UniProtKB - Q86SW4 (Q86SW4_HUMAN)
Protein
Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex
Gene
DLST
Organism
Homo sapiens (Human)
Status
Functioni
Cofactori
(R)-lipoateUniRule annotation
GO - Molecular functioni
- transferase activity, transferring acyl groups Source: UniProtKB-KW
Keywordsi
Molecular function | AcyltransferaseUniRule annotation, Transferase |
Names & Taxonomyi
Protein namesi | Recommended name: Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation (EC:2.3.1.-UniRule annotation) |
Gene namesi | Name:DLSTImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:2911, DLST |
VEuPathDBi | HostDB:ENSG00000119689.14 |
Subcellular locationi
Mitochondrion
- Mitochondrion matrix ARBA annotation
Mitochondrion
- mitochondrion Source: UniProtKB
Keywords - Cellular componenti
MitochondrionARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000119689, Expressed in heart and 239 other tissues |
ExpressionAtlasi | Q86SW4, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 53 – 127 | Lipoyl-bindingInterPro annotationAdd BLAST | 75 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 135 – 209 | DisorderedSequence analysisAdd BLAST | 75 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 152 – 180 | Pro-richSequence analysisAdd BLAST | 29 |
Sequence similaritiesi
Keywords - Domaini
LipoylUniRule annotationARBA annotation, Transit peptideARBA annotationPhylogenomic databases
GeneTreei | ENSGT00930000151014 |
HOGENOMi | CLU_086867_0_0_1 |
Family and domain databases
Gene3Di | 3.30.559.10, 1 hit |
InterProi | View protein in InterPro IPR003016, 2-oxoA_DH_lipoyl-BS IPR001078, 2-oxoacid_DH_actylTfrase IPR000089, Biotin_lipoyl IPR023213, CAT-like_dom_sf IPR011053, Single_hybrid_motif |
Pfami | View protein in Pfam PF00198, 2-oxoacid_dh, 1 hit PF00364, Biotin_lipoyl, 1 hit |
SUPFAMi | SSF51230, SSF51230, 1 hit |
PROSITEi | View protein in PROSITE PS50968, BIOTINYL_LIPOYL, 1 hit PS00189, LIPOYL, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All
Q86SW4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
AVPIPLCVSG VQPLALRLPE GELPSRETFP ACINNSVFSV RFFRTTAVCK
60 70 80 90 100
DDLVTVKTPA FAESVTEGDV RWEKAVGDTV AEDEVVCEIE TDKTSVQVPS
110 120 130 140 150
PANGVIEALL VPDGGKVEGG TPLFTLRKTG AAPAKAKPAE APAAAAPKAE
160 170 180 190 200
PTAAAVPPPA APIPTQMPPV PSPSQPPSGK PVSAVKPTVA PPLAEPGAGK
210 220 230 240 250
GLRSEHREKM NRMRQRIAQR LKEAQNTCAM LTTFNEIDMS NIQEMRARHK
260 270
EAFLKKHNLK LGFMSAFVKA SAFALQEQP
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP36957 | ODO2_HUMAN | Dihydrolipoyllysine-residue succiny... | DLST DLTS | 453 | Annotation score: | ||
B7ZAZ8 | B7ZAZ8_HUMAN | Dihydrolipoyllysine-residue succiny... | DLST | 67 | Annotation score: | ||
G3V3F0 | G3V3F0_HUMAN | Dihydrolipoyllysine-residue succiny... | DLST | 104 | Annotation score: | ||
H0YJF9 | H0YJF9_HUMAN | Dihydrolipoyllysine-residue succiny... | DLST | 74 | Annotation score: | ||
G3V5M3 | G3V5M3_HUMAN | Dihydrolipoyllysine-residue succiny... | DLST | 83 | Annotation score: | ||
G3V5L9 | G3V5L9_HUMAN | Dihydrolipoyllysine-residue succiny... | DLST | 110 | Annotation score: | ||
G3V498 | G3V498_HUMAN | Dihydrolipoyllysine-residue succiny... | DLST | 37 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | Imported | 1 | |
Non-terminal residuei | 279 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC006530 Genomic DNA No translation available. BX248774 mRNA Translation: CAD66581.1 |
Genome annotation databases
Ensembli | ENST00000554806; ENSP00000451957; ENSG00000119689 |
UCSCi | uc059dkt.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC006530 Genomic DNA No translation available. BX248774 mRNA Translation: CAD66581.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
MaxQBi | Q86SW4 |
PRIDEi | Q86SW4 |
ProteomicsDBi | 69640 |
Protocols and materials databases
Antibodypediai | 45, 200 antibodies |
Genome annotation databases
Ensembli | ENST00000554806; ENSP00000451957; ENSG00000119689 |
UCSCi | uc059dkt.1, human |
Organism-specific databases
HGNCi | HGNC:2911, DLST |
OpenTargetsi | ENSG00000119689 |
VEuPathDBi | HostDB:ENSG00000119689.14 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00930000151014 |
HOGENOMi | CLU_086867_0_0_1 |
Miscellaneous databases
ChiTaRSi | DLST, human |
Gene expression databases
Bgeei | ENSG00000119689, Expressed in heart and 239 other tissues |
ExpressionAtlasi | Q86SW4, baseline and differential |
Family and domain databases
Gene3Di | 3.30.559.10, 1 hit |
InterProi | View protein in InterPro IPR003016, 2-oxoA_DH_lipoyl-BS IPR001078, 2-oxoacid_DH_actylTfrase IPR000089, Biotin_lipoyl IPR023213, CAT-like_dom_sf IPR011053, Single_hybrid_motif |
Pfami | View protein in Pfam PF00198, 2-oxoacid_dh, 1 hit PF00364, Biotin_lipoyl, 1 hit |
SUPFAMi | SSF51230, SSF51230, 1 hit |
PROSITEi | View protein in PROSITE PS50968, BIOTINYL_LIPOYL, 1 hit PS00189, LIPOYL, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q86SW4_HUMAN | |
Accessioni | Q86SW4Primary (citable) accession number: Q86SW4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 1, 2003 |
Last sequence update: | June 1, 2003 | |
Last modified: | April 7, 2021 | |
This is version 123 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |