HOXC4

Functionⁱ

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	156 – 215	HomeoboxPROSITE-ProRule annotationAdd BLAST		60

GO - Molecular functionⁱ

DNA-binding transcription factor activity Source: InterPro
sequence-specific DNA binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

multicellular organism development Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Developmental proteinSAAS annotation, DNA-bindingPROSITE-ProRule annotationSAAS annotationImported

Molecular function

Developmental proteinSAAS annotation, DNA-bindingPROSITE-ProRule annotationSAAS annotationImported

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Homeobox C4Imported
Gene namesⁱ	Name:HOXC4Imported
Organismⁱ	Homo sapiens (Human)Imported
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Keywords - Cellular componentⁱ

NucleusPROSITE-ProRule annotationSAAS annotation

Pathology & Biotechⁱ

Organism-specific databases

PharmGKBⁱ	PA29401

PharmGKBⁱ

PA29401

PTM / Processingⁱ

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q86TF7
PeptideAtlas More...PeptideAtlasⁱ	Q86TF7

Expressionⁱ

Gene expression databases

Genevisibleⁱ	Q86TF7 HS

Genevisibleⁱ

Q86TF7 HS

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
NCK2	O43639	3	EBI-10185009,EBI-713635

With

Entry

#Exp.

IntAct

Notes

NCK2

O43639

3

EBI-10185009,EBI-713635

Protein-protein interaction databases

IntActⁱ	Q86TF7, 1 interactor

IntActⁱ

Q86TF7, 1 interactor

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q86TF7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	154 – 214	HomeoboxInterPro annotationAdd BLAST		61

Sequence similaritiesⁱ

Belongs to the Antp homeobox family.UniRule annotationSAAS annotation

Keywords - Domainⁱ

HomeoboxPROSITE-ProRule annotationSAAS annotationImported

Phylogenomic databases

eggNOGⁱ	KOG0489 Eukaryota ENOG410ZTBY LUCA
HOVERGENⁱ	HBG016849
KEGG Orthology (KO) More...KOⁱ	K09304

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00086 homeodomain, 1 hit
InterProⁱ	View protein in InterPro IPR009057 Homeobox-like_sf IPR017995 Homeobox_antennapedia IPR001827 Homeobox_Antennapedia_CS IPR017970 Homeobox_CS IPR001356 Homeobox_dom IPR020479 Homeobox_metazoa
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00046 Homeobox, 1 hit
PRINTSⁱ	PR00025 ANTENNAPEDIA PR00024 HOMEOBOX
SMARTⁱ	View protein in SMART SM00389 HOX, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit
PROSITEⁱ	View protein in PROSITE PS00032 ANTENNAPEDIA, 1 hit PS00027 HOMEOBOX_1, 1 hit PS50071 HOMEOBOX_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q86TF7-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MIMSSYLMDS NYIDPKFPPC EEYSQNSYIP EHSPEYYGRT RESGFQHHHQ 
        60         70         80         90        100
ELYPPPPPRP SYPERQYSCT SLQGPGNSRG HGPAQAGHHH PEKSQSLCEP 
       110        120        130        140        150
APLSGASASP SPAPPACSQP APDHPSSAAS KQPIVYPWMK KIHVSTVNPS 
       160        170        180        190        200
YNGGEPKRSR TAYTRQQVLE LEKEFHYNRY LTRRRRIEIA HSLCLSERQI 
       210        220        230        240        250
KIWFQNRRMK WKKDHRLPNT KVRSAPPAGA APSTLSAATP GTSEDHSQSA 
       260 
TPPEQQRAED ITRL

Length:264

Mass (Da):29,784

Last modified:June 1, 2003 - v1

Checksum:ⁱB1CD1A0B08C2F903

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC050442 mRNA Translation: AAH50442.1
NCBI Reference Sequences More...RefSeqⁱ	NP_055435.2, NM_014620.5 NP_705897.1, NM_153633.2
UniGeneⁱ	Hs.549040

Genome annotation databases

GeneIDⁱ	3221
KEGGⁱ	hsa:3221

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q86TF7	Homeobox protein Hox-C4		MOUSE		264	UniRef90_Q08624
Homeobox protein Hox-C4		TUPCH		270
Homeo box C4 (Mapped)		RAT		264
homeobox protein Hox-C4		MESAU		264
HOXC4 isoform 1		PONAB		264
+43

Protein	Similar proteins		Species	Score	Length	Source
Q86TF7	Homeobox protein Hox-C4		MOUSE		264	UniRef50_Q08624
Homeobox protein Hox-B4		CHICK		245
Homeobox protein Hox-C4a		DANRE		268
Homeobox protein Hox-C4a		TAKRU		264
Homeobox protein Hox-C4		ORYLA		261
+226

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC050442 mRNA Translation: AAH50442.1
RefSeqⁱ	NP_055435.2, NM_014620.5 NP_705897.1, NM_153633.2
UniGeneⁱ	Hs.549040

3D structure databases

ProteinModelPortalⁱ	Q86TF7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	Q86TF7, 1 interactor

IntActⁱ

Q86TF7, 1 interactor

Proteomic databases

MaxQBⁱ	Q86TF7
PeptideAtlasⁱ	Q86TF7

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	3221
Structural Biology Knowledgebase	Search...

Genome annotation databases

GeneIDⁱ	3221
KEGGⁱ	hsa:3221

Organism-specific databases

CTDⁱ	3221
PharmGKBⁱ	PA29401

Phylogenomic databases

eggNOGⁱ	KOG0489 Eukaryota ENOG410ZTBY LUCA
HOVERGENⁱ	HBG016849
KOⁱ	K09304

Miscellaneous databases

ChiTaRSⁱ	HOXC4 human
GenomeRNAiⁱ	3221

Gene expression databases

Genevisibleⁱ	Q86TF7 HS

Genevisibleⁱ

Q86TF7 HS

Family and domain databases

CDDⁱ	cd00086 homeodomain, 1 hit
InterProⁱ	View protein in InterPro IPR009057 Homeobox-like_sf IPR017995 Homeobox_antennapedia IPR001827 Homeobox_Antennapedia_CS IPR017970 Homeobox_CS IPR001356 Homeobox_dom IPR020479 Homeobox_metazoa
Pfamⁱ	View protein in Pfam PF00046 Homeobox, 1 hit
PRINTSⁱ	PR00025 ANTENNAPEDIA PR00024 HOMEOBOX
SMARTⁱ	View protein in SMART SM00389 HOX, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit
PROSITEⁱ	View protein in PROSITE PS00032 ANTENNAPEDIA, 1 hit PS00027 HOMEOBOX_1, 1 hit PS50071 HOMEOBOX_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q86TF7_HUMAN
Accessionⁱ	Q86TF7Primary (citable) accession number: Q86TF7
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	June 1, 2003
	Last sequence update:	June 1, 2003
	Last modified:	September 12, 2018
	This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Supporting data

UniProtKB - Q86TF7 (Q86TF7_HUMAN)

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Homeobox C4

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ