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Entry version 142 (17 Jun 2020)
Sequence version 3 (30 Nov 2010)
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Protein

Adhesion G protein-coupled receptor A1

Gene

ADGRA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Orphan receptor.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Adhesion G protein-coupled receptor A11 Publication
Alternative name(s):
G-protein coupled receptor 123
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ADGRA1Imported
Synonyms:GPR123, KIAA1828
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000197177.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13838 ADGRA1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
612302 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q86SQ6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 19ExtracellularCuratedAdd BLAST19
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei20 – 40Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini41 – 53CytoplasmicCuratedAdd BLAST13
Transmembranei54 – 74Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini75 – 84ExtracellularCurated10
Transmembranei85 – 105Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini106 – 134CytoplasmicCuratedAdd BLAST29
Transmembranei135 – 155Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini156 – 175ExtracellularCuratedAdd BLAST20
Transmembranei176 – 196Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini197 – 257CytoplasmicCuratedAdd BLAST61
Transmembranei258 – 278Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini279 – 284ExtracellularCurated6
Transmembranei285 – 305Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini306 – 560CytoplasmicCuratedAdd BLAST255

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
84435

Open Targets

More...
OpenTargetsi
ENSG00000197177

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134910893

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q86SQ6 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ADGRA1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
313104230

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000703371 – 560Adhesion G protein-coupled receptor A1Add BLAST560

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi75N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q86SQ6

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q86SQ6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q86SQ6

PeptideAtlas

More...
PeptideAtlasi
Q86SQ6

PRoteomics IDEntifications database

More...
PRIDEi
Q86SQ6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
69613 [Q86SQ6-3]
69614 [Q86SQ6-1]
69615 [Q86SQ6-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q86SQ6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q86SQ6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000197177 Expressed in anterior cingulate cortex and 63 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q86SQ6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000197177 Tissue enhanced (adrenal gland, brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q86SQ6, 1 interactor

Molecular INTeraction database

More...
MINTi
Q86SQ6

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000376384

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q86SQ6 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0619 Eukaryota
COG4886 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160175

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_008933_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q86SQ6

KEGG Orthology (KO)

More...
KOi
K08460

Identification of Orthologs from Complete Genome Data

More...
OMAi
MHEEDAF

Database of Orthologous Groups

More...
OrthoDBi
31536at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q86SQ6

TreeFam database of animal gene trees

More...
TreeFami
TF331206

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR017981 GPCR_2-like
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00002 7tm_2, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 3 (identifier: Q86SQ6-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDLKTVLSLP RYPGEFLHPV VYACTAVMLL CLLASFVTYI VHQSAIRISR
60 70 80 90 100
KGRHTLLNFC FHAALTFTVF AGGINRTKYP ILCQAVGIVL HYSTLSTMLW
110 120 130 140 150
IGVTARNIYK QVTKKAPLCL DTDQPPYPRQ PLLRFYLVSG GVPFIICGVT
160 170 180 190 200
AATNIRNYGT EDEDTAYCWM AWEPSLGAFY GPAAIITLVT CVYFLGTYVQ
210 220 230 240 250
LRRHPGRRYE LRTQPEEQRR LATPEGGRGI RPGTPPAHDA PGASVLQNEH
260 270 280 290 300
SFQAQLRAAA FTLFLFTATW AFGALAVSQG HFLDMVFSCL YGAFCVTLGL
310 320 330 340 350
FVLIHHCAKR EDVWQCWWAC CPPRKDAHPA LDANGAALGR AACLHSPGLG
360 370 380 390 400
QPRGFAHPPG PCKMTNLQAA QGHASCLSPA TPCCAKMHCE PLTADEAHVH
410 420 430 440 450
LQEEGAFGHD PHLHGCLQGR TKPPYFSRHP AEEPEYAYHI PSSLDGSPRS
460 470 480 490 500
SRTDSPPSSL DGPAGTHTLA CCTQGDPFPM VTQPEGSDGS PALYSCPTQP
510 520 530 540 550
GREAALGPGH LEMLRRTQSL PFGGPSQNGL PKGKLLEGLP FGTDGTGNIR
560
TGPWKNETTV
Length:560
Mass (Da):60,885
Last modified:November 30, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1529EA836A679C5C
GO
Isoform 1 (identifier: Q86SQ6-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MRGHGNHSRL...GPLAACIPTQ
     167-167: Missing.

Show »
Length:1,279
Mass (Da):137,203
Checksum:iAF7FDE6401E30D54
GO
Isoform 2 (identifier: Q86SQ6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-97: Missing.

Show »
Length:463
Mass (Da):50,101
Checksum:i620377131CF9B583
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB47457 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti560V → VW in AAO27353 (PubMed:12565841).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_055931183A → S. Corresponds to variant dbSNP:rs34915504Ensembl.1
Natural variantiVAR_055932214Q → L. Corresponds to variant dbSNP:rs34679676Ensembl.1
Isoform 1 (identifier: Q86SQ6-1)
Natural variantiVAR_08282638T → I in an acute myeloid leukemia, somatic mutation. Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0402071 – 97Missing in isoform 2. 1 PublicationAdd BLAST97
Alternative sequenceiVSP_0402081M → MRGHGNHSRLKSRCASLGNV HHHQAQMAHGAHCRGGRTPQ SPDSRGPTAGGHTRGRWTYR PIEALINVSFPGAKGGRTAE GEPSWAWVFRSGYLQRQALP GLPVSTRVAACWWQHHPGRD SGFLGPGFIDLLREEPSGRA DGKAAAQKTGRLYLFPTFLG NKLPEAADSFGEIASGNSVI FTSVLQSSHPPGTPPPSARK PSPGAAMLVCEETLELGAQG CWGSTSPRGQAVSLVGGPTA GGSRLGGAGCTMGLLMALQA RRPRDGTWADPRRCSRAVEG SGLTRAALVSPGPSGVEEDT RREGCVLVGSWRSSTHRSRV LIINTPSGRTPWSQGSLGST GRYNQTRAPGSQQQGLCSDA ALHEDFVPEPTPAFFQYPPQ AFSKTKVRDLGRGGLYAFSK EEKVSEAQRVEAYETHGLGL STGRQNPVPSPCKPGCVCQG LALDAEAWPRHPGRRPCAAK EACLGPPGCSGELSLPEEEG IAPGAATAAPAWVPHGRVSR FLTVKLFTYVTMYQCKQERI LRLCISGESGRYVRRSRFRN FAALMVSTGVPGVLQLGARP LRGGGHPYGDSQAGKVVEWR AGDRASGLSAGERRFLSQSE LQTWPRTPHCVGKKVPQPVG AADLAPDTSLCRKEGSSASR SCRPGPGHLTRREEDSFRQL AFPRFEEVTFPPLTAAERAP SVHGGHSLASQGLVLAGRTR SVASGGKQELSGPLAACIPT Q in isoform 1. 1 Publication1
Alternative sequenceiVSP_040209167Missing in isoform 1. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY181241 mRNA Translation: AAO27353.1
EF536972 mRNA Translation: ABQ08572.1
AB058731 mRNA Translation: BAB47457.1 Different initiation.
AL445199 Genomic DNA No translation available.
AY255564 mRNA Translation: AAO85076.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS41580.1 [Q86SQ6-3]
CCDS76362.1 [Q86SQ6-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001077378.1, NM_001083909.2 [Q86SQ6-3]
NP_001278014.1, NM_001291085.1 [Q86SQ6-2]
XP_005252752.1, XM_005252695.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000392606; ENSP00000376383; ENSG00000197177 [Q86SQ6-2]
ENST00000392607; ENSP00000376384; ENSG00000197177 [Q86SQ6-3]
ENST00000607359; ENSP00000475778; ENSG00000197177 [Q86SQ6-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
84435

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:84435

UCSC genome browser

More...
UCSCi
uc001llw.3 human [Q86SQ6-3]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY181241 mRNA Translation: AAO27353.1
EF536972 mRNA Translation: ABQ08572.1
AB058731 mRNA Translation: BAB47457.1 Different initiation.
AL445199 Genomic DNA No translation available.
AY255564 mRNA Translation: AAO85076.1
CCDSiCCDS41580.1 [Q86SQ6-3]
CCDS76362.1 [Q86SQ6-2]
RefSeqiNP_001077378.1, NM_001083909.2 [Q86SQ6-3]
NP_001278014.1, NM_001291085.1 [Q86SQ6-2]
XP_005252752.1, XM_005252695.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ86SQ6, 1 interactor
MINTiQ86SQ6
STRINGi9606.ENSP00000376384

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...
GPCRDBi
Search...

PTM databases

iPTMnetiQ86SQ6
PhosphoSitePlusiQ86SQ6

Polymorphism and mutation databases

BioMutaiADGRA1
DMDMi313104230

Proteomic databases

jPOSTiQ86SQ6
MassIVEiQ86SQ6
PaxDbiQ86SQ6
PeptideAtlasiQ86SQ6
PRIDEiQ86SQ6
ProteomicsDBi69613 [Q86SQ6-3]
69614 [Q86SQ6-1]
69615 [Q86SQ6-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
48655 62 antibodies

The DNASU plasmid repository

More...
DNASUi
84435

Genome annotation databases

EnsembliENST00000392606; ENSP00000376383; ENSG00000197177 [Q86SQ6-2]
ENST00000392607; ENSP00000376384; ENSG00000197177 [Q86SQ6-3]
ENST00000607359; ENSP00000475778; ENSG00000197177 [Q86SQ6-1]
GeneIDi84435
KEGGihsa:84435
UCSCiuc001llw.3 human [Q86SQ6-3]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
84435
DisGeNETi84435
EuPathDBiHostDB:ENSG00000197177.15

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ADGRA1
HGNCiHGNC:13838 ADGRA1
HPAiENSG00000197177 Tissue enhanced (adrenal gland, brain)
MIMi612302 gene
neXtProtiNX_Q86SQ6
OpenTargetsiENSG00000197177
PharmGKBiPA134910893

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00940000160175
HOGENOMiCLU_008933_0_0_1
InParanoidiQ86SQ6
KOiK08460
OMAiMHEEDAF
OrthoDBi31536at2759
PhylomeDBiQ86SQ6
TreeFamiTF331206

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
84435 1 hit in 787 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ADGRA1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
GPR123

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
84435
PharosiQ86SQ6 Tdark

Protein Ontology

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PROi
PR:Q86SQ6
RNActiQ86SQ6 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000197177 Expressed in anterior cingulate cortex and 63 other tissues
GenevisibleiQ86SQ6 HS

Family and domain databases

InterProiView protein in InterPro
IPR017981 GPCR_2-like
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PROSITEiView protein in PROSITE
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAGRA1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86SQ6
Secondary accession number(s): A5HL16
, A6NG50, Q5T234, Q86SN7, Q96JJ9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: November 30, 2010
Last modified: June 17, 2020
This is version 142 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  6. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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