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Entry version 146 (16 Oct 2019)
Sequence version 1 (01 Jun 2003)
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Protein

Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase

Gene

PIP4P1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P) (PubMed:16365287). Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (PubMed:16365287). Regulates lysosomal positioning by recruiting JIP4 to lysosomal membranes, thus inducing retrograde transport of lysosomes along microtubules (PubMed:29146937). Contributes to assembly of the V-ATPase complex in lipid rafts of the lysosomal membrane and to subsequent amino acid-dependent activation of mTORC1 (PubMed:29644770). May play a role in the regulation of cellular cholesterol metabolism (PubMed:25035345).4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei133By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS15363-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.1.3.78 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6811555 PI5P Regulates TP53 Acetylation
R-HSA-8847453 Synthesis of PIPs in the nucleus

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000000850

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase (EC:3.1.3.781 Publication)
Short name:
Type 1 PtdIns-4,5-P2 4-Ptase
Alternative name(s):
PtdIns-4,5-P2 4-Ptase I
Transmembrane protein 55B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PIP4P1Imported
Synonyms:C14orf9Imported, TMEM55BImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:19299 PIP4P1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
609865 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q86T03

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei212 – 232HelicalSequence analysisAdd BLAST21
Transmembranei242 – 262HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Endosome, Lysosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000165782

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134919069

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q86T03

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PIP4P1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
33112243

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000725791 – 277Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphataseAdd BLAST277

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei162PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q86T03

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q86T03

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q86T03

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q86T03

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q86T03

PeptideAtlas

More...
PeptideAtlasi
Q86T03

PRoteomics IDEntifications database

More...
PRIDEi
Q86T03

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
69653 [Q86T03-1]
69654 [Q86T03-2]
69655 [Q86T03-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q86T03

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q86T03

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q86T03

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By sterol depletion.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000165782 Expressed in 188 organ(s), highest expression level in cerebellum

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q86T03 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q86T03 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA048528

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via transmembrane domain) with ATP6V0D1 (PubMed:29644770).

Interacts with LAMTOR1 (PubMed:29644770).

Interacts with RRAGA and RRAGC (By similarity).

By similarity1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
124764, 15 interactors

Protein interaction database and analysis system

More...
IntActi
Q86T03, 18 interactors

Molecular INTeraction database

More...
MINTi
Q86T03

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000381102

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi133 – 139CX5R motif7

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi17 – 37Gly-richAdd BLAST21
Compositional biasi34 – 80Pro-richAdd BLAST47

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4684 Eukaryota
ENOG410XSVD LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000003680

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231722

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q86T03

KEGG Orthology (KO)

More...
KOi
K13084

Identification of Orthologs from Complete Genome Data

More...
OMAi
PYGVPNK

Database of Orthologous Groups

More...
OrthoDBi
1346704at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q86T03

TreeFam database of animal gene trees

More...
TreeFami
TF316367

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019178 PtdIns-P2-Ptase

The PANTHER Classification System

More...
PANTHERi
PTHR21014 PTHR21014, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09788 Tmemb_55A, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86T03-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAADGERSPL LSEPIDGGAG GNGLVGPGGS GAGPGGGLTP SAPPYGAAFP
60 70 80 90 100
PFPEGHPAVL PGEDPPPYSP LTSPDSGSAP MITCRVCQSL INVEGKMHQH
110 120 130 140 150
VVKCGVCNEA TPIKNAPPGK KYVRCPCNCL LICKVTSQRI ACPRPYCKRI
160 170 180 190 200
INLGPVHPGP LSPEPQPMGV RVICGHCKNT FLWTEFTDRT LARCPHCRKV
210 220 230 240 250
SSIGRRYPRK RCICCFLLGL LLAVTATGLA FGTWKHARRY GGIYAAWAFV
260 270
ILLAVLCLGR ALYWACMKVS HPVQNFS
Length:277
Mass (Da):29,470
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA85FE1F736366CBC
GO
Isoform 2 (identifier: Q86T03-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     47-47: A → AGKHAPPQ

Note: No experimental confirmation available.
Show »
Length:284
Mass (Da):30,185
Checksum:i7EA24D2735640FDF
GO
Isoform 3 (identifier: Q86T03-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     48-224: AFPPFPEGHP...CFLLGLLLAV → GKHAPPQGKP...TTVEHQWGCK
     225-277: Missing.

Note: May be due to intron retention.
Show »
Length:149
Mass (Da):15,191
Checksum:i89AC50824E6CFF55
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YJ90H0YJ90_HUMAN
Phosphatidylinositol-4,5-bisphospha...
PIP4P1
112Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V5T5G3V5T5_HUMAN
Phosphatidylinositol-4,5-bisphospha...
PIP4P1
43Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAB70896 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAD62347 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti208P → T in AAH20947 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00781547A → AGKHAPPQ in isoform 2. 1 Publication1
Alternative sequenceiVSP_00781648 – 224AFPPF…LLLAV → GKHAPPQGKPGRVRGAPRGT LKAGEGAGPRAEAGPSRQVR DCCTCDWARLPSLRNRDHSL GTEGGSEQPDRSANYEKPSE LGQRVEDQKDFPTTVEHQWG CK in isoform 3. 1 PublicationAdd BLAST177
Alternative sequenceiVSP_007817225 – 277Missing in isoform 3. 1 PublicationAdd BLAST53

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX161490 mRNA Translation: CAD61939.1
BX248025 mRNA Translation: CAD62347.1 Different initiation.
AK314021 mRNA Translation: BAG36732.1
AL137727 mRNA Translation: CAB70896.1 Different initiation.
CH471078 Genomic DNA Translation: EAW66461.1
BC002867 mRNA Translation: AAH02867.2
BC020947 mRNA Translation: AAH20947.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS41911.1 [Q86T03-2]
CCDS9551.1 [Q86T03-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
T46382

NCBI Reference Sequences

More...
RefSeqi
NP_001094284.1, NM_001100814.2 [Q86T03-2]
NP_653169.2, NM_144568.3 [Q86T03-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000250489; ENSP00000250489; ENSG00000165782 [Q86T03-1]
ENST00000398020; ENSP00000381102; ENSG00000165782 [Q86T03-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
90809

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:90809

UCSC genome browser

More...
UCSCi
uc001vxk.4 human [Q86T03-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX161490 mRNA Translation: CAD61939.1
BX248025 mRNA Translation: CAD62347.1 Different initiation.
AK314021 mRNA Translation: BAG36732.1
AL137727 mRNA Translation: CAB70896.1 Different initiation.
CH471078 Genomic DNA Translation: EAW66461.1
BC002867 mRNA Translation: AAH02867.2
BC020947 mRNA Translation: AAH20947.1
CCDSiCCDS41911.1 [Q86T03-2]
CCDS9551.1 [Q86T03-1]
PIRiT46382
RefSeqiNP_001094284.1, NM_001100814.2 [Q86T03-2]
NP_653169.2, NM_144568.3 [Q86T03-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi124764, 15 interactors
IntActiQ86T03, 18 interactors
MINTiQ86T03
STRINGi9606.ENSP00000381102

Chemistry databases

SwissLipidsiSLP:000000850

PTM databases

iPTMnetiQ86T03
PhosphoSitePlusiQ86T03
SwissPalmiQ86T03

Polymorphism and mutation databases

BioMutaiPIP4P1
DMDMi33112243

Proteomic databases

EPDiQ86T03
jPOSTiQ86T03
MassIVEiQ86T03
MaxQBiQ86T03
PaxDbiQ86T03
PeptideAtlasiQ86T03
PRIDEiQ86T03
ProteomicsDBi69653 [Q86T03-1]
69654 [Q86T03-2]
69655 [Q86T03-3]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
90809

Genome annotation databases

EnsembliENST00000250489; ENSP00000250489; ENSG00000165782 [Q86T03-1]
ENST00000398020; ENSP00000381102; ENSG00000165782 [Q86T03-2]
GeneIDi90809
KEGGihsa:90809
UCSCiuc001vxk.4 human [Q86T03-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
90809

GeneCards: human genes, protein and diseases

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GeneCardsi
PIP4P1
HGNCiHGNC:19299 PIP4P1
HPAiHPA048528
MIMi609865 gene
neXtProtiNX_Q86T03
OpenTargetsiENSG00000165782
PharmGKBiPA134919069

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG4684 Eukaryota
ENOG410XSVD LUCA
GeneTreeiENSGT00390000003680
HOGENOMiHOG000231722
InParanoidiQ86T03
KOiK13084
OMAiPYGVPNK
OrthoDBi1346704at2759
PhylomeDBiQ86T03
TreeFamiTF316367

Enzyme and pathway databases

BioCyciMetaCyc:HS15363-MONOMER
BRENDAi3.1.3.78 2681
ReactomeiR-HSA-6811555 PI5P Regulates TP53 Acetylation
R-HSA-8847453 Synthesis of PIPs in the nucleus

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TMEM55B human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
90809
PharosiQ86T03

Protein Ontology

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PROi
PR:Q86T03

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000165782 Expressed in 188 organ(s), highest expression level in cerebellum
ExpressionAtlasiQ86T03 baseline and differential
GenevisibleiQ86T03 HS

Family and domain databases

InterProiView protein in InterPro
IPR019178 PtdIns-P2-Ptase
PANTHERiPTHR21014 PTHR21014, 1 hit
PfamiView protein in Pfam
PF09788 Tmemb_55A, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPP4P1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86T03
Secondary accession number(s): B2RA35
, Q86U09, Q8WUC0, Q9BU67, Q9NSU8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: June 1, 2003
Last modified: October 16, 2019
This is version 146 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
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