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Protein

Adhesion G-protein coupled receptor G6

Gene

ADGRG6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

G-protein coupled receptor which is activated by type IV collagen, a major constituent of the basement membrane (By similarity). Couples to G(i)-proteins as well as G(s)-proteins (PubMed:24227709). Essential for normal differentiation of promyelinating Schwann cells and for normal myelination of axons (PubMed:24227709). Regulates neural, cardiac and ear development via G-protein- and/or N-terminus-dependent signaling (By similarity). May act as a receptor for PRNP which may promote myelin homeostasis (By similarity).By similarity2 Publications

GO - Molecular functioni

  • collagen binding Source: UniProtKB
  • extracellular matrix binding Source: UniProtKB
  • G protein-coupled receptor activity Source: UniProtKB
  • laminin binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

SignaLinkiQ86SQ4

Protein family/group databases

MEROPSiP02.017

Names & Taxonomyi

Protein namesi
Recommended name:
Adhesion G-protein coupled receptor G6
Alternative name(s):
Developmentally regulated G-protein-coupled receptor1 Publication
G-protein coupled receptor 126
Vascular inducible G protein-coupled receptor1 Publication
Cleaved into the following 2 chains:
ADGRG6 N-terminal fragment
Short name:
ADGRG6-NTF
ADGRG6 C-terminal fragment
Short name:
ADGRG6-CTF
Gene namesi
Name:ADGRG6Imported
Synonyms:DREG, GPR126, VIGR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000112414.14
HGNCiHGNC:13841 ADGRG6
MIMi612243 gene
neXtProtiNX_Q86SQ4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini38 – 862ExtracellularSequence analysisAdd BLAST825
Transmembranei863 – 883Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini884 – 903CytoplasmicSequence analysisAdd BLAST20
Transmembranei904 – 924Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini925 – 929ExtracellularSequence analysis5
Transmembranei930 – 950Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini951 – 970CytoplasmicSequence analysisAdd BLAST20
Transmembranei971 – 991Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini992 – 1024ExtracellularSequence analysisAdd BLAST33
Transmembranei1025 – 1045Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini1046 – 1069CytoplasmicSequence analysisAdd BLAST24
Transmembranei1070 – 1090Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini1091 – 1092ExtracellularSequence analysis2
Transmembranei1093 – 1113Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini1114 – 1221CytoplasmicSequence analysisAdd BLAST108

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Lethal congenital contracture syndrome 9 (LCCS9)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of lethal congenital contracture syndrome, an autosomal recessive disorder characterized by degeneration of anterior horn neurons, extreme skeletal muscle atrophy and congenital non-progressive joint contractures. The contractures can involve the upper or lower limbs and/or the vertebral column, leading to various degrees of flexion or extension limitations evident at birth.
See also OMIM:616503
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_075146741V → E in LCCS9; decreases the autoprocessing/cleavage of the receptor. 1 Publication1
Natural variantiVAR_075147769V → E in LCCS9. 1 PublicationCorresponds to variant dbSNP:rs793888525EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi468R → A: No cleavage. 1 Publication1
Mutagenesisi469S → A: No effect on cleavage. 1 Publication1
Mutagenesisi803C → S: No cleavage and not detected at the cell surface. 1 Publication1
Mutagenesisi813S → A: No effect on G-protein-mediated cAMP release. 1 Publication1
Mutagenesisi815G → A: Abolishes G-protein-mediated cAMP release. 1 Publication1
Mutagenesisi818N → A: Abolishes G-protein-mediated cAMP release. 1 Publication1
Mutagenesisi819T → A: Abolishes G-protein-mediated cAMP release. 1 Publication1
Mutagenesisi822C → S: No cleavage and not detected at the cell surface. 1 Publication1
Mutagenesisi835C → S: No cleavage and not detected at the cell surface. 1 Publication1
Mutagenesisi837C → S: No cleavage and not detected at the cell surface. 1 Publication1
Mutagenesisi841T → A: No cleavage but detected at cell surface. 1 Publication1
Mutagenesisi841T → P: No cleavage and not detected at the cell surface. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi57211
MalaCardsiADGRG6
MIMi606255 phenotype
616503 phenotype
OpenTargetsiENSG00000112414
PharmGKBiPA134878328

Polymorphism and mutation databases

BioMutaiGPR126
DMDMi215274152

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 37Sequence analysisAdd BLAST37
ChainiPRO_000001290238 – 1221Adhesion G-protein coupled receptor G6Add BLAST1184
ChainiPRO_000043859638 – 840ADGRG6 N-terminal fragment1 PublicationAdd BLAST803
ChainiPRO_0000438597841 – 1221ADGRG6 C-terminal fragment1 PublicationAdd BLAST381

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi41 ↔ 67PROSITE-ProRule annotation
Disulfide bondi94 ↔ 111PROSITE-ProRule annotation
Glycosylationi121N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi143N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi186 ↔ 254PROSITE-ProRule annotation
Glycosylationi206N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi258N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi314N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi324N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi353N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi438N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi445N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi452N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi485N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi488N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi505N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi563N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi593N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi600N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi605N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi667N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi673N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi695N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi704N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi750N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi776N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi811N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi818N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei1165PhosphoserineCombined sources1
Modified residuei1168PhosphoserineBy similarity1

Post-translational modificationi

Proteolytically cleaved into 2 conserved sites: one in the GPS domain (S1 site) and the other in the middle of the extracellular domain (S2 site). The proteolytic cleavage at S1 site generates an extracellular subunit and a seven-transmembrane subunit. Furin is involved in the cleavage of the S2 site generating a soluble fragment. Processing at the GPS domain occurred independent of and probably prior to the cleavage at the S2 site. Proteolytic cleavage is required for activation of the receptor.2 Publications
Highly glycosylated.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei467 – 468Cleavage; by furin like-convertase1 Publication2
Sitei840 – 841Cleavage1 Publication2

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ86SQ4
PaxDbiQ86SQ4
PeptideAtlasiQ86SQ4
PRIDEiQ86SQ4
ProteomicsDBi69609
69610 [Q86SQ4-2]
69611 [Q86SQ4-3]
69612 [Q86SQ4-4]

PTM databases

GlyConnecti1287
iPTMnetiQ86SQ4
PhosphoSitePlusiQ86SQ4
SwissPalmiQ86SQ4

Expressioni

Tissue specificityi

Expressed in placenta and to a lower extent in pancreas and liver. Detected in aortic endothelial cells but not in skin microvascular endothelial cells.1 Publication

Inductioni

Up-regulated by bacterial lipopolysaccharides (LPS) and thrombin, but not by other inflammatory stimuli in primary umbilical veins.1 Publication

Gene expression databases

BgeeiENSG00000112414 Expressed in 179 organ(s), highest expression level in lung
CleanExiHS_GPR126
ExpressionAtlasiQ86SQ4 baseline and differential
GenevisibleiQ86SQ4 HS

Organism-specific databases

HPAiHPA017346

Interactioni

Subunit structurei

Interacts with Laminin-2; this interaction stabilizes the receptor in an inactive state. Laminin-2 polymerization could facilitate ADGRG6-NTF removal, thereby exposing the tethered agonist to drive myelination. Interacts with PRNP.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi121449, 2 interactors
STRINGi9606.ENSP00000356581

Structurei

3D structure databases

ProteinModelPortaliQ86SQ4
SMRiQ86SQ4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 149CUBPROSITE-ProRule annotationAdd BLAST109
Domaini154 – 356Pentraxin (PTX)PROSITE-ProRule annotationAdd BLAST203
Domaini800 – 852GPSPROSITE-ProRule annotationAdd BLAST53

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni41 – 852Inhibits receptor signaling in absence of type IV collagenBy similarityAdd BLAST812
Regioni41 – 355Mediates interaction with type IV collagenBy similarityAdd BLAST315
Regioni473 – 837Mediates interaction with laminin-2By similarityAdd BLAST365

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi842 – 850Stachel1 Publication9

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1153 – 1205Ser-richAdd BLAST53

Domaini

A short peptide sequence (termed the Stachel sequence) in the C-terminal part of the extra-cellular domain (ECD) functions as a tethered agonist. Upon structural changes within the ECD, e.g. due to extracellular ligand binding or mechanical movements, this intramolecular agonist is exposed to the 7TM domain, triggering G-protein activation.1 Publication

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3714 Eukaryota
KOG4193 Eukaryota
ENOG410XSD2 LUCA
GeneTreeiENSGT00930000150821
HOVERGENiHBG051778
InParanoidiQ86SQ4
KOiK08463
OMAiGYFGIMF
OrthoDBiEOG091G00P5
PhylomeDBiQ86SQ4
TreeFamiTF321769

Family and domain databases

CDDicd00041 CUB, 1 hit
Gene3Di2.60.120.290, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR000859 CUB_dom
IPR017981 GPCR_2-like
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
IPR000203 GPS
IPR001759 Pentraxin-related
IPR035914 Sperma_CUB_dom_sf
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF00431 CUB, 1 hit
PF01825 GPS, 1 hit
PF00354 Pentaxin, 1 hit
PRINTSiPR00249 GPCRSECRETIN
SMARTiView protein in SMART
SM00042 CUB, 1 hit
SM00303 GPS, 1 hit
SM00159 PTX, 1 hit
SUPFAMiSSF49854 SSF49854, 1 hit
SSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS01180 CUB, 1 hit
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
PS50221 GPS, 1 hit
PS51828 PTX_2, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86SQ4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMFRSDRMWS CHWKWKPSPL LFLFALYIMC VPHSVWGCAN CRVVLSNPSG
60 70 80 90 100
TFTSPCYPND YPNSQACMWT LRAPTGYIIQ ITFNDFDIEE APNCIYDSLS
110 120 130 140 150
LDNGESQTKF CGATAKGLSF NSSANEMHVS FSSDFSIQKK GFNASYIRVA
160 170 180 190 200
VSLRNQKVIL PQTSDAYQVS VAKSISIPEL SAFTLCFEAT KVGHEDSDWT
210 220 230 240 250
AFSYSNASFT QLLSFGKAKS GYFLSISDSK CLLNNALPVK EKEDIFAESF
260 270 280 290 300
EQLCLVWNNS LGSIGVNFKR NYETVPCDST ISKVIPGNGK LLLGSNQNEI
310 320 330 340 350
VSLKGDIYNF RLWNFTMNAK ILSNLSCNVK GNVVDWQNDF WNIPNLALKA
360 370 380 390 400
ESNLSCGSYL IPLPAAELAS CADLGTLCQA TVNSPSTTPP TVTTNMPVTN
410 420 430 440 450
RIDKQRNDGI IYRISVVIQN ILRHPEVKVQ SKVAEWLNST FQNWNYTVYV
460 470 480 490 500
VNISFHLSAG EDKIKVKRSL EDEPRLVLWA LLVYNATNNT NLEGKIIQQK
510 520 530 540 550
LLKNNESLDE GLRLHTVNVR QLGHCLAMEE PKGYYWPSIQ PSEYVLPCPD
560 570 580 590 600
KPGFSASRIC FYNATNPLVT YWGPVDISNC LKEANEVANQ ILNLTADGQN
610 620 630 640 650
LTSANITNIV EQVKRIVNKE ENIDITLGST LMNIFSNILS SSDSDLLESS
660 670 680 690 700
SEALKTIDEL AFKIDLNSTS HVNITTRNLA LSVSSLLPGT NAISNFSIGL
710 720 730 740 750
PSNNESYFQM DFESGQVDPL ASVILPPNLL ENLSPEDSVL VRRAQFTFFN
760 770 780 790 800
KTGLFQDVGP QRKTLVSYVM ACSIGNITIQ NLKDPVQIKI KHTRTQEVHH
810 820 830 840 850
PICAFWDLNK NKSFGGWNTS GCVAHRDSDA SETVCLCNHF THFGVLMDLP
860 870 880 890 900
RSASQLDARN TKVLTFISYI GCGISAIFSA ATLLTYVAFE KLRRDYPSKI
910 920 930 940 950
LMNLSTALLF LNLLFLLDGW ITSFNVDGLC IAVAVLLHFF LLATFTWMGL
960 970 980 990 1000
EAIHMYIALV KVFNTYIRRY ILKFCIIGWG LPALVVSVVL ASRNNNEVYG
1010 1020 1030 1040 1050
KESYGKEKGD EFCWIQDPVI FYVTCAGYFG VMFFLNIAMF IVVMVQICGR
1060 1070 1080 1090 1100
NGKRSNRTLR EEVLRNLRSV VSLTFLLGMT WGFAFFAWGP LNIPFMYLFS
1110 1120 1130 1140 1150
IFNSLQGLFI FIFHCAMKEN VQKQWRQHLC CGRFRLADNS DWSKTATNII
1160 1170 1180 1190 1200
KKSSDNLGKS LSSSSIGSNS TYLTSKSKSS STTYFKRNSH TDNVSYEHSF
1210 1220
NKSGSLRQCF HGQVLVKTGP C
Length:1,221
Mass (Da):136,695
Last modified:November 25, 2008 - v3
Checksum:i1950DE5AE648F1C4
GO
Isoform 2 (identifier: Q86SQ4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     380-407: Missing.

Show »
Length:1,193
Mass (Da):133,671
Checksum:iEDE274EF3096A242
GO
Isoform 3 (identifier: Q86SQ4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1193-1221: NVSYEHSFNKSGSLRQCFHGQVLVKTGPC → SASMDKSLSK...SDTFSHSTKF

Show »
Length:1,250
Mass (Da):139,901
Checksum:iBDDABA6A755A445B
GO
Isoform 4 (identifier: Q86SQ4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     380-407: Missing.
     1193-1221: NVSYEHSFNKSGSLRQCFHGQVLVKTGPC → SASMDKSLSK...SDTFSHSTKF

Show »
Length:1,222
Mass (Da):136,878
Checksum:i7B50E167F0EBBA97
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H2L1F5H2L1_HUMAN
Adhesion G-protein-coupled receptor...
ADGRG6
241Annotation score:
F5H054F5H054_HUMAN
Adhesion G-protein-coupled receptor...
ADGRG6
141Annotation score:
H0YGP2H0YGP2_HUMAN
Adhesion G-protein-coupled receptor...
ADGRG6
135Annotation score:
H0YFM8H0YFM8_HUMAN
Adhesion G-protein-coupled receptor...
ADGRG6
103Annotation score:

Sequence cautioni

The sequence AAO13250 differs from that shown. Sequencing errors.Curated
The sequence BAB55406 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC11393 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAE45930 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti622N → S in CAE45986 (PubMed:17974005).Curated1
Sequence conflicti623I → V in CAE45930 (PubMed:17974005).Curated1
Sequence conflicti708F → S in CAE45986 (PubMed:17974005).Curated1
Sequence conflicti763K → Q in CAE45930 (PubMed:17974005).Curated1
Sequence conflicti908L → P in AAH75798 (PubMed:15489334).Curated1

Polymorphismi

Genetic variations in ADGRG6 influences stature as a quantitative trait (STQTL) [MIMi:606255]. Adult height is an easily observable and highly heritable complex continuous trait. Because of this, it is a model trait for studying genetic influence on quantitative traits.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_054128123S → G. Corresponds to variant dbSNP:rs17280293Ensembl.1
Natural variantiVAR_024478230K → Q1 PublicationCorresponds to variant dbSNP:rs11155242Ensembl.1
Natural variantiVAR_075146741V → E in LCCS9; decreases the autoprocessing/cleavage of the receptor. 1 Publication1
Natural variantiVAR_075147769V → E in LCCS9. 1 PublicationCorresponds to variant dbSNP:rs793888525EnsemblClinVar.1
Natural variantiVAR_0769651057R → Q Found in patients with aggressive periodontitis; impairs cAMP production; abrogates osteoblastic differentiation. 1 PublicationCorresponds to variant dbSNP:rs536714306Ensembl.1
Natural variantiVAR_0541291127Q → R6 PublicationsCorresponds to variant dbSNP:rs1262686Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_010747380 – 407Missing in isoform 2 and isoform 4. 4 PublicationsAdd BLAST28
Alternative sequenceiVSP_0107481193 – 1221NVSYE…KTGPC → SASMDKSLSKLAHADGDQTS IIPVHQVIDKVKGYCNAHSD NFYKNIIMSDTFSHSTKF in isoform 3 and isoform 4. 4 PublicationsAdd BLAST29

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF216967 mRNA Translation: AAO13250.1 Sequence problems.
AB183546 mRNA Translation: BAD27571.1
AB183547 mRNA Translation: BAD27572.1
AB183548 mRNA Translation: BAD27573.1
AB183549 mRNA Translation: BAD27574.1
BX640971 mRNA Translation: CAE45986.1
BX640873 mRNA Translation: CAE45930.1 Different initiation.
AL033377 Genomic DNA No translation available.
AL360007 Genomic DNA No translation available.
BC075798 mRNA Translation: AAH75798.1
AK027843 mRNA Translation: BAB55406.1 Different initiation.
AK075087 mRNA Translation: BAC11393.1 Different initiation.
AY181244 mRNA Translation: AAO27356.1
AY426673 mRNA Translation: AAR88427.1
CCDSiCCDS47489.1 [Q86SQ4-3]
CCDS47490.1 [Q86SQ4-1]
CCDS47491.1 [Q86SQ4-2]
CCDS55064.1 [Q86SQ4-4]
RefSeqiNP_001027566.1, NM_001032394.2
NP_001027567.1, NM_001032395.2
NP_065188.4, NM_020455.5
NP_940971.1, NM_198569.2
UniGeneiHs.743302

Genome annotation databases

EnsembliENST00000230173; ENSP00000230173; ENSG00000112414 [Q86SQ4-1]
ENST00000296932; ENSP00000296932; ENSG00000112414 [Q86SQ4-2]
ENST00000367608; ENSP00000356580; ENSG00000112414 [Q86SQ4-4]
ENST00000367609; ENSP00000356581; ENSG00000112414 [Q86SQ4-3]
GeneIDi57211
KEGGihsa:57211
UCSCiuc010khc.4 human [Q86SQ4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF216967 mRNA Translation: AAO13250.1 Sequence problems.
AB183546 mRNA Translation: BAD27571.1
AB183547 mRNA Translation: BAD27572.1
AB183548 mRNA Translation: BAD27573.1
AB183549 mRNA Translation: BAD27574.1
BX640971 mRNA Translation: CAE45986.1
BX640873 mRNA Translation: CAE45930.1 Different initiation.
AL033377 Genomic DNA No translation available.
AL360007 Genomic DNA No translation available.
BC075798 mRNA Translation: AAH75798.1
AK027843 mRNA Translation: BAB55406.1 Different initiation.
AK075087 mRNA Translation: BAC11393.1 Different initiation.
AY181244 mRNA Translation: AAO27356.1
AY426673 mRNA Translation: AAR88427.1
CCDSiCCDS47489.1 [Q86SQ4-3]
CCDS47490.1 [Q86SQ4-1]
CCDS47491.1 [Q86SQ4-2]
CCDS55064.1 [Q86SQ4-4]
RefSeqiNP_001027566.1, NM_001032394.2
NP_001027567.1, NM_001032395.2
NP_065188.4, NM_020455.5
NP_940971.1, NM_198569.2
UniGeneiHs.743302

3D structure databases

ProteinModelPortaliQ86SQ4
SMRiQ86SQ4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121449, 2 interactors
STRINGi9606.ENSP00000356581

Protein family/group databases

MEROPSiP02.017
GPCRDBiSearch...

PTM databases

GlyConnecti1287
iPTMnetiQ86SQ4
PhosphoSitePlusiQ86SQ4
SwissPalmiQ86SQ4

Polymorphism and mutation databases

BioMutaiGPR126
DMDMi215274152

Proteomic databases

MaxQBiQ86SQ4
PaxDbiQ86SQ4
PeptideAtlasiQ86SQ4
PRIDEiQ86SQ4
ProteomicsDBi69609
69610 [Q86SQ4-2]
69611 [Q86SQ4-3]
69612 [Q86SQ4-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000230173; ENSP00000230173; ENSG00000112414 [Q86SQ4-1]
ENST00000296932; ENSP00000296932; ENSG00000112414 [Q86SQ4-2]
ENST00000367608; ENSP00000356580; ENSG00000112414 [Q86SQ4-4]
ENST00000367609; ENSP00000356581; ENSG00000112414 [Q86SQ4-3]
GeneIDi57211
KEGGihsa:57211
UCSCiuc010khc.4 human [Q86SQ4-1]

Organism-specific databases

CTDi57211
DisGeNETi57211
EuPathDBiHostDB:ENSG00000112414.14
GeneCardsiADGRG6
HGNCiHGNC:13841 ADGRG6
HPAiHPA017346
MalaCardsiADGRG6
MIMi606255 phenotype
612243 gene
616503 phenotype
neXtProtiNX_Q86SQ4
OpenTargetsiENSG00000112414
PharmGKBiPA134878328
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3714 Eukaryota
KOG4193 Eukaryota
ENOG410XSD2 LUCA
GeneTreeiENSGT00930000150821
HOVERGENiHBG051778
InParanoidiQ86SQ4
KOiK08463
OMAiGYFGIMF
OrthoDBiEOG091G00P5
PhylomeDBiQ86SQ4
TreeFamiTF321769

Enzyme and pathway databases

SignaLinkiQ86SQ4

Miscellaneous databases

ChiTaRSiADGRG6 human
GeneWikiiGPR126
GenomeRNAii57211
PROiPR:Q86SQ4
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000112414 Expressed in 179 organ(s), highest expression level in lung
CleanExiHS_GPR126
ExpressionAtlasiQ86SQ4 baseline and differential
GenevisibleiQ86SQ4 HS

Family and domain databases

CDDicd00041 CUB, 1 hit
Gene3Di2.60.120.290, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR000859 CUB_dom
IPR017981 GPCR_2-like
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
IPR000203 GPS
IPR001759 Pentraxin-related
IPR035914 Sperma_CUB_dom_sf
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF00431 CUB, 1 hit
PF01825 GPS, 1 hit
PF00354 Pentaxin, 1 hit
PRINTSiPR00249 GPCRSECRETIN
SMARTiView protein in SMART
SM00042 CUB, 1 hit
SM00303 GPS, 1 hit
SM00159 PTX, 1 hit
SUPFAMiSSF49854 SSF49854, 1 hit
SSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS01180 CUB, 1 hit
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
PS50221 GPS, 1 hit
PS51828 PTX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAGRG6_HUMAN
AccessioniPrimary (citable) accession number: Q86SQ4
Secondary accession number(s): Q5TGN7
, Q6DHZ4, Q6F3F5, Q6F3F6, Q6F3F7, Q6F3F8, Q6MZU7, Q8IXA4, Q8NC14, Q96JW0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: November 25, 2008
Last modified: November 7, 2018
This is version 154 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  6. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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