UniProtKB - Q86T13 (CLC14_HUMAN)
Protein
C-type lectin domain family 14 member A
Gene
CLEC14A
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- carbohydrate binding Source: UniProtKB-KW
- extracellular matrix binding Source: GO_Central
- extracellular matrix protein binding Source: MGI
GO - Biological processi
- cell migration Source: GO_Central
- cell migration involved in sprouting angiogenesis Source: Ensembl
Keywordsi
Ligand | Lectin |
Names & Taxonomyi
Protein namesi | Recommended name: C-type lectin domain family 14 member AAlternative name(s): Epidermal growth factor receptor 5 Short name: EGFR-5 |
Gene namesi | Name:CLEC14A Synonyms:C14orf27, EGFR5 ORF Names:UNQ236/PRO269 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:19832 CLEC14A |
neXtProti | NX_Q86T13 |
Subcellular locationi
Other locations
- Membrane Curated; Single-pass type I membrane protein Curated
Extracellular region or secreted
- collagen-containing extracellular matrix Source: BHF-UCL
Plasma Membrane
- external side of plasma membrane Source: MGI
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 22 – 397 | ExtracellularSequence analysisAdd BLAST | 376 | |
Transmembranei | 398 – 418 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 419 – 490 | CytoplasmicSequence analysisAdd BLAST | 72 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 161198 |
OpenTargetsi | ENSG00000176435 |
PharmGKBi | PA134890576 |
Miscellaneous databases
Pharosi | Q86T13 |
Chemistry databases
DrugBanki | DB02709 Resveratrol |
Polymorphism and mutation databases
BioMutai | CLEC14A |
DMDMi | 34582300 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | 1 PublicationAdd BLAST | 21 | |
ChainiPRO_0000017377 | 22 – 490 | C-type lectin domain family 14 member AAdd BLAST | 469 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 143 ↔ 162 | PROSITE-ProRule annotation | ||
Glycosylationi | 189 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 381 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
jPOSTi | Q86T13 |
MassIVEi | Q86T13 |
PaxDbi | Q86T13 |
PeptideAtlasi | Q86T13 |
PRIDEi | Q86T13 |
ProteomicsDBi | 69656 |
PTM databases
iPTMneti | Q86T13 |
PhosphoSitePlusi | Q86T13 |
SwissPalmi | Q86T13 |
Expressioni
Gene expression databases
Bgeei | ENSG00000176435 Expressed in 197 organ(s), highest expression level in right lung |
Genevisiblei | Q86T13 HS |
Organism-specific databases
HPAi | HPA039468 HPA048119 |
Interactioni
GO - Molecular functioni
- extracellular matrix protein binding Source: MGI
Protein-protein interaction databases
BioGridi | 127776, 54 interactors |
IntActi | Q86T13, 17 interactors |
STRINGi | 9606.ENSP00000353013 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 33 – 173 | C-type lectinPROSITE-ProRule annotationAdd BLAST | 141 | |
Domaini | 245 – 287 | EGF-likeAdd BLAST | 43 |
Keywords - Domaini
EGF-like domain, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG410IGD4 Eukaryota ENOG41119V9 LUCA |
GeneTreei | ENSGT00930000151088 |
HOGENOMi | HOG000111782 |
InParanoidi | Q86T13 |
KOi | K17528 |
OMAi | CLLWQAL |
OrthoDBi | 747312at2759 |
PhylomeDBi | Q86T13 |
TreeFami | TF330714 |
Family and domain databases
Gene3Di | 3.10.100.10, 1 hit |
InterProi | View protein in InterPro IPR001304 C-type_lectin-like IPR016186 C-type_lectin-like/link_sf IPR016187 CTDL_fold |
SMARTi | View protein in SMART SM00034 CLECT, 1 hit |
SUPFAMi | SSF56436 SSF56436, 1 hit |
PROSITEi | View protein in PROSITE PS00010 ASX_HYDROXYL, 1 hit PS50041 C_TYPE_LECTIN_2, 1 hit PS01186 EGF_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q86T13-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRPAFALCLL WQALWPGPGG GEHPTADRAG CSASGACYSL HHATMKRQAA
60 70 80 90 100
EEACILRGGA LSTVRAGAEL RAVLALLRAG PGPGGGSKDL LFWVALERRR
110 120 130 140 150
SHCTLENEPL RGFSWLSSDP GGLESDTLQW VEEPQRSCTA RRCAVLQATG
160 170 180 190 200
GVEPAGWKEM RCHLRANGYL CKYQFEVLCP APRPGAASNL SYRAPFQLHS
210 220 230 240 250
AALDFSPPGT EVSALCRGQL PISVTCIADE IGARWDKLSG DVLCPCPGRY
260 270 280 290 300
LRAGKCAELP NCLDDLGGFA CECATGFELG KDGRSCVTSG EGQPTLGGTG
310 320 330 340 350
VPTRRPPATA TSPVPQRTWP IRVDEKLGET PLVPEQDNSV TSIPEIPRWG
360 370 380 390 400
SQSTMSTLQM SLQAESKATI TPSGSVISKF NSTTSSATPQ AFDSSSAVVF
410 420 430 440 450
IFVSTAVVVL VILTMTVLGL VKLCFHESPS SQPRKESMGP PGLESDPEPA
460 470 480 490
ALGSSSAHCT NNGVKVGDCD LRDRAEGALL AESPLGSSDA
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 432 | Q → H in AAS77882 (PubMed:15636369).Curated | 1 | |
Sequence conflicti | 437 | S → F in AAS77882 (PubMed:15636369).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY573061 mRNA Translation: AAS77882.1 AY606132 mRNA Translation: AAT92280.1 BX248017 mRNA Translation: CAD62342.1 AY358395 mRNA Translation: AAQ88761.1 AL161751 Genomic DNA No translation available. BC031567 mRNA Translation: AAH31567.2 |
CCDSi | CCDS9667.1 |
RefSeqi | NP_778230.1, NM_175060.2 |
Genome annotation databases
Ensembli | ENST00000342213; ENSP00000353013; ENSG00000176435 |
GeneIDi | 161198 |
KEGGi | hsa:161198 |
UCSCi | uc001wum.3 human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY573061 mRNA Translation: AAS77882.1 AY606132 mRNA Translation: AAT92280.1 BX248017 mRNA Translation: CAD62342.1 AY358395 mRNA Translation: AAQ88761.1 AL161751 Genomic DNA No translation available. BC031567 mRNA Translation: AAH31567.2 |
CCDSi | CCDS9667.1 |
RefSeqi | NP_778230.1, NM_175060.2 |
3D structure databases
SMRi | Q86T13 |
ModBasei | Search... |
Protein-protein interaction databases
BioGridi | 127776, 54 interactors |
IntActi | Q86T13, 17 interactors |
STRINGi | 9606.ENSP00000353013 |
Chemistry databases
DrugBanki | DB02709 Resveratrol |
PTM databases
iPTMneti | Q86T13 |
PhosphoSitePlusi | Q86T13 |
SwissPalmi | Q86T13 |
Polymorphism and mutation databases
BioMutai | CLEC14A |
DMDMi | 34582300 |
Proteomic databases
jPOSTi | Q86T13 |
MassIVEi | Q86T13 |
PaxDbi | Q86T13 |
PeptideAtlasi | Q86T13 |
PRIDEi | Q86T13 |
ProteomicsDBi | 69656 |
Genome annotation databases
Ensembli | ENST00000342213; ENSP00000353013; ENSG00000176435 |
GeneIDi | 161198 |
KEGGi | hsa:161198 |
UCSCi | uc001wum.3 human |
Organism-specific databases
CTDi | 161198 |
DisGeNETi | 161198 |
GeneCardsi | CLEC14A |
HGNCi | HGNC:19832 CLEC14A |
HPAi | HPA039468 HPA048119 |
neXtProti | NX_Q86T13 |
OpenTargetsi | ENSG00000176435 |
PharmGKBi | PA134890576 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG410IGD4 Eukaryota ENOG41119V9 LUCA |
GeneTreei | ENSGT00930000151088 |
HOGENOMi | HOG000111782 |
InParanoidi | Q86T13 |
KOi | K17528 |
OMAi | CLLWQAL |
OrthoDBi | 747312at2759 |
PhylomeDBi | Q86T13 |
TreeFami | TF330714 |
Miscellaneous databases
ChiTaRSi | CLEC14A human |
GenomeRNAii | 161198 |
Pharosi | Q86T13 |
PROi | PR:Q86T13 |
Gene expression databases
Bgeei | ENSG00000176435 Expressed in 197 organ(s), highest expression level in right lung |
Genevisiblei | Q86T13 HS |
Family and domain databases
Gene3Di | 3.10.100.10, 1 hit |
InterProi | View protein in InterPro IPR001304 C-type_lectin-like IPR016186 C-type_lectin-like/link_sf IPR016187 CTDL_fold |
SMARTi | View protein in SMART SM00034 CLECT, 1 hit |
SUPFAMi | SSF56436 SSF56436, 1 hit |
PROSITEi | View protein in PROSITE PS00010 ASX_HYDROXYL, 1 hit PS50041 C_TYPE_LECTIN_2, 1 hit PS01186 EGF_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CLC14_HUMAN | |
Accessioni | Q86T13Primary (citable) accession number: Q86T13 Secondary accession number(s): Q695G9, Q6PWT6, Q8N5V5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 9, 2003 |
Last sequence update: | June 1, 2003 | |
Last modified: | October 16, 2019 | |
This is version 145 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM