC1 and OS9. May form a complex with ERLEC1; HSPA5; OS9 AND SEL1L (PubMed:16186509, PubMed:16186510, PubMed:16289116, PubMed:17141218, PubMed:17170702, PubMed:18264092, PubMed:18502753, PubMed:18656546, PubMed:26471130). Interacts with BAG6 (PubMed:21636303). Interacts with NFE2L1 (By similarity).By similarity10 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
ERN1	O75460	2	EBI-947849,EBI-371750
ERN1	O75460-1	3	EBI-947849,EBI-15600828
TP53	P04637	5	EBI-947849,EBI-366083

GO - Molecular functionⁱ

ATPase binding
Source: ParkinsonsUK-UCL
Inferred from physical interactionⁱ
- 16186510
- 22590560
chaperone binding
Source: ParkinsonsUK-UCL
Inferred from physical interactionⁱ
- 21636303
ubiquitin-specific protease binding
Source: ParkinsonsUK-UCL
Inferred from physical interactionⁱ
- 22590560
- 24068323
unfolded protein binding
Source: ParkinsonsUK-UCL
Inferred from physical interactionⁱ
- 17059562

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	124085, 99 interactors
CORUMⁱ	Q86TM6
Database of interacting proteins More...DIPⁱ	DIP-43982N
IntActⁱ	Q86TM6, 21 interactors
Molecular INTeraction database More...MINTⁱ	Q86TM6
STRINGⁱ	9606.ENSP00000366395

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q86TM6
SMRⁱ	Q86TM6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	21 – 42	Interaction with SEL1LBy similarityAdd BLAST		22
Regionⁱ	236 – 270	Interaction with p53/TP531 PublicationAdd BLAST		35

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	339 – 478	Pro-richAdd BLAST		140

Domainⁱ

The RING-type zinc finger is required for E3 ligase activity.

Sequence similaritiesⁱ

Belongs to the HRD1 family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	291 – 330	RING-type; atypicalPROSITE-ProRule annotationAdd BLAST		40

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG0802 Eukaryota COG5243 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000062938
HOGENOMⁱ	HOG000294196
HOVERGENⁱ	HBG094015
InParanoidⁱ	Q86TM6
KEGG Orthology (KO) More...KOⁱ	K10601
OMAⁱ	FPFPPPW
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G13IJ
PhylomeDBⁱ	Q86TM6
TreeFamⁱ	TF318635

Family and domain databases

Gene3Dⁱ	3.30.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR032832 E3_lig_synoviolin/Hrd1 IPR001841 Znf_RING IPR013083 Znf_RING/FYVE/PHD
PANTHERⁱ	PTHR44251 PTHR44251, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13639 zf-RING_2, 1 hit
SMARTⁱ	View protein in SMART SM00184 RING, 1 hit
PROSITEⁱ	View protein in PROSITE PS50089 ZF_RING_2, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q86TM6-1) [UniParc]FASTA Add to basket

Also known as: b, long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFRTAVMMAA SLALTGAVVA HAYYLKHQFY PTVVYLTKSS PSMAVLYIQA 
        60         70         80         90        100
FVLVFLLGKV MGKVFFGQLR AAEMEHLLER SWYAVTETCL AFTVFRDDFS 
       110        120        130        140        150
PRFVALFTLL LFLKCFHWLA EDRVDFMERS PNISWLFHCR IVSLMFLLGI 
       160        170        180        190        200
LDFLFVSHAY HSILTRGASV QLVFGFEYAI LMTMVLTIFI KYVLHSVDLQ 
       210        220        230        240        250
SENPWDNKAV YMLYTELFTG FIKVLLYMAF MTIMIKVHTF PLFAIRPMYL 
       260        270        280        290        300
AMRQFKKAVT DAIMSRRAIR NMNTLYPDAT PEELQAMDNV CIICREEMVT 
       310        320        330        340        350
GAKRLPCNHI FHTSCLRSWF QRQQTCPTCR MDVLRASLPA QSPPPPEPAD 
       360        370        380        390        400
QGPPPAPHPP PLLPQPPNFP QGLLPPFPPG MFPLWPPMGP FPPVPPPPSS 
       410        420        430        440        450
GEAVAPPSTS AAALSRPSGA ATTTAAGTSA TAASATASGP GSGSAPEAGP 
       460        470        480        490        500
APGFPFPPPW MGMPLPPPFA FPPMPVPPAG FAGLTPEELR ALEGHERQHL 
       510        520        530        540        550
EARLQSLRNI HTLLDAAMLQ INQYLTVLAS LGPPRPATSV NSTEETATTV 
       560        570        580        590        600
VAAASSTSIP SSEATTPTPG ASPPAPEMER PPAPESVGTE EMPEDGEPDA 
       610 
AELRRRRLQK LESPVAH

Length:617

Mass (Da):67,685

Last modified:March 20, 2007 - v2

Checksum:ⁱB8A6BACBAF9673C1

GO

Isoform 2 (identifier: Q86TM6-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
127-177: Missing.
411-411: Missing.

« Hide

        10         20         30         40         50
MFRTAVMMAA SLALTGAVVA HAYYLKHQFY PTVVYLTKSS PSMAVLYIQA 
        60         70         80         90        100
FVLVFLLGKV MGKVFFGQLR AAEMEHLLER SWYAVTETCL AFTVFRDDFS 
       110        120        130        140        150
PRFVALFTLL LFLKCFHWLA EDRVDFYAIL MTMVLTIFIK YVLHSVDLQS 
       160        170        180        190        200
ENPWDNKAVY MLYTELFTGF IKVLLYMAFM TIMIKVHTFP LFAIRPMYLA 
       210        220        230        240        250
MRQFKKAVTD AIMSRRAIRN MNTLYPDATP EELQAMDNVC IICREEMVTG 
       260        270        280        290        300
AKRLPCNHIF HTSCLRSWFQ RQQTCPTCRM DVLRASLPAQ SPPPPEPADQ 
       310        320        330        340        350
GPPPAPHPPP LLPQPPNFPQ GLLPPFPPGM FPLWPPMGPF PPVPPPPSSG 
       360        370        380        390        400
EAVAPPSTSA ALSRPSGAAT TTAAGTSATA ASATASGPGS GSAPEAGPAP 
       410        420        430        440        450
GFPFPPPWMG MPLPPPFAFP PMPVPPAGFA GLTPEELRAL EGHERQHLEA 
       460        470        480        490        500
RLQSLRNIHT LLDAAMLQIN QYLTVLASLG PPRPATSVNS TEETATTVVA 
       510        520        530        540        550
AASSTSIPSS EATTPTPGAS PPAPEMERPP APESVGTEEM PEDGEPDAAE 
       560 
LRRRRLQKLE SPVAH

Show »

Length:565

Mass (Da):61,732

Checksum:ⁱ8C2226662D099D15

GO

Isoform 3 (identifier: Q86TM6-3) [UniParc]FASTA Add to basket

Also known as: a, short

The sequence of this isoform differs from the canonical sequence as follows:
411-411: Missing.

« Hide

        10         20         30         40         50
MFRTAVMMAA SLALTGAVVA HAYYLKHQFY PTVVYLTKSS PSMAVLYIQA 
        60         70         80         90        100
FVLVFLLGKV MGKVFFGQLR AAEMEHLLER SWYAVTETCL AFTVFRDDFS 
       110        120        130        140        150
PRFVALFTLL LFLKCFHWLA EDRVDFMERS PNISWLFHCR IVSLMFLLGI 
       160        170        180        190        200
LDFLFVSHAY HSILTRGASV QLVFGFEYAI LMTMVLTIFI KYVLHSVDLQ 
       210        220        230        240        250
SENPWDNKAV YMLYTELFTG FIKVLLYMAF MTIMIKVHTF PLFAIRPMYL 
       260        270        280        290        300
AMRQFKKAVT DAIMSRRAIR NMNTLYPDAT PEELQAMDNV CIICREEMVT 
       310        320        330        340        350
GAKRLPCNHI FHTSCLRSWF QRQQTCPTCR MDVLRASLPA QSPPPPEPAD 
       360        370        380        390        400
QGPPPAPHPP PLLPQPPNFP QGLLPPFPPG MFPLWPPMGP FPPVPPPPSS 
       410        420        430        440        450
GEAVAPPSTS AALSRPSGAA TTTAAGTSAT AASATASGPG SGSAPEAGPA 
       460        470        480        490        500
PGFPFPPPWM GMPLPPPFAF PPMPVPPAGF AGLTPEELRA LEGHERQHLE 
       510        520        530        540        550
ARLQSLRNIH TLLDAAMLQI NQYLTVLASL GPPRPATSVN STEETATTVV 
       560        570        580        590        600
AAASSTSIPS SEATTPTPGA SPPAPEMERP PAPESVGTEE MPEDGEPDAA 
       610 
ELRRRRLQKL ESPVAH

Show »

Length:616

Mass (Da):67,614

Checksum:ⁱ3D035485BDF67376

GO

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

E9PMA1	E9PMA1_HUMAN	E3 ubiquitin-protein ligase synovio... E3 ubiquitin-protein ligase synoviolin	SYVN1	236	Annotation score:
H0YCR6	H0YCR6_HUMAN	E3 ubiquitin-protein ligase synovio... E3 ubiquitin-protein ligase synoviolin	SYVN1	149	Annotation score:
E9PN88	E9PN88_HUMAN	E3 ubiquitin-protein ligase synovio... E3 ubiquitin-protein ligase synoviolin	SYVN1	149	Annotation score:
E9PK19	E9PK19_HUMAN	E3 ubiquitin-protein ligase synovio... E3 ubiquitin-protein ligase synoviolin	SYVN1	237	Annotation score:

Sequence cautionⁱ

The sequence BAB47439 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	145	M → I in BAC24801 (PubMed:12459480).Curated	1
Sequence conflictⁱ	145	M → I in AAL26903 (PubMed:14593114).Curated	1
Sequence conflictⁱ	545	E → G in BAC57449 (PubMed:12975321).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_023777	127 – 177	Missing in isoform 2. 1 PublicationAdd BLAST		51
Alternative sequenceⁱVSP_023778	411	Missing in isoform 2 and isoform 3. 4 Publications		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB085847 mRNA Translation: BAC24801.1 AB024690 mRNA Translation: BAC57449.1 AF317634 mRNA Translation: AAL26903.1 AB058713 mRNA Translation: BAB47439.1 Different initiation. AL834262 mRNA Translation: CAD38937.1 BC030530 mRNA Translation: AAH30530.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS31605.1 [Q86TM6-1] CCDS8097.1 [Q86TM6-3]
NCBI Reference Sequences More...RefSeqⁱ	NP_115807.1, NM_032431.2 [Q86TM6-3] NP_757385.1, NM_172230.2 [Q86TM6-1] XP_011543605.1, XM_011545303.2 [Q86TM6-1]
UniGeneⁱ	Hs.75859

Genome annotation databases

Ensemblⁱ	ENST00000294256; ENSP00000294256; ENSG00000162298 [Q86TM6-3] ENST00000307289; ENSP00000302035; ENSG00000162298 [Q86TM6-2] ENST00000377190; ENSP00000366395; ENSG00000162298 [Q86TM6-1] ENST00000526060; ENSP00000436984; ENSG00000162298 [Q86TM6-3]
GeneIDⁱ	84447
KEGGⁱ	hsa:84447
UCSC genome browser More...UCSCⁱ	uc001odb.4 human [Q86TM6-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q86TM6	E3 ubiquitin-protein ligase synoviolin		MOUSE		612	UniRef90_Q86TM6
E3 ubiquitin-protein ligase synoviolin		Yangtze finless porpoise		620
Synoviolin 1		PANTR		619
Uncharacterized protein		NOMLE		617
E3 ubiquitin-protein ligase synoviolin isoform b		MACMU		617
+77
Q86TM6-2	Uncharacterized protein		AOTNA		572	UniRef90_Q86TM6-2
Uncharacterized protein		PROCO		570
Synoviolin 1		PANTR		567
Uncharacterized protein		PANPA		567
SYVN1 isoform 4		PONAB		565
+22

Protein	Similar proteins		Species	Score	Length	Source
Q86TM6	E3 ubiquitin-protein ligase synoviolin		MOUSE		612	UniRef50_Q86TM6
E3 ubiquitin-protein ligase synoviolin A		XENLA		605
E3 ubiquitin-protein ligase synoviolin		DANRE		625
E3 ubiquitin-protein ligase synoviolin		Yangtze finless porpoise		620
SYVN1 isoform 1		PANTR		619
+377
Q86TM6-2	Uncharacterized protein		AOTNA		572	UniRef50_Q86TM6-2
Uncharacterized protein		PROCO		570
SYVN1 isoform 6		PANTR		567
Uncharacterized protein		PANPA		567
Synoviolin 1		GORGO		565
+25

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB085847 mRNA Translation: BAC24801.1 AB024690 mRNA Translation: BAC57449.1 AF317634 mRNA Translation: AAL26903.1 AB058713 mRNA Translation: BAB47439.1 Different initiation. AL834262 mRNA Translation: CAD38937.1 BC030530 mRNA Translation: AAH30530.1
CCDSⁱ	CCDS31605.1 [Q86TM6-1] CCDS8097.1 [Q86TM6-3]
RefSeqⁱ	NP_115807.1, NM_032431.2 [Q86TM6-3] NP_757385.1, NM_172230.2 [Q86TM6-1] XP_011543605.1, XM_011545303.2 [Q86TM6-1]
UniGeneⁱ	Hs.75859

3D structure databases

ProteinModelPortalⁱ	Q86TM6
SMRⁱ	Q86TM6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	124085, 99 interactors
CORUMⁱ	Q86TM6
DIPⁱ	DIP-43982N
IntActⁱ	Q86TM6, 21 interactors
MINTⁱ	Q86TM6
STRINGⁱ	9606.ENSP00000366395

PTM databases

iPTMnetⁱ	Q86TM6
PhosphoSitePlusⁱ	Q86TM6

Polymorphism and mutation databases

BioMutaⁱ	SYVN1
DMDMⁱ	134035039

Proteomic databases

EPDⁱ	Q86TM6
MaxQBⁱ	Q86TM6
PaxDbⁱ	Q86TM6
PeptideAtlasⁱ	Q86TM6
PRIDEⁱ	Q86TM6
ProteomicsDBⁱ	69713 69714 [Q86TM6-2] 69715 [Q86TM6-3]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	84447
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000294256; ENSP00000294256; ENSG00000162298 [Q86TM6-3] ENST00000307289; ENSP00000302035; ENSG00000162298 [Q86TM6-2] ENST00000377190; ENSP00000366395; ENSG00000162298 [Q86TM6-1] ENST00000526060; ENSP00000436984; ENSG00000162298 [Q86TM6-3]
GeneIDⁱ	84447
KEGGⁱ	hsa:84447
UCSCⁱ	uc001odb.4 human [Q86TM6-1]

Organism-specific databases

CTDⁱ	84447
DisGeNETⁱ	84447
EuPathDBⁱ	HostDB:ENSG00000162298.16
GeneCardsⁱ	SYVN1
HGNCⁱ	HGNC:20738 SYVN1
HPAⁱ	CAB037030 HPA005480 HPA024300
MIMⁱ	608046 gene
neXtProtⁱ	NX_Q86TM6
OpenTargetsⁱ	ENSG00000162298
PharmGKBⁱ	PA128394735
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0802 Eukaryota COG5243 LUCA
GeneTreeⁱ	ENSGT00530000062938
HOGENOMⁱ	HOG000294196
HOVERGENⁱ	HBG094015
InParanoidⁱ	Q86TM6
KOⁱ	K10601
OMAⁱ	FPFPPPW
OrthoDBⁱ	EOG091G13IJ
PhylomeDBⁱ	Q86TM6
TreeFamⁱ	TF318635

Enzyme and pathway databases

UniPathwayⁱ	UPA00143
Reactomeⁱ	R-HSA-381038 XBP1(S) activates chaperone genes R-HSA-5358346 Hedgehog ligand biogenesis R-HSA-5362768 Hh mutants that don't undergo autocatalytic processing are degraded by ERAD R-HSA-901032 ER Quality Control Compartment (ERQC)

Miscellaneous databases

ChiTaRSⁱ	SYVN1 human
GeneWikiⁱ	SYVN1
GenomeRNAiⁱ	84447
Protein Ontology More...PROⁱ	PR:Q86TM6
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000162298 Expressed in 193 organ(s), highest expression level in right lobe of liver
CleanExⁱ	HS_SYVN1
ExpressionAtlasⁱ	Q86TM6 baseline and differential
Genevisibleⁱ	Q86TM6 HS

Family and domain databases

Gene3Dⁱ	3.30.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR032832 E3_lig_synoviolin/Hrd1 IPR001841 Znf_RING IPR013083 Znf_RING/FYVE/PHD
PANTHERⁱ	PTHR44251 PTHR44251, 1 hit
Pfamⁱ	View protein in Pfam PF13639 zf-RING_2, 1 hit
SMARTⁱ	View protein in SMART SM00184 RING, 1 hit
PROSITEⁱ	View protein in PROSITE PS50089 ZF_RING_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SYVN1_HUMAN
Accessionⁱ	Q86TM6Primary (citable) accession number: Q86TM6 Secondary accession number(s): Q8N3K3 , Q8N6E8, Q96JL5, Q96PK3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 20, 2007
	Last sequence update:	March 20, 2007
	Last modified:	September 12, 2018
	This is version 152 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
PATHWAY comments
Index of metabolic and biosynthesis pathways
Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - Q86TM6 (SYVN1_HUMAN)

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E3 ubiquitin-protein ligase synoviolin

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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GO - Biological processi

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<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

Pathwayⁱ: protein ubiquitination

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

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GO - Molecular functionⁱ

Structureⁱ

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Keywords - Domainⁱ

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Keywords - Coding sequence diversityⁱ

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Miscellaneousⁱ

Keywords - Technical termⁱ