CLEC14A

Functionⁱ

GO - Molecular functionⁱ

carbohydrate binding Source: UniProtKB-KW
extracellular matrix protein binding
Source: MGI
Inferred from direct assayⁱ
- 25745997

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell migration involved in sprouting angiogenesis Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	Lectin

Ligand

Lectin

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: C-type lectin domain family 14 member A Alternative name(s): Epidermal growth factor receptor 5 Short name: EGFR-5
Gene namesⁱ	Name:CLEC14A Synonyms:C14orf27, EGFR5 ORF Names:UNQ236/PRO269
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 14

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000176435.6
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:19832 CLEC14A
neXtProtⁱ	NX_Q86T13

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	22 – 397	ExtracellularSequence analysisAdd BLAST	376
Transmembraneⁱ	398 – 418	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	419 – 490	CytoplasmicSequence analysisAdd BLAST	72

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	161198
Open Targets More...OpenTargetsⁱ	ENSG00000176435
PharmGKBⁱ	PA134890576

Polymorphism and mutation databases

BioMutaⁱ	CLEC14A
DMDMⁱ	34582300

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 21	1 PublicationAdd BLAST		21
ChainⁱPRO_0000017377	22 – 490	C-type lectin domain family 14 member AAdd BLAST		469

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	143 ↔ 162	PROSITE-ProRule annotation
Glycosylationⁱ	189	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	381	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	Q86T13
PeptideAtlas More...PeptideAtlasⁱ	Q86T13
PRIDEⁱ	Q86T13
ProteomicsDBⁱ	69656

PTM databases

iPTMnetⁱ	Q86T13
PhosphoSitePlusⁱ	Q86T13
SwissPalmⁱ	Q86T13

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000176435
CleanExⁱ	HS_CLEC14A
Genevisibleⁱ	Q86T13 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA039468 HPA048119

HPAⁱ

HPA039468
HPA048119

Interactionⁱ

GO - Molecular functionⁱ

extracellular matrix protein binding
Source: MGI
Inferred from direct assayⁱ
- 25745997

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	127776, 5 interactors
IntActⁱ	Q86T13, 12 interactors
STRINGⁱ	9606.ENSP00000353013

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q86T13
SMRⁱ	Q86T13
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	33 – 173	C-type lectinPROSITE-ProRule annotationAdd BLAST		141
Domainⁱ	245 – 287	EGF-likeAdd BLAST		43

Keywords - Domainⁱ

EGF-like domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IGD4 Eukaryota ENOG41119V9 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00920000148956
HOGENOMⁱ	HOG000111782
HOVERGENⁱ	HBG051004
InParanoidⁱ	Q86T13
KEGG Orthology (KO) More...KOⁱ	K17528
OMAⁱ	CYSLHHA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0O44
PhylomeDBⁱ	Q86T13
TreeFamⁱ	TF330714

Family and domain databases

Gene3Dⁱ	3.10.100.10, 1 hit
InterProⁱ	View protein in InterPro IPR001304 C-type_lectin-like IPR016186 C-type_lectin-like/link_sf IPR016187 CTDL_fold
SMARTⁱ	View protein in SMART SM00034 CLECT, 1 hit
SUPFAMⁱ	SSF56436 SSF56436, 1 hit
PROSITEⁱ	View protein in PROSITE PS00010 ASX_HYDROXYL, 1 hit PS50041 C_TYPE_LECTIN_2, 1 hit PS01186 EGF_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q86T13-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MRPAFALCLL WQALWPGPGG GEHPTADRAG CSASGACYSL HHATMKRQAA 
        60         70         80         90        100
EEACILRGGA LSTVRAGAEL RAVLALLRAG PGPGGGSKDL LFWVALERRR 
       110        120        130        140        150
SHCTLENEPL RGFSWLSSDP GGLESDTLQW VEEPQRSCTA RRCAVLQATG 
       160        170        180        190        200
GVEPAGWKEM RCHLRANGYL CKYQFEVLCP APRPGAASNL SYRAPFQLHS 
       210        220        230        240        250
AALDFSPPGT EVSALCRGQL PISVTCIADE IGARWDKLSG DVLCPCPGRY 
       260        270        280        290        300
LRAGKCAELP NCLDDLGGFA CECATGFELG KDGRSCVTSG EGQPTLGGTG 
       310        320        330        340        350
VPTRRPPATA TSPVPQRTWP IRVDEKLGET PLVPEQDNSV TSIPEIPRWG 
       360        370        380        390        400
SQSTMSTLQM SLQAESKATI TPSGSVISKF NSTTSSATPQ AFDSSSAVVF 
       410        420        430        440        450
IFVSTAVVVL VILTMTVLGL VKLCFHESPS SQPRKESMGP PGLESDPEPA 
       460        470        480        490
ALGSSSAHCT NNGVKVGDCD LRDRAEGALL AESPLGSSDA

Length:490

Mass (Da):51,636

Last modified:June 1, 2003 - v1

Checksum:ⁱCE453A274CD39BF6

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	432	Q → H in AAS77882 (PubMed:15636369).Curated		1
Sequence conflictⁱ	437	S → F in AAS77882 (PubMed:15636369).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY573061 mRNA Translation: AAS77882.1 AY606132 mRNA Translation: AAT92280.1 BX248017 mRNA Translation: CAD62342.1 AY358395 mRNA Translation: AAQ88761.1 AL161751 Genomic DNA No translation available. BC031567 mRNA Translation: AAH31567.2
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS9667.1
NCBI Reference Sequences More...RefSeqⁱ	NP_778230.1, NM_175060.2
UniGeneⁱ	Hs.525307

Genome annotation databases

Ensemblⁱ	ENST00000342213; ENSP00000353013; ENSG00000176435
GeneIDⁱ	161198
KEGGⁱ	hsa:161198
UCSC genome browser More...UCSCⁱ	uc001wum.3 human

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q86T13	Uncharacterized protein		MACMU		491
C-type lectin domain containing 14A		COLAP		491
C-type lectin domain containing 14A		CHLSB		491
Uncharacterized protein		MACFA		491
UPI00027F3DAA		PAPAN		491
+14

Protein	Similar proteins		Species	Score	Length
Q86T13	UPI0005F55A0C		MANLE		491
UPI0005F3BA41		CERAT		491
UPI00027F3DAA		PAPAN		491
C-type lectin domain containing 14A		COLAP		491
C-type lectin domain containing 14A		CHLSB		491
+99

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY573061 mRNA Translation: AAS77882.1 AY606132 mRNA Translation: AAT92280.1 BX248017 mRNA Translation: CAD62342.1 AY358395 mRNA Translation: AAQ88761.1 AL161751 Genomic DNA No translation available. BC031567 mRNA Translation: AAH31567.2
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS9667.1
NCBI Reference Sequences More...RefSeqⁱ	NP_778230.1, NM_175060.2
UniGeneⁱ	Hs.525307

3D structure databases

ProteinModelPortalⁱ	Q86T13
SMRⁱ	Q86T13
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	127776, 5 interactors
IntActⁱ	Q86T13, 12 interactors
STRINGⁱ	9606.ENSP00000353013

PTM databases

iPTMnetⁱ	Q86T13
PhosphoSitePlusⁱ	Q86T13
SwissPalmⁱ	Q86T13

Polymorphism and mutation databases

BioMutaⁱ	CLEC14A
DMDMⁱ	34582300

Proteomic databases

PaxDbⁱ	Q86T13
PeptideAtlas More...PeptideAtlasⁱ	Q86T13
PRIDEⁱ	Q86T13
ProteomicsDBⁱ	69656

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000342213; ENSP00000353013; ENSG00000176435
GeneIDⁱ	161198
KEGGⁱ	hsa:161198
UCSC genome browser More...UCSCⁱ	uc001wum.3 human

Organism-specific databases

CTDⁱ	161198
DisGeNET More...DisGeNETⁱ	161198
EuPathDBⁱ	HostDB:ENSG00000176435.6
GeneCardsⁱ	CLEC14A
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:19832 CLEC14A
Human Protein Atlas More...HPAⁱ	HPA039468 HPA048119
neXtProtⁱ	NX_Q86T13
Open Targets More...OpenTargetsⁱ	ENSG00000176435
PharmGKBⁱ	PA134890576
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IGD4 Eukaryota ENOG41119V9 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00920000148956
HOGENOMⁱ	HOG000111782
HOVERGENⁱ	HBG051004
InParanoidⁱ	Q86T13
KEGG Orthology (KO) More...KOⁱ	K17528
OMAⁱ	CYSLHHA
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0O44
PhylomeDBⁱ	Q86T13
TreeFamⁱ	TF330714

Miscellaneous databases

ChiTaRSⁱ	CLEC14A human
GenomeRNAiⁱ	161198
Protein Ontology More...PROⁱ	PR:Q86T13

Gene expression databases

Bgeeⁱ	ENSG00000176435
CleanExⁱ	HS_CLEC14A
Genevisibleⁱ	Q86T13 HS

Family and domain databases

Gene3Dⁱ	3.10.100.10, 1 hit
InterProⁱ	View protein in InterPro IPR001304 C-type_lectin-like IPR016186 C-type_lectin-like/link_sf IPR016187 CTDL_fold
SMARTⁱ	View protein in SMART SM00034 CLECT, 1 hit
SUPFAMⁱ	SSF56436 SSF56436, 1 hit
PROSITEⁱ	View protein in PROSITE PS00010 ASX_HYDROXYL, 1 hit PS50041 C_TYPE_LECTIN_2, 1 hit PS01186 EGF_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CLC14_HUMAN
Accessionⁱ	Q86T13Primary (citable) accession number: Q86T13 Secondary accession number(s): Q695G9, Q6PWT6, Q8N5V5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 9, 2003
	Last sequence update:	June 1, 2003
	Last modified:	July 18, 2018
	This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q86T13 (CLC14_HUMAN)

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C-type lectin domain family 14 member A

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Extracellular region or secreted

Plasma Membrane

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ