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UniProtKB - Q86TA1 (MOB3B_HUMAN)

Entry version 132 (16 Oct 2019)
Sequence version 2 (21 Dec 2004)
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Protein

MOB kinase activator 3B

Gene

MOB3B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Modulates LATS1 expression in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi82ZincBy similarity1
Metal bindingi87ZincBy similarity1
Metal bindingi164ZincBy similarity1
Metal bindingi169ZincBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
MOB kinase activator 3B
Alternative name(s):
Mob1 homolog 2b
Mps one binder kinase activator-like 2B
Short name:
MOB kinase activator-like 2B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MOB3BImported
Synonyms:C9orf35Imported, MOBKL2BImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:23825 MOB3B

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		617652 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q86TA1

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		79817

Open Targets

More...OpenTargetsi		ENSG00000120162

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134886513

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q86TA1

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		MOB3B

Domain mapping of disease mutations (DMDM)

More...DMDMi		56749334

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001935721 – 216MOB kinase activator 3BAdd BLAST216

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q86TA1

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q86TA1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q86TA1

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q86TA1

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q86TA1

PeptideAtlas

More...PeptideAtlasi		Q86TA1

PRoteomics IDEntifications database

More...PRIDEi		Q86TA1

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		69676

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q86TA1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q86TA1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Expression at transcriptional lelvel is activated by the expression of the neighboring long non-coding RNA (lncRNA) EMICERI.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000120162 Expressed in 208 organ(s), highest expression level in caudate nucleus

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q86TA1 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA057744

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
NT5C2P499023EBI-751703,EBI-742084

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		122912, 8 interactors

Protein interaction database and analysis system

More...IntActi		Q86TA1, 3 interactors

Molecular INTeraction database

More...MINTi		Q86TA1

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000262244

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q86TA1

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MOB1/phocein family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1903 Eukaryota
ENOG410XSM4 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00950000182681

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000164685

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q86TA1

Identification of Orthologs from Complete Genome Data

More...OMAi		CDSASCP

Database of Orthologous Groups

More...OrthoDBi		1127941at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q86TA1

TreeFam database of animal gene trees

More...TreeFami		TF300789

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.140.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR005301 MOB_kinase_act_fam
IPR036703 MOB_kinase_act_sf

The PANTHER Classification System

More...PANTHERi		PTHR22599 PTHR22599, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03637 Mob1_phocein, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01388 Mob1_phocein, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF101152 SSF101152, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q86TA1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSIALKQVFN KDKTFRPKRK FEPGTQRFEL HKRAQASLNS GVDLKAAVQL 
        60         70         80         90        100
PSGEDQNDWV AVHVVDFFNR INLIYGTICE FCTERTCPVM SGGPKYEYRW 
       110        120        130        140        150
QDDLKYKKPT ALPAPQYMNL LMDWIEVQIN NEEIFPTCVG VPFPKNFLQI 
       160        170        180        190        200
CKKILCRLFR VFVHVYIHHF DRVIVMGAEA HVNTCYKHFY YFVTEMNLID 
       210 
RKELEPLKEM TSRMCH
Length:216
Mass (Da):25,464
Last modified:December 21, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i377F1FA8096103FC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti67F → L in CAD89934 (PubMed:17974005).Curated1
Sequence conflicti152K → M in AAH33027 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AJ580636 mRNA Translation: CAE45268.1
AL832572 mRNA Translation: CAD89934.1
AK023266 mRNA Translation: BAB14497.1
CR457307 mRNA Translation: CAG33588.1
BC033027 mRNA Translation: AAH33027.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS6520.1

NCBI Reference Sequences

More...RefSeqi		NP_079037.3, NM_024761.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000262244; ENSP00000262244; ENSG00000120162

Database of genes from NCBI RefSeq genomes

More...GeneIDi		79817

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:79817

UCSC genome browser

More...UCSCi		uc003zqn.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ580636 mRNA Translation: CAE45268.1
AL832572 mRNA Translation: CAD89934.1
AK023266 mRNA Translation: BAB14497.1
CR457307 mRNA Translation: CAG33588.1
BC033027 mRNA Translation: AAH33027.1
CCDSiCCDS6520.1
RefSeqiNP_079037.3, NM_024761.4

3D structure databases

SMRiQ86TA1
ModBaseiSearch...

Protein-protein interaction databases

BioGridi122912, 8 interactors
IntActiQ86TA1, 3 interactors
MINTiQ86TA1
STRINGi9606.ENSP00000262244

PTM databases

iPTMnetiQ86TA1
PhosphoSitePlusiQ86TA1

Polymorphism and mutation databases

BioMutaiMOB3B
DMDMi56749334

Proteomic databases

EPDiQ86TA1
jPOSTiQ86TA1
MassIVEiQ86TA1
MaxQBiQ86TA1
PaxDbiQ86TA1
PeptideAtlasiQ86TA1
PRIDEiQ86TA1
ProteomicsDBi69676

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		79817

Genome annotation databases

EnsembliENST00000262244; ENSP00000262244; ENSG00000120162
GeneIDi79817
KEGGihsa:79817
UCSCiuc003zqn.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		79817
DisGeNETi79817

GeneCards: human genes, protein and diseases

More...GeneCardsi		MOB3B
HGNCiHGNC:23825 MOB3B
HPAiHPA057744
MIMi617652 gene
neXtProtiNX_Q86TA1
OpenTargetsiENSG00000120162
PharmGKBiPA134886513

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1903 Eukaryota
ENOG410XSM4 LUCA
GeneTreeiENSGT00950000182681
HOGENOMiHOG000164685
InParanoidiQ86TA1
OMAiCDSASCP
OrthoDBi1127941at2759
PhylomeDBiQ86TA1
TreeFamiTF300789

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		MOB3B human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		79817
PharosiQ86TA1

Protein Ontology

More...PROi		PR:Q86TA1

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000120162 Expressed in 208 organ(s), highest expression level in caudate nucleus
GenevisibleiQ86TA1 HS

Family and domain databases

Gene3Di1.20.140.30, 1 hit
InterProiView protein in InterPro
IPR005301 MOB_kinase_act_fam
IPR036703 MOB_kinase_act_sf
PANTHERiPTHR22599 PTHR22599, 1 hit
PfamiView protein in Pfam
PF03637 Mob1_phocein, 1 hit
SMARTiView protein in SMART
SM01388 Mob1_phocein, 1 hit
SUPFAMiSSF101152 SSF101152, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMOB3B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86TA1
Secondary accession number(s): Q8NEB4, Q9H8V4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: December 21, 2004
Last modified: October 16, 2019
This is version 132 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
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