UniProtKB - Q86TF7 (Q86TF7_HUMAN)
Protein
Submitted name:
Homeobox C4
Gene
HOXC4
Organism
Homo sapiens (Human)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 156 – 215 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-UniRule
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: InterPro
GO - Biological processi
- multicellular organism development Source: UniProtKB-KW
Keywordsi
Molecular function | Developmental proteinARBA annotation, DNA-bindingPROSITE-ProRule annotationImportedARBA annotation |
Biological process | Transcription, Transcription regulationARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Homeobox C4Imported |
Gene namesi | Name:HOXC4Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Subcellular locationi
Keywords - Cellular componenti
NucleusPROSITE-ProRule annotationARBA annotationInteractioni
Binary interactionsi
Q86TF7
With | #Exp. | IntAct |
---|---|---|
NCK2 [O43639] | 3 | EBI-10185009,EBI-713635 |
Protein-protein interaction databases
IntActi | Q86TF7, 1 interactor |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 154 – 214 | HomeoboxInterPro annotationAdd BLAST | 61 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 19 – 130 | DisorderedSequence analysisAdd BLAST | 112 | |
Regioni | 214 – 264 | DisorderedSequence analysisAdd BLAST | 51 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 64 – 78 | PolarSequence analysisAdd BLAST | 15 | |
Compositional biasi | 107 – 121 | Pro-richSequence analysisAdd BLAST | 15 | |
Compositional biasi | 235 – 256 | PolarSequence analysisAdd BLAST | 22 |
Sequence similaritiesi
Belongs to the Antp homeobox family.UniRule annotation
Keywords - Domaini
HomeoboxPROSITE-ProRule annotationImportedARBA annotationPhylogenomic databases
OrthoDBi | 1154159at2759 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017995, Homeobox_antennapedia IPR001827, Homeobox_Antennapedia_CS IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
PRINTSi | PR00025, ANTENNAPEDIA PR00024, HOMEOBOX |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00032, ANTENNAPEDIA, 1 hit PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q86TF7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MIMSSYLMDS NYIDPKFPPC EEYSQNSYIP EHSPEYYGRT RESGFQHHHQ
60 70 80 90 100
ELYPPPPPRP SYPERQYSCT SLQGPGNSRG HGPAQAGHHH PEKSQSLCEP
110 120 130 140 150
APLSGASASP SPAPPACSQP APDHPSSAAS KQPIVYPWMK KIHVSTVNPS
160 170 180 190 200
YNGGEPKRSR TAYTRQQVLE LEKEFHYNRY LTRRRRIEIA HSLCLSERQI
210 220 230 240 250
KIWFQNRRMK WKKDHRLPNT KVRSAPPAGA APSTLSAATP GTSEDHSQSA
260
TPPEQQRAED ITRL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC050442 mRNA Translation: AAH50442.1 |
RefSeqi | NP_055435.2, NM_014620.5 NP_705897.1, NM_153633.2 |
Genome annotation databases
GeneIDi | 3221 |
KEGGi | hsa:3221 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC050442 mRNA Translation: AAH50442.1 |
RefSeqi | NP_055435.2, NM_014620.5 NP_705897.1, NM_153633.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | Q86TF7, 1 interactor |
Proteomic databases
MaxQBi | Q86TF7 |
PeptideAtlasi | Q86TF7 |
Protocols and materials databases
DNASUi | 3221 |
Genome annotation databases
GeneIDi | 3221 |
KEGGi | hsa:3221 |
Organism-specific databases
CTDi | 3221 |
PharmGKBi | PA29401 |
Phylogenomic databases
OrthoDBi | 1154159at2759 |
Miscellaneous databases
BioGRID-ORCSi | 3221, 14 hits in 891 CRISPR screens |
ChiTaRSi | HOXC4, human |
GenomeRNAii | 3221 |
Gene expression databases
Genevisiblei | Q86TF7, HS |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017995, Homeobox_antennapedia IPR001827, Homeobox_Antennapedia_CS IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
PRINTSi | PR00025, ANTENNAPEDIA PR00024, HOMEOBOX |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00032, ANTENNAPEDIA, 1 hit PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q86TF7_HUMAN | |
Accessioni | Q86TF7Primary (citable) accession number: Q86TF7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 1, 2003 |
Last sequence update: | June 1, 2003 | |
Last modified: | February 10, 2021 | |
This is version 151 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |