UniProtKB - Q86SP6 (GP149_HUMAN)
Protein
Probable G-protein coupled receptor 149
Gene
GPR149
Organism
Homo sapiens (Human)
Status
Functioni
Orphan receptor.
GO - Molecular functioni
- G protein-coupled receptor activity Source: GO_Central
- neuropeptide binding Source: GO_Central
- peptide binding Source: GO_Central
GO - Biological processi
- antral ovarian follicle growth Source: Ensembl
- negative regulation of ovulation Source: Ensembl
- neuropeptide signaling pathway Source: GO_Central
- preantral ovarian follicle growth Source: Ensembl
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
PathwayCommonsi | Q86SP6 |
Names & Taxonomyi
Protein namesi | Recommended name: Probable G-protein coupled receptor 149Alternative name(s): G-protein coupled receptor PGR10 |
Gene namesi | Name:GPR149 Synonyms:PGR10 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:23627, GPR149 |
neXtProti | NX_Q86SP6 |
VEuPathDBi | HostDB:ENSG00000174948.5 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
Other locations
- neuron projection Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 35 | ExtracellularSequence analysisAdd BLAST | 35 | |
Transmembranei | 36 – 56 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 57 – 69 | CytoplasmicSequence analysisAdd BLAST | 13 | |
Transmembranei | 70 – 90 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 91 – 109 | ExtracellularSequence analysisAdd BLAST | 19 | |
Transmembranei | 110 – 132 | Helical; Name=3Sequence analysisAdd BLAST | 23 | |
Topological domaini | 133 – 155 | CytoplasmicSequence analysisAdd BLAST | 23 | |
Transmembranei | 156 – 176 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 177 – 189 | ExtracellularSequence analysisAdd BLAST | 13 | |
Transmembranei | 190 – 210 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 211 – 310 | CytoplasmicSequence analysisAdd BLAST | 100 | |
Transmembranei | 311 – 331 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 332 – 342 | ExtracellularSequence analysisAdd BLAST | 11 | |
Transmembranei | 343 – 363 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 364 – 731 | CytoplasmicSequence analysisAdd BLAST | 368 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 344758 |
OpenTargetsi | ENSG00000174948 |
PharmGKBi | PA134981369 |
Miscellaneous databases
Pharosi | Q86SP6, Tdark |
Genetic variation databases
BioMutai | GPR149 |
DMDMi | 84029267 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069626 | 1 – 731 | Probable G-protein coupled receptor 149Add BLAST | 731 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 7 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 11 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 21 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 105 ↔ 182 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q86SP6 |
PeptideAtlasi | Q86SP6 |
PRIDEi | Q86SP6 |
ProteomicsDBi | 69603 |
PTM databases
GlyGeni | Q86SP6, 3 sites |
iPTMneti | Q86SP6 |
PhosphoSitePlusi | Q86SP6 |
Expressioni
Gene expression databases
Bgeei | ENSG00000174948, Expressed in caudate nucleus and 23 other tissues |
ExpressionAtlasi | Q86SP6, baseline and differential |
Organism-specific databases
HPAi | ENSG00000174948, Group enriched (brain, pituitary gland, seminal vesicle) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 131320, 1 interactor |
STRINGi | 9606.ENSP00000374390 |
Miscellaneous databases
RNActi | Q86SP6, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0331, Eukaryota |
GeneTreei | ENSGT00390000003715 |
HOGENOMi | CLU_021967_0_0_1 |
InParanoidi | Q86SP6 |
OMAi | NYECETT |
OrthoDBi | 352121at2759 |
PhylomeDBi | Q86SP6 |
TreeFami | TF331679 |
Family and domain databases
InterProi | View protein in InterPro IPR017452, GPCR_Rhodpsn_7TM |
PROSITEi | View protein in PROSITE PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q86SP6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSLFLSNLST NDSSLWKENH NSTDLLNPPG TLNIYLFCLT CLMTFAALVG
60 70 80 90 100
SIYSLISLLK MQNRTVVSML VASWSVDDLM SVLSVTIFMF LQWPNEVPGY
110 120 130 140 150
FQFLCTTSAL MYLCQGLSSN LKATLLVSYN FYTMHRGVGS QTASRRSGQV
160 170 180 190 200
LGVVLTVWAA SLLLSALPLC GWGAFVRTPW GCLVDCSSSY VLFLSIVYAL
210 220 230 240 250
AFGLLVGLSV PLTHRLLCSE EPPRLHSNYQ EISRGASIPG TPPTAGRVVS
260 270 280 290 300
LSPEDAPGPS LRRSGGCSPS SDTVFGPGAP AAAGAEACRR ENRGTLYGTR
310 320 330 340 350
SFTVSVAQKR FALILALTKV VLWLPMMMHM VVQNVVGFQS LPLETFSFLL
360 370 380 390 400
TLLATTVTPV FVLSKRWTHL PCGCIINCRQ NAYAVASDGK KIKRKGFEFN
410 420 430 440 450
LSFQKSYGIY KIAHEDYYDD DENSIFYHNL MNSECETTKD PQRDNRNIFN
460 470 480 490 500
AIKVEISTTP SLDSSTQRGI NKCTNTDITE AKQDSNNKKD AFSDKTGGDI
510 520 530 540 550
NYEETTFSEG PERRLSHEES QKPDLSDWEW CRSKSERTPR QRSGYALAIP
560 570 580 590 600
LCAFQGTVSL HAPTGKTLSL STYEVSAEGQ KITPASKKIE VYRSKSVGHE
610 620 630 640 650
PNSEDSSSTF VDTSVKIHLE VLEICDNEEA LDTVSIISNI SQSSTQVRSP
660 670 680 690 700
SLRYSRKENR FVSCDLGETA SYSLFLPTSN PDGDINISIP DTVEAHRQNS
710 720 730
KRQHQERDGY QEEIQLLNKA YRKREEESKG S
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC092946 Genomic DNA No translation available. AY255534 mRNA Translation: AAO85046.1 |
CCDSi | CCDS43162.1 |
RefSeqi | NP_001033794.1, NM_001038705.1 |
Genome annotation databases
Ensembli | ENST00000389740; ENSP00000374390; ENSG00000174948 |
GeneIDi | 344758 |
KEGGi | hsa:344758 |
UCSCi | uc003faa.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC092946 Genomic DNA No translation available. AY255534 mRNA Translation: AAO85046.1 |
CCDSi | CCDS43162.1 |
RefSeqi | NP_001033794.1, NM_001038705.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 131320, 1 interactor |
STRINGi | 9606.ENSP00000374390 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | Q86SP6, 3 sites |
iPTMneti | Q86SP6 |
PhosphoSitePlusi | Q86SP6 |
Genetic variation databases
BioMutai | GPR149 |
DMDMi | 84029267 |
Proteomic databases
PaxDbi | Q86SP6 |
PeptideAtlasi | Q86SP6 |
PRIDEi | Q86SP6 |
ProteomicsDBi | 69603 |
Protocols and materials databases
Antibodypediai | 9095, 207 antibodies |
DNASUi | 344758 |
Genome annotation databases
Ensembli | ENST00000389740; ENSP00000374390; ENSG00000174948 |
GeneIDi | 344758 |
KEGGi | hsa:344758 |
UCSCi | uc003faa.3, human |
Organism-specific databases
CTDi | 344758 |
DisGeNETi | 344758 |
GeneCardsi | GPR149 |
HGNCi | HGNC:23627, GPR149 |
HPAi | ENSG00000174948, Group enriched (brain, pituitary gland, seminal vesicle) |
neXtProti | NX_Q86SP6 |
OpenTargetsi | ENSG00000174948 |
PharmGKBi | PA134981369 |
VEuPathDBi | HostDB:ENSG00000174948.5 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0331, Eukaryota |
GeneTreei | ENSGT00390000003715 |
HOGENOMi | CLU_021967_0_0_1 |
InParanoidi | Q86SP6 |
OMAi | NYECETT |
OrthoDBi | 352121at2759 |
PhylomeDBi | Q86SP6 |
TreeFami | TF331679 |
Enzyme and pathway databases
PathwayCommonsi | Q86SP6 |
Miscellaneous databases
BioGRID-ORCSi | 344758, 1 hit in 867 CRISPR screens |
GenomeRNAii | 344758 |
Pharosi | Q86SP6, Tdark |
PROi | PR:Q86SP6 |
RNActi | Q86SP6, protein |
Gene expression databases
Bgeei | ENSG00000174948, Expressed in caudate nucleus and 23 other tissues |
ExpressionAtlasi | Q86SP6, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR017452, GPCR_Rhodpsn_7TM |
PROSITEi | View protein in PROSITE PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GP149_HUMAN | |
Accessioni | Q86SP6Primary (citable) accession number: Q86SP6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 20, 2005 |
Last sequence update: | December 20, 2005 | |
Last modified: | February 10, 2021 | |
This is version 111 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - SIMILARITY comments
Index of protein domains and families