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Entry version 126 (17 Jun 2020)
Sequence version 2 (26 Feb 2008)
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Protein

Protein PAT1 homolog 1

Gene

PATL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs. Acts as a scaffold protein that connects deadenylation and decapping machinery. Required for cytoplasmic mRNA processing body (P-body) assembly. In case of infection, required for translation and replication of hepatitis C virus (HCV).5 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-430039 mRNA decay by 5' to 3' exoribonuclease

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein PAT1 homolog 1
Alternative name(s):
PAT1-like protein 1
Protein PAT1 homolog b
Short name:
Pat1b
Short name:
hPat1b
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PATL1
ORF Names:OK/KNS-cl.5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000166889.13

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26721 PATL1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
614660 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q86TB9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi86L → A: Loss of nuclear export; when associated with A-90, A-93 and A-95. 1 Publication1
Mutagenesisi90L → A: Loss of nuclear export; when associated with A-86, A-93 and A-95. 1 Publication1
Mutagenesisi93M → A: Loss of nuclear export; when associated with A-86, A-90 and A-95. 1 Publication1
Mutagenesisi95I → A: Loss of nuclear export; when associated with A-86, A-90 and A-93. 1 Publication1
Mutagenesisi519R → A in mut1; Abolishes RNA-binding, localization to P-body and interaction with the decapping machinery; when associated with A-520; A-591; A-595; A-625 and A-626. 1 Publication1
Mutagenesisi520R → A in mut1; Abolishes RNA-binding, localization to P-body and interaction with the decapping machinery; when associated with A-519; A-591; A-595; A-625 and A-626. 1 Publication1
Mutagenesisi523L → A in mut2; Abolishes interaction with the decapping machinery and localization to P-body; when associated with A-527; A-530 and S-534. 1 Publication1
Mutagenesisi527E → A in mut2; Abolishes interaction with the decapping machinery and localization to P-body; when associated with S-523; A-530 and S-534. 1 Publication1
Mutagenesisi530Y → A in mut2; Abolishes interaction with the decapping machinery and localization to P-body; when associated with S-523; A-527 and S-534. 1 Publication1
Mutagenesisi534L → S in mut2; Abolishes interaction with the decapping machinery and localization to P-body; when associated with S-523; A-527 and A-530. 1 Publication1
Mutagenesisi539 – 557YERRY…ALMDD → GSGSGSG in mut3; does not affect neither RNA-binding,interaction with the decapping machinery, nor localization to P-body. 1 PublicationAdd BLAST19
Mutagenesisi591R → A in mut1; Abolishes RNA-binding, localization to P-body and interaction with the decapping machinery; when associated with A-519; A-520; A-595; A-625 and A-626. 1 Publication1
Mutagenesisi595R → A in mut1; Abolishes RNA-binding, localization to P-body and interaction with the decapping machinery; when associated with A-519; A-520; A-591; A-625 and A-626. 1 Publication1
Mutagenesisi625K → A in mut1; Abolishes RNA-binding, localization to P-body and interaction with the decapping machinery; when associated with A-519; A-520; A-591; A-595 and A-626. 1 Publication1
Mutagenesisi626K → A in mut1; Abolishes RNA-binding, localization to P-body and interaction with the decapping machinery; when associated with A-519; A-520; A-591; A-595 and A-625. 1 Publication1

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000166889

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162398769

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q86TB9 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PATL1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
182705251

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003209631 – 770Protein PAT1 homolog 1Add BLAST770

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei177PhosphoserineCombined sources1
Modified residuei178PhosphothreonineBy similarity1
Modified residuei179PhosphoserineCombined sources1
Modified residuei184PhosphoserineCombined sources1
Modified residuei194PhosphothreonineCombined sources1
Modified residuei217Asymmetric dimethylarginineCombined sources1
Modified residuei223Asymmetric dimethylarginineCombined sources1
Modified residuei263Asymmetric dimethylarginineCombined sources1
Modified residuei278PhosphoserineCombined sources1
Modified residuei284Asymmetric dimethylarginineBy similarity1
Modified residuei385Omega-N-methylarginineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q86TB9

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q86TB9

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q86TB9

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q86TB9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q86TB9

PeptideAtlas

More...
PeptideAtlasi
Q86TB9

PRoteomics IDEntifications database

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PRIDEi
Q86TB9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
69679 [Q86TB9-1]
69680 [Q86TB9-2]
69681 [Q86TB9-3]
69682 [Q86TB9-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q86TB9

MetOSite database of methionine sulfoxide sites

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MetOSitei
Q86TB9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q86TB9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000166889 Expressed in skeletal muscle tissue and 195 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q86TB9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000166889 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via region A) with DDX6/RCK (PubMed:20584987, PubMed:31422817, PubMed:20543818).

Interacts (via region H and region C) with LSM1 and LSM4.

Interacts (via region N) with DCP1A, DCP2, EDC3, EDC4 and XRN1.

Interacts with the CCR4-NOT complex.

Interacts with the Lsm-containing SMN-Sm protein complex.

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
128613, 56 interactors

Protein interaction database and analysis system

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IntActi
Q86TB9, 25 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000300146

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q86TB9 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1770
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q86TB9

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q86TB9

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 397Involved in nuclear foci localizationAdd BLAST397
Regioni1 – 84Region A; interaction with DDX6/RCKAdd BLAST84
Regioni85 – 388Region N; interaction with decapping machineryAdd BLAST304
Regioni223 – 397Involved in RNA-bindingAdd BLAST175
Regioni389 – 448Region HAdd BLAST60
Regioni398 – 770Involved in nuclear spleckles localizationAdd BLAST373
Regioni449 – 770Region CAdd BLAST322

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi86 – 95Nuclear export signal10

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi155 – 338Pro-richAdd BLAST184

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The region A, also named N-term, mediates the interaction with DDX6/RCK and is required for cytoplasmic mRNA processing body assembly.
The region C, also named Pat-C, is required for RNA-binding and mediates the binding with the Lsm-containing SMN-Sm protein complex and the decapping machinery. It folds into an alpha-alpha superhelix, exposing conserved and basic residues on one side of the domain.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PAT1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4592 Eukaryota
ENOG4110Q9I LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00520000055649

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_009778_1_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q86TB9

KEGG Orthology (KO)

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KOi
K12617

Identification of Orthologs from Complete Genome Data

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OMAi
RVTILTM

Database of Orthologous Groups

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OrthoDBi
950451at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q86TB9

TreeFam database of animal gene trees

More...
TreeFami
TF323322

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR039900 Pat1-like
IPR019167 PAT1_dom

The PANTHER Classification System

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PANTHERi
PTHR21551 PTHR21551, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09770 PAT1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q86TB9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MFRYESLEDC PLDEDEDAFQ GLGEEDEEID QFNDDTFGSG AVDDDWQEAH
60 70 80 90 100
ERLAELEEKL PVAVNEQTGN GERDEMDLLG DHEENLAERL SKMVIENELE
110 120 130 140 150
DPAIMRAVQT RPVLQPQPGS LNSSIWDGSE VLRRIRGPLL AQEMPTVSVL
160 170 180 190 200
EYALPQRPPQ GPEDDRDLSE RALPRRSTSP IIGSPPVRAV PIGTPPKQMA
210 220 230 240 250
VPSFTQQILC PKPVHVRPPM PPRYPAPYGE RMSPNQLCSV PNSSLLGHPF
260 270 280 290 300
PPSVPPVLSP LQRAQLLGGA QLQPGRMSPS QFARVPGFVG SPLAAMNPKL
310 320 330 340 350
LQGRVGQMLP PAPGFRAFFS APPSATPPPQ QHPPGPGPHL QNLRSQAPMF
360 370 380 390 400
RPDTTHLHPQ HRRLLHQRQQ QNRSQHRNLN GAGDRGSHRS SHQDHLRKDP
410 420 430 440 450
YANLMLQREK DWVSKIQMMQ LQSTDPYLDD FYYQNYFEKL EKLSAAEEIQ
460 470 480 490 500
GDGPKKERTK LITPQVAKLE HAYKPVQFEG SLGKLTVSSV NNPRKMIDAV
510 520 530 540 550
VTSRSEDDET KEKQVRDKRR KTLVIIEKTY SLLLDVEDYE RRYLLSLEEE
560 570 580 590 600
RPALMDDRKH KICSMYDNLR GKLPGQERPS DDHFVQIMCI RKGKRMVARI
610 620 630 640 650
LPFLSTEQAA DILMTTARNL PFLIKKDAQD EVLPCLLSPF SLLLYHLPSV
660 670 680 690 700
SITSLLRQLM NLPQSAATPA LSNPHLTAVL QNKFGLSLLL ILLSRGEDLQ
710 720 730 740 750
SSDPATESTQ NNQWTEVMFM ATRELLRIPQ AALAKPISIP TNLVSLFSRY
760 770
VDRQKLNLLE TKLQLVQGIR
Length:770
Mass (Da):86,850
Last modified:February 26, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i65F7038C4AAC356B
GO
Isoform 2 (identifier: Q86TB9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-143: Missing.

Show »
Length:627
Mass (Da):70,639
Checksum:iDF1CAE822EF7C076
GO
Isoform 3 (identifier: Q86TB9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-659: Missing.

Show »
Length:111
Mass (Da):12,340
Checksum:i46794530E9E99090
GO
Isoform 4 (identifier: Q86TB9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     242-271: Missing.
     662-698: Missing.

Show »
Length:703
Mass (Da):79,908
Checksum:iA4FEE89882057391
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAD89916 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti160Q → H in BAG54601 (PubMed:14702039).Curated1
Sequence conflicti735K → R in BAC04305 (PubMed:14702039).Curated1
Sequence conflicti735K → R in CAD89916 (PubMed:17974005).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0317771 – 659Missing in isoform 3. 1 PublicationAdd BLAST659
Alternative sequenceiVSP_0317781 – 143Missing in isoform 2. 2 PublicationsAdd BLAST143
Alternative sequenceiVSP_040576242 – 271Missing in isoform 4. 1 PublicationAdd BLAST30
Alternative sequenceiVSP_040577662 – 698Missing in isoform 4. 1 PublicationAdd BLAST37

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AB065087 mRNA Translation: BAB93524.1
AK094193 mRNA Translation: BAC04305.1
AK127943 mRNA Translation: BAG54601.1
AL831992 mRNA Translation: CAD89916.1 Different initiation.
AP000442 Genomic DNA No translation available.
AP000640 Genomic DNA No translation available.
BC065264 mRNA Translation: AAH65264.2
BC109038 mRNA Translation: AAI09039.1
BC109039 mRNA Translation: AAI09040.1
BC111047 mRNA Translation: AAI11048.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS44613.1 [Q86TB9-1]

NCBI Reference Sequences

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RefSeqi
NP_689929.2, NM_152716.2 [Q86TB9-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000300146; ENSP00000300146; ENSG00000166889 [Q86TB9-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
219988

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:219988

UCSC genome browser

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UCSCi
uc001noe.6 human [Q86TB9-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB065087 mRNA Translation: BAB93524.1
AK094193 mRNA Translation: BAC04305.1
AK127943 mRNA Translation: BAG54601.1
AL831992 mRNA Translation: CAD89916.1 Different initiation.
AP000442 Genomic DNA No translation available.
AP000640 Genomic DNA No translation available.
BC065264 mRNA Translation: AAH65264.2
BC109038 mRNA Translation: AAI09039.1
BC109039 mRNA Translation: AAI09040.1
BC111047 mRNA Translation: AAI11048.1
CCDSiCCDS44613.1 [Q86TB9-1]
RefSeqiNP_689929.2, NM_152716.2 [Q86TB9-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2XEQX-ray3.10A/B/C/D517-767[»]
2XERX-ray2.95A/B/C517-767[»]
2XESX-ray2.10A/B517-767[»]
SMRiQ86TB9
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi128613, 56 interactors
IntActiQ86TB9, 25 interactors
STRINGi9606.ENSP00000300146

PTM databases

iPTMnetiQ86TB9
MetOSiteiQ86TB9
PhosphoSitePlusiQ86TB9

Polymorphism and mutation databases

BioMutaiPATL1
DMDMi182705251

Proteomic databases

EPDiQ86TB9
jPOSTiQ86TB9
MassIVEiQ86TB9
MaxQBiQ86TB9
PaxDbiQ86TB9
PeptideAtlasiQ86TB9
PRIDEiQ86TB9
ProteomicsDBi69679 [Q86TB9-1]
69680 [Q86TB9-2]
69681 [Q86TB9-3]
69682 [Q86TB9-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
49853 83 antibodies

The DNASU plasmid repository

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DNASUi
219988

Genome annotation databases

EnsembliENST00000300146; ENSP00000300146; ENSG00000166889 [Q86TB9-1]
GeneIDi219988
KEGGihsa:219988
UCSCiuc001noe.6 human [Q86TB9-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
219988
EuPathDBiHostDB:ENSG00000166889.13

GeneCards: human genes, protein and diseases

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GeneCardsi
PATL1
HGNCiHGNC:26721 PATL1
HPAiENSG00000166889 Low tissue specificity
MIMi614660 gene
neXtProtiNX_Q86TB9
OpenTargetsiENSG00000166889
PharmGKBiPA162398769

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4592 Eukaryota
ENOG4110Q9I LUCA
GeneTreeiENSGT00520000055649
HOGENOMiCLU_009778_1_0_1
InParanoidiQ86TB9
KOiK12617
OMAiRVTILTM
OrthoDBi950451at2759
PhylomeDBiQ86TB9
TreeFamiTF323322

Enzyme and pathway databases

ReactomeiR-HSA-430039 mRNA decay by 5' to 3' exoribonuclease

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
219988 6 hits in 798 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PATL1 human
EvolutionaryTraceiQ86TB9

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
219988
PharosiQ86TB9 Tbio

Protein Ontology

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PROi
PR:Q86TB9
RNActiQ86TB9 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000166889 Expressed in skeletal muscle tissue and 195 other tissues
GenevisibleiQ86TB9 HS

Family and domain databases

InterProiView protein in InterPro
IPR039900 Pat1-like
IPR019167 PAT1_dom
PANTHERiPTHR21551 PTHR21551, 1 hit
PfamiView protein in Pfam
PF09770 PAT1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPATL1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86TB9
Secondary accession number(s): B3KXT9
, Q2TA86, Q6P166, Q8N9M6, Q8NI63
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: June 17, 2020
This is version 126 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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