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Entry version 146 (11 Dec 2019)
Sequence version 1 (01 Jun 2003)
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Protein

Trafficking protein particle complex subunit 6B

Gene

TRAPPC6B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of a transport protein particle (TRAPP) complex that may function in specific stages of inter-organelle traffic (PubMed:16025134, PubMed:16828797). Specifically involved in the early development of neural circuitry, likely by controlling the frequency and amplitude of intracellular calcium transients implicated in the regulation of neuron differentiation and survival (Probable).1 Publication2 Publications

Caution

May not be essential for endoplasmic reticulum-to-Golgi transport.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processNeurogenesis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-204005 COPII-mediated vesicle transport
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Trafficking protein particle complex subunit 6B1 Publication
Short name:
TRAPP complex subunit 6B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TRAPPC6B2 PublicationsImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000182400.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23066 TRAPPC6B

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610397 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q86SZ2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Neurodevelopmental disorder with microcephaly, epilepsy, and brain atrophy (NEDMEBA)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive neurodevelopmental disorder characterized by microcephaly, global developmental delay, hypotonia, intellectual disability, autistic features such as poor social interaction, language impairment and repetitive automatism behaviors, and generalized tonic-clonic seizures. Brain imaging shows cortical atrophy, thin corpus callosum, and cerebellar and brainstem atrophy.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_08072942 – 158Missing in NEDMEBA. 1 PublicationAdd BLAST117

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi31 – 32RC → EL: Impairs interaction with TRAPPC1. 1 Publication2

Keywords - Diseasei

Disease mutation, Epilepsy, Mental retardation

Organism-specific databases

DisGeNET

More...
DisGeNETi
122553

MalaCards human disease database

More...
MalaCardsi
TRAPPC6B
MIMi617862 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000182400

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134973191

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q86SZ2 Tdark

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB08342 S-PALMITOYL-L-CYSTEINE

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TRAPPC6B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
45477299

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002115871 – 158Trafficking protein particle complex subunit 6BAdd BLAST158

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q86SZ2

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q86SZ2

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q86SZ2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q86SZ2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q86SZ2

PeptideAtlas

More...
PeptideAtlasi
Q86SZ2

PRoteomics IDEntifications database

More...
PRIDEi
Q86SZ2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
69650 [Q86SZ2-1]
69651 [Q86SZ2-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q86SZ2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q86SZ2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Both isoforms are expressed ubiquitously (at transcript level), isoform 1 being the most predominant (PubMed:28626029). Expressed in the fetal brain and different regions of the adult brain and spinal cord (PubMed:28626029).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000182400 Expressed in 201 organ(s), highest expression level in frontal cortex

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q86SZ2 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q86SZ2 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA047928

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (PubMed:16025134, PubMed:16828797).

Part of a TRAPP complex. Heterodimer with TRAPPC3 (PubMed:16025134, PubMed:16828797). The heterodimer TRAPPC6B-TRAPPC3 interacts with TRAPPC1 likely providing a core for TRAPP complex formation (PubMed:16828797).

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
O436173EBI-6160531,EBI-743566

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
125777, 22 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-4749 TRAPP II complex

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q86SZ2

Database of interacting proteins

More...
DIPi
DIP-47626N

Protein interaction database and analysis system

More...
IntActi
Q86SZ2, 15 interactors

Molecular INTeraction database

More...
MINTi
Q86SZ2

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000330289

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q86SZ2 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1158
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q86SZ2

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q86SZ2

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3316 Eukaryota
ENOG410YUYH LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000012948

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000200502

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q86SZ2

KEGG Orthology (KO)

More...
KOi
K20304

Identification of Orthologs from Complete Genome Data

More...
OMAi
RTNHHGV

Database of Orthologous Groups

More...
OrthoDBi
1566836at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q86SZ2

TreeFam database of animal gene trees

More...
TreeFami
TF313010

Family and domain databases

Conserved Domains Database

More...
CDDi
cd14944 TRAPPC6A_Trs33, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024096 NO_sig/Golgi_transp_ligand-bd
IPR007194 TRAPP_component
IPR037992 TRAPPC6/Trs33

The PANTHER Classification System

More...
PANTHERi
PTHR12817 PTHR12817, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04051 TRAPP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF111126 SSF111126, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86SZ2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MADEALFLLL HNEMVSGVYK SAEQGEVENG RCITKLENMG FRVGQGLIER
60 70 80 90 100
FTKDTARFKD ELDIMKFICK DFWTTVFKKQ IDNLRTNHQG IYVLQDNKFR
110 120 130 140 150
LLTQMSAGKQ YLEHASKYLA FTCGLIRGGL SNLGIKSIVT AEVSSMPACK

FQVMIQKL
Length:158
Mass (Da):17,983
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5A8B0474548C304B
GO
Isoform 2 (identifier: Q86SZ2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     90-117: Missing.

Show »
Length:130
Mass (Da):14,761
Checksum:i780D0777899093DD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V2H7G3V2H7_HUMAN
Trafficking protein particle comple...
TRAPPC6B
102Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V4C3G3V4C3_HUMAN
Trafficking protein particle comple...
TRAPPC6B
50Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAD62341 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_08072942 – 158Missing in NEDMEBA. 1 PublicationAdd BLAST117

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00965990 – 117Missing in isoform 2. 2 PublicationsAdd BLAST28

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BX161510 mRNA Translation: CAD61947.1
BX248013 mRNA Translation: CAD62341.1 Different initiation.
AL833179 mRNA Translation: CAI46185.1
AK056690 mRNA Translation: BAG51784.1
CH471078 Genomic DNA Translation: EAW65823.1
CH471078 Genomic DNA Translation: EAW65824.1
BC047328 mRNA Translation: AAH47328.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS41947.1 [Q86SZ2-1]
CCDS9670.1 [Q86SZ2-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001073005.1, NM_001079537.1 [Q86SZ2-1]
NP_803235.1, NM_177452.3 [Q86SZ2-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000330149; ENSP00000330289; ENSG00000182400 [Q86SZ2-1]
ENST00000347691; ENSP00000335171; ENSG00000182400 [Q86SZ2-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
122553

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:122553

UCSC genome browser

More...
UCSCi
uc001wut.2 human [Q86SZ2-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX161510 mRNA Translation: CAD61947.1
BX248013 mRNA Translation: CAD62341.1 Different initiation.
AL833179 mRNA Translation: CAI46185.1
AK056690 mRNA Translation: BAG51784.1
CH471078 Genomic DNA Translation: EAW65823.1
CH471078 Genomic DNA Translation: EAW65824.1
BC047328 mRNA Translation: AAH47328.1
CCDSiCCDS41947.1 [Q86SZ2-1]
CCDS9670.1 [Q86SZ2-2]
RefSeqiNP_001073005.1, NM_001079537.1 [Q86SZ2-1]
NP_803235.1, NM_177452.3 [Q86SZ2-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BJNX-ray1.70A/B1-158[»]
2CFHX-ray2.30C/D1-158[»]
3KXCX-ray2.00C1-158[»]
SMRiQ86SZ2
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi125777, 22 interactors
ComplexPortaliCPX-4749 TRAPP II complex
CORUMiQ86SZ2
DIPiDIP-47626N
IntActiQ86SZ2, 15 interactors
MINTiQ86SZ2
STRINGi9606.ENSP00000330289

Chemistry databases

DrugBankiDB08342 S-PALMITOYL-L-CYSTEINE

PTM databases

iPTMnetiQ86SZ2
PhosphoSitePlusiQ86SZ2

Polymorphism and mutation databases

BioMutaiTRAPPC6B
DMDMi45477299

Proteomic databases

EPDiQ86SZ2
jPOSTiQ86SZ2
MassIVEiQ86SZ2
MaxQBiQ86SZ2
PaxDbiQ86SZ2
PeptideAtlasiQ86SZ2
PRIDEiQ86SZ2
ProteomicsDBi69650 [Q86SZ2-1]
69651 [Q86SZ2-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
122553

Genome annotation databases

EnsembliENST00000330149; ENSP00000330289; ENSG00000182400 [Q86SZ2-1]
ENST00000347691; ENSP00000335171; ENSG00000182400 [Q86SZ2-2]
GeneIDi122553
KEGGihsa:122553
UCSCiuc001wut.2 human [Q86SZ2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
122553
DisGeNETi122553
EuPathDBiHostDB:ENSG00000182400.14

GeneCards: human genes, protein and diseases

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GeneCardsi
TRAPPC6B
HGNCiHGNC:23066 TRAPPC6B
HPAiHPA047928
MalaCardsiTRAPPC6B
MIMi610397 gene
617862 phenotype
neXtProtiNX_Q86SZ2
OpenTargetsiENSG00000182400
PharmGKBiPA134973191

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3316 Eukaryota
ENOG410YUYH LUCA
GeneTreeiENSGT00390000012948
HOGENOMiHOG000200502
InParanoidiQ86SZ2
KOiK20304
OMAiRTNHHGV
OrthoDBi1566836at2759
PhylomeDBiQ86SZ2
TreeFamiTF313010

Enzyme and pathway databases

ReactomeiR-HSA-204005 COPII-mediated vesicle transport
R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TRAPPC6B human
EvolutionaryTraceiQ86SZ2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
122553
PharosiQ86SZ2 Tdark

Protein Ontology

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PROi
PR:Q86SZ2
RNActiQ86SZ2 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000182400 Expressed in 201 organ(s), highest expression level in frontal cortex
ExpressionAtlasiQ86SZ2 baseline and differential
GenevisibleiQ86SZ2 HS

Family and domain databases

CDDicd14944 TRAPPC6A_Trs33, 1 hit
InterProiView protein in InterPro
IPR024096 NO_sig/Golgi_transp_ligand-bd
IPR007194 TRAPP_component
IPR037992 TRAPPC6/Trs33
PANTHERiPTHR12817 PTHR12817, 1 hit
PfamiView protein in Pfam
PF04051 TRAPP, 1 hit
SUPFAMiSSF111126 SSF111126, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTPC6B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86SZ2
Secondary accession number(s): B3KPS2
, Q5JPD6, Q86U35, Q86X35
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: June 1, 2003
Last modified: December 11, 2019
This is version 146 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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