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UniProtKB - Q86SP6 (GP149_HUMAN)

Entry version 107 (22 Apr 2020)
Sequence version 2 (20 Dec 2005)
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Protein

Probable G-protein coupled receptor 149

Gene

GPR149

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Orphan receptor.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable G-protein coupled receptor 149
Alternative name(s):
G-protein coupled receptor PGR10
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GPR149
Synonyms:PGR10
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:23627 GPR149

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q86SP6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 35ExtracellularSequence analysisAdd BLAST35
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei36 – 56Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini57 – 69CytoplasmicSequence analysisAdd BLAST13
Transmembranei70 – 90Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini91 – 109ExtracellularSequence analysisAdd BLAST19
Transmembranei110 – 132Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini133 – 155CytoplasmicSequence analysisAdd BLAST23
Transmembranei156 – 176Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini177 – 189ExtracellularSequence analysisAdd BLAST13
Transmembranei190 – 210Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini211 – 310CytoplasmicSequence analysisAdd BLAST100
Transmembranei311 – 331Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini332 – 342ExtracellularSequence analysisAdd BLAST11
Transmembranei343 – 363Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini364 – 731CytoplasmicSequence analysisAdd BLAST368

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		344758

Open Targets

More...OpenTargetsi		ENSG00000174948

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134981369

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q86SP6 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		GPR149

Domain mapping of disease mutations (DMDM)

More...DMDMi		84029267

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000696261 – 731Probable G-protein coupled receptor 149Add BLAST731

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi7N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi11N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi21N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi105 ↔ 182PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q86SP6

PeptideAtlas

More...PeptideAtlasi		Q86SP6

PRoteomics IDEntifications database

More...PRIDEi		Q86SP6

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		69603

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q86SP6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q86SP6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000174948 Expressed in caudate nucleus and 16 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q86SP6 baseline and differential

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000174948 Group enriched (brain, pituitary gland, seminal vesicle)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		131320, 1 interactor

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000374390

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q86SP6 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0331 Eukaryota
COG0513 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00390000003715

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_021967_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q86SP6

KEGG Orthology (KO)

More...KOi		K08433

Identification of Orthologs from Complete Genome Data

More...OMAi		ECETTKD

Database of Orthologous Groups

More...OrthoDBi		352121at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q86SP6

TreeFam database of animal gene trees

More...TreeFami		TF331679

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR017452 GPCR_Rhodpsn_7TM

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q86SP6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLFLSNLST NDSSLWKENH NSTDLLNPPG TLNIYLFCLT CLMTFAALVG 
        60         70         80         90        100
SIYSLISLLK MQNRTVVSML VASWSVDDLM SVLSVTIFMF LQWPNEVPGY 
       110        120        130        140        150
FQFLCTTSAL MYLCQGLSSN LKATLLVSYN FYTMHRGVGS QTASRRSGQV 
       160        170        180        190        200
LGVVLTVWAA SLLLSALPLC GWGAFVRTPW GCLVDCSSSY VLFLSIVYAL 
       210        220        230        240        250
AFGLLVGLSV PLTHRLLCSE EPPRLHSNYQ EISRGASIPG TPPTAGRVVS 
       260        270        280        290        300
LSPEDAPGPS LRRSGGCSPS SDTVFGPGAP AAAGAEACRR ENRGTLYGTR 
       310        320        330        340        350
SFTVSVAQKR FALILALTKV VLWLPMMMHM VVQNVVGFQS LPLETFSFLL 
       360        370        380        390        400
TLLATTVTPV FVLSKRWTHL PCGCIINCRQ NAYAVASDGK KIKRKGFEFN 
       410        420        430        440        450
LSFQKSYGIY KIAHEDYYDD DENSIFYHNL MNSECETTKD PQRDNRNIFN 
       460        470        480        490        500
AIKVEISTTP SLDSSTQRGI NKCTNTDITE AKQDSNNKKD AFSDKTGGDI 
       510        520        530        540        550
NYEETTFSEG PERRLSHEES QKPDLSDWEW CRSKSERTPR QRSGYALAIP 
       560        570        580        590        600
LCAFQGTVSL HAPTGKTLSL STYEVSAEGQ KITPASKKIE VYRSKSVGHE 
       610        620        630        640        650
PNSEDSSSTF VDTSVKIHLE VLEICDNEEA LDTVSIISNI SQSSTQVRSP 
       660        670        680        690        700
SLRYSRKENR FVSCDLGETA SYSLFLPTSN PDGDINISIP DTVEAHRQNS 
       710        720        730 
KRQHQERDGY QEEIQLLNKA YRKREEESKG S
Length:731
Mass (Da):80,984
Last modified:December 20, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i57A43042CB958A05
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AC092946 Genomic DNA No translation available.
AY255534 mRNA Translation: AAO85046.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS43162.1

NCBI Reference Sequences

More...RefSeqi		NP_001033794.1, NM_001038705.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000389740; ENSP00000374390; ENSG00000174948

Database of genes from NCBI RefSeq genomes

More...GeneIDi		344758

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:344758

UCSC genome browser

More...UCSCi		uc003faa.3 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC092946 Genomic DNA No translation available.
AY255534 mRNA Translation: AAO85046.1
CCDSiCCDS43162.1
RefSeqiNP_001033794.1, NM_001038705.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGridi131320, 1 interactor
STRINGi9606.ENSP00000374390

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...GPCRDBi		Search...

PTM databases

iPTMnetiQ86SP6
PhosphoSitePlusiQ86SP6

Polymorphism and mutation databases

BioMutaiGPR149
DMDMi84029267

Proteomic databases

PaxDbiQ86SP6
PeptideAtlasiQ86SP6
PRIDEiQ86SP6
ProteomicsDBi69603

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		9095 205 antibodies

The DNASU plasmid repository

More...DNASUi		344758

Genome annotation databases

EnsembliENST00000389740; ENSP00000374390; ENSG00000174948
GeneIDi344758
KEGGihsa:344758
UCSCiuc003faa.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		344758
DisGeNETi344758

GeneCards: human genes, protein and diseases

More...GeneCardsi		GPR149
HGNCiHGNC:23627 GPR149
HPAiENSG00000174948 Group enriched (brain, pituitary gland, seminal vesicle)
neXtProtiNX_Q86SP6
OpenTargetsiENSG00000174948
PharmGKBiPA134981369

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0331 Eukaryota
COG0513 LUCA
GeneTreeiENSGT00390000003715
HOGENOMiCLU_021967_0_0_1
InParanoidiQ86SP6
KOiK08433
OMAiECETTKD
OrthoDBi352121at2759
PhylomeDBiQ86SP6
TreeFamiTF331679

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		344758
PharosiQ86SP6 Tdark

Protein Ontology

More...PROi		PR:Q86SP6
RNActiQ86SP6 protein

Gene expression databases

BgeeiENSG00000174948 Expressed in caudate nucleus and 16 other tissues
ExpressionAtlasiQ86SP6 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR017452 GPCR_Rhodpsn_7TM
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGP149_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86SP6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: December 20, 2005
Last modified: April 22, 2020
This is version 107 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
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