UniProtKB - Q86SQ4 (AGRG6_HUMAN)
Adhesion G-protein coupled receptor G6
ADGRG6
Functioni
GO - Molecular functioni
- collagen binding Source: UniProtKB
- extracellular matrix binding Source: UniProtKB
- G protein-coupled receptor activity Source: UniProtKB
- laminin binding Source: UniProtKB
GO - Biological processi
- adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: GO_Central
- cAMP-mediated signaling Source: UniProtKB
- cell surface receptor signaling pathway Source: UniProtKB
- G protein-coupled receptor signaling pathway Source: UniProtKB
- heart trabecula formation Source: GO_Central
- mitochondrion organization Source: Ensembl
- myelination Source: UniProtKB
- myelination in peripheral nervous system Source: UniProtKB
- Schwann cell differentiation Source: UniProtKB
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
PathwayCommonsi | Q86SQ4 |
Reactomei | R-HSA-9619665, EGR2 and SOX10-mediated initiation of Schwann cell myelination |
SignaLinki | Q86SQ4 |
Protein family/group databases
MEROPSi | P02.017 |
Names & Taxonomyi
Protein namesi | Recommended name: Adhesion G-protein coupled receptor G6Alternative name(s): Developmentally regulated G-protein-coupled receptor1 Publication G-protein coupled receptor 126 Vascular inducible G protein-coupled receptor1 Publication Cleaved into the following 2 chains: |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:13841, ADGRG6 |
MIMi | 612243, gene |
neXtProti | NX_Q86SQ4 |
VEuPathDBi | HostDB:ENSG00000112414.14 |
Subcellular locationi
Plasma membrane
- Cell membrane 3 Publications; Multi-pass membrane protein Sequence analysis
Note: Detected on the cell surface of activated but not resting umbilical vein.1 Publication
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: UniProtKB
Other locations
- cell surface Source: MGI
- cytoplasm Source: MGI
- integral component of membrane Source: GDB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 38 – 862 | ExtracellularSequence analysisAdd BLAST | 825 | |
Transmembranei | 863 – 883 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 884 – 903 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 904 – 924 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 925 – 929 | ExtracellularSequence analysis | 5 | |
Transmembranei | 930 – 950 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 951 – 970 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 971 – 991 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 992 – 1024 | ExtracellularSequence analysisAdd BLAST | 33 | |
Transmembranei | 1025 – 1045 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 1046 – 1069 | CytoplasmicSequence analysisAdd BLAST | 24 | |
Transmembranei | 1070 – 1090 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 1091 – 1092 | ExtracellularSequence analysis | 2 | |
Transmembranei | 1093 – 1113 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 1114 – 1221 | CytoplasmicSequence analysisAdd BLAST | 108 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Involvement in diseasei
Lethal congenital contracture syndrome 9 (LCCS9)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_075146 | 741 | V → E in LCCS9; decreases the autoprocessing/cleavage of the receptor. 1 Publication | 1 | |
Natural variantiVAR_075147 | 769 | V → E in LCCS9. 1 PublicationCorresponds to variant dbSNP:rs793888525EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 468 | R → A: No cleavage. 1 Publication | 1 | |
Mutagenesisi | 469 | S → A: No effect on cleavage. 1 Publication | 1 | |
Mutagenesisi | 803 | C → S: No cleavage and not detected at the cell surface. 1 Publication | 1 | |
Mutagenesisi | 813 | S → A: No effect on G-protein-mediated cAMP release. 1 Publication | 1 | |
Mutagenesisi | 815 | G → A: Abolishes G-protein-mediated cAMP release. 1 Publication | 1 | |
Mutagenesisi | 818 | N → A: Abolishes G-protein-mediated cAMP release. 1 Publication | 1 | |
Mutagenesisi | 819 | T → A: Abolishes G-protein-mediated cAMP release. 1 Publication | 1 | |
Mutagenesisi | 822 | C → S: No cleavage and not detected at the cell surface. 1 Publication | 1 | |
Mutagenesisi | 835 | C → S: No cleavage and not detected at the cell surface. 1 Publication | 1 | |
Mutagenesisi | 837 | C → S: No cleavage and not detected at the cell surface. 1 Publication | 1 | |
Mutagenesisi | 841 | T → A: No cleavage but detected at cell surface. 1 Publication | 1 | |
Mutagenesisi | 841 | T → P: No cleavage and not detected at the cell surface. 1 Publication | 1 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 57211 |
MalaCardsi | ADGRG6 |
MIMi | 606255, phenotype 616503, phenotype |
OpenTargetsi | ENSG00000112414 |
PharmGKBi | PA134878328 |
Miscellaneous databases
Pharosi | Q86SQ4, Tbio |
Genetic variation databases
BioMutai | ADGRG6 |
DMDMi | 215274152 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 37 | Sequence analysisAdd BLAST | 37 | |
ChainiPRO_0000012902 | 38 – 1221 | Adhesion G-protein coupled receptor G6Add BLAST | 1184 | |
ChainiPRO_0000438596 | 38 – 840 | ADGRG6 N-terminal fragment1 PublicationAdd BLAST | 803 | |
ChainiPRO_0000438597 | 841 – 1221 | ADGRG6 C-terminal fragment1 PublicationAdd BLAST | 381 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 41 ↔ 67 | PROSITE-ProRule annotation | ||
Disulfide bondi | 94 ↔ 111 | PROSITE-ProRule annotation | ||
Glycosylationi | 121 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 143 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 186 ↔ 254 | PROSITE-ProRule annotation | ||
Glycosylationi | 206 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 258 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 314 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 324 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 353 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 438 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 445 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 452 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 485 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 488 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 505 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 563 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 593 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 600 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 605 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 667 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 673 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 695 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 704 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 750 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 776 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 811 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 818 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 1165 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1168 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 467 – 468 | Cleavage; by furin like-convertase1 Publication | 2 | |
Sitei | 840 – 841 | Cleavage1 Publication | 2 |
Keywords - PTMi
Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
jPOSTi | Q86SQ4 |
MassIVEi | Q86SQ4 |
MaxQBi | Q86SQ4 |
PaxDbi | Q86SQ4 |
PeptideAtlasi | Q86SQ4 |
PRIDEi | Q86SQ4 |
ProteomicsDBi | 69609 [Q86SQ4-1] 69610 [Q86SQ4-2] 69611 [Q86SQ4-3] 69612 [Q86SQ4-4] |
PTM databases
GlyConnecti | 1287, 19 N-Linked glycans (8 sites) |
GlyGeni | Q86SQ4, 27 sites |
iPTMneti | Q86SQ4 |
PhosphoSitePlusi | Q86SQ4 |
SwissPalmi | Q86SQ4 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000112414, Expressed in lung and 191 other tissues |
ExpressionAtlasi | Q86SQ4, baseline and differential |
Genevisiblei | Q86SQ4, HS |
Organism-specific databases
HPAi | ENSG00000112414, Group enriched (liver, placenta) |
Interactioni
Subunit structurei
Interacts with Laminin-2; this interaction stabilizes the receptor in an inactive state. Laminin-2 polymerization could facilitate ADGRG6-NTF removal, thereby exposing the tethered agonist to drive myelination.
Interacts with PRNP.
By similarityGO - Molecular functioni
- laminin binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 121449, 15 interactors |
IntActi | Q86SQ4, 1 interactor |
STRINGi | 9606.ENSP00000356581 |
Miscellaneous databases
RNActi | Q86SQ4, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 41 – 149 | CUBPROSITE-ProRule annotationAdd BLAST | 109 | |
Domaini | 154 – 356 | Pentraxin (PTX)PROSITE-ProRule annotationAdd BLAST | 203 | |
Domaini | 800 – 852 | GPSPROSITE-ProRule annotationAdd BLAST | 53 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 41 – 852 | Inhibits receptor signaling in absence of type IV collagenBy similarityAdd BLAST | 812 | |
Regioni | 41 – 355 | Mediates interaction with type IV collagenBy similarityAdd BLAST | 315 | |
Regioni | 473 – 837 | Mediates interaction with laminin-2By similarityAdd BLAST | 365 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 842 – 850 | Stachel1 Publication | 9 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1153 – 1205 | Ser-richAdd BLAST | 53 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4193, Eukaryota |
GeneTreei | ENSGT00940000155621 |
HOGENOMi | CLU_002753_3_3_1 |
InParanoidi | Q86SQ4 |
OMAi | MPDTNRT |
OrthoDBi | 148879at2759 |
PhylomeDBi | Q86SQ4 |
TreeFami | TF321769 |
Family and domain databases
CDDi | cd00041, CUB, 1 hit |
Gene3Di | 2.60.120.290, 1 hit |
InterProi | View protein in InterPro IPR013320, ConA-like_dom_sf IPR000859, CUB_dom IPR017981, GPCR_2-like IPR000832, GPCR_2_secretin-like IPR017983, GPCR_2_secretin-like_CS IPR000203, GPS IPR001759, Pentraxin-related IPR035914, Sperma_CUB_dom_sf |
Pfami | View protein in Pfam PF00002, 7tm_2, 1 hit PF00431, CUB, 1 hit PF01825, GPS, 1 hit PF00354, Pentaxin, 1 hit |
PRINTSi | PR00249, GPCRSECRETIN |
SMARTi | View protein in SMART SM00042, CUB, 1 hit SM00303, GPS, 1 hit SM00159, PTX, 1 hit |
SUPFAMi | SSF49854, SSF49854, 1 hit SSF49899, SSF49899, 1 hit |
PROSITEi | View protein in PROSITE PS01180, CUB, 1 hit PS00650, G_PROTEIN_RECEP_F2_2, 1 hit PS50261, G_PROTEIN_RECEP_F2_4, 1 hit PS50221, GPS, 1 hit PS51828, PTX_2, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MMFRSDRMWS CHWKWKPSPL LFLFALYIMC VPHSVWGCAN CRVVLSNPSG
60 70 80 90 100
TFTSPCYPND YPNSQACMWT LRAPTGYIIQ ITFNDFDIEE APNCIYDSLS
110 120 130 140 150
LDNGESQTKF CGATAKGLSF NSSANEMHVS FSSDFSIQKK GFNASYIRVA
160 170 180 190 200
VSLRNQKVIL PQTSDAYQVS VAKSISIPEL SAFTLCFEAT KVGHEDSDWT
210 220 230 240 250
AFSYSNASFT QLLSFGKAKS GYFLSISDSK CLLNNALPVK EKEDIFAESF
260 270 280 290 300
EQLCLVWNNS LGSIGVNFKR NYETVPCDST ISKVIPGNGK LLLGSNQNEI
310 320 330 340 350
VSLKGDIYNF RLWNFTMNAK ILSNLSCNVK GNVVDWQNDF WNIPNLALKA
360 370 380 390 400
ESNLSCGSYL IPLPAAELAS CADLGTLCQA TVNSPSTTPP TVTTNMPVTN
410 420 430 440 450
RIDKQRNDGI IYRISVVIQN ILRHPEVKVQ SKVAEWLNST FQNWNYTVYV
460 470 480 490 500
VNISFHLSAG EDKIKVKRSL EDEPRLVLWA LLVYNATNNT NLEGKIIQQK
510 520 530 540 550
LLKNNESLDE GLRLHTVNVR QLGHCLAMEE PKGYYWPSIQ PSEYVLPCPD
560 570 580 590 600
KPGFSASRIC FYNATNPLVT YWGPVDISNC LKEANEVANQ ILNLTADGQN
610 620 630 640 650
LTSANITNIV EQVKRIVNKE ENIDITLGST LMNIFSNILS SSDSDLLESS
660 670 680 690 700
SEALKTIDEL AFKIDLNSTS HVNITTRNLA LSVSSLLPGT NAISNFSIGL
710 720 730 740 750
PSNNESYFQM DFESGQVDPL ASVILPPNLL ENLSPEDSVL VRRAQFTFFN
760 770 780 790 800
KTGLFQDVGP QRKTLVSYVM ACSIGNITIQ NLKDPVQIKI KHTRTQEVHH
810 820 830 840 850
PICAFWDLNK NKSFGGWNTS GCVAHRDSDA SETVCLCNHF THFGVLMDLP
860 870 880 890 900
RSASQLDARN TKVLTFISYI GCGISAIFSA ATLLTYVAFE KLRRDYPSKI
910 920 930 940 950
LMNLSTALLF LNLLFLLDGW ITSFNVDGLC IAVAVLLHFF LLATFTWMGL
960 970 980 990 1000
EAIHMYIALV KVFNTYIRRY ILKFCIIGWG LPALVVSVVL ASRNNNEVYG
1010 1020 1030 1040 1050
KESYGKEKGD EFCWIQDPVI FYVTCAGYFG VMFFLNIAMF IVVMVQICGR
1060 1070 1080 1090 1100
NGKRSNRTLR EEVLRNLRSV VSLTFLLGMT WGFAFFAWGP LNIPFMYLFS
1110 1120 1130 1140 1150
IFNSLQGLFI FIFHCAMKEN VQKQWRQHLC CGRFRLADNS DWSKTATNII
1160 1170 1180 1190 1200
KKSSDNLGKS LSSSSIGSNS TYLTSKSKSS STTYFKRNSH TDNVSYEHSF
1210 1220
NKSGSLRQCF HGQVLVKTGP C
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF5H2L1 | F5H2L1_HUMAN | Adhesion G-protein-coupled receptor... | ADGRG6 | 241 | Annotation score: | ||
F5H054 | F5H054_HUMAN | Adhesion G-protein-coupled receptor... | ADGRG6 | 141 | Annotation score: | ||
H0YFM8 | H0YFM8_HUMAN | Adhesion G-protein-coupled receptor... | ADGRG6 | 103 | Annotation score: | ||
H0YGP2 | H0YGP2_HUMAN | Adhesion G-protein-coupled receptor... | ADGRG6 | 135 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 622 | N → S in CAE45986 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 623 | I → V in CAE45930 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 708 | F → S in CAE45986 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 763 | K → Q in CAE45930 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 908 | L → P in AAH75798 (PubMed:15489334).Curated | 1 |
Polymorphismi
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_054128 | 123 | S → G. Corresponds to variant dbSNP:rs17280293Ensembl. | 1 | |
Natural variantiVAR_024478 | 230 | K → Q1 PublicationCorresponds to variant dbSNP:rs11155242Ensembl. | 1 | |
Natural variantiVAR_075146 | 741 | V → E in LCCS9; decreases the autoprocessing/cleavage of the receptor. 1 Publication | 1 | |
Natural variantiVAR_075147 | 769 | V → E in LCCS9. 1 PublicationCorresponds to variant dbSNP:rs793888525EnsemblClinVar. | 1 | |
Natural variantiVAR_076965 | 1057 | R → Q Found in patients with aggressive periodontitis; impairs cAMP production; abrogates osteoblastic differentiation. 1 PublicationCorresponds to variant dbSNP:rs536714306EnsemblClinVar. | 1 | |
Natural variantiVAR_054129 | 1127 | Q → R6 PublicationsCorresponds to variant dbSNP:rs1262686EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_010747 | 380 – 407 | Missing in isoform 2 and isoform 4. 4 PublicationsAdd BLAST | 28 | |
Alternative sequenceiVSP_010748 | 1193 – 1221 | NVSYE…KTGPC → SASMDKSLSKLAHADGDQTS IIPVHQVIDKVKGYCNAHSD NFYKNIIMSDTFSHSTKF in isoform 3 and isoform 4. 4 PublicationsAdd BLAST | 29 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF216967 mRNA Translation: AAO13250.1 Sequence problems. AB183546 mRNA Translation: BAD27571.1 AB183547 mRNA Translation: BAD27572.1 AB183548 mRNA Translation: BAD27573.1 AB183549 mRNA Translation: BAD27574.1 BX640971 mRNA Translation: CAE45986.1 BX640873 mRNA Translation: CAE45930.1 Different initiation. AL033377 Genomic DNA No translation available. AL360007 Genomic DNA No translation available. BC075798 mRNA Translation: AAH75798.1 AK027843 mRNA Translation: BAB55406.1 Different initiation. AK075087 mRNA Translation: BAC11393.1 Different initiation. AY181244 mRNA Translation: AAO27356.1 AY426673 mRNA Translation: AAR88427.1 |
CCDSi | CCDS47489.1 [Q86SQ4-3] CCDS47490.1 [Q86SQ4-1] CCDS47491.1 [Q86SQ4-2] CCDS55064.1 [Q86SQ4-4] |
RefSeqi | NP_001027566.1, NM_001032394.2 [Q86SQ4-2] NP_001027567.1, NM_001032395.2 [Q86SQ4-4] NP_065188.4, NM_020455.5 [Q86SQ4-1] NP_940971.1, NM_198569.2 [Q86SQ4-3] |
Genome annotation databases
Ensembli | ENST00000230173; ENSP00000230173; ENSG00000112414 [Q86SQ4-1] ENST00000296932; ENSP00000296932; ENSG00000112414 [Q86SQ4-2] ENST00000367608; ENSP00000356580; ENSG00000112414 [Q86SQ4-4] ENST00000367609; ENSP00000356581; ENSG00000112414 [Q86SQ4-3] |
GeneIDi | 57211 |
KEGGi | hsa:57211 |
UCSCi | uc010khc.4, human [Q86SQ4-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF216967 mRNA Translation: AAO13250.1 Sequence problems. AB183546 mRNA Translation: BAD27571.1 AB183547 mRNA Translation: BAD27572.1 AB183548 mRNA Translation: BAD27573.1 AB183549 mRNA Translation: BAD27574.1 BX640971 mRNA Translation: CAE45986.1 BX640873 mRNA Translation: CAE45930.1 Different initiation. AL033377 Genomic DNA No translation available. AL360007 Genomic DNA No translation available. BC075798 mRNA Translation: AAH75798.1 AK027843 mRNA Translation: BAB55406.1 Different initiation. AK075087 mRNA Translation: BAC11393.1 Different initiation. AY181244 mRNA Translation: AAO27356.1 AY426673 mRNA Translation: AAR88427.1 |
CCDSi | CCDS47489.1 [Q86SQ4-3] CCDS47490.1 [Q86SQ4-1] CCDS47491.1 [Q86SQ4-2] CCDS55064.1 [Q86SQ4-4] |
RefSeqi | NP_001027566.1, NM_001032394.2 [Q86SQ4-2] NP_001027567.1, NM_001032395.2 [Q86SQ4-4] NP_065188.4, NM_020455.5 [Q86SQ4-1] NP_940971.1, NM_198569.2 [Q86SQ4-3] |
3D structure databases
SASBDBi | Q86SQ4 |
SMRi | Q86SQ4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 121449, 15 interactors |
IntActi | Q86SQ4, 1 interactor |
STRINGi | 9606.ENSP00000356581 |
Protein family/group databases
MEROPSi | P02.017 |
GPCRDBi | Search... |
PTM databases
GlyConnecti | 1287, 19 N-Linked glycans (8 sites) |
GlyGeni | Q86SQ4, 27 sites |
iPTMneti | Q86SQ4 |
PhosphoSitePlusi | Q86SQ4 |
SwissPalmi | Q86SQ4 |
Genetic variation databases
BioMutai | ADGRG6 |
DMDMi | 215274152 |
Proteomic databases
jPOSTi | Q86SQ4 |
MassIVEi | Q86SQ4 |
MaxQBi | Q86SQ4 |
PaxDbi | Q86SQ4 |
PeptideAtlasi | Q86SQ4 |
PRIDEi | Q86SQ4 |
ProteomicsDBi | 69609 [Q86SQ4-1] 69610 [Q86SQ4-2] 69611 [Q86SQ4-3] 69612 [Q86SQ4-4] |
Protocols and materials databases
Antibodypediai | 1571, 202 antibodies |
Genome annotation databases
Ensembli | ENST00000230173; ENSP00000230173; ENSG00000112414 [Q86SQ4-1] ENST00000296932; ENSP00000296932; ENSG00000112414 [Q86SQ4-2] ENST00000367608; ENSP00000356580; ENSG00000112414 [Q86SQ4-4] ENST00000367609; ENSP00000356581; ENSG00000112414 [Q86SQ4-3] |
GeneIDi | 57211 |
KEGGi | hsa:57211 |
UCSCi | uc010khc.4, human [Q86SQ4-1] |
Organism-specific databases
CTDi | 57211 |
DisGeNETi | 57211 |
GeneCardsi | ADGRG6 |
HGNCi | HGNC:13841, ADGRG6 |
HPAi | ENSG00000112414, Group enriched (liver, placenta) |
MalaCardsi | ADGRG6 |
MIMi | 606255, phenotype 612243, gene 616503, phenotype |
neXtProti | NX_Q86SQ4 |
OpenTargetsi | ENSG00000112414 |
PharmGKBi | PA134878328 |
VEuPathDBi | HostDB:ENSG00000112414.14 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4193, Eukaryota |
GeneTreei | ENSGT00940000155621 |
HOGENOMi | CLU_002753_3_3_1 |
InParanoidi | Q86SQ4 |
OMAi | MPDTNRT |
OrthoDBi | 148879at2759 |
PhylomeDBi | Q86SQ4 |
TreeFami | TF321769 |
Enzyme and pathway databases
PathwayCommonsi | Q86SQ4 |
Reactomei | R-HSA-9619665, EGR2 and SOX10-mediated initiation of Schwann cell myelination |
SignaLinki | Q86SQ4 |
Miscellaneous databases
BioGRID-ORCSi | 57211, 3 hits in 867 CRISPR screens |
ChiTaRSi | ADGRG6, human |
GeneWikii | GPR126 |
GenomeRNAii | 57211 |
Pharosi | Q86SQ4, Tbio |
PROi | PR:Q86SQ4 |
RNActi | Q86SQ4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000112414, Expressed in lung and 191 other tissues |
ExpressionAtlasi | Q86SQ4, baseline and differential |
Genevisiblei | Q86SQ4, HS |
Family and domain databases
CDDi | cd00041, CUB, 1 hit |
Gene3Di | 2.60.120.290, 1 hit |
InterProi | View protein in InterPro IPR013320, ConA-like_dom_sf IPR000859, CUB_dom IPR017981, GPCR_2-like IPR000832, GPCR_2_secretin-like IPR017983, GPCR_2_secretin-like_CS IPR000203, GPS IPR001759, Pentraxin-related IPR035914, Sperma_CUB_dom_sf |
Pfami | View protein in Pfam PF00002, 7tm_2, 1 hit PF00431, CUB, 1 hit PF01825, GPS, 1 hit PF00354, Pentaxin, 1 hit |
PRINTSi | PR00249, GPCRSECRETIN |
SMARTi | View protein in SMART SM00042, CUB, 1 hit SM00303, GPS, 1 hit SM00159, PTX, 1 hit |
SUPFAMi | SSF49854, SSF49854, 1 hit SSF49899, SSF49899, 1 hit |
PROSITEi | View protein in PROSITE PS01180, CUB, 1 hit PS00650, G_PROTEIN_RECEP_F2_2, 1 hit PS50261, G_PROTEIN_RECEP_F2_4, 1 hit PS50221, GPS, 1 hit PS51828, PTX_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | AGRG6_HUMAN | |
Accessioni | Q86SQ4Primary (citable) accession number: Q86SQ4 Secondary accession number(s): Q5TGN7 Q96JW0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2004 |
Last sequence update: | November 25, 2008 | |
Last modified: | February 10, 2021 | |
This is version 170 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families