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Entry version 146 (17 Jun 2020)
Sequence version 3 (05 Oct 2010)
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Protein

WD repeat-containing protein 86

Gene

WDR86

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q86TI4

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
WD repeat-containing protein 86
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:WDR86
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000187260.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:28020 WDR86

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q86TI4

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000187260

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA145147619

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q86TI4 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
WDR86

Domain mapping of disease mutations (DMDM)

More...
DMDMi
308153536

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003206741 – 376WD repeat-containing protein 86Add BLAST376

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q86TI4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q86TI4

PeptideAtlas

More...
PeptideAtlasi
Q86TI4

PRoteomics IDEntifications database

More...
PRIDEi
Q86TI4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
12112
69702 [Q86TI4-3]
69703 [Q86TI4-1]
69704 [Q86TI4-2]
9331

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q86TI4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q86TI4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000187260 Expressed in right lobe of thyroid gland and 116 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q86TI4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q86TI4 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000187260 Tissue enhanced (thyroid)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
131548, 13 interactors

Protein interaction database and analysis system

More...
IntActi
Q86TI4, 13 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000419162

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q86TI4 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati13 – 52WD 1Add BLAST40
Repeati55 – 94WD 2Add BLAST40
Repeati95 – 132WD 3Add BLAST38
Repeati135 – 188WD 4Add BLAST54
Repeati191 – 232WD 5Add BLAST42
Repeati234 – 272WD 6Add BLAST39
Repeati274 – 310WD 7Add BLAST37
Repeati313 – 350WD 8Add BLAST38

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IQCU Eukaryota
ENOG410Z3TA LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161049

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000288_57_14_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q86TI4

Identification of Orthologs from Complete Genome Data

More...
OMAi
WPARGEE

Database of Orthologous Groups

More...
OrthoDBi
988404at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q86TI4

TreeFam database of animal gene trees

More...
TreeFami
TF338411

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR011047 Quinoprotein_ADH-like_supfam
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00400 WD40, 7 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00320 GPROTEINBRPT

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320 WD40, 8 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978 SSF50978, 1 hit
SSF50998 SSF50998, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 7 hits
PS50294 WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 3 (identifier: Q86TI4-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGGGGSALRV CADHRGGINW LSLSPDGQRL LTGSEDGTAR LWSTADGQCC
60 70 80 90 100
ALLQGHESYV TFCQLEDEAA FTCSADCTIR RWDVLTGQCL QVYRGHTSIV
110 120 130 140 150
NRILVANNQL FSSSYDRTAR VWSVDKGQMS REFRGHRNCV LTLAYSAPWD
160 170 180 190 200
LPSTPCAEEA AAGGLLVTGS TDGTAKVWQV ASGCCHQTLR GHTGAVLCLV
210 220 230 240 250
LDTPGHTAFT GSTDATIRAW DILSGEQLRV FREHRGSVIC LELVNRLVYS
260 270 280 290 300
GSADRTVKCW LADTGECVRT FTAHRRNVSA LKYHAGTLFT GSGDACARAF
310 320 330 340 350
DAQSGELRRV FRGHTFIINC IQVHGQVLYT ASHDGALRLW DVRGLRGAPR
360 370
PPPPMRSLSR LFSNKVGCAA APLQPA
Length:376
Mass (Da):40,731
Last modified:October 5, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1911439E465CAB15
GO
Isoform 1 (identifier: Q86TI4-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     54-54: Q → QGRPSHSLPD...PTYRRGNRLG

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:491
Mass (Da):53,068
Checksum:iD98E26A38D8DADBD
GO
Isoform 2 (identifier: Q86TI4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-128: Missing.
     243-376: LVNRLVYSGS...GCAAAPLQPA → CSRAAGTLAP...SPWGPPPFPF

Show »
Length:277
Mass (Da):29,044
Checksum:i8075771DA5DD9CC0
GO
Isoform 4 (identifier: Q86TI4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     243-376: LVNRLVYSGS...GCAAAPLQPA → RERSGGLQSC...RVAPVLPPHP

Show »
Length:482
Mass (Da):52,228
Checksum:i5AD731C71EB033EA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0C4DGX6A0A0C4DGX6_HUMAN
WD repeat-containing protein 86
WDR86
248Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAI07126 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti54Q → E in AAI07126 (PubMed:15489334).Curated1
Isoform 4 (identifier: Q86TI4-4)
Sequence conflicti182S → R in BAC86140 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_063633355M → T1 PublicationCorresponds to variant dbSNP:rs4141455Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0317251 – 128Missing in isoform 2. 1 PublicationAdd BLAST128
Alternative sequenceiVSP_03981854Q → QGRPSHSLPDLFAAAHRPQT ADPSSCARRPLSRSPAPAHP GTLAEERLSGPSIWLLSARQ GRVPCGLFVANCALLLAFPV DDSHSNNRRLLRASGAEKCA VVTLCYPTYRRGNRLG in isoform 1. 1 Publication1
Alternative sequenceiVSP_031726243 – 376LVNRL…PLQPA → CSRAAGTLAPGPSTRSLESC GGCSGATHSSSTASRCTARC STPPRTTAPCASGTCAGSEV PRGPLRPCAASRGSSATRWA APPRPCSRPDPAGPLQTPAQ TPSGSQSAPPCYPRWWRPMA GEGRGARKPGREESPSQASG FSLVARRRWERECSPWGPPP FPF in isoform 2. 1 PublicationAdd BLAST134
Alternative sequenceiVSP_054908243 – 376LVNRL…PLQPA → RERSGGLQSCPSCRPSLLLL AAGEPTRVLWQRGQDRQVLA GRHRGVCAHVHGPQTQRERP QVPRGHLVHGQRGRLRPGLR RAVWRAAEGVPGPHIHHQLH PGARPGALHRLARRRPAPLG RARAPRCPAAPSAHAQPLAA LQQQGGLRRRAPAAGLIPRG PCRRQPRHPAAPRAPRPATR GGGARWPARGEERGSPGGRR ARRRRLVFLWWPGGAGSGSA RPGDRPLFPFRVAPVLPPHP in isoform 4. 1 PublicationAdd BLAST134

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK125347 mRNA Translation: BAC86140.1
AK296049 mRNA Translation: BAG58813.1
AC005486 Genomic DNA No translation available.
AC005996 Genomic DNA No translation available.
CH471173 Genomic DNA Translation: EAW53997.1
BC047921 mRNA No translation available.
BC107125 mRNA Translation: AAI07126.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS5925.2 [Q86TI4-3]
CCDS64805.1 [Q86TI4-2]
CCDS64806.1 [Q86TI4-4]

NCBI Reference Sequences

More...
RefSeqi
NP_001271189.1, NM_001284260.1 [Q86TI4-4]
NP_001271190.1, NM_001284261.1 [Q86TI4-2]
NP_001271191.1, NM_001284262.1
NP_938026.2, NM_198285.2 [Q86TI4-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000334493; ENSP00000335522; ENSG00000187260 [Q86TI4-3]
ENST00000469830; ENSP00000419162; ENSG00000187260 [Q86TI4-4]
ENST00000477459; ENSP00000417512; ENSG00000187260 [Q86TI4-2]
ENST00000628331; ENSP00000486705; ENSG00000187260 [Q86TI4-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
349136

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:349136

UCSC genome browser

More...
UCSCi
uc003wkb.3 human [Q86TI4-3]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK125347 mRNA Translation: BAC86140.1
AK296049 mRNA Translation: BAG58813.1
AC005486 Genomic DNA No translation available.
AC005996 Genomic DNA No translation available.
CH471173 Genomic DNA Translation: EAW53997.1
BC047921 mRNA No translation available.
BC107125 mRNA Translation: AAI07126.1 Different initiation.
CCDSiCCDS5925.2 [Q86TI4-3]
CCDS64805.1 [Q86TI4-2]
CCDS64806.1 [Q86TI4-4]
RefSeqiNP_001271189.1, NM_001284260.1 [Q86TI4-4]
NP_001271190.1, NM_001284261.1 [Q86TI4-2]
NP_001271191.1, NM_001284262.1
NP_938026.2, NM_198285.2 [Q86TI4-3]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi131548, 13 interactors
IntActiQ86TI4, 13 interactors
STRINGi9606.ENSP00000419162

PTM databases

iPTMnetiQ86TI4
PhosphoSitePlusiQ86TI4

Polymorphism and mutation databases

BioMutaiWDR86
DMDMi308153536

Proteomic databases

jPOSTiQ86TI4
PaxDbiQ86TI4
PeptideAtlasiQ86TI4
PRIDEiQ86TI4
ProteomicsDBi12112
69702 [Q86TI4-3]
69703 [Q86TI4-1]
69704 [Q86TI4-2]
9331

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
18758 75 antibodies

Genome annotation databases

EnsembliENST00000334493; ENSP00000335522; ENSG00000187260 [Q86TI4-3]
ENST00000469830; ENSP00000419162; ENSG00000187260 [Q86TI4-4]
ENST00000477459; ENSP00000417512; ENSG00000187260 [Q86TI4-2]
ENST00000628331; ENSP00000486705; ENSG00000187260 [Q86TI4-2]
GeneIDi349136
KEGGihsa:349136
UCSCiuc003wkb.3 human [Q86TI4-3]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
349136
EuPathDBiHostDB:ENSG00000187260.15

GeneCards: human genes, protein and diseases

More...
GeneCardsi
WDR86
HGNCiHGNC:28020 WDR86
HPAiENSG00000187260 Tissue enhanced (thyroid)
neXtProtiNX_Q86TI4
OpenTargetsiENSG00000187260
PharmGKBiPA145147619

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IQCU Eukaryota
ENOG410Z3TA LUCA
GeneTreeiENSGT00940000161049
HOGENOMiCLU_000288_57_14_1
InParanoidiQ86TI4
OMAiWPARGEE
OrthoDBi988404at2759
PhylomeDBiQ86TI4
TreeFamiTF338411

Enzyme and pathway databases

SignaLinkiQ86TI4

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
349136 18 hits in 784 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
349136
PharosiQ86TI4 Tdark

Protein Ontology

More...
PROi
PR:Q86TI4
RNActiQ86TI4 protein

Gene expression databases

BgeeiENSG00000187260 Expressed in right lobe of thyroid gland and 116 other tissues
ExpressionAtlasiQ86TI4 baseline and differential
GenevisibleiQ86TI4 HS

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR011047 Quinoprotein_ADH-like_supfam
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 7 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 8 hits
SUPFAMiSSF50978 SSF50978, 1 hit
SSF50998 SSF50998, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 2 hits
PS50082 WD_REPEATS_2, 7 hits
PS50294 WD_REPEATS_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiWDR86_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86TI4
Secondary accession number(s): B4DJF1
, C9JAJ5, C9JXE3, Q3KNT1, Q6ZUS8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 5, 2010
Last modified: June 17, 2020
This is version 146 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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