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Protein

Transcriptional adapter 2-beta

Gene

TADA2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Coactivates PAX5-dependent transcription together with either SMARCA4 or GCN5L2.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri3 – 49ZZ-typePROSITE-ProRule annotationAdd BLAST47

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-3214847 HATs acetylate histones
R-HSA-5689880 Ub-specific processing proteases

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional adapter 2-beta
Alternative name(s):
ADA2-like protein beta
Short name:
ADA2-beta
Gene namesi
Name:TADA2B
Synonyms:ADA2B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000173011.11
HGNCiHGNC:30781 TADA2B
MIMi608790 gene
neXtProtiNX_Q86TJ2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi93624
OpenTargetsiENSG00000173011
PharmGKBiPA165664556

Polymorphism and mutation databases

BioMutaiTADA2B
DMDMi166225686

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003137111 – 420Transcriptional adapter 2-betaAdd BLAST420

Proteomic databases

EPDiQ86TJ2
MaxQBiQ86TJ2
PaxDbiQ86TJ2
PeptideAtlasiQ86TJ2
PRIDEiQ86TJ2
ProteomicsDBi69705
69706 [Q86TJ2-2]
69707 [Q86TJ2-3]

PTM databases

iPTMnetiQ86TJ2
PhosphoSitePlusiQ86TJ2

Expressioni

Gene expression databases

BgeeiENSG00000173011 Expressed in 204 organ(s), highest expression level in amniotic fluid
ExpressionAtlasiQ86TJ2 baseline and differential
GenevisibleiQ86TJ2 HS

Organism-specific databases

HPAiHPA035770

Interactioni

Subunit structurei

Interacts with GCN5L2, SMARCA4, SMARCE1 and PAX5. Component of the TFTC-HAT complex.2 Publications

Protein-protein interaction databases

BioGridi125041, 23 interactors
ComplexPortaliCPX-900 SAGA complex
CORUMiQ86TJ2
IntActiQ86TJ2, 5 interactors
STRINGi9606.ENSP00000308022

Structurei

3D structure databases

ProteinModelPortaliQ86TJ2
SMRiQ86TJ2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini65 – 118SANTPROSITE-ProRule annotationAdd BLAST54

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri3 – 49ZZ-typePROSITE-ProRule annotationAdd BLAST47

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG0457 Eukaryota
COG5114 LUCA
GeneTreeiENSGT00530000063657
HOGENOMiHOG000007843
HOVERGENiHBG102016
InParanoidiQ86TJ2
KOiK15127
OMAiENMHKER
OrthoDBiEOG091G0CQZ
PhylomeDBiQ86TJ2
TreeFamiTF313975

Family and domain databases

CDDicd00167 SANT, 1 hit
InterProiView protein in InterPro
IPR016827 Ada2/TADA2
IPR009057 Homeobox-like_sf
IPR001005 SANT/Myb
IPR017884 SANT_dom
IPR000433 Znf_ZZ
PfamiView protein in Pfam
PF00249 Myb_DNA-binding, 1 hit
PIRSFiPIRSF025024 Transcriptional_adaptor_2, 1 hit
SMARTiView protein in SMART
SM00717 SANT, 1 hit
SM00291 ZnF_ZZ, 1 hit
SUPFAMiSSF46689 SSF46689, 2 hits
PROSITEiView protein in PROSITE
PS51293 SANT, 1 hit
PS01357 ZF_ZZ_1, 1 hit
PS50135 ZF_ZZ_2, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: Q86TJ2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAELGKKYCV YCLAEVSPLR FRCTECQDIE LCPECFSAGA EIGHHRRYHG
60 70 80 90 100
YQLVDGGRFT LWGPEAEGGW TSREEQLLLD AIEQFGFGNW EDMAAHVGAS
110 120 130 140 150
RTPQEVMEHY VSMYIHGNLG KACIPDTIPN RVTDHTCPSG GPLSPSLTTP
160 170 180 190 200
LPPLDISVAE QQQLGYMPLR DDYEIEYDQD AETLISGLSV NYDDDDVEIE
210 220 230 240 250
LKRAHVDMYV RKLKERQRRK NIARDYNLVP AFLGKDKKEK EKALKRKITK
260 270 280 290 300
EEKELRLKLR PLYQFMSCKE FDDLFENMHK EKMLRAKIRE LQRYRRNGIT
310 320 330 340 350
KMEESAEYEA ARHKREKRKE NKNLAGSKRG KEDGKDSEFA AIENLPGFEL
360 370 380 390 400
LSDREKVLCS SLNLSPARYV TVKTIIIKDH LQKRQGIPSK SRLPSYLDKV
410 420
LKKRILNFLT ESGWISRDAS
Length:420
Mass (Da):48,470
Last modified:January 15, 2008 - v2
Checksum:i89C3365128DF5EBC
GO
Isoform 2 (identifier: Q86TJ2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     16-90: Missing.

Note: No experimental confirmation available.
Show »
Length:345
Mass (Da):39,914
Checksum:iB4171B04BBBB32C9
GO
Isoform 3 (identifier: Q86TJ2-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-92: Missing.

Show »
Length:328
Mass (Da):37,967
Checksum:iBD6453E0703FE736
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RC20D6RC20_HUMAN
Transcriptional adapter 2-beta
TADA2B
121Annotation score:
D6RJ05D6RJ05_HUMAN
Transcriptional adapter 2-beta
TADA2B
129Annotation score:

Sequence cautioni

The sequence AAH47794 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAI01338 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti251E → K in CAE46064 (PubMed:17974005).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0301091 – 92Missing in isoform 3. 2 PublicationsAdd BLAST92
Alternative sequenceiVSP_03011016 – 90Missing in isoform 2. 1 PublicationAdd BLAST75

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK093974 mRNA Translation: BAG52792.1
AK096655 mRNA Translation: BAG53348.1
AC097382 Genomic DNA No translation available.
CH471131 Genomic DNA Translation: EAW82372.1
BC047794 mRNA Translation: AAH47794.1 Sequence problems.
BC101334 mRNA Translation: AAI01335.1
BC101335 mRNA Translation: AAI01336.1
BC101336 mRNA Translation: AAI01337.1
BC101337 mRNA Translation: AAI01338.1 Different initiation.
BX641147 mRNA Translation: CAE46064.1
CCDSiCCDS47007.1 [Q86TJ2-1]
RefSeqiNP_689506.2, NM_152293.2 [Q86TJ2-1]
XP_011511897.1, XM_011513595.1 [Q86TJ2-3]
UniGeneiHs.518614

Genome annotation databases

EnsembliENST00000310074; ENSP00000308022; ENSG00000173011 [Q86TJ2-1]
ENST00000512388; ENSP00000423947; ENSG00000173011 [Q86TJ2-2]
ENST00000515646; ENSP00000423181; ENSG00000173011 [Q86TJ2-3]
GeneIDi93624
KEGGihsa:93624
UCSCiuc003gjw.5 human [Q86TJ2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTAD2B_HUMAN
AccessioniPrimary (citable) accession number: Q86TJ2
Secondary accession number(s): A0AUJ8
, A4QMR7, B3KSN0, B3KU86, Q6MZG9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: September 12, 2018
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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