UniProtKB - Q86SM8 (MRGRE_HUMAN)
Protein
Mas-related G-protein coupled receptor member E
Gene
MRGPRE
Organism
Homo sapiens (Human)
Status
Functioni
Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain.
GO - Molecular functioni
- G protein-coupled receptor activity Source: GO_Central
GO - Biological processi
- G protein-coupled receptor signaling pathway Source: GO_Central
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Names & Taxonomyi
Protein namesi | Recommended name: Mas-related G-protein coupled receptor member EAlternative name(s): G-protein coupled receptor 167 |
Gene namesi | Name:MRGPRE Synonyms:GPR167, MRGE |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000184350.9 |
HGNCi | HGNC:30694 MRGPRE |
MIMi | 607232 gene |
neXtProti | NX_Q86SM8 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 20 | ExtracellularSequence analysisAdd BLAST | 20 | |
Transmembranei | 21 – 41 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 42 – 59 | CytoplasmicSequence analysisAdd BLAST | 18 | |
Transmembranei | 60 – 80 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 81 – 106 | ExtracellularSequence analysisAdd BLAST | 26 | |
Transmembranei | 107 – 127 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 128 – 141 | CytoplasmicSequence analysisAdd BLAST | 14 | |
Transmembranei | 142 – 162 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 163 – 176 | ExtracellularSequence analysisAdd BLAST | 14 | |
Transmembranei | 177 – 197 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 198 – 217 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 218 – 238 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 239 – 241 | ExtracellularSequence analysis | 3 | |
Transmembranei | 242 – 262 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 263 – 312 | CytoplasmicSequence analysisAdd BLAST | 50 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000184350 |
PharmGKBi | PA134939296 |
Polymorphism and mutation databases
BioMutai | MRGPRE |
DMDMi | 115502418 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069760 | 1 – 312 | Mas-related G-protein coupled receptor member EAdd BLAST | 312 |
Proteomic databases
PaxDbi | Q86SM8 |
PeptideAtlasi | Q86SM8 |
PRIDEi | Q86SM8 |
ProteomicsDBi | 69602 |
PTM databases
PhosphoSitePlusi | Q86SM8 |
Expressioni
Gene expression databases
Bgeei | ENSG00000184350 Expressed in 42 organ(s), highest expression level in ectocervix |
ExpressionAtlasi | Q86SM8 baseline and differential |
Organism-specific databases
HPAi | HPA046556 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG410JC07 Eukaryota ENOG4111507 LUCA |
GeneTreei | ENSGT00940000153585 |
HOGENOMi | HOG000015412 |
HOVERGENi | HBG102287 |
InParanoidi | Q86SM8 |
KOi | K08393 |
OMAi | PFGIYWL |
OrthoDBi | 1123658at2759 |
PhylomeDBi | Q86SM8 |
TreeFami | TF336336 |
Family and domain databases
InterProi | View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR026230 MRGPCRE IPR026234 MRGPCRFAMILY |
PANTHERi | PTHR11334 PTHR11334, 1 hit PTHR11334:SF26 PTHR11334:SF26, 1 hit |
Pfami | View protein in Pfam PF00001 7tm_1, 1 hit |
PRINTSi | PR00237 GPCRRHODOPSN PR02111 MRGPCRE PR02108 MRGPCRFAMILY |
PROSITEi | View protein in PROSITE PS50262 G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q86SM8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MMEPREAGQH VGAANGAQED VAFNLIILSL TEGLGLGGLL GNGAVLWLLS
60 70 80 90 100
SNVYRNPFAI YLLDVACADL IFLGCHMVAI VPDLLQGRLD FPGFVQTSLA
110 120 130 140 150
TLRFFCYIVG LSLLAAVSVE QCLAALFPAW YSCRRPRHLT TCVCALTWAL
160 170 180 190 200
CLLLHLLLSG ACTQFFGEPS RHLCRTLWLV AAVLLALLCC TMCGASLMLL
210 220 230 240 250
LRVERGPQRP PPRGFPGLIL LTVLLFLFCG LPFGIYWLSR NLLWYIPHYF
260 270 280 290 300
YHFSFLMAAV HCAAKPVVYF CLGSAQGRRL PLRLVLQRAL GDEAELGAVR
310
ETSRRGLVDI AA
Sequence cautioni
The sequence AAI04890 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI12204 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_059325 | 16 | G → S. Corresponds to variant dbSNP:rs12295710Ensembl. | 1 | |
Natural variantiVAR_059326 | 160 | G → S. Corresponds to variant dbSNP:rs4391795Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC104889 mRNA Translation: AAI04890.1 Different initiation. BC112203 mRNA Translation: AAI12204.1 Different initiation. AY255572 mRNA Translation: AAO85084.1 |
CCDSi | CCDS41603.2 |
RefSeqi | NP_001034254.2, NM_001039165.2 |
UniGenei | Hs.745512 |
Genome annotation databases
Ensembli | ENST00000389832; ENSP00000374482; ENSG00000184350 |
GeneIDi | 116534 |
KEGGi | hsa:116534 |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC104889 mRNA Translation: AAI04890.1 Different initiation. BC112203 mRNA Translation: AAI12204.1 Different initiation. AY255572 mRNA Translation: AAO85084.1 |
CCDSi | CCDS41603.2 |
RefSeqi | NP_001034254.2, NM_001039165.2 |
UniGenei | Hs.745512 |
3D structure databases
ProteinModelPortali | Q86SM8 |
ModBasei | Search... |
MobiDBi | Search... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000374482 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
PhosphoSitePlusi | Q86SM8 |
Polymorphism and mutation databases
BioMutai | MRGPRE |
DMDMi | 115502418 |
Proteomic databases
PaxDbi | Q86SM8 |
PeptideAtlasi | Q86SM8 |
PRIDEi | Q86SM8 |
ProteomicsDBi | 69602 |
Protocols and materials databases
DNASUi | 116534 |
Structural Biology Knowledgebase | Search... |
Genome annotation databases
Ensembli | ENST00000389832; ENSP00000374482; ENSG00000184350 |
GeneIDi | 116534 |
KEGGi | hsa:116534 |
Organism-specific databases
CTDi | 116534 |
EuPathDBi | HostDB:ENSG00000184350.9 |
GeneCardsi | MRGPRE |
H-InvDBi | HIX0171334 |
HGNCi | HGNC:30694 MRGPRE |
HPAi | HPA046556 |
MIMi | 607232 gene |
neXtProti | NX_Q86SM8 |
OpenTargetsi | ENSG00000184350 |
PharmGKBi | PA134939296 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG410JC07 Eukaryota ENOG4111507 LUCA |
GeneTreei | ENSGT00940000153585 |
HOGENOMi | HOG000015412 |
HOVERGENi | HBG102287 |
InParanoidi | Q86SM8 |
KOi | K08393 |
OMAi | PFGIYWL |
OrthoDBi | 1123658at2759 |
PhylomeDBi | Q86SM8 |
TreeFami | TF336336 |
Miscellaneous databases
GeneWikii | MRGPRE |
GenomeRNAii | 116534 |
PROi | PR:Q86SM8 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000184350 Expressed in 42 organ(s), highest expression level in ectocervix |
ExpressionAtlasi | Q86SM8 baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR026230 MRGPCRE IPR026234 MRGPCRFAMILY |
PANTHERi | PTHR11334 PTHR11334, 1 hit PTHR11334:SF26 PTHR11334:SF26, 1 hit |
Pfami | View protein in Pfam PF00001 7tm_1, 1 hit |
PRINTSi | PR00237 GPCRRHODOPSN PR02111 MRGPCRE PR02108 MRGPCRFAMILY |
PROSITEi | View protein in PROSITE PS50262 G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | MRGRE_HUMAN | |
Accessioni | Q86SM8Primary (citable) accession number: Q86SM8 Secondary accession number(s): Q2M1V7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 31, 2004 |
Last sequence update: | July 9, 2014 | |
Last modified: | February 13, 2019 | |
This is version 127 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries