Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

C-type lectin domain family 14 member A

Gene

CLEC14A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • carbohydrate binding Source: UniProtKB-KW
  • extracellular matrix binding Source: GO_Central
  • extracellular matrix protein binding Source: MGI

GO - Biological processi

Keywordsi

LigandLectin

Names & Taxonomyi

Protein namesi
Recommended name:
C-type lectin domain family 14 member A
Alternative name(s):
Epidermal growth factor receptor 5
Short name:
EGFR-5
Gene namesi
Name:CLEC14A
Synonyms:C14orf27, EGFR5
ORF Names:UNQ236/PRO269
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000176435.6
HGNCiHGNC:19832 CLEC14A
neXtProtiNX_Q86T13

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 397ExtracellularSequence analysisAdd BLAST376
Transmembranei398 – 418HelicalSequence analysisAdd BLAST21
Topological domaini419 – 490CytoplasmicSequence analysisAdd BLAST72

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi161198
OpenTargetsiENSG00000176435
PharmGKBiPA134890576

Polymorphism and mutation databases

BioMutaiCLEC14A
DMDMi34582300

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 211 PublicationAdd BLAST21
ChainiPRO_000001737722 – 490C-type lectin domain family 14 member AAdd BLAST469

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi143 ↔ 162PROSITE-ProRule annotation
Glycosylationi189N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi381N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ86T13
PeptideAtlasiQ86T13
PRIDEiQ86T13
ProteomicsDBi69656

PTM databases

iPTMnetiQ86T13
PhosphoSitePlusiQ86T13
SwissPalmiQ86T13

Expressioni

Gene expression databases

BgeeiENSG00000176435 Expressed in 197 organ(s), highest expression level in right lung
CleanExiHS_CLEC14A
GenevisibleiQ86T13 HS

Organism-specific databases

HPAiHPA039468
HPA048119

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi127776, 54 interactors
IntActiQ86T13, 12 interactors
STRINGi9606.ENSP00000353013

Structurei

3D structure databases

ProteinModelPortaliQ86T13
SMRiQ86T13
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 173C-type lectinPROSITE-ProRule annotationAdd BLAST141
Domaini245 – 287EGF-likeAdd BLAST43

Keywords - Domaini

EGF-like domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IGD4 Eukaryota
ENOG41119V9 LUCA
GeneTreeiENSGT00930000151088
HOGENOMiHOG000111782
HOVERGENiHBG051004
InParanoidiQ86T13
KOiK17528
OMAiCYSLHHA
OrthoDBiEOG091G0O44
PhylomeDBiQ86T13
TreeFamiTF330714

Family and domain databases

Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit
PS01186 EGF_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q86T13-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRPAFALCLL WQALWPGPGG GEHPTADRAG CSASGACYSL HHATMKRQAA
60 70 80 90 100
EEACILRGGA LSTVRAGAEL RAVLALLRAG PGPGGGSKDL LFWVALERRR
110 120 130 140 150
SHCTLENEPL RGFSWLSSDP GGLESDTLQW VEEPQRSCTA RRCAVLQATG
160 170 180 190 200
GVEPAGWKEM RCHLRANGYL CKYQFEVLCP APRPGAASNL SYRAPFQLHS
210 220 230 240 250
AALDFSPPGT EVSALCRGQL PISVTCIADE IGARWDKLSG DVLCPCPGRY
260 270 280 290 300
LRAGKCAELP NCLDDLGGFA CECATGFELG KDGRSCVTSG EGQPTLGGTG
310 320 330 340 350
VPTRRPPATA TSPVPQRTWP IRVDEKLGET PLVPEQDNSV TSIPEIPRWG
360 370 380 390 400
SQSTMSTLQM SLQAESKATI TPSGSVISKF NSTTSSATPQ AFDSSSAVVF
410 420 430 440 450
IFVSTAVVVL VILTMTVLGL VKLCFHESPS SQPRKESMGP PGLESDPEPA
460 470 480 490
ALGSSSAHCT NNGVKVGDCD LRDRAEGALL AESPLGSSDA
Length:490
Mass (Da):51,636
Last modified:June 1, 2003 - v1
Checksum:iCE453A274CD39BF6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti432Q → H in AAS77882 (PubMed:15636369).Curated1
Sequence conflicti437S → F in AAS77882 (PubMed:15636369).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY573061 mRNA Translation: AAS77882.1
AY606132 mRNA Translation: AAT92280.1
BX248017 mRNA Translation: CAD62342.1
AY358395 mRNA Translation: AAQ88761.1
AL161751 Genomic DNA No translation available.
BC031567 mRNA Translation: AAH31567.2
CCDSiCCDS9667.1
RefSeqiNP_778230.1, NM_175060.2
UniGeneiHs.525307

Genome annotation databases

EnsembliENST00000342213; ENSP00000353013; ENSG00000176435
GeneIDi161198
KEGGihsa:161198
UCSCiuc001wum.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY573061 mRNA Translation: AAS77882.1
AY606132 mRNA Translation: AAT92280.1
BX248017 mRNA Translation: CAD62342.1
AY358395 mRNA Translation: AAQ88761.1
AL161751 Genomic DNA No translation available.
BC031567 mRNA Translation: AAH31567.2
CCDSiCCDS9667.1
RefSeqiNP_778230.1, NM_175060.2
UniGeneiHs.525307

3D structure databases

ProteinModelPortaliQ86T13
SMRiQ86T13
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127776, 54 interactors
IntActiQ86T13, 12 interactors
STRINGi9606.ENSP00000353013

PTM databases

iPTMnetiQ86T13
PhosphoSitePlusiQ86T13
SwissPalmiQ86T13

Polymorphism and mutation databases

BioMutaiCLEC14A
DMDMi34582300

Proteomic databases

PaxDbiQ86T13
PeptideAtlasiQ86T13
PRIDEiQ86T13
ProteomicsDBi69656

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000342213; ENSP00000353013; ENSG00000176435
GeneIDi161198
KEGGihsa:161198
UCSCiuc001wum.3 human

Organism-specific databases

CTDi161198
DisGeNETi161198
EuPathDBiHostDB:ENSG00000176435.6
GeneCardsiCLEC14A
HGNCiHGNC:19832 CLEC14A
HPAiHPA039468
HPA048119
neXtProtiNX_Q86T13
OpenTargetsiENSG00000176435
PharmGKBiPA134890576
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IGD4 Eukaryota
ENOG41119V9 LUCA
GeneTreeiENSGT00930000151088
HOGENOMiHOG000111782
HOVERGENiHBG051004
InParanoidiQ86T13
KOiK17528
OMAiCYSLHHA
OrthoDBiEOG091G0O44
PhylomeDBiQ86T13
TreeFamiTF330714

Miscellaneous databases

ChiTaRSiCLEC14A human
GenomeRNAii161198
PROiPR:Q86T13

Gene expression databases

BgeeiENSG00000176435 Expressed in 197 organ(s), highest expression level in right lung
CleanExiHS_CLEC14A
GenevisibleiQ86T13 HS

Family and domain databases

Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit
PS01186 EGF_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCLC14_HUMAN
AccessioniPrimary (citable) accession number: Q86T13
Secondary accession number(s): Q695G9, Q6PWT6, Q8N5V5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 9, 2003
Last sequence update: June 1, 2003
Last modified: November 7, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again