ADGRG6

Functionⁱ

G-protein coupled receptor which is activated by type IV collagen, a major constituent of the basement membrane (By similarity). Couples to G(i)-proteins as well as G(s)-proteins (PubMed:24227709). Essential for normal differentiation of promyelinating Schwann cells and for normal myelination of axons (PubMed:24227709). Regulates neural, cardiac and ear development via G-protein- and/or N-terminus-dependent signaling (By similarity). May act as a receptor for PRNP which may promote myelin homeostasis (By similarity).By similarity2 Publications

GO - Molecular functionⁱ

collagen binding Source: UniProtKB
extracellular matrix binding Source: UniProtKB
G protein-coupled receptor activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 24227709
laminin binding Source: UniProtKB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adenylate cyclase-activating G protein-coupled receptor signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cAMP-mediated signaling
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 24227709
cell surface receptor signaling pathway Source: UniProtKB
G protein-coupled receptor signaling pathway Source: UniProtKB
heart trabecula formation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
mitochondrion organization Source: Ensembl
myelination
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 26004201
myelination in peripheral nervous system Source: UniProtKB
Schwann cell differentiation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 24227709

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer

Molecular function

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

SignaLinkⁱ	Q86SQ4

SignaLinkⁱ

Q86SQ4

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	P02.017

MEROPSⁱ

P02.017

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Adhesion G-protein coupled receptor G6 Alternative name(s): Developmentally regulated G-protein-coupled receptor1 Publication G-protein coupled receptor 126 Vascular inducible G protein-coupled receptor1 Publication Cleaved into the following 2 chains: ADGRG6 N-terminal fragment Short name: ADGRG6-NTF ADGRG6 C-terminal fragment Short name: ADGRG6-CTF
Gene namesⁱ	Name:ADGRG6Imported Synonyms:DREG, GPR126, VIGR
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000112414.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:13841 ADGRG6
MIMⁱ	612243 gene
neXtProtⁱ	NX_Q86SQ4

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	38 – 862	ExtracellularSequence analysisAdd BLAST	825
Transmembraneⁱ	863 – 883	Helical; Name=1Sequence analysisAdd BLAST	21
Topological domainⁱ	884 – 903	CytoplasmicSequence analysisAdd BLAST	20
Transmembraneⁱ	904 – 924	Helical; Name=2Sequence analysisAdd BLAST	21
Topological domainⁱ	925 – 929	ExtracellularSequence analysis	5
Transmembraneⁱ	930 – 950	Helical; Name=3Sequence analysisAdd BLAST	21
Topological domainⁱ	951 – 970	CytoplasmicSequence analysisAdd BLAST	20
Transmembraneⁱ	971 – 991	Helical; Name=4Sequence analysisAdd BLAST	21
Topological domainⁱ	992 – 1024	ExtracellularSequence analysisAdd BLAST	33
Transmembraneⁱ	1025 – 1045	Helical; Name=5Sequence analysisAdd BLAST	21
Topological domainⁱ	1046 – 1069	CytoplasmicSequence analysisAdd BLAST	24
Transmembraneⁱ	1070 – 1090	Helical; Name=6Sequence analysisAdd BLAST	21
Topological domainⁱ	1091 – 1092	ExtracellularSequence analysis	2
Transmembraneⁱ	1093 – 1113	Helical; Name=7Sequence analysisAdd BLAST	21
Topological domainⁱ	1114 – 1221	CytoplasmicSequence analysisAdd BLAST	108

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Lethal congenital contracture syndrome 9 (LCCS9)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA form of lethal congenital contracture syndrome, an autosomal recessive disorder characterized by degeneration of anterior horn neurons, extreme skeletal muscle atrophy and congenital non-progressive joint contractures. The contractures can involve the upper or lower limbs and/or the vertebral column, leading to various degrees of flexion or extension limitations evident at birth.

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_075146	741	V → E in LCCS9; decreases the autoprocessing/cleavage of the receptor. 1 Publication		1
Natural variantⁱVAR_075147	769	V → E in LCCS9. 1 PublicationCorresponds to variant dbSNP:rs793888525EnsemblClinVar.		1

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	468	R → A: No cleavage. 1 Publication	1
Mutagenesisⁱ	469	S → A: No effect on cleavage. 1 Publication	1
Mutagenesisⁱ	803	C → S: No cleavage and not detected at the cell surface. 1 Publication	1
Mutagenesisⁱ	813	S → A: No effect on G-protein-mediated cAMP release. 1 Publication	1
Mutagenesisⁱ	815	G → A: Abolishes G-protein-mediated cAMP release. 1 Publication	1
Mutagenesisⁱ	818	N → A: Abolishes G-protein-mediated cAMP release. 1 Publication	1
Mutagenesisⁱ	819	T → A: Abolishes G-protein-mediated cAMP release. 1 Publication	1
Mutagenesisⁱ	822	C → S: No cleavage and not detected at the cell surface. 1 Publication	1
Mutagenesisⁱ	835	C → S: No cleavage and not detected at the cell surface. 1 Publication	1
Mutagenesisⁱ	837	C → S: No cleavage and not detected at the cell surface. 1 Publication	1
Mutagenesisⁱ	841	T → A: No cleavage but detected at cell surface. 1 Publication	1
Mutagenesisⁱ	841	T → P: No cleavage and not detected at the cell surface. 1 Publication	1

Keywords - Diseaseⁱ

Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	57211
MalaCards human disease database More...MalaCardsⁱ	ADGRG6
MIMⁱ	606255 phenotype 616503 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000112414
PharmGKBⁱ	PA134878328

Polymorphism and mutation databases

BioMutaⁱ	GPR126
DMDMⁱ	215274152

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 37	Sequence analysisAdd BLAST	37
ChainⁱPRO_0000012902	38 – 1221	Adhesion G-protein coupled receptor G6Add BLAST	1184
ChainⁱPRO_0000438596	38 – 840	ADGRG6 N-terminal fragment1 PublicationAdd BLAST	803
ChainⁱPRO_0000438597	841 – 1221	ADGRG6 C-terminal fragment1 PublicationAdd BLAST	381

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	41 ↔ 67	PROSITE-ProRule annotation
Disulfide bondⁱ	94 ↔ 111	PROSITE-ProRule annotation
Glycosylationⁱ	121	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	143	N-linked (GlcNAc...) asparagine1 Publication	1
Disulfide bondⁱ	186 ↔ 254	PROSITE-ProRule annotation
Glycosylationⁱ	206	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	258	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	314	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	324	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	353	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	438	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	445	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	452	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	485	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	488	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	505	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	563	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	593	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	600	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	605	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	667	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	673	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	695	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	704	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	750	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	776	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	811	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	818	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	1165	PhosphoserineCombined sources	1
Modified residueⁱ	1168	PhosphoserineBy similarity	1

Post-translational modificationⁱ

Proteolytically cleaved into 2 conserved sites: one in the GPS domain (S1 site) and the other in the middle of the extracellular domain (S2 site). The proteolytic cleavage at S1 site generates an extracellular subunit and a seven-transmembrane subunit. Furin is involved in the cleavage of the S2 site generating a soluble fragment. Processing at the GPS domain occurred independent of and probably prior to the cleavage at the S2 site. Proteolytic cleavage is required for activation of the receptor.2 Publications

Highly glycosylated.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	467 – 468	Cleavage; by furin like-convertase1 Publication		2
Siteⁱ	840 – 841	Cleavage1 Publication		2

Keywords - PTMⁱ

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q86SQ4
PaxDbⁱ	Q86SQ4
PeptideAtlas More...PeptideAtlasⁱ	Q86SQ4
PRIDEⁱ	Q86SQ4
ProteomicsDBⁱ	69609 69610 [Q86SQ4-2] 69611 [Q86SQ4-3] 69612 [Q86SQ4-4]

PTM databases

GlyConnectⁱ	1287
iPTMnetⁱ	Q86SQ4
PhosphoSitePlusⁱ	Q86SQ4
SwissPalmⁱ	Q86SQ4

Expressionⁱ

Tissue specificityⁱ

Expressed in placenta and to a lower extent in pancreas and liver. Detected in aortic endothelial cells but not in skin microvascular endothelial cells.1 Publication

Inductionⁱ

Up-regulated by bacterial lipopolysaccharides (LPS) and thrombin, but not by other inflammatory stimuli in primary umbilical veins.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000112414 Expressed in 179 organ(s), highest expression level in lung
CleanExⁱ	HS_GPR126
ExpressionAtlasⁱ	Q86SQ4 baseline and differential
Genevisibleⁱ	Q86SQ4 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA017346

HPAⁱ

HPA017346

Interactionⁱ

Subunit structureⁱ

Interacts with Laminin-2; this interaction stabilizes the receptor in an inactive state. Laminin-2 polymerization could facilitate ADGRG6-NTF removal, thereby exposing the tethered agonist to drive myelination. Interacts with PRNP.By similarity

GO - Molecular functionⁱ

laminin binding Source: UniProtKB

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	121449, 2 interactors
STRINGⁱ	9606.ENSP00000356581

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q86SQ4
SMRⁱ	Q86SQ4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	41 – 149	CUBPROSITE-ProRule annotationAdd BLAST	109
Domainⁱ	154 – 356	Pentraxin (PTX)PROSITE-ProRule annotationAdd BLAST	203
Domainⁱ	800 – 852	GPSPROSITE-ProRule annotationAdd BLAST	53

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	41 – 852	Inhibits receptor signaling in absence of type IV collagenBy similarityAdd BLAST	812
Regionⁱ	41 – 355	Mediates interaction with type IV collagenBy similarityAdd BLAST	315
Regionⁱ	473 – 837	Mediates interaction with laminin-2By similarityAdd BLAST	365

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	842 – 850	Stachel1 Publication		9

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	1153 – 1205	Ser-richAdd BLAST		53

Domainⁱ

A short peptide sequence (termed the Stachel sequence) in the C-terminal part of the extra-cellular domain (ECD) functions as a tethered agonist. Upon structural changes within the ECD, e.g. due to extracellular ligand binding or mechanical movements, this intramolecular agonist is exposed to the 7TM domain, triggering G-protein activation.1 Publication

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.Curated

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3714 Eukaryota KOG4193 Eukaryota ENOG410XSD2 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00930000150821
HOVERGENⁱ	HBG051778
InParanoidⁱ	Q86SQ4
KEGG Orthology (KO) More...KOⁱ	K08463
OMAⁱ	GYFGIMF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G00P5
PhylomeDBⁱ	Q86SQ4
TreeFamⁱ	TF321769

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00041 CUB, 1 hit
Gene3Dⁱ	2.60.120.290, 1 hit
InterProⁱ	View protein in InterPro IPR013320 ConA-like_dom_sf IPR000859 CUB_dom IPR017981 GPCR_2-like IPR000832 GPCR_2_secretin-like IPR017983 GPCR_2_secretin-like_CS IPR000203 GPS IPR001759 Pentraxin-related IPR035914 Sperma_CUB_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00002 7tm_2, 1 hit PF00431 CUB, 1 hit PF01825 GPS, 1 hit PF00354 Pentaxin, 1 hit
PRINTSⁱ	PR00249 GPCRSECRETIN
SMARTⁱ	View protein in SMART SM00042 CUB, 1 hit SM00303 GPS, 1 hit SM00159 PTX, 1 hit
SUPFAMⁱ	SSF49854 SSF49854, 1 hit SSF49899 SSF49899, 1 hit
PROSITEⁱ	View protein in PROSITE PS01180 CUB, 1 hit PS00650 G_PROTEIN_RECEP_F2_2, 1 hit PS50261 G_PROTEIN_RECEP_F2_4, 1 hit PS50221 GPS, 1 hit PS51828 PTX_2, 1 hit

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q86SQ4-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMFRSDRMWS CHWKWKPSPL LFLFALYIMC VPHSVWGCAN CRVVLSNPSG 
        60         70         80         90        100
TFTSPCYPND YPNSQACMWT LRAPTGYIIQ ITFNDFDIEE APNCIYDSLS 
       110        120        130        140        150
LDNGESQTKF CGATAKGLSF NSSANEMHVS FSSDFSIQKK GFNASYIRVA 
       160        170        180        190        200
VSLRNQKVIL PQTSDAYQVS VAKSISIPEL SAFTLCFEAT KVGHEDSDWT 
       210        220        230        240        250
AFSYSNASFT QLLSFGKAKS GYFLSISDSK CLLNNALPVK EKEDIFAESF 
       260        270        280        290        300
EQLCLVWNNS LGSIGVNFKR NYETVPCDST ISKVIPGNGK LLLGSNQNEI 
       310        320        330        340        350
VSLKGDIYNF RLWNFTMNAK ILSNLSCNVK GNVVDWQNDF WNIPNLALKA 
       360        370        380        390        400
ESNLSCGSYL IPLPAAELAS CADLGTLCQA TVNSPSTTPP TVTTNMPVTN 
       410        420        430        440        450
RIDKQRNDGI IYRISVVIQN ILRHPEVKVQ SKVAEWLNST FQNWNYTVYV 
       460        470        480        490        500
VNISFHLSAG EDKIKVKRSL EDEPRLVLWA LLVYNATNNT NLEGKIIQQK 
       510        520        530        540        550
LLKNNESLDE GLRLHTVNVR QLGHCLAMEE PKGYYWPSIQ PSEYVLPCPD 
       560        570        580        590        600
KPGFSASRIC FYNATNPLVT YWGPVDISNC LKEANEVANQ ILNLTADGQN 
       610        620        630        640        650
LTSANITNIV EQVKRIVNKE ENIDITLGST LMNIFSNILS SSDSDLLESS 
       660        670        680        690        700
SEALKTIDEL AFKIDLNSTS HVNITTRNLA LSVSSLLPGT NAISNFSIGL 
       710        720        730        740        750
PSNNESYFQM DFESGQVDPL ASVILPPNLL ENLSPEDSVL VRRAQFTFFN 
       760        770        780        790        800
KTGLFQDVGP QRKTLVSYVM ACSIGNITIQ NLKDPVQIKI KHTRTQEVHH 
       810        820        830        840        850
PICAFWDLNK NKSFGGWNTS GCVAHRDSDA SETVCLCNHF THFGVLMDLP 
       860        870        880        890        900
RSASQLDARN TKVLTFISYI GCGISAIFSA ATLLTYVAFE KLRRDYPSKI 
       910        920        930        940        950
LMNLSTALLF LNLLFLLDGW ITSFNVDGLC IAVAVLLHFF LLATFTWMGL 
       960        970        980        990       1000
EAIHMYIALV KVFNTYIRRY ILKFCIIGWG LPALVVSVVL ASRNNNEVYG 
      1010       1020       1030       1040       1050
KESYGKEKGD EFCWIQDPVI FYVTCAGYFG VMFFLNIAMF IVVMVQICGR 
      1060       1070       1080       1090       1100
NGKRSNRTLR EEVLRNLRSV VSLTFLLGMT WGFAFFAWGP LNIPFMYLFS 
      1110       1120       1130       1140       1150
IFNSLQGLFI FIFHCAMKEN VQKQWRQHLC CGRFRLADNS DWSKTATNII 
      1160       1170       1180       1190       1200
KKSSDNLGKS LSSSSIGSNS TYLTSKSKSS STTYFKRNSH TDNVSYEHSF 
      1210       1220 
NKSGSLRQCF HGQVLVKTGP C

Length:1,221

Mass (Da):136,695

Last modified:November 25, 2008 - v3

Checksum:ⁱ1950DE5AE648F1C4

GO

Isoform 2 (identifier: Q86SQ4-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
380-407: Missing.

« Hide

        10         20         30         40         50
MMFRSDRMWS CHWKWKPSPL LFLFALYIMC VPHSVWGCAN CRVVLSNPSG 
        60         70         80         90        100
TFTSPCYPND YPNSQACMWT LRAPTGYIIQ ITFNDFDIEE APNCIYDSLS 
       110        120        130        140        150
LDNGESQTKF CGATAKGLSF NSSANEMHVS FSSDFSIQKK GFNASYIRVA 
       160        170        180        190        200
VSLRNQKVIL PQTSDAYQVS VAKSISIPEL SAFTLCFEAT KVGHEDSDWT 
       210        220        230        240        250
AFSYSNASFT QLLSFGKAKS GYFLSISDSK CLLNNALPVK EKEDIFAESF 
       260        270        280        290        300
EQLCLVWNNS LGSIGVNFKR NYETVPCDST ISKVIPGNGK LLLGSNQNEI 
       310        320        330        340        350
VSLKGDIYNF RLWNFTMNAK ILSNLSCNVK GNVVDWQNDF WNIPNLALKA 
       360        370        380        390        400
ESNLSCGSYL IPLPAAELAS CADLGTLCQD GIIYRISVVI QNILRHPEVK 
       410        420        430        440        450
VQSKVAEWLN STFQNWNYTV YVVNISFHLS AGEDKIKVKR SLEDEPRLVL 
       460        470        480        490        500
WALLVYNATN NTNLEGKIIQ QKLLKNNESL DEGLRLHTVN VRQLGHCLAM 
       510        520        530        540        550
EEPKGYYWPS IQPSEYVLPC PDKPGFSASR ICFYNATNPL VTYWGPVDIS 
       560        570        580        590        600
NCLKEANEVA NQILNLTADG QNLTSANITN IVEQVKRIVN KEENIDITLG 
       610        620        630        640        650
STLMNIFSNI LSSSDSDLLE SSSEALKTID ELAFKIDLNS TSHVNITTRN 
       660        670        680        690        700
LALSVSSLLP GTNAISNFSI GLPSNNESYF QMDFESGQVD PLASVILPPN 
       710        720        730        740        750
LLENLSPEDS VLVRRAQFTF FNKTGLFQDV GPQRKTLVSY VMACSIGNIT 
       760        770        780        790        800
IQNLKDPVQI KIKHTRTQEV HHPICAFWDL NKNKSFGGWN TSGCVAHRDS 
       810        820        830        840        850
DASETVCLCN HFTHFGVLMD LPRSASQLDA RNTKVLTFIS YIGCGISAIF 
       860        870        880        890        900
SAATLLTYVA FEKLRRDYPS KILMNLSTAL LFLNLLFLLD GWITSFNVDG 
       910        920        930        940        950
LCIAVAVLLH FFLLATFTWM GLEAIHMYIA LVKVFNTYIR RYILKFCIIG 
       960        970        980        990       1000
WGLPALVVSV VLASRNNNEV YGKESYGKEK GDEFCWIQDP VIFYVTCAGY 
      1010       1020       1030       1040       1050
FGVMFFLNIA MFIVVMVQIC GRNGKRSNRT LREEVLRNLR SVVSLTFLLG 
      1060       1070       1080       1090       1100
MTWGFAFFAW GPLNIPFMYL FSIFNSLQGL FIFIFHCAMK ENVQKQWRQH 
      1110       1120       1130       1140       1150
LCCGRFRLAD NSDWSKTATN IIKKSSDNLG KSLSSSSIGS NSTYLTSKSK 
      1160       1170       1180       1190 
SSSTTYFKRN SHTDNVSYEH SFNKSGSLRQ CFHGQVLVKT GPC

Show »

Length:1,193

Mass (Da):133,671

Checksum:ⁱEDE274EF3096A242

GO

Isoform 3 (identifier: Q86SQ4-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1193-1221: NVSYEHSFNKSGSLRQCFHGQVLVKTGPC → SASMDKSLSK...SDTFSHSTKF

« Hide

        10         20         30         40         50
MMFRSDRMWS CHWKWKPSPL LFLFALYIMC VPHSVWGCAN CRVVLSNPSG 
        60         70         80         90        100
TFTSPCYPND YPNSQACMWT LRAPTGYIIQ ITFNDFDIEE APNCIYDSLS 
       110        120        130        140        150
LDNGESQTKF CGATAKGLSF NSSANEMHVS FSSDFSIQKK GFNASYIRVA 
       160        170        180        190        200
VSLRNQKVIL PQTSDAYQVS VAKSISIPEL SAFTLCFEAT KVGHEDSDWT 
       210        220        230        240        250
AFSYSNASFT QLLSFGKAKS GYFLSISDSK CLLNNALPVK EKEDIFAESF 
       260        270        280        290        300
EQLCLVWNNS LGSIGVNFKR NYETVPCDST ISKVIPGNGK LLLGSNQNEI 
       310        320        330        340        350
VSLKGDIYNF RLWNFTMNAK ILSNLSCNVK GNVVDWQNDF WNIPNLALKA 
       360        370        380        390        400
ESNLSCGSYL IPLPAAELAS CADLGTLCQA TVNSPSTTPP TVTTNMPVTN 
       410        420        430        440        450
RIDKQRNDGI IYRISVVIQN ILRHPEVKVQ SKVAEWLNST FQNWNYTVYV 
       460        470        480        490        500
VNISFHLSAG EDKIKVKRSL EDEPRLVLWA LLVYNATNNT NLEGKIIQQK 
       510        520        530        540        550
LLKNNESLDE GLRLHTVNVR QLGHCLAMEE PKGYYWPSIQ PSEYVLPCPD 
       560        570        580        590        600
KPGFSASRIC FYNATNPLVT YWGPVDISNC LKEANEVANQ ILNLTADGQN 
       610        620        630        640        650
LTSANITNIV EQVKRIVNKE ENIDITLGST LMNIFSNILS SSDSDLLESS 
       660        670        680        690        700
SEALKTIDEL AFKIDLNSTS HVNITTRNLA LSVSSLLPGT NAISNFSIGL 
       710        720        730        740        750
PSNNESYFQM DFESGQVDPL ASVILPPNLL ENLSPEDSVL VRRAQFTFFN 
       760        770        780        790        800
KTGLFQDVGP QRKTLVSYVM ACSIGNITIQ NLKDPVQIKI KHTRTQEVHH 
       810        820        830        840        850
PICAFWDLNK NKSFGGWNTS GCVAHRDSDA SETVCLCNHF THFGVLMDLP 
       860        870        880        890        900
RSASQLDARN TKVLTFISYI GCGISAIFSA ATLLTYVAFE KLRRDYPSKI 
       910        920        930        940        950
LMNLSTALLF LNLLFLLDGW ITSFNVDGLC IAVAVLLHFF LLATFTWMGL 
       960        970        980        990       1000
EAIHMYIALV KVFNTYIRRY ILKFCIIGWG LPALVVSVVL ASRNNNEVYG 
      1010       1020       1030       1040       1050
KESYGKEKGD EFCWIQDPVI FYVTCAGYFG VMFFLNIAMF IVVMVQICGR 
      1060       1070       1080       1090       1100
NGKRSNRTLR EEVLRNLRSV VSLTFLLGMT WGFAFFAWGP LNIPFMYLFS 
      1110       1120       1130       1140       1150
IFNSLQGLFI FIFHCAMKEN VQKQWRQHLC CGRFRLADNS DWSKTATNII 
      1160       1170       1180       1190       1200
KKSSDNLGKS LSSSSIGSNS TYLTSKSKSS STTYFKRNSH TDSASMDKSL 
      1210       1220       1230       1240       1250
SKLAHADGDQ TSIIPVHQVI DKVKGYCNAH SDNFYKNIIM SDTFSHSTKF

Show »

Length:1,250

Mass (Da):139,901

Checksum:ⁱBDDABA6A755A445B

GO

Isoform 4 (identifier: Q86SQ4-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
380-407: Missing.
1193-1221: NVSYEHSFNKSGSLRQCFHGQVLVKTGPC → SASMDKSLSK...SDTFSHSTKF

« Hide

        10         20         30         40         50
MMFRSDRMWS CHWKWKPSPL LFLFALYIMC VPHSVWGCAN CRVVLSNPSG 
        60         70         80         90        100
TFTSPCYPND YPNSQACMWT LRAPTGYIIQ ITFNDFDIEE APNCIYDSLS 
       110        120        130        140        150
LDNGESQTKF CGATAKGLSF NSSANEMHVS FSSDFSIQKK GFNASYIRVA 
       160        170        180        190        200
VSLRNQKVIL PQTSDAYQVS VAKSISIPEL SAFTLCFEAT KVGHEDSDWT 
       210        220        230        240        250
AFSYSNASFT QLLSFGKAKS GYFLSISDSK CLLNNALPVK EKEDIFAESF 
       260        270        280        290        300
EQLCLVWNNS LGSIGVNFKR NYETVPCDST ISKVIPGNGK LLLGSNQNEI 
       310        320        330        340        350
VSLKGDIYNF RLWNFTMNAK ILSNLSCNVK GNVVDWQNDF WNIPNLALKA 
       360        370        380        390        400
ESNLSCGSYL IPLPAAELAS CADLGTLCQD GIIYRISVVI QNILRHPEVK 
       410        420        430        440        450
VQSKVAEWLN STFQNWNYTV YVVNISFHLS AGEDKIKVKR SLEDEPRLVL 
       460        470        480        490        500
WALLVYNATN NTNLEGKIIQ QKLLKNNESL DEGLRLHTVN VRQLGHCLAM 
       510        520        530        540        550
EEPKGYYWPS IQPSEYVLPC PDKPGFSASR ICFYNATNPL VTYWGPVDIS 
       560        570        580        590        600
NCLKEANEVA NQILNLTADG QNLTSANITN IVEQVKRIVN KEENIDITLG 
       610        620        630        640        650
STLMNIFSNI LSSSDSDLLE SSSEALKTID ELAFKIDLNS TSHVNITTRN 
       660        670        680        690        700
LALSVSSLLP GTNAISNFSI GLPSNNESYF QMDFESGQVD PLASVILPPN 
       710        720        730        740        750
LLENLSPEDS VLVRRAQFTF FNKTGLFQDV GPQRKTLVSY VMACSIGNIT 
       760        770        780        790        800
IQNLKDPVQI KIKHTRTQEV HHPICAFWDL NKNKSFGGWN TSGCVAHRDS 
       810        820        830        840        850
DASETVCLCN HFTHFGVLMD LPRSASQLDA RNTKVLTFIS YIGCGISAIF 
       860        870        880        890        900
SAATLLTYVA FEKLRRDYPS KILMNLSTAL LFLNLLFLLD GWITSFNVDG 
       910        920        930        940        950
LCIAVAVLLH FFLLATFTWM GLEAIHMYIA LVKVFNTYIR RYILKFCIIG 
       960        970        980        990       1000
WGLPALVVSV VLASRNNNEV YGKESYGKEK GDEFCWIQDP VIFYVTCAGY 
      1010       1020       1030       1040       1050
FGVMFFLNIA MFIVVMVQIC GRNGKRSNRT LREEVLRNLR SVVSLTFLLG 
      1060       1070       1080       1090       1100
MTWGFAFFAW GPLNIPFMYL FSIFNSLQGL FIFIFHCAMK ENVQKQWRQH 
      1110       1120       1130       1140       1150
LCCGRFRLAD NSDWSKTATN IIKKSSDNLG KSLSSSSIGS NSTYLTSKSK 
      1160       1170       1180       1190       1200
SSSTTYFKRN SHTDSASMDK SLSKLAHADG DQTSIIPVHQ VIDKVKGYCN 
      1210       1220 
AHSDNFYKNI IMSDTFSHST KF

Show »

Length:1,222

Mass (Da):136,878

Checksum:ⁱ7B50E167F0EBBA97

GO

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F5H2L1	F5H2L1_HUMAN	Adhesion G-protein-coupled receptor... Adhesion G-protein-coupled receptor G6	ADGRG6	241	Annotation score:
F5H054	F5H054_HUMAN	Adhesion G-protein-coupled receptor... Adhesion G-protein-coupled receptor G6	ADGRG6	141	Annotation score:
H0YGP2	H0YGP2_HUMAN	Adhesion G-protein-coupled receptor... Adhesion G-protein-coupled receptor G6	ADGRG6	135	Annotation score:
H0YFM8	H0YFM8_HUMAN	Adhesion G-protein-coupled receptor... Adhesion G-protein-coupled receptor G6	ADGRG6	103	Annotation score:

Sequence cautionⁱ

The sequence AAO13250 differs from that shown. Sequencing errors.Curated

The sequence BAB55406 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence BAC11393 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence CAE45930 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	622	N → S in CAE45986 (PubMed:17974005).Curated	1
Sequence conflictⁱ	623	I → V in CAE45930 (PubMed:17974005).Curated	1
Sequence conflictⁱ	708	F → S in CAE45986 (PubMed:17974005).Curated	1
Sequence conflictⁱ	763	K → Q in CAE45930 (PubMed:17974005).Curated	1
Sequence conflictⁱ	908	L → P in AAH75798 (PubMed:15489334).Curated	1

Polymorphismⁱ

Genetic variations in ADGRG6 influences stature as a quantitative trait (STQTL) [MIMⁱ:606255]. Adult height is an easily observable and highly heritable complex continuous trait. Because of this, it is a model trait for studying genetic influence on quantitative traits.1 Publication

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_054128	123	S → G. Corresponds to variant dbSNP:rs17280293Ensembl.	1
Natural variantⁱVAR_024478	230	K → Q1 PublicationCorresponds to variant dbSNP:rs11155242Ensembl.	1
Natural variantⁱVAR_075146	741	V → E in LCCS9; decreases the autoprocessing/cleavage of the receptor. 1 Publication	1
Natural variantⁱVAR_075147	769	V → E in LCCS9. 1 PublicationCorresponds to variant dbSNP:rs793888525EnsemblClinVar.	1
Natural variantⁱVAR_076965	1057	R → Q Found in patients with aggressive periodontitis; impairs cAMP production; abrogates osteoblastic differentiation. 1 PublicationCorresponds to variant dbSNP:rs536714306Ensembl.	1
Natural variantⁱVAR_054129	1127	Q → R6 PublicationsCorresponds to variant dbSNP:rs1262686Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_010747	380 – 407	Missing in isoform 2 and isoform 4. 4 PublicationsAdd BLAST		28
Alternative sequenceⁱVSP_010748	1193 – 1221	NVSYE…KTGPC → SASMDKSLSKLAHADGDQTS IIPVHQVIDKVKGYCNAHSD NFYKNIIMSDTFSHSTKF in isoform 3 and isoform 4. 4 PublicationsAdd BLAST		29

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF216967 mRNA Translation: AAO13250.1 Sequence problems. AB183546 mRNA Translation: BAD27571.1 AB183547 mRNA Translation: BAD27572.1 AB183548 mRNA Translation: BAD27573.1 AB183549 mRNA Translation: BAD27574.1 BX640971 mRNA Translation: CAE45986.1 BX640873 mRNA Translation: CAE45930.1 Different initiation. AL033377 Genomic DNA No translation available. AL360007 Genomic DNA No translation available. BC075798 mRNA Translation: AAH75798.1 AK027843 mRNA Translation: BAB55406.1 Different initiation. AK075087 mRNA Translation: BAC11393.1 Different initiation. AY181244 mRNA Translation: AAO27356.1 AY426673 mRNA Translation: AAR88427.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS47489.1 [Q86SQ4-3] CCDS47490.1 [Q86SQ4-1] CCDS47491.1 [Q86SQ4-2] CCDS55064.1 [Q86SQ4-4]
NCBI Reference Sequences More...RefSeqⁱ	NP_001027566.1, NM_001032394.2 NP_001027567.1, NM_001032395.2 NP_065188.4, NM_020455.5 NP_940971.1, NM_198569.2
UniGeneⁱ	Hs.743302

Genome annotation databases

Ensemblⁱ	ENST00000230173; ENSP00000230173; ENSG00000112414 [Q86SQ4-1] ENST00000296932; ENSP00000296932; ENSG00000112414 [Q86SQ4-2] ENST00000367608; ENSP00000356580; ENSG00000112414 [Q86SQ4-4] ENST00000367609; ENSP00000356581; ENSG00000112414 [Q86SQ4-3]
GeneIDⁱ	57211
KEGGⁱ	hsa:57211
UCSC genome browser More...UCSCⁱ	uc010khc.4 human [Q86SQ4-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q86SQ4	ADGRG6 isoform 3		PANTR		1250	UniRef90_Q86SQ4
Adhesion G-protein-coupled receptor G6 (Fragment)		HUMAN		241
Adhesion G protein-coupled receptor G6		SAIBB		1250
Adhesion G protein-coupled receptor G6		CALJA		1250
Uncharacterized protein		Cebus capucinus imitator		1250
+93
Q86SQ4-2	Adhesion G protein-coupled receptor G6		SAIBB		1222	UniRef90_Q86SQ4-2
Adhesion G protein-coupled receptor G6		CALJA		1222
Uncharacterized protein		Cebus capucinus imitator		1222
Uncharacterized protein		AOTNA		1222
Uncharacterized protein		RHIBE		1220
+29
Q86SQ4-4	Uncharacterized protein		NOMLE		1224	UniRef90_Q86SQ4-4
ADGRG6 isoform 2		PANTR		1222
ADGRG6 isoform 2		PONAB		1222
Uncharacterized protein		PANPA		1222
Adhesion G protein-coupled receptor G6		GORGO		1222
+19

Protein	Similar proteins		Species	Score	Length	Source
Q86SQ4	Adhesion G protein-coupled receptor G6		SAIBB		1250	UniRef50_Q86SQ4
ADGRG6 isoform 3		PANTR		1250
Adhesion G-protein-coupled receptor G6 (Fragment)		HUMAN		241
Uncharacterized protein		Cebus capucinus imitator		1250
Adhesion G protein-coupled receptor G6		GORGO		1250
+365
Q86SQ4-2	Isoform 4 of Adhesion G-protein coupled receptor G6		HUMAN		1222	UniRef50_Q86SQ4-4
Adhesion G-protein coupled receptor G6		MOUSE		1165
Uncharacterized protein		NOMLE		1224
ADGRG6 isoform 2		PANTR		1222
Adhesion G protein-coupled receptor G6		GORGO		1222
+187
Q86SQ4-4	Adhesion G-protein coupled receptor G6		MOUSE		1165	UniRef50_Q86SQ4-4
Uncharacterized protein		NOMLE		1224
ADGRG6 isoform 2		PANTR		1222
Adhesion G protein-coupled receptor G6		GORGO		1222
ADGRG6 isoform 2		PONAB		1222
+187

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF216967 mRNA Translation: AAO13250.1 Sequence problems. AB183546 mRNA Translation: BAD27571.1 AB183547 mRNA Translation: BAD27572.1 AB183548 mRNA Translation: BAD27573.1 AB183549 mRNA Translation: BAD27574.1 BX640971 mRNA Translation: CAE45986.1 BX640873 mRNA Translation: CAE45930.1 Different initiation. AL033377 Genomic DNA No translation available. AL360007 Genomic DNA No translation available. BC075798 mRNA Translation: AAH75798.1 AK027843 mRNA Translation: BAB55406.1 Different initiation. AK075087 mRNA Translation: BAC11393.1 Different initiation. AY181244 mRNA Translation: AAO27356.1 AY426673 mRNA Translation: AAR88427.1
CCDSⁱ	CCDS47489.1 [Q86SQ4-3] CCDS47490.1 [Q86SQ4-1] CCDS47491.1 [Q86SQ4-2] CCDS55064.1 [Q86SQ4-4]
RefSeqⁱ	NP_001027566.1, NM_001032394.2 NP_001027567.1, NM_001032395.2 NP_065188.4, NM_020455.5 NP_940971.1, NM_198569.2
UniGeneⁱ	Hs.743302

3D structure databases

ProteinModelPortalⁱ	Q86SQ4
SMRⁱ	Q86SQ4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	121449, 2 interactors
STRINGⁱ	9606.ENSP00000356581

Protein family/group databases

MEROPSⁱ	P02.017
GPCRDBⁱ	Search...

PTM databases

GlyConnectⁱ	1287
iPTMnetⁱ	Q86SQ4
PhosphoSitePlusⁱ	Q86SQ4
SwissPalmⁱ	Q86SQ4

Polymorphism and mutation databases

BioMutaⁱ	GPR126
DMDMⁱ	215274152

Proteomic databases

MaxQBⁱ	Q86SQ4
PaxDbⁱ	Q86SQ4
PeptideAtlasⁱ	Q86SQ4
PRIDEⁱ	Q86SQ4
ProteomicsDBⁱ	69609 69610 [Q86SQ4-2] 69611 [Q86SQ4-3] 69612 [Q86SQ4-4]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000230173; ENSP00000230173; ENSG00000112414 [Q86SQ4-1] ENST00000296932; ENSP00000296932; ENSG00000112414 [Q86SQ4-2] ENST00000367608; ENSP00000356580; ENSG00000112414 [Q86SQ4-4] ENST00000367609; ENSP00000356581; ENSG00000112414 [Q86SQ4-3]
GeneIDⁱ	57211
KEGGⁱ	hsa:57211
UCSCⁱ	uc010khc.4 human [Q86SQ4-1]

Organism-specific databases

CTDⁱ	57211
DisGeNETⁱ	57211
EuPathDBⁱ	HostDB:ENSG00000112414.14
GeneCardsⁱ	ADGRG6
HGNCⁱ	HGNC:13841 ADGRG6
HPAⁱ	HPA017346
MalaCardsⁱ	ADGRG6
MIMⁱ	606255 phenotype 612243 gene 616503 phenotype
neXtProtⁱ	NX_Q86SQ4
OpenTargetsⁱ	ENSG00000112414
PharmGKBⁱ	PA134878328
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3714 Eukaryota KOG4193 Eukaryota ENOG410XSD2 LUCA
GeneTreeⁱ	ENSGT00930000150821
HOVERGENⁱ	HBG051778
InParanoidⁱ	Q86SQ4
KOⁱ	K08463
OMAⁱ	GYFGIMF
OrthoDBⁱ	EOG091G00P5
PhylomeDBⁱ	Q86SQ4
TreeFamⁱ	TF321769

Enzyme and pathway databases

SignaLinkⁱ	Q86SQ4

SignaLinkⁱ

Q86SQ4

Miscellaneous databases

ChiTaRSⁱ	ADGRG6 human
GeneWikiⁱ	GPR126
GenomeRNAiⁱ	57211
Protein Ontology More...PROⁱ	PR:Q86SQ4
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000112414 Expressed in 179 organ(s), highest expression level in lung
CleanExⁱ	HS_GPR126
ExpressionAtlasⁱ	Q86SQ4 baseline and differential
Genevisibleⁱ	Q86SQ4 HS

Family and domain databases

CDDⁱ	cd00041 CUB, 1 hit
Gene3Dⁱ	2.60.120.290, 1 hit
InterProⁱ	View protein in InterPro IPR013320 ConA-like_dom_sf IPR000859 CUB_dom IPR017981 GPCR_2-like IPR000832 GPCR_2_secretin-like IPR017983 GPCR_2_secretin-like_CS IPR000203 GPS IPR001759 Pentraxin-related IPR035914 Sperma_CUB_dom_sf
Pfamⁱ	View protein in Pfam PF00002 7tm_2, 1 hit PF00431 CUB, 1 hit PF01825 GPS, 1 hit PF00354 Pentaxin, 1 hit
PRINTSⁱ	PR00249 GPCRSECRETIN
SMARTⁱ	View protein in SMART SM00042 CUB, 1 hit SM00303 GPS, 1 hit SM00159 PTX, 1 hit
SUPFAMⁱ	SSF49854 SSF49854, 1 hit SSF49899 SSF49899, 1 hit
PROSITEⁱ	View protein in PROSITE PS01180 CUB, 1 hit PS00650 G_PROTEIN_RECEP_F2_2, 1 hit PS50261 G_PROTEIN_RECEP_F2_4, 1 hit PS50221 GPS, 1 hit PS51828 PTX_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	AGRG6_HUMAN
Accessionⁱ	Q86SQ4Primary (citable) accession number: Q86SQ4 Secondary accession number(s): Q5TGN7 Q96JW0
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
	Last sequence update:	November 25, 2008
	Last modified:	November 7, 2018
	This is version 154 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM
7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries

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UniProtKB - Q86SQ4 (AGRG6_HUMAN)

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Adhesion G-protein coupled receptor G6

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

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<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

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<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

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<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

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<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

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<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

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Keywords - Coding sequence diversityi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

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GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

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Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ