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Protein
Submitted name:

CEL protein

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseSAAS annotation

Protein family/group databases

ESTHERihuman-CEL Cholesterol_esterase

Names & Taxonomyi

Protein namesi
Submitted name:
CEL proteinImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_500732351224 – 722Sequence analysisAdd BLAST699

Proteomic databases

MaxQBiQ86SR3
PeptideAtlasiQ86SR3

Structurei

3D structure databases

ProteinModelPortaliQ86SR3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 544COesteraseInterPro annotationAdd BLAST516
Domaini557 – 639Mucin-likeInterPro annotationAdd BLAST83
Domaini619 – 715Mucin-likeInterPro annotationAdd BLAST97

Sequence similaritiesi

Belongs to the type-B carboxylesterase/lipase family.SAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG1516 Eukaryota
COG2272 LUCA
HOVERGENiHBG008839
KOiK12298

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR033560 BAL
IPR002018 CarbesteraseB
IPR019826 Carboxylesterase_B_AS
IPR019819 Carboxylesterase_B_CS
IPR032059 Mucin-like
PANTHERiPTHR43903:SF1 PTHR43903:SF1, 1 hit
PfamiView protein in Pfam
PF00135 COesterase, 1 hit
PF16058 Mucin-like, 2 hits
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00122 CARBOXYLESTERASE_B_1, 1 hit
PS00941 CARBOXYLESTERASE_B_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q86SR3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLTMGRLQLV VLGLTCCWAV ASAAKLGAVY TEGGFVEGVN KKLGLLGDSV
60 70 80 90 100
DIFKGIPFAA PTKALENPQP HPGWQGTLKA KNFKKRCLQA TITQDSTYGD
110 120 130 140 150
EDCLYLNIWV PQGRKQVSRD LPVMIWIYGG AFLMGSGHGA NFLNNYLYDG
160 170 180 190 200
EEIATRGNVI VVTFNYRVGP LGFLSTGDAN LPGNYGLRDQ HMAIAWVKRN
210 220 230 240 250
IAAFGGDPNN ITLFGESAGG ASVSLQTLSP YNKGLIRRAI SQSGVALSPW
260 270 280 290 300
VIQKNPLFWA KKVAEKVGCP VGDAARMAQC LKVTDPRALT LAYKVPLAGL
310 320 330 340 350
EYPMLHYVGF VPVIDGDFIP ADPINLYANA ADIDYIAGTN NMDGHIFASI
360 370 380 390 400
DMPAINKGNK KVTEDFYKLV SEFTITKGLR GAKTTFDVYT ESWAQDPSQE
410 420 430 440 450
NKKKTVVDFE TDVLFLVPTE IALAQHRANA KSAKTYAYLF SHPSRMPVYP
460 470 480 490 500
KWVGADHADD IQYVFGKPFA TPTGYRPQDR TVSKAMIAYW TNFAKTGDPN
510 520 530 540 550
MGDSAVPTHW EPYTTENSGY LEITKKMGSS SMKRSLRTNF LRYWTLTYLA
560 570 580 590 600
LPTVTDQEAT PVPPTGDSEA TPVPPTGDSE TAPVPPTGDS GAPPVPPTGD
610 620 630 640 650
SGAPPVPPTG DSGAPPVPPT GDSGAPPVPP TGDSGAPPVP PTGDAGPPPV
660 670 680 690 700
PPTGDSGAPP VPPTGDSGAP PVTPTGDSET APVPPTGDSG APPVPPTGDS
710 720
EAAPVPPTDD SKEAQMPAVI RF
Length:722
Mass (Da):76,610
Last modified:June 1, 2003 - v1
Checksum:i8AA686E4CF02928B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC042510 mRNA Translation: AAH42510.1
RefSeqiNP_001798.2, NM_001807.4
UniGeneiHs.533258

Genome annotation databases

GeneIDi1056
KEGGihsa:1056

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC042510 mRNA Translation: AAH42510.1
RefSeqiNP_001798.2, NM_001807.4
UniGeneiHs.533258

3D structure databases

ProteinModelPortaliQ86SR3
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

ESTHERihuman-CEL Cholesterol_esterase

Proteomic databases

MaxQBiQ86SR3
PeptideAtlasiQ86SR3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1056
KEGGihsa:1056

Organism-specific databases

CTDi1056

Phylogenomic databases

eggNOGiKOG1516 Eukaryota
COG2272 LUCA
HOVERGENiHBG008839
KOiK12298

Miscellaneous databases

GenomeRNAii1056

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR033560 BAL
IPR002018 CarbesteraseB
IPR019826 Carboxylesterase_B_AS
IPR019819 Carboxylesterase_B_CS
IPR032059 Mucin-like
PANTHERiPTHR43903:SF1 PTHR43903:SF1, 1 hit
PfamiView protein in Pfam
PF00135 COesterase, 1 hit
PF16058 Mucin-like, 2 hits
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS00122 CARBOXYLESTERASE_B_1, 1 hit
PS00941 CARBOXYLESTERASE_B_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ86SR3_HUMAN
AccessioniPrimary (citable) accession number: Q86SR3
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: February 28, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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