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Protein

Retrotransposon-derived protein PEG10

Gene

PEG10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Prevents apoptosis in hepatocellular carcinoma (HCC) cells through interaction with SIAH1, a mediator of apoptosis. May also have a role in cell growth promotion and hepatoma formation. Inhibits the TGF-beta signaling by interacting with the TGF-beta receptor ALK1. When overexpressed, induces the formation of cellular extension, such as filipodia in association with ALK1. Involved at the immediate early stage of adipocyte differentiation (By similarity). May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter (By similarity).By similarity4 Publications

Miscellaneous

The PEG10 locus is imprinted, giving rise to paternally expressed proteins.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri293 – 310CCHC-typePROSITE-ProRule annotationAdd BLAST18

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processApoptosis, Differentiation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Retrotransposon-derived protein PEG10
Alternative name(s):
Embryonal carcinoma differentiation-regulated protein
Mammalian retrotransposon-derived protein 2
Myelin expression factor 3-like protein 1
Short name:
MEF3-like protein 1
Paternally expressed gene 10 protein
Retrotransposon gag domain-containing protein 3
Retrotransposon-derived gag-like polyprotein
Ty3/Gypsy-like protein
Gene namesi
Name:PEG10
Synonyms:EDR, KIAA1051, MAR2, MART2, MEF3L1, RGAG3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000242265.5
HGNCiHGNC:14005 PEG10
MIMi609810 gene
neXtProtiNX_Q86TG7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi370D → A: Inhibits proteolytic cleavage. 1 Publication1

Organism-specific databases

DisGeNETi23089
OpenTargetsiENSG00000242265
PharmGKBiPA33170

Polymorphism and mutation databases

BioMutaiPEG10
DMDMi172046699

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003230261 – 708Retrotransposon-derived protein PEG10Add BLAST708

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei507Omega-N-methylarginineBy similarity1
Modified residuei598Omega-N-methylarginineBy similarity1
Modified residuei611Omega-N-methylarginineBy similarity1
Isoform 2 (identifier: Q86TG7-2)
Modified residuei316PhosphoserineCombined sources1
Modified residuei321PhosphoserineCombined sources1

Post-translational modificationi

Isoform 1 undergoes proteolytic cleavage.1 Publication

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ86TG7
MaxQBiQ86TG7
PaxDbiQ86TG7
PeptideAtlasiQ86TG7
PRIDEiQ86TG7
ProteomicsDBi69693
69694 [Q86TG7-2]

PTM databases

iPTMnetiQ86TG7
PhosphoSitePlusiQ86TG7

Expressioni

Tissue specificityi

Expressed in the cytotrophoblast layer but not in the overlying syncytiotrophoblast of the placenta. Expressed in prostate and breast carcinomas but not in normal breast and prostate epithelial cells. Expressed in the Hep-G2 cell line (at protein level). Expressed in brain, liver, spleen, kidney, thymus, lung, ovary, testis, reactive lymph node, skeletal muscle, adipose tissue and placenta. Expressed in pancreatic and hepatocellular carcinomas (HCC).5 Publications

Developmental stagei

Expressed in placenta during the first trimester of gestation (at protein level). In placenta, down-regulated at early hypoxic phase, and highly activated at 11-12 week of gestation.2 Publications

Inductioni

Up-regulated by MYC and dihydrotestosterone (DHT).2 Publications

Gene expression databases

BgeeiENSG00000242265 Expressed in 217 organ(s), highest expression level in placenta
CleanExiHS_PEG10
ExpressionAtlasiQ86TG7 baseline and differential
GenevisibleiQ86TG7 HS

Organism-specific databases

HPAiHPA021324
HPA029915
HPA051038

Interactioni

Subunit structurei

Interacts with ALK1, SIAH1 and SIAH2.2 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi116717, 39 interactors
ELMiQ86TG7
IntActiQ86TG7, 23 interactors
MINTiQ86TG7
STRINGi9606.ENSP00000417587

Structurei

3D structure databases

ProteinModelPortaliQ86TG7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni76 – 275Necessary for interaction with ALK11 PublicationAdd BLAST200

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1 – 50Sequence analysisAdd BLAST50

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi682 – 703Pro-richAdd BLAST22

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri293 – 310CCHC-typePROSITE-ProRule annotationAdd BLAST18

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiENOG410J3P7 Eukaryota
ENOG410Y6K0 LUCA
GeneTreeiENSGT00880000138027
HOGENOMiHOG000169580
HOVERGENiHBG108242
InParanoidiQ86TG7
PhylomeDBiQ86TG7
TreeFamiTF335133

Family and domain databases

Gene3Di2.40.70.10, 1 hit
InterProiView protein in InterPro
IPR032549 DUF4939
IPR032567 LDOC1-rel
IPR021109 Peptidase_aspartic_dom_sf
IPR001878 Znf_CCHC
IPR036875 Znf_CCHC_sf
PANTHERiPTHR15503 PTHR15503, 1 hit
PfamiView protein in Pfam
PF16297 DUF4939, 1 hit
SUPFAMiSSF50630 SSF50630, 1 hit
SSF57756 SSF57756, 1 hit
PROSITEiView protein in PROSITE
PS50158 ZF_CCHC, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by ribosomal frameshifting. AlignAdd to basket
Note: The ribosomal frameshifting efficiency yield up to 66% of isoform 1 compared to isoform 2.1 Publication

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86TG7-1) [UniParc]FASTAAdd to basket
Also known as: RF1/RF2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTERRRDELS EEINNLREKV MKQSEENNNL QSQVQKLTEE NTTLREQVEP
60 70 80 90 100
TPEDEDDDIE LRGAAAAAAP PPPIEEECPE DLPEKFDGNP DMLAPFMAQC
110 120 130 140 150
QIFMEKSTRD FSVDRVRVCF VTSMMTGRAA RWASAKLERS HYLMHNYPAF
160 170 180 190 200
MMEMKHVFED PQRREVAKRK IRRLRQGMGS VIDYSNAFQM IAQDLDWNEP
210 220 230 240 250
ALIDQYHEGL SDHIQEELSH LEVAKSLSAL IGQCIHIERR LARAAAARKP
260 270 280 290 300
RSPPRALVLP HIASHHQVDP TEPVGGARMR LTQEEKERRR KLNLCLYCGT
310 320 330 340 350
GGHYADNCPA KASKSSPAGK LPGPAVEGPS ATGPEIIRSP QDDASSPHLQ
360 370 380 390 400
VMLQIHLPGR HTLFVRAMID SGASGNFIDH EYVAQNGIPL RIKDWPILVE
410 420 430 440 450
AIDGRPIASG PVVHETHDLI VDLGDHREVL SFDVTQSPFF PVVLGVRWLS
460 470 480 490 500
THDPNITWST RSIVFDSEYC RYHCRMYSPI PPSLPPPAPQ PPLYYPVDGY
510 520 530 540 550
RVYQPVRYYY VQNVYTPVDE HVYPDHRLVD PHIEMIPGAH SIPSGHVYSL
560 570 580 590 600
SEPEMAALRD FVARNVKDGL ITPTIAPNGA QVLQVKRGWK LQVSYDCRAP
610 620 630 640 650
NNFTIQNQYP RLSIPNLEDQ AHLATYTEFV PQIPGYQTYP TYAAYPTYPV
660 670 680 690 700
GFAWYPVGRD GQGRSLYVPV MITWNPHWYR QPPVPQYPPP QPPPPPPPPP

PPPSYSTL
Note: Produced by a -1 ribosomal frameshifting due to a slippery site occurring between the codons for Gly-319 and Lys-320.
Length:708
Mass (Da):80,173
Last modified:March 18, 2008 - v2
Checksum:iBFAA2FA24941D5D1
GO
Isoform 2 (identifier: Q86TG7-2) [UniParc]FASTAAdd to basket
Also known as: RF1

The sequence of this isoform differs from the canonical sequence as follows:
     320-325: KLPGPA → NSPAPL
     326-708: Missing.

Note: Produced by conventional translation.Combined sources
Show »
Length:325
Mass (Da):36,966
Checksum:i118E4CFAF97F2A76
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B4DSP0B4DSP0_HUMAN
HCG1642748, isoform CRA_b
PEG10 hCG_1642748
401Annotation score:
A0A087WX23A0A087WX23_HUMAN
Retrotransposon-derived protein PEG...
PEG10
783Annotation score:
A0A087WUL4A0A087WUL4_HUMAN
Retrotransposon-derived protein PEG...
PEG10
741Annotation score:
A0A087WZG9A0A087WZG9_HUMAN
Retrotransposon-derived protein PEG...
PEG10
359Annotation score:
A0A087WXK2A0A087WXK2_HUMAN
Retrotransposon-derived protein PEG...
PEG10
707Annotation score:
A0A087WYS2A0A087WYS2_HUMAN
Retrotransposon-derived protein PEG...
PEG10
31Annotation score:

Sequence cautioni

The sequence BAA83003 differs from that shown. Reason: Erroneous translation. Wrong choice of frame.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_032007320 – 325KLPGPA → NSPAPL in isoform 2. Curated6
Alternative sequenceiVSP_032008326 – 708Missing in isoform 2. CuratedAdd BLAST383

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049834 mRNA Translation: BAB43951.1
AB028974 mRNA Translation: BAA83003.2 Sequence problems.
AB049150 mRNA Translation: BAB68387.1
AC069292 Genomic DNA Translation: AAS07484.1
BC050659 mRNA Translation: AAH50659.1
CCDSiCCDS55126.1 [Q86TG7-2]
RefSeqiNP_001035242.1, NM_001040152.1 [Q86TG7-2]
NP_001171890.1, NM_001184961.1
NP_001171891.1, NM_001184962.1
NP_055883.2, NM_015068.3 [Q86TG7-1]
UniGeneiHs.147492

Genome annotation databases

EnsembliENST00000482108; ENSP00000417587; ENSG00000242265 [Q86TG7-2]
GeneIDi23089
KEGGihsa:23089
UCSCiuc064flv.1 human [Q86TG7-1]

Keywords - Coding sequence diversityi

Ribosomal frameshifting

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB049834 mRNA Translation: BAB43951.1
AB028974 mRNA Translation: BAA83003.2 Sequence problems.
AB049150 mRNA Translation: BAB68387.1
AC069292 Genomic DNA Translation: AAS07484.1
BC050659 mRNA Translation: AAH50659.1
CCDSiCCDS55126.1 [Q86TG7-2]
RefSeqiNP_001035242.1, NM_001040152.1 [Q86TG7-2]
NP_001171890.1, NM_001184961.1
NP_001171891.1, NM_001184962.1
NP_055883.2, NM_015068.3 [Q86TG7-1]
UniGeneiHs.147492

3D structure databases

ProteinModelPortaliQ86TG7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116717, 39 interactors
ELMiQ86TG7
IntActiQ86TG7, 23 interactors
MINTiQ86TG7
STRINGi9606.ENSP00000417587

PTM databases

iPTMnetiQ86TG7
PhosphoSitePlusiQ86TG7

Polymorphism and mutation databases

BioMutaiPEG10
DMDMi172046699

Proteomic databases

EPDiQ86TG7
MaxQBiQ86TG7
PaxDbiQ86TG7
PeptideAtlasiQ86TG7
PRIDEiQ86TG7
ProteomicsDBi69693
69694 [Q86TG7-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000482108; ENSP00000417587; ENSG00000242265 [Q86TG7-2]
GeneIDi23089
KEGGihsa:23089
UCSCiuc064flv.1 human [Q86TG7-1]

Organism-specific databases

CTDi23089
DisGeNETi23089
EuPathDBiHostDB:ENSG00000242265.5
GeneCardsiPEG10
HGNCiHGNC:14005 PEG10
HPAiHPA021324
HPA029915
HPA051038
MIMi609810 gene
neXtProtiNX_Q86TG7
OpenTargetsiENSG00000242265
PharmGKBiPA33170
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J3P7 Eukaryota
ENOG410Y6K0 LUCA
GeneTreeiENSGT00880000138027
HOGENOMiHOG000169580
HOVERGENiHBG108242
InParanoidiQ86TG7
PhylomeDBiQ86TG7
TreeFamiTF335133

Miscellaneous databases

ChiTaRSiPEG10 human
GeneWikiiPEG10
GenomeRNAii23089
PROiPR:Q86TG7
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000242265 Expressed in 217 organ(s), highest expression level in placenta
CleanExiHS_PEG10
ExpressionAtlasiQ86TG7 baseline and differential
GenevisibleiQ86TG7 HS

Family and domain databases

Gene3Di2.40.70.10, 1 hit
InterProiView protein in InterPro
IPR032549 DUF4939
IPR032567 LDOC1-rel
IPR021109 Peptidase_aspartic_dom_sf
IPR001878 Znf_CCHC
IPR036875 Znf_CCHC_sf
PANTHERiPTHR15503 PTHR15503, 1 hit
PfamiView protein in Pfam
PF16297 DUF4939, 1 hit
SUPFAMiSSF50630 SSF50630, 1 hit
SSF57756 SSF57756, 1 hit
PROSITEiView protein in PROSITE
PS50158 ZF_CCHC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPEG10_HUMAN
AccessioniPrimary (citable) accession number: Q86TG7
Secondary accession number(s): Q96A68, Q9UPV1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: March 18, 2008
Last modified: September 12, 2018
This is version 140 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome, Transposable element

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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