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UniProtKB - Q86SQ4 (AGRG6_HUMAN)

Entry version 173 (29 Sep 2021)
Sequence version 3 (25 Nov 2008)
Previous versions | rss
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Protein

Adhesion G-protein coupled receptor G6

Gene

ADGRG6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

G-protein coupled receptor which is activated by type IV collagen, a major constituent of the basement membrane (By similarity).

Couples to G(i)-proteins as well as G(s)-proteins (PubMed:24227709).

Essential for normal differentiation of promyelinating Schwann cells and for normal myelination of axons (PubMed:24227709).

Regulates neural, cardiac and ear development via G-protein- and/or N-terminus-dependent signaling (By similarity).

May act as a receptor for PRNP which may promote myelin homeostasis (By similarity).

By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q86SQ4

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-9619665, EGR2 and SOX10-mediated initiation of Schwann cell myelination

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q86SQ4

Protein family/group databases

MEROPS protease database

More...MEROPSi		P02.017

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Adhesion G-protein coupled receptor G6
Alternative name(s):
Developmentally regulated G-protein-coupled receptor1 Publication
G-protein coupled receptor 126
Vascular inducible G protein-coupled receptor1 Publication
Cleaved into the following 2 chains:
ADGRG6 N-terminal fragment
Short name:
ADGRG6-NTF
ADGRG6 C-terminal fragment
Short name:
ADGRG6-CTF
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ADGRG6Imported
Synonyms:DREG, GPR126, VIGR
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:13841, ADGRG6

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		612243, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q86SQ4

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000112414

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini38 – 862ExtracellularSequence analysisAdd BLAST825
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei863 – 883Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini884 – 903CytoplasmicSequence analysisAdd BLAST20
Transmembranei904 – 924Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini925 – 929ExtracellularSequence analysis5
Transmembranei930 – 950Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini951 – 970CytoplasmicSequence analysisAdd BLAST20
Transmembranei971 – 991Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini992 – 1024ExtracellularSequence analysisAdd BLAST33
Transmembranei1025 – 1045Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini1046 – 1069CytoplasmicSequence analysisAdd BLAST24
Transmembranei1070 – 1090Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini1091 – 1092ExtracellularSequence analysis2
Transmembranei1093 – 1113Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini1114 – 1221CytoplasmicSequence analysisAdd BLAST108

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Lethal congenital contracture syndrome 9 (LCCS9)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of lethal congenital contracture syndrome, an autosomal recessive disorder characterized by degeneration of anterior horn neurons, extreme skeletal muscle atrophy and congenital non-progressive joint contractures. The contractures can involve the upper or lower limbs and/or the vertebral column, leading to various degrees of flexion or extension limitations evident at birth.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_075146741V → E in LCCS9; decreases the autoprocessing/cleavage of the receptor. 1 Publication1
Natural variantiVAR_075147769V → E in LCCS9. 1 PublicationCorresponds to variant dbSNP:rs793888525EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi468R → A: No cleavage. 1 Publication1
Mutagenesisi469S → A: No effect on cleavage. 1 Publication1
Mutagenesisi803C → S: No cleavage and not detected at the cell surface. 1 Publication1
Mutagenesisi813S → A: No effect on G-protein-mediated cAMP release. 1 Publication1
Mutagenesisi815G → A: Abolishes G-protein-mediated cAMP release. 1 Publication1
Mutagenesisi818N → A: Abolishes G-protein-mediated cAMP release. 1 Publication1
Mutagenesisi819T → A: Abolishes G-protein-mediated cAMP release. 1 Publication1
Mutagenesisi822C → S: No cleavage and not detected at the cell surface. 1 Publication1
Mutagenesisi835C → S: No cleavage and not detected at the cell surface. 1 Publication1
Mutagenesisi837C → S: No cleavage and not detected at the cell surface. 1 Publication1
Mutagenesisi841T → A: No cleavage but detected at cell surface. 1 Publication1
Mutagenesisi841T → P: No cleavage and not detected at the cell surface. 1 Publication1

Keywords - Diseasei

Disease variant

Organism-specific databases

DisGeNET

More...DisGeNETi		57211

MalaCards human disease database

More...MalaCardsi		ADGRG6
MIMi606255, phenotype
616503, phenotype

Open Targets

More...OpenTargetsi		ENSG00000112414

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134878328

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q86SQ4, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4523884

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ADGRG6

Domain mapping of disease mutations (DMDM)

More...DMDMi		215274152

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 37Sequence analysisAdd BLAST37
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001290238 – 1221Adhesion G-protein coupled receptor G6Add BLAST1184
ChainiPRO_000043859638 – 840ADGRG6 N-terminal fragment1 PublicationAdd BLAST803
ChainiPRO_0000438597841 – 1221ADGRG6 C-terminal fragment1 PublicationAdd BLAST381

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi41 ↔ 67PROSITE-ProRule annotation
Disulfide bondi94 ↔ 111PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi121N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi143N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi186 ↔ 254PROSITE-ProRule annotation
Glycosylationi206N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi258N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi314N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi324N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi353N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi438N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi445N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi452N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi485N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi488N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi505N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi563N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi593N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi600N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi605N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi667N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi673N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi695N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi704N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi750N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi776N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi811N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi818N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1165PhosphoserineCombined sources1
Modified residuei1168PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Proteolytically cleaved into 2 conserved sites: one in the GPS domain (S1 site) and the other in the middle of the extracellular domain (S2 site). The proteolytic cleavage at S1 site generates an extracellular subunit and a seven-transmembrane subunit. Furin is involved in the cleavage of the S2 site generating a soluble fragment. Processing at the GPS domain occurred independent of and probably prior to the cleavage at the S2 site. Proteolytic cleavage is required for activation of the receptor.2 Publications
Highly glycosylated.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei467 – 468Cleavage; by furin like-convertase1 Publication2
Sitei840 – 841Cleavage1 Publication2

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q86SQ4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q86SQ4

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q86SQ4

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q86SQ4

PeptideAtlas

More...PeptideAtlasi		Q86SQ4

PRoteomics IDEntifications database

More...PRIDEi		Q86SQ4

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		69609 [Q86SQ4-1]
69610 [Q86SQ4-2]
69611 [Q86SQ4-3]
69612 [Q86SQ4-4]

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		1287, 19 N-Linked glycans (8 sites)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q86SQ4, 27 sites, 19 N-linked glycans (8 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q86SQ4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q86SQ4

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q86SQ4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in placenta and to a lower extent in pancreas and liver. Detected in aortic endothelial cells but not in skin microvascular endothelial cells.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by bacterial lipopolysaccharides (LPS) and thrombin, but not by other inflammatory stimuli in primary umbilical veins.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000112414, Expressed in lung and 192 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q86SQ4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q86SQ4, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000112414, Group enriched (liver, placenta)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with Laminin-2; this interaction stabilizes the receptor in an inactive state. Laminin-2 polymerization could facilitate ADGRG6-NTF removal, thereby exposing the tethered agonist to drive myelination.

Interacts with PRNP.

By similarity

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		121449, 15 interactors

Protein interaction database and analysis system

More...IntActi		Q86SQ4, 2 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000356581

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q86SQ4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Small Angle Scattering Biological Data Bank

More...SASBDBi		Q86SQ4

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q86SQ4

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini41 – 149CUBPROSITE-ProRule annotationAdd BLAST109
Domaini154 – 356Pentraxin (PTX)PROSITE-ProRule annotationAdd BLAST203
Domaini800 – 852GPSPROSITE-ProRule annotationAdd BLAST53

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni41 – 852Inhibits receptor signaling in absence of type IV collagenBy similarityAdd BLAST812
Regioni41 – 355Mediates interaction with type IV collagenBy similarityAdd BLAST315
Regioni473 – 837Mediates interaction with laminin-2By similarityAdd BLAST365
Regioni1156 – 1176DisorderedSequence analysisAdd BLAST21

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi842 – 850Stachel1 Publication9

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

A short peptide sequence (termed the Stachel sequence) in the C-terminal part of the extra-cellular domain (ECD) functions as a tethered agonist. Upon structural changes within the ECD, e.g. due to extracellular ligand binding or mechanical movements, this intramolecular agonist is exposed to the 7TM domain, triggering G-protein activation.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4193, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155621

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002753_3_3_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q86SQ4

Identification of Orthologs from Complete Genome Data

More...OMAi		AWGCANC

Database of Orthologous Groups

More...OrthoDBi		148879at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q86SQ4

TreeFam database of animal gene trees

More...TreeFami		TF321769

Family and domain databases

Conserved Domains Database

More...CDDi		cd00041, CUB, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.120.290, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013320, ConA-like_dom_sf
IPR000859, CUB_dom
IPR017981, GPCR_2-like
IPR000832, GPCR_2_secretin-like
IPR017983, GPCR_2_secretin-like_CS
IPR000203, GPS
IPR001759, Pentraxin-related
IPR035914, Sperma_CUB_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00002, 7tm_2, 1 hit
PF00431, CUB, 1 hit
PF01825, GPS, 1 hit
PF00354, Pentaxin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00249, GPCRSECRETIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00042, CUB, 1 hit
SM00303, GPS, 1 hit
SM00159, PTX, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49854, SSF49854, 1 hit
SSF49899, SSF49899, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01180, CUB, 1 hit
PS00650, G_PROTEIN_RECEP_F2_2, 1 hit
PS50261, G_PROTEIN_RECEP_F2_4, 1 hit
PS50221, GPS, 1 hit
PS51828, PTX_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86SQ4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMFRSDRMWS CHWKWKPSPL LFLFALYIMC VPHSVWGCAN CRVVLSNPSG 
        60         70         80         90        100
TFTSPCYPND YPNSQACMWT LRAPTGYIIQ ITFNDFDIEE APNCIYDSLS 
       110        120        130        140        150
LDNGESQTKF CGATAKGLSF NSSANEMHVS FSSDFSIQKK GFNASYIRVA 
       160        170        180        190        200
VSLRNQKVIL PQTSDAYQVS VAKSISIPEL SAFTLCFEAT KVGHEDSDWT 
       210        220        230        240        250
AFSYSNASFT QLLSFGKAKS GYFLSISDSK CLLNNALPVK EKEDIFAESF 
       260        270        280        290        300
EQLCLVWNNS LGSIGVNFKR NYETVPCDST ISKVIPGNGK LLLGSNQNEI 
       310        320        330        340        350
VSLKGDIYNF RLWNFTMNAK ILSNLSCNVK GNVVDWQNDF WNIPNLALKA 
       360        370        380        390        400
ESNLSCGSYL IPLPAAELAS CADLGTLCQA TVNSPSTTPP TVTTNMPVTN 
       410        420        430        440        450
RIDKQRNDGI IYRISVVIQN ILRHPEVKVQ SKVAEWLNST FQNWNYTVYV 
       460        470        480        490        500
VNISFHLSAG EDKIKVKRSL EDEPRLVLWA LLVYNATNNT NLEGKIIQQK 
       510        520        530        540        550
LLKNNESLDE GLRLHTVNVR QLGHCLAMEE PKGYYWPSIQ PSEYVLPCPD 
       560        570        580        590        600
KPGFSASRIC FYNATNPLVT YWGPVDISNC LKEANEVANQ ILNLTADGQN 
       610        620        630        640        650
LTSANITNIV EQVKRIVNKE ENIDITLGST LMNIFSNILS SSDSDLLESS 
       660        670        680        690        700
SEALKTIDEL AFKIDLNSTS HVNITTRNLA LSVSSLLPGT NAISNFSIGL 
       710        720        730        740        750
PSNNESYFQM DFESGQVDPL ASVILPPNLL ENLSPEDSVL VRRAQFTFFN 
       760        770        780        790        800
KTGLFQDVGP QRKTLVSYVM ACSIGNITIQ NLKDPVQIKI KHTRTQEVHH 
       810        820        830        840        850
PICAFWDLNK NKSFGGWNTS GCVAHRDSDA SETVCLCNHF THFGVLMDLP 
       860        870        880        890        900
RSASQLDARN TKVLTFISYI GCGISAIFSA ATLLTYVAFE KLRRDYPSKI 
       910        920        930        940        950
LMNLSTALLF LNLLFLLDGW ITSFNVDGLC IAVAVLLHFF LLATFTWMGL 
       960        970        980        990       1000
EAIHMYIALV KVFNTYIRRY ILKFCIIGWG LPALVVSVVL ASRNNNEVYG 
      1010       1020       1030       1040       1050
KESYGKEKGD EFCWIQDPVI FYVTCAGYFG VMFFLNIAMF IVVMVQICGR 
      1060       1070       1080       1090       1100
NGKRSNRTLR EEVLRNLRSV VSLTFLLGMT WGFAFFAWGP LNIPFMYLFS 
      1110       1120       1130       1140       1150
IFNSLQGLFI FIFHCAMKEN VQKQWRQHLC CGRFRLADNS DWSKTATNII 
      1160       1170       1180       1190       1200
KKSSDNLGKS LSSSSIGSNS TYLTSKSKSS STTYFKRNSH TDNVSYEHSF 
      1210       1220 
NKSGSLRQCF HGQVLVKTGP C
Length:1,221
Mass (Da):136,695
Last modified:November 25, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1950DE5AE648F1C4
GO
Isoform 2 (identifier: Q86SQ4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     380-407: Missing.

Show »
Length:1,193
Mass (Da):133,671
Checksum:iEDE274EF3096A242
GO
Isoform 3 (identifier: Q86SQ4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1193-1221: NVSYEHSFNKSGSLRQCFHGQVLVKTGPC → SASMDKSLSK...SDTFSHSTKF

Show »
Length:1,250
Mass (Da):139,901
Checksum:iBDDABA6A755A445B
GO
Isoform 4 (identifier: Q86SQ4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     380-407: Missing.
     1193-1221: NVSYEHSFNKSGSLRQCFHGQVLVKTGPC → SASMDKSLSK...SDTFSHSTKF

Show »
Length:1,222
Mass (Da):136,878
Checksum:i7B50E167F0EBBA97
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F5H2L1F5H2L1_HUMAN
Adhesion G-protein-coupled receptor...
ADGRG6
241Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H054F5H054_HUMAN
Adhesion G-protein-coupled receptor...
ADGRG6
141Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YFM8H0YFM8_HUMAN
Adhesion G-protein-coupled receptor...
ADGRG6
103Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YGP2H0YGP2_HUMAN
Adhesion G-protein-coupled receptor...
ADGRG6
135Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAO13250 differs from that shown. Sequencing errors.Curated
The sequence BAB55406 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAC11393 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence CAE45930 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti622N → S in CAE45986 (PubMed:17974005).Curated1
Sequence conflicti623I → V in CAE45930 (PubMed:17974005).Curated1
Sequence conflicti708F → S in CAE45986 (PubMed:17974005).Curated1
Sequence conflicti763K → Q in CAE45930 (PubMed:17974005).Curated1
Sequence conflicti908L → P in AAH75798 (PubMed:15489334).Curated1

<p>This subsection of the 'Sequence' section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Genetic variations in ADGRG6 influences stature as a quantitative trait (STQTL) [MIMi:606255]. Adult height is an easily observable and highly heritable complex continuous trait. Because of this, it is a model trait for studying genetic influence on quantitative traits.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_054128123S → G. Corresponds to variant dbSNP:rs17280293Ensembl.1
Natural variantiVAR_024478230K → Q1 PublicationCorresponds to variant dbSNP:rs11155242Ensembl.1
Natural variantiVAR_075146741V → E in LCCS9; decreases the autoprocessing/cleavage of the receptor. 1 Publication1
Natural variantiVAR_075147769V → E in LCCS9. 1 PublicationCorresponds to variant dbSNP:rs793888525EnsemblClinVar.1
Natural variantiVAR_0769651057R → Q Found in patients with aggressive periodontitis; impairs cAMP production; abrogates osteoblastic differentiation. 1 PublicationCorresponds to variant dbSNP:rs536714306EnsemblClinVar.1
Natural variantiVAR_0541291127Q → R6 PublicationsCorresponds to variant dbSNP:rs1262686EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_010747380 – 407Missing in isoform 2 and isoform 4. 4 PublicationsAdd BLAST28
Alternative sequenceiVSP_0107481193 – 1221NVSYE…KTGPC → SASMDKSLSKLAHADGDQTS IIPVHQVIDKVKGYCNAHSD NFYKNIIMSDTFSHSTKF in isoform 3 and isoform 4. 4 PublicationsAdd BLAST29

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF216967 mRNA Translation: AAO13250.1 Sequence problems.
AB183546 mRNA Translation: BAD27571.1
AB183547 mRNA Translation: BAD27572.1
AB183548 mRNA Translation: BAD27573.1
AB183549 mRNA Translation: BAD27574.1
BX640971 mRNA Translation: CAE45986.1
BX640873 mRNA Translation: CAE45930.1 Different initiation.
AL033377 Genomic DNA No translation available.
AL360007 Genomic DNA No translation available.
BC075798 mRNA Translation: AAH75798.1
AK027843 mRNA Translation: BAB55406.1 Different initiation.
AK075087 mRNA Translation: BAC11393.1 Different initiation.
AY181244 mRNA Translation: AAO27356.1
AY426673 mRNA Translation: AAR88427.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS47489.1 [Q86SQ4-3]
CCDS47490.1 [Q86SQ4-1]
CCDS47491.1 [Q86SQ4-2]
CCDS55064.1 [Q86SQ4-4]

NCBI Reference Sequences

More...RefSeqi		NP_001027566.1, NM_001032394.2 [Q86SQ4-2]
NP_001027567.1, NM_001032395.2 [Q86SQ4-4]
NP_065188.4, NM_020455.5 [Q86SQ4-1]
NP_940971.1, NM_198569.2 [Q86SQ4-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000230173; ENSP00000230173; ENSG00000112414 [Q86SQ4-1]
ENST00000296932; ENSP00000296932; ENSG00000112414 [Q86SQ4-2]
ENST00000367608; ENSP00000356580; ENSG00000112414 [Q86SQ4-4]
ENST00000367609; ENSP00000356581; ENSG00000112414 [Q86SQ4-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		57211

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:57211

UCSC genome browser

More...UCSCi		uc010khc.4, human [Q86SQ4-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF216967 mRNA Translation: AAO13250.1 Sequence problems.
AB183546 mRNA Translation: BAD27571.1
AB183547 mRNA Translation: BAD27572.1
AB183548 mRNA Translation: BAD27573.1
AB183549 mRNA Translation: BAD27574.1
BX640971 mRNA Translation: CAE45986.1
BX640873 mRNA Translation: CAE45930.1 Different initiation.
AL033377 Genomic DNA No translation available.
AL360007 Genomic DNA No translation available.
BC075798 mRNA Translation: AAH75798.1
AK027843 mRNA Translation: BAB55406.1 Different initiation.
AK075087 mRNA Translation: BAC11393.1 Different initiation.
AY181244 mRNA Translation: AAO27356.1
AY426673 mRNA Translation: AAR88427.1
CCDSiCCDS47489.1 [Q86SQ4-3]
CCDS47490.1 [Q86SQ4-1]
CCDS47491.1 [Q86SQ4-2]
CCDS55064.1 [Q86SQ4-4]
RefSeqiNP_001027566.1, NM_001032394.2 [Q86SQ4-2]
NP_001027567.1, NM_001032395.2 [Q86SQ4-4]
NP_065188.4, NM_020455.5 [Q86SQ4-1]
NP_940971.1, NM_198569.2 [Q86SQ4-3]

3D structure databases

SASBDBiQ86SQ4
SMRiQ86SQ4
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi121449, 15 interactors
IntActiQ86SQ4, 2 interactors
STRINGi9606.ENSP00000356581

Chemistry databases

ChEMBLiCHEMBL4523884

Protein family/group databases

MEROPSiP02.017

Information system for G protein-coupled receptors (GPCRs)

More...GPCRDBi		Search...

PTM databases

GlyConnecti1287, 19 N-Linked glycans (8 sites)
GlyGeniQ86SQ4, 27 sites, 19 N-linked glycans (8 sites)
iPTMnetiQ86SQ4
PhosphoSitePlusiQ86SQ4
SwissPalmiQ86SQ4

Genetic variation databases

BioMutaiADGRG6
DMDMi215274152

Proteomic databases

jPOSTiQ86SQ4
MassIVEiQ86SQ4
MaxQBiQ86SQ4
PaxDbiQ86SQ4
PeptideAtlasiQ86SQ4
PRIDEiQ86SQ4
ProteomicsDBi69609 [Q86SQ4-1]
69610 [Q86SQ4-2]
69611 [Q86SQ4-3]
69612 [Q86SQ4-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1571, 213 antibodies

The DNASU plasmid repository

More...DNASUi		57211

Genome annotation databases

EnsembliENST00000230173; ENSP00000230173; ENSG00000112414 [Q86SQ4-1]
ENST00000296932; ENSP00000296932; ENSG00000112414 [Q86SQ4-2]
ENST00000367608; ENSP00000356580; ENSG00000112414 [Q86SQ4-4]
ENST00000367609; ENSP00000356581; ENSG00000112414 [Q86SQ4-3]
GeneIDi57211
KEGGihsa:57211
UCSCiuc010khc.4, human [Q86SQ4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		57211
DisGeNETi57211

GeneCards: human genes, protein and diseases

More...GeneCardsi		ADGRG6
HGNCiHGNC:13841, ADGRG6
HPAiENSG00000112414, Group enriched (liver, placenta)
MalaCardsiADGRG6
MIMi606255, phenotype
612243, gene
616503, phenotype
neXtProtiNX_Q86SQ4
OpenTargetsiENSG00000112414
PharmGKBiPA134878328
VEuPathDBiHostDB:ENSG00000112414

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4193, Eukaryota
GeneTreeiENSGT00940000155621
HOGENOMiCLU_002753_3_3_1
InParanoidiQ86SQ4
OMAiAWGCANC
OrthoDBi148879at2759
PhylomeDBiQ86SQ4
TreeFamiTF321769

Enzyme and pathway databases

PathwayCommonsiQ86SQ4
ReactomeiR-HSA-9619665, EGR2 and SOX10-mediated initiation of Schwann cell myelination
SignaLinkiQ86SQ4

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		57211, 5 hits in 1010 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ADGRG6, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		GPR126

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		57211
PharosiQ86SQ4, Tbio

Protein Ontology

More...PROi		PR:Q86SQ4
RNActiQ86SQ4, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000112414, Expressed in lung and 192 other tissues
ExpressionAtlasiQ86SQ4, baseline and differential
GenevisibleiQ86SQ4, HS

Family and domain databases

CDDicd00041, CUB, 1 hit
Gene3Di2.60.120.290, 1 hit
InterProiView protein in InterPro
IPR013320, ConA-like_dom_sf
IPR000859, CUB_dom
IPR017981, GPCR_2-like
IPR000832, GPCR_2_secretin-like
IPR017983, GPCR_2_secretin-like_CS
IPR000203, GPS
IPR001759, Pentraxin-related
IPR035914, Sperma_CUB_dom_sf
PfamiView protein in Pfam
PF00002, 7tm_2, 1 hit
PF00431, CUB, 1 hit
PF01825, GPS, 1 hit
PF00354, Pentaxin, 1 hit
PRINTSiPR00249, GPCRSECRETIN
SMARTiView protein in SMART
SM00042, CUB, 1 hit
SM00303, GPS, 1 hit
SM00159, PTX, 1 hit
SUPFAMiSSF49854, SSF49854, 1 hit
SSF49899, SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS01180, CUB, 1 hit
PS00650, G_PROTEIN_RECEP_F2_2, 1 hit
PS50261, G_PROTEIN_RECEP_F2_4, 1 hit
PS50221, GPS, 1 hit
PS51828, PTX_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAGRG6_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86SQ4
Secondary accession number(s): Q5TGN7
, Q6DHZ4, Q6F3F5, Q6F3F6, Q6F3F7, Q6F3F8, Q6MZU7, Q8IXA4, Q8NC14, Q96JW0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: November 25, 2008
Last modified: September 29, 2021
This is version 173 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families
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