UniProtKB - Q86TA1 (MOB3B_HUMAN)
Protein
MOB kinase activator 3B
Gene
MOB3B
Organism
Homo sapiens (Human)
Status
Functioni
Modulates LATS1 expression in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 82 | ZincBy similarity | 1 | |
Metal bindingi | 87 | ZincBy similarity | 1 | |
Metal bindingi | 164 | ZincBy similarity | 1 | |
Metal bindingi | 169 | ZincBy similarity | 1 |
GO - Molecular functioni
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- regulation of hippo signaling Source: UniProtKB
Keywordsi
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q86TA1 |
Names & Taxonomyi
Protein namesi | Recommended name: MOB kinase activator 3BAlternative name(s): Mob1 homolog 2b Mps one binder kinase activator-like 2B Short name: MOB kinase activator-like 2B |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:23825, MOB3B |
MIMi | 617652, gene |
neXtProti | NX_Q86TA1 |
VEuPathDBi | HostDB:ENSG00000120162.9 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 79817 |
OpenTargetsi | ENSG00000120162 |
PharmGKBi | PA134886513 |
Miscellaneous databases
Pharosi | Q86TA1, Tbio |
Genetic variation databases
BioMutai | MOB3B |
DMDMi | 56749334 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000193572 | 1 – 216 | MOB kinase activator 3BAdd BLAST | 216 |
Proteomic databases
EPDi | Q86TA1 |
jPOSTi | Q86TA1 |
MassIVEi | Q86TA1 |
MaxQBi | Q86TA1 |
PaxDbi | Q86TA1 |
PeptideAtlasi | Q86TA1 |
PRIDEi | Q86TA1 |
ProteomicsDBi | 69676 |
PTM databases
iPTMneti | Q86TA1 |
PhosphoSitePlusi | Q86TA1 |
Expressioni
Inductioni
Expression at transcriptional level is activated by the expression of the neighboring long non-coding RNA (lncRNA) EMICERI.1 Publication
Gene expression databases
Bgeei | ENSG00000120162, Expressed in caudate nucleus and 223 other tissues |
Genevisiblei | Q86TA1, HS |
Organism-specific databases
HPAi | ENSG00000120162, Tissue enhanced (brain, ovary) |
Interactioni
Binary interactionsi
Hide detailsProtein-protein interaction databases
BioGRIDi | 122912, 9 interactors |
IntActi | Q86TA1, 4 interactors |
MINTi | Q86TA1 |
STRINGi | 9606.ENSP00000262244 |
Miscellaneous databases
RNActi | Q86TA1, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the MOB1/phocein family.Curated
Phylogenomic databases
eggNOGi | KOG1903, Eukaryota |
GeneTreei | ENSGT01000000214552 |
HOGENOMi | CLU_038321_3_0_1 |
InParanoidi | Q86TA1 |
OMAi | YKKPTPL |
OrthoDBi | 1127941at2759 |
PhylomeDBi | Q86TA1 |
TreeFami | TF300789 |
Family and domain databases
Gene3Di | 1.20.140.30, 1 hit |
InterProi | View protein in InterPro IPR005301, MOB_kinase_act_fam IPR036703, MOB_kinase_act_sf |
PANTHERi | PTHR22599, PTHR22599, 1 hit |
Pfami | View protein in Pfam PF03637, Mob1_phocein, 1 hit |
SMARTi | View protein in SMART SM01388, Mob1_phocein, 1 hit |
SUPFAMi | SSF101152, SSF101152, 1 hit |
i Sequence
Sequence statusi: Complete.
Q86TA1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSIALKQVFN KDKTFRPKRK FEPGTQRFEL HKRAQASLNS GVDLKAAVQL
60 70 80 90 100
PSGEDQNDWV AVHVVDFFNR INLIYGTICE FCTERTCPVM SGGPKYEYRW
110 120 130 140 150
QDDLKYKKPT ALPAPQYMNL LMDWIEVQIN NEEIFPTCVG VPFPKNFLQI
160 170 180 190 200
CKKILCRLFR VFVHVYIHHF DRVIVMGAEA HVNTCYKHFY YFVTEMNLID
210
RKELEPLKEM TSRMCH
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 67 | F → L in CAD89934 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 152 | K → M in AAH33027 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ580636 mRNA Translation: CAE45268.1 AL832572 mRNA Translation: CAD89934.1 AK023266 mRNA Translation: BAB14497.1 CR457307 mRNA Translation: CAG33588.1 BC033027 mRNA Translation: AAH33027.1 |
CCDSi | CCDS6520.1 |
RefSeqi | NP_079037.3, NM_024761.4 |
Genome annotation databases
Ensembli | ENST00000262244; ENSP00000262244; ENSG00000120162 |
GeneIDi | 79817 |
KEGGi | hsa:79817 |
UCSCi | uc003zqn.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ580636 mRNA Translation: CAE45268.1 AL832572 mRNA Translation: CAD89934.1 AK023266 mRNA Translation: BAB14497.1 CR457307 mRNA Translation: CAG33588.1 BC033027 mRNA Translation: AAH33027.1 |
CCDSi | CCDS6520.1 |
RefSeqi | NP_079037.3, NM_024761.4 |
3D structure databases
SMRi | Q86TA1 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 122912, 9 interactors |
IntActi | Q86TA1, 4 interactors |
MINTi | Q86TA1 |
STRINGi | 9606.ENSP00000262244 |
PTM databases
iPTMneti | Q86TA1 |
PhosphoSitePlusi | Q86TA1 |
Genetic variation databases
BioMutai | MOB3B |
DMDMi | 56749334 |
Proteomic databases
EPDi | Q86TA1 |
jPOSTi | Q86TA1 |
MassIVEi | Q86TA1 |
MaxQBi | Q86TA1 |
PaxDbi | Q86TA1 |
PeptideAtlasi | Q86TA1 |
PRIDEi | Q86TA1 |
ProteomicsDBi | 69676 |
Protocols and materials databases
Antibodypediai | 56611, 284 antibodies |
DNASUi | 79817 |
Genome annotation databases
Ensembli | ENST00000262244; ENSP00000262244; ENSG00000120162 |
GeneIDi | 79817 |
KEGGi | hsa:79817 |
UCSCi | uc003zqn.4, human |
Organism-specific databases
CTDi | 79817 |
DisGeNETi | 79817 |
GeneCardsi | MOB3B |
HGNCi | HGNC:23825, MOB3B |
HPAi | ENSG00000120162, Tissue enhanced (brain, ovary) |
MIMi | 617652, gene |
neXtProti | NX_Q86TA1 |
OpenTargetsi | ENSG00000120162 |
PharmGKBi | PA134886513 |
VEuPathDBi | HostDB:ENSG00000120162.9 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1903, Eukaryota |
GeneTreei | ENSGT01000000214552 |
HOGENOMi | CLU_038321_3_0_1 |
InParanoidi | Q86TA1 |
OMAi | YKKPTPL |
OrthoDBi | 1127941at2759 |
PhylomeDBi | Q86TA1 |
TreeFami | TF300789 |
Enzyme and pathway databases
PathwayCommonsi | Q86TA1 |
Miscellaneous databases
BioGRID-ORCSi | 79817, 4 hits in 994 CRISPR screens |
ChiTaRSi | MOB3B, human |
GenomeRNAii | 79817 |
Pharosi | Q86TA1, Tbio |
PROi | PR:Q86TA1 |
RNActi | Q86TA1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000120162, Expressed in caudate nucleus and 223 other tissues |
Genevisiblei | Q86TA1, HS |
Family and domain databases
Gene3Di | 1.20.140.30, 1 hit |
InterProi | View protein in InterPro IPR005301, MOB_kinase_act_fam IPR036703, MOB_kinase_act_sf |
PANTHERi | PTHR22599, PTHR22599, 1 hit |
Pfami | View protein in Pfam PF03637, Mob1_phocein, 1 hit |
SMARTi | View protein in SMART SM01388, Mob1_phocein, 1 hit |
SUPFAMi | SSF101152, SSF101152, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MOB3B_HUMAN | |
Accessioni | Q86TA1Primary (citable) accession number: Q86TA1 Secondary accession number(s): Q8NEB4, Q9H8V4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 21, 2004 |
Last sequence update: | December 21, 2004 | |
Last modified: | April 7, 2021 | |
This is version 142 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families