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Protein

Synaptotagmin-9

Gene

SYT9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in Ca2+-dependent exocytosis of secretory vesicles through Ca2+ and phospholipid binding to the C2 domain or may serve as Ca2+ sensors in the process of vesicular trafficking and exocytosis.

Cofactori

Ca2+By similarityNote: Binds 3 Ca2+ ions per subunit. The ions are bound to the C2 domains.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi251Calcium 1By similarity1
Metal bindingi251Calcium 2By similarity1
Metal bindingi257Calcium 1By similarity1
Metal bindingi309Calcium 1By similarity1
Metal bindingi309Calcium 2By similarity1
Metal bindingi310Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi311Calcium 1By similarity1
Metal bindingi311Calcium 2By similarity1
Metal bindingi311Calcium 3By similarity1
Metal bindingi314Calcium 3By similarity1
Metal bindingi317Calcium 2By similarity1
Metal bindingi317Calcium 3By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-6794361 Neurexins and neuroligins
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828 Clathrin-mediated endocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptotagmin-9
Alternative name(s):
Synaptotagmin IX
Short name:
SytIX
Gene namesi
Name:SYT9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000170743.16
HGNCiHGNC:19265 SYT9
MIMi613528 gene
neXtProtiNX_Q86SS6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 52VesicularSequence analysisAdd BLAST52
Transmembranei53 – 73HelicalSequence analysisAdd BLAST21
Topological domaini74 – 491CytoplasmicSequence analysisAdd BLAST418

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi143425
OpenTargetsiENSG00000170743
PharmGKBiPA134984583

Polymorphism and mutation databases

BioMutaiSYT9
DMDMi33112457

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001839621 – 491Synaptotagmin-9Add BLAST491

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei177PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

EPDiQ86SS6
MaxQBiQ86SS6
PaxDbiQ86SS6
PeptideAtlasiQ86SS6
PRIDEiQ86SS6
ProteomicsDBi69631

PTM databases

iPTMnetiQ86SS6
PhosphoSitePlusiQ86SS6

Expressioni

Gene expression databases

BgeeiENSG00000170743 Expressed in 127 organ(s), highest expression level in medial globus pallidus
CleanExiHS_SYT9
ExpressionAtlasiQ86SS6 baseline and differential
GenevisibleiQ86SS6 HS

Interactioni

Subunit structurei

Homodimer; disulfide-linked via the cysteine motif. Can also form heterodimers with SYT3, SYT6, SYT7 and SYT10.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi126802, 8 interactors
ELMiQ86SS6
IntActiQ86SS6, 1 interactor
STRINGi9606.ENSP00000324419

Structurei

3D structure databases

ProteinModelPortaliQ86SS6
SMRiQ86SS6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini222 – 323C2 1PROSITE-ProRule annotationAdd BLAST102
Domaini354 – 457C2 2PROSITE-ProRule annotationAdd BLAST104

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni9 – 31Cysteine motifBy similarityAdd BLAST23

Domaini

The cysteine motif mediates homo- or heterodimer formation via formation of disulfide bonds.By similarity

Sequence similaritiesi

Belongs to the synaptotagmin family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1028 Eukaryota
ENOG410XQZ9 LUCA
GeneTreeiENSGT00760000118973
HOGENOMiHOG000232128
HOVERGENiHBG005010
InParanoidiQ86SS6
KOiK19909
OMAiCWVPLSG
OrthoDBiEOG091G0XMQ
PhylomeDBiQ86SS6
TreeFamiTF315600

Family and domain databases

Gene3Di2.60.40.150, 2 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR001565 Synaptotagmin
IPR028691 SYT9
PANTHERiPTHR10024:SF180 PTHR10024:SF180, 1 hit
PfamiView protein in Pfam
PF00168 C2, 2 hits
PRINTSiPR00360 C2DOMAIN
PR00399 SYNAPTOTAGMN
SMARTiView protein in SMART
SM00239 C2, 2 hits
PROSITEiView protein in PROSITE
PS50004 C2, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q86SS6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPGARDALCH QALQLLAELC ARGALEHDSC QDFIYHLRDR ARPRLRDPDI
60 70 80 90 100
SVSLLTLVVT ACGLALFGVS LFVSWKLCWV PWRERGLPSG SKDNNQEPLN
110 120 130 140 150
YMDTETNEQE NSEDFLDPPT PCPDSSMKIS HTSPDIPLST QTGIQENCAH
160 170 180 190 200
GVRVQRQVTE PTSSARHNSI RRQLNLSNPD FNIQQLQKQE QLTGIGRIKP
210 220 230 240 250
ELYKQRSLDN DDGRRSNSKA CGKLNFILKY DCDLEQLIVK IHKAVNLPAK
260 270 280 290 300
DFSGTSDPYV KIYLLPDRKT KHQTKVHRKT LNPVFDEVFL FPVPYNDLEA
310 320 330 340 350
RKLHFSVYDF DRFSRHDLIG QVVVDHFLDL ADFPRECILW KDIEYVTNDN
360 370 380 390 400
VDLGELMFSL CYLPTAGRLT ITIIKARNLK AMDITGASDP YVKVSLMCDG
410 420 430 440 450
RRLKKRKTST KRNTLNPVYN EAIVFDVPPE NIDQIHLSIA VMDYDRVGHN
460 470 480 490
EIIGVCQVGN EAERLGRDHW SEMLSYPRKP IAHWHSLVEK R
Length:491
Mass (Da):56,188
Last modified:June 1, 2003 - v1
Checksum:iA9808E5E49153BB3
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PDN4E9PDN4_HUMAN
Synaptotagmin-9
SYT9
319Annotation score:
B3KNT7B3KNT7_HUMAN
cDNA FLJ30441 fis, clone BRACE20091...
SYT9
173Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_065760154V → M1 PublicationCorresponds to variant dbSNP:rs78477754Ensembl.1
Natural variantiVAR_065761238I → V1 PublicationCorresponds to variant dbSNP:rs1001166978Ensembl.1
Natural variantiVAR_065762353L → V1 PublicationCorresponds to variant dbSNP:rs117876446Ensembl.1
Natural variantiVAR_036390445D → N in a colorectal cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC046367 mRNA Translation: AAH46367.1
CCDSiCCDS7778.1
RefSeqiNP_783860.1, NM_175733.3
UniGeneiHs.177193

Genome annotation databases

EnsembliENST00000318881; ENSP00000324419; ENSG00000170743
GeneIDi143425
KEGGihsa:143425
UCSCiuc001mfe.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC046367 mRNA Translation: AAH46367.1
CCDSiCCDS7778.1
RefSeqiNP_783860.1, NM_175733.3
UniGeneiHs.177193

3D structure databases

ProteinModelPortaliQ86SS6
SMRiQ86SS6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126802, 8 interactors
ELMiQ86SS6
IntActiQ86SS6, 1 interactor
STRINGi9606.ENSP00000324419

PTM databases

iPTMnetiQ86SS6
PhosphoSitePlusiQ86SS6

Polymorphism and mutation databases

BioMutaiSYT9
DMDMi33112457

Proteomic databases

EPDiQ86SS6
MaxQBiQ86SS6
PaxDbiQ86SS6
PeptideAtlasiQ86SS6
PRIDEiQ86SS6
ProteomicsDBi69631

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000318881; ENSP00000324419; ENSG00000170743
GeneIDi143425
KEGGihsa:143425
UCSCiuc001mfe.4 human

Organism-specific databases

CTDi143425
DisGeNETi143425
EuPathDBiHostDB:ENSG00000170743.16
GeneCardsiSYT9
HGNCiHGNC:19265 SYT9
MIMi613528 gene
neXtProtiNX_Q86SS6
OpenTargetsiENSG00000170743
PharmGKBiPA134984583
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1028 Eukaryota
ENOG410XQZ9 LUCA
GeneTreeiENSGT00760000118973
HOGENOMiHOG000232128
HOVERGENiHBG005010
InParanoidiQ86SS6
KOiK19909
OMAiCWVPLSG
OrthoDBiEOG091G0XMQ
PhylomeDBiQ86SS6
TreeFamiTF315600

Enzyme and pathway databases

ReactomeiR-HSA-6794361 Neurexins and neuroligins
R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis
R-HSA-8856828 Clathrin-mediated endocytosis

Miscellaneous databases

ChiTaRSiSYT9 human
GeneWikiiSYT9
GenomeRNAii143425
PROiPR:Q86SS6
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000170743 Expressed in 127 organ(s), highest expression level in medial globus pallidus
CleanExiHS_SYT9
ExpressionAtlasiQ86SS6 baseline and differential
GenevisibleiQ86SS6 HS

Family and domain databases

Gene3Di2.60.40.150, 2 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR001565 Synaptotagmin
IPR028691 SYT9
PANTHERiPTHR10024:SF180 PTHR10024:SF180, 1 hit
PfamiView protein in Pfam
PF00168 C2, 2 hits
PRINTSiPR00360 C2DOMAIN
PR00399 SYNAPTOTAGMN
SMARTiView protein in SMART
SM00239 C2, 2 hits
PROSITEiView protein in PROSITE
PS50004 C2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiSYT9_HUMAN
AccessioniPrimary (citable) accession number: Q86SS6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: June 1, 2003
Last modified: November 7, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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