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Protein

Pleckstrin homology-like domain family B member 2

Gene

PHLDB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pleckstrin homology-like domain family B member 2
Alternative name(s):
Protein LL5-beta
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PHLDB2
Synonyms:LL5B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000144824.19

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29573 PHLDB2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
610298 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q86SQ0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1162 – 1163KR → AA: Loss of binding to PtdIns(3,4,5)P3. 1 Publication2

Organism-specific databases

DisGeNET

More...
DisGeNETi
90102

Open Targets

More...
OpenTargetsi
ENSG00000144824

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134884060

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PHLDB2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
84029396

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000538941 – 1253Pleckstrin homology-like domain family B member 2Add BLAST1253

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei71PhosphoserineCombined sources1
Modified residuei73PhosphoserineCombined sources1
Modified residuei157PhosphoserineCombined sources1
Modified residuei204PhosphoserineBy similarity1
Modified residuei212PhosphoserineCombined sources1
Modified residuei242PhosphoserineBy similarity1
Modified residuei245PhosphoserineBy similarity1
Modified residuei330PhosphoserineBy similarity1
Modified residuei334PhosphoserineCombined sources1
Modified residuei348PhosphoserineBy similarity1
Modified residuei351PhosphoserineCombined sources1
Modified residuei384PhosphoserineCombined sources1
Modified residuei387PhosphoserineCombined sources1
Modified residuei415PhosphoserineCombined sources1
Modified residuei420PhosphoserineCombined sources1
Modified residuei468PhosphoserineCombined sources1
Modified residuei489PhosphoserineCombined sources1
Modified residuei501PhosphoserineCombined sources1
Modified residuei504PhosphothreonineCombined sources1
Modified residuei513PhosphoserineCombined sources1
Modified residuei550PhosphothreonineCombined sources1
Modified residuei574PhosphothreonineCombined sources1
Modified residuei898PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q86SQ0

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q86SQ0

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q86SQ0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q86SQ0

PeptideAtlas

More...
PeptideAtlasi
Q86SQ0

PRoteomics IDEntifications database

More...
PRIDEi
Q86SQ0

ProteomicsDB human proteome resource

More...
ProteomicsDBi
69604
69605 [Q86SQ0-2]
69606 [Q86SQ0-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q86SQ0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q86SQ0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000144824 Expressed in 196 organ(s), highest expression level in placenta

CleanEx database of gene expression profiles

More...
CleanExi
HS_PHLDB2

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q86SQ0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q86SQ0 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA035146
HPA035147

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with FLNC.1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
FLNAP213333EBI-2798483,EBI-350432

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
124661, 85 interactors

Database of interacting proteins

More...
DIPi
DIP-42196N

Protein interaction database and analysis system

More...
IntActi
Q86SQ0, 40 interactors

Molecular INTeraction database

More...
MINTi
Q86SQ0

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000377502

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q86SQ0

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q86SQ0

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1143 – 1246PHPROSITE-ProRule annotationAdd BLAST104

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili584 – 696Sequence analysisAdd BLAST113
Coiled coili722 – 807Sequence analysisAdd BLAST86
Coiled coili1032 – 1098Sequence analysisAdd BLAST67

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PH domain mediates the binding to phosphoinositides.

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IFMW Eukaryota
ENOG4111JWX LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156371

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG082124

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q86SQ0

Identification of Orthologs from Complete Genome Data

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OMAi
EDLMDYH

Database of Orthologous Groups

More...
OrthoDBi
70229at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q86SQ0

TreeFam database of animal gene trees

More...
TreeFami
TF329165

Family and domain databases

Conserved Domains Database

More...
CDDi
cd14673 PH_PHLDB1_2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR037810 PHLDB1/2/3_PH

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00169 PH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00233 PH, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50003 PH_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86SQ0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEEHSYIQKE LDLQNGSLEE DSVVHSVEND SQNMMESLSP KKYSSSLRFK
60 70 80 90 100
ANGDYSGSYL TLSQPVPAKR SPSPLGTSVR SSPSLAKIQG SKQFSYDGTD
110 120 130 140 150
KNIPMKPPTP LLNTTSSLSG YPLGRADFDH YTGRDSERAL RLSEKPPYSK
160 170 180 190 200
YSSRHKSHDN VYSLGGLEGR KASGSLLAMW NGSSLSDAGP PPISRSGAAS
210 220 230 240 250
MPSSPKQARK MSIQDSLALQ PKLTRHKELA SENINLRTRK YSSSSLSHMG
260 270 280 290 300
AYSRSLPRLY RATENQLTPL SLPPRNSLGN SKRTKLGEKD LPHSVIDNDN
310 320 330 340 350
YLNFSSLSSG ALPYKTSASE GNPYVSSTLS VPASPRVARK MLLASTSSCA
360 370 380 390 400
SDDFDQASYV GTNPSHSLLA GESDRVFATR RNFSCGSVEF DEADLESLRQ
410 420 430 440 450
ASGTPQPALR ERKSSISSIS GRDDLMDYHR RQREERLREQ EMERLERQRL
460 470 480 490 500
ETILSLCAEY TKPDSRLSTG TTVEDVQKIN KELEKLQLSD EESVFEEALM
510 520 530 540 550
SPDTRYRCHR KDSLPDADLA SCGSLSQSSA SFFTPRSTRN DELLSDLTRT
560 570 580 590 600
PPPPSSTFPK ASSESSYLSI LPKTPEGISE EQRSQELAAM EETRIVILNN
610 620 630 640 650
LEELKQKIKD INDQMDESFR ELDMECALLD GEQKSETTEL MKEKEILDHL
660 670 680 690 700
NRKIAELEKN IVGEKTKEKV KLDAEREKLE RLQELYSEQK TQLDNCPESM
710 720 730 740 750
REQLQQQLKR DADLLDVESK HFEDLEFQQL EHESRLDEEK ENLTQQLLRE
760 770 780 790 800
VAEYQRNIVS RKEKISALKK QANHIVQQAQ REQDHFVKEK NNLIMMLQRE
810 820 830 840 850
KENLCNLEKK YSSLSGGKGF PVNPNTLKEG YISVNEINEP CGNSTNLSPS
860 870 880 890 900
TQFPADADAV ATEPATAVLA SQPQSKEHFR SLEERKKQHK EGLYLSDTLP
910 920 930 940 950
RKKTTSSISP HFSSATMGRS ITPKAHLPLG QSNSCGSVLP PSLAAMAKDS
960 970 980 990 1000
ESRRMLRGYN HQQMSEGHRQ KSEFYNRTAS ESNVYLNSFH YPDHSYKDQA
1010 1020 1030 1040 1050
FDTLSLDSSD SMETSISACS PDNISSASTS NIARIEEMER LLKQAHAEKT
1060 1070 1080 1090 1100
RLLESREREM EAKKRALEEE KRRREILEKR LQEETSQRQK LIEKEVKIRE
1110 1120 1130 1140 1150
RQRAQARPLT RYLPVRKEDF DLRSHVETAG HNIDTCYHVS ITEKTCRGFL
1160 1170 1180 1190 1200
IKMGGKIKTW KKRWFVFDRN KRTFSYYADK HETKLKGVIY FQAIEEVYYD
1210 1220 1230 1240 1250
HLKNANKSPN PLLTFSVKTH DRIYYMVAPS PEAMRIWMDV IVTGAEGYTH

FLL
Length:1,253
Mass (Da):142,158
Last modified:December 20, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD0950E96AEE1B020
GO
Isoform 2 (identifier: Q86SQ0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     668-710: Missing.

Show »
Length:1,210
Mass (Da):136,886
Checksum:iD05881C68D0A811C
GO
Isoform 3 (identifier: Q86SQ0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MEEEDTKREVPKEDGVGDVQHFDSSKIM
     668-710: Missing.

Show »
Length:1,237
Mass (Da):139,974
Checksum:iBF9C4AF0F1DEC613
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PDY7E9PDY7_HUMAN
Pleckstrin homology-like domain fam...
PHLDB2
519Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G5E9V3G5E9V3_HUMAN
Pleckstrin homology-like domain fam...
PHLDB2 hCG_2036872
581Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PFQ4E9PFQ4_HUMAN
Pleckstrin homology-like domain fam...
PHLDB2
1,115Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PGF6E9PGF6_HUMAN
Pleckstrin homology-like domain fam...
PHLDB2
744Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PRT1A0A1W2PRT1_HUMAN
Pleckstrin homology-like domain fam...
PHLDB2
418Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PQ63A0A1W2PQ63_HUMAN
Pleckstrin homology-like domain fam...
PHLDB2
741Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1W2PRJ2A0A1W2PRJ2_HUMAN
Pleckstrin homology-like domain fam...
PHLDB2
125Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH69194 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAD93140 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti96Y → H in BAC04014 (PubMed:14702039).Curated1
Sequence conflicti346T → A in CAH18447 (PubMed:17974005).Curated1
Sequence conflicti585Q → E in CAD42711 (PubMed:12376540).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_024760941P → S1 PublicationCorresponds to variant dbSNP:rs3749298Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0167441M → MEEEDTKREVPKEDGVGDVQ HFDSSKIM in isoform 3. 1 Publication1
Alternative sequenceiVSP_016745668 – 710Missing in isoform 2 and isoform 3. 4 PublicationsAdd BLAST43

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AJ496194 mRNA Translation: CAD42711.1
AF506820 mRNA Translation: AAM33634.1
AB209903 mRNA Translation: BAD93140.1 Different initiation.
CR749654 mRNA Translation: CAH18447.1
CH471052 Genomic DNA Translation: EAW79690.1
BC069194 mRNA Translation: AAH69194.1 Sequence problems.
BC142678 mRNA Translation: AAI42679.1
BC150210 mRNA Translation: AAI50211.1
AK092996 mRNA Translation: BAC04014.1
AK096151 mRNA Translation: BAC04713.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS2962.1 [Q86SQ0-2]
CCDS46885.1 [Q86SQ0-3]
CCDS46886.1 [Q86SQ0-1]

NCBI Reference Sequences

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RefSeqi
NP_001127909.1, NM_001134437.1 [Q86SQ0-3]
NP_001127910.1, NM_001134438.1 [Q86SQ0-1]
NP_001127911.1, NM_001134439.1 [Q86SQ0-1]
NP_665696.1, NM_145753.2 [Q86SQ0-2]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.603252
Hs.679140

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000393923; ENSP00000377500; ENSG00000144824 [Q86SQ0-3]
ENST00000393925; ENSP00000377502; ENSG00000144824 [Q86SQ0-1]
ENST00000412622; ENSP00000405292; ENSG00000144824 [Q86SQ0-2]
ENST00000431670; ENSP00000405405; ENSG00000144824 [Q86SQ0-1]
ENST00000481953; ENSP00000418319; ENSG00000144824 [Q86SQ0-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
90102

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:90102

UCSC genome browser

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UCSCi
uc003dyc.4 human [Q86SQ0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ496194 mRNA Translation: CAD42711.1
AF506820 mRNA Translation: AAM33634.1
AB209903 mRNA Translation: BAD93140.1 Different initiation.
CR749654 mRNA Translation: CAH18447.1
CH471052 Genomic DNA Translation: EAW79690.1
BC069194 mRNA Translation: AAH69194.1 Sequence problems.
BC142678 mRNA Translation: AAI42679.1
BC150210 mRNA Translation: AAI50211.1
AK092996 mRNA Translation: BAC04014.1
AK096151 mRNA Translation: BAC04713.1
CCDSiCCDS2962.1 [Q86SQ0-2]
CCDS46885.1 [Q86SQ0-3]
CCDS46886.1 [Q86SQ0-1]
RefSeqiNP_001127909.1, NM_001134437.1 [Q86SQ0-3]
NP_001127910.1, NM_001134438.1 [Q86SQ0-1]
NP_001127911.1, NM_001134439.1 [Q86SQ0-1]
NP_665696.1, NM_145753.2 [Q86SQ0-2]
UniGeneiHs.603252
Hs.679140

3D structure databases

ProteinModelPortaliQ86SQ0
SMRiQ86SQ0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124661, 85 interactors
DIPiDIP-42196N
IntActiQ86SQ0, 40 interactors
MINTiQ86SQ0
STRINGi9606.ENSP00000377502

PTM databases

iPTMnetiQ86SQ0
PhosphoSitePlusiQ86SQ0

Polymorphism and mutation databases

BioMutaiPHLDB2
DMDMi84029396

Proteomic databases

EPDiQ86SQ0
jPOSTiQ86SQ0
MaxQBiQ86SQ0
PaxDbiQ86SQ0
PeptideAtlasiQ86SQ0
PRIDEiQ86SQ0
ProteomicsDBi69604
69605 [Q86SQ0-2]
69606 [Q86SQ0-3]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000393923; ENSP00000377500; ENSG00000144824 [Q86SQ0-3]
ENST00000393925; ENSP00000377502; ENSG00000144824 [Q86SQ0-1]
ENST00000412622; ENSP00000405292; ENSG00000144824 [Q86SQ0-2]
ENST00000431670; ENSP00000405405; ENSG00000144824 [Q86SQ0-1]
ENST00000481953; ENSP00000418319; ENSG00000144824 [Q86SQ0-2]
GeneIDi90102
KEGGihsa:90102
UCSCiuc003dyc.4 human [Q86SQ0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
90102
DisGeNETi90102
EuPathDBiHostDB:ENSG00000144824.19

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PHLDB2
HGNCiHGNC:29573 PHLDB2
HPAiHPA035146
HPA035147
MIMi610298 gene
neXtProtiNX_Q86SQ0
OpenTargetsiENSG00000144824
PharmGKBiPA134884060

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IFMW Eukaryota
ENOG4111JWX LUCA
GeneTreeiENSGT00940000156371
HOVERGENiHBG082124
InParanoidiQ86SQ0
OMAiEDLMDYH
OrthoDBi70229at2759
PhylomeDBiQ86SQ0
TreeFamiTF329165

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PHLDB2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
PHLDB2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
90102

Protein Ontology

More...
PROi
PR:Q86SQ0

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000144824 Expressed in 196 organ(s), highest expression level in placenta
CleanExiHS_PHLDB2
ExpressionAtlasiQ86SQ0 baseline and differential
GenevisibleiQ86SQ0 HS

Family and domain databases

CDDicd14673 PH_PHLDB1_2, 1 hit
Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR037810 PHLDB1/2/3_PH
PfamiView protein in Pfam
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
PROSITEiView protein in PROSITE
PS50003 PH_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPHLB2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86SQ0
Secondary accession number(s): A5PKZ3
, Q59EA8, Q68CY3, Q6NT98, Q8N8U8, Q8NAB1, Q8NCU5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: January 16, 2019
This is version 134 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
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