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Entry version 136 (02 Jun 2021)
Sequence version 2 (04 Dec 2007)
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Protein

Stearoyl-CoA desaturase 5

Gene

SCD5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Stearoyl-CoA desaturase that utilizes O2 and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. Catalyzes the insertion of a cis double bond at the delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed:15610069, PubMed:15907797, PubMed:22745828).

Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids (PubMed:15610069, PubMed:15907797).

Involved in neuronal cell proliferation and differentiation through down-regulation of EGFR/AKT/MAPK and Wnt signaling pathways (PubMed:22745828).

3 Publications

Miscellaneous

This protein has no ortholog in rodents.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Fe2+By similarityNote: Expected to bind 2 Fe2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei49SubstrateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi94Iron 1By similarity1
Metal bindingi99Iron 1By similarity1
Binding sitei122SubstrateBy similarity1
Binding sitei129SubstrateBy similarity1
Binding sitei130SubstrateBy similarity1
Metal bindingi131Iron 1By similarity1
Metal bindingi134Iron 2By similarity1
Metal bindingi135Iron 1By similarity1
Binding sitei162SubstrateBy similarity1
Binding sitei163SubstrateBy similarity1
Binding sitei236SubstrateBy similarity1
Metal bindingi243Iron 2By similarity1
Metal bindingi272Iron 2By similarity1
Metal bindingi275Iron 1By similarity1
Metal bindingi276Iron 2By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
Biological processFatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism
LigandIron, Metal-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
1.14.19.1, 2681

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q86SK9

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-75105, Fatty acyl-CoA biosynthesis
R-HSA-9619665, EGR2 and SOX10-mediated initiation of Schwann cell myelination

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000001074

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Stearoyl-CoA desaturase 51 Publication (EC:1.14.19.13 Publications)
Alternative name(s):
Acyl-CoA-desaturase 41 Publication
HSCD51 Publication
Stearoyl-CoA 9-desaturase1 Publication
Stearoyl-CoA desaturase 21 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SCD5
Synonyms:ACOD41 Publication, SCD21 Publication, SCD4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:21088, SCD5

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608370, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q86SK9

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000145284.11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 49CytoplasmicCuratedAdd BLAST49
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei50 – 70HelicalSequence analysisAdd BLAST21
Topological domaini71 – 72LumenalCurated2
Transmembranei73 – 93HelicalSequence analysisAdd BLAST21
Topological domaini94 – 193CytoplasmicCuratedAdd BLAST100
Transmembranei194 – 214HelicalSequence analysisAdd BLAST21
Topological domaini215LumenalCurated1
Transmembranei216 – 238HelicalSequence analysisAdd BLAST23
Topological domaini239 – 330CytoplasmicCuratedAdd BLAST92

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
79966

Open Targets

More...
OpenTargetsi
ENSG00000145284

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134934692

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q86SK9, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1275210

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SCD5

Domain mapping of disease mutations (DMDM)

More...
DMDMi
162416247

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003126531 – 330Stearoyl-CoA desaturase 5Add BLAST330

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q86SK9

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q86SK9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q86SK9

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q86SK9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q86SK9

PeptideAtlas

More...
PeptideAtlasi
Q86SK9

PRoteomics IDEntifications database

More...
PRIDEi
Q86SK9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
69599 [Q86SK9-1]
69600 [Q86SK9-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q86SK9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q86SK9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in fetal brain, and at lower levels in fetal kidney. Detected in adult brain and pancreas, and at lower levels in kidney and lung.4 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000145284, Expressed in ventral tegmental area and 235 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q86SK9, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000145284, Group enriched (adrenal gland, brain, epididymis, ovary)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May self-associate and form homodimers.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
123034, 15 interactors

Protein interaction database and analysis system

More...
IntActi
Q86SK9, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000316329

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q86SK9

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q86SK9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q86SK9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi94 – 99Histidine box-1Curated6
Motifi131 – 135Histidine box-2Curated5
Motifi272 – 276Histidine box-3Curated5

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The histidine box domains are involved in binding the catalytic metal ions.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1600, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162090

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_027359_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q86SK9

Identification of Orthologs from Complete Genome Data

More...
OMAi
INSICHA

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q86SK9

TreeFam database of animal gene trees

More...
TreeFami
TF313251

Family and domain databases

Conserved Domains Database

More...
CDDi
cd03505, Delta9-FADS-like, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015876, Acyl-CoA_DS
IPR005804, FA_desaturase_dom
IPR001522, FADS-1_CS

The PANTHER Classification System

More...
PANTHERi
PTHR11351, PTHR11351, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00487, FA_desaturase, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00075, FACDDSATRASE

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00476, FATTY_ACID_DESATUR_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q86SK9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPGPATDAGK IPFCDAKEEI RAGLESSEGG GGPERPGARG QRQNIVWRNV
60 70 80 90 100
VLMSLLHLGA VYSLVLIPKA KPLTLLWAYF CFLLAALGVT AGAHRLWSHR
110 120 130 140 150
SYRAKLPLRI FLAVANSMAF QNDIFEWSRD HRAHHKYSET DADPHNARRG
160 170 180 190 200
FFFSHIGWLF VRKHRDVIEK GRKLDVTDLL ADPVVRIQRK YYKISVVLMC
210 220 230 240 250
FVVPTLVPWY IWGESLWNSY FLASILRYTI SLNISWLVNS AAHMYGNRPY
260 270 280 290 300
DKHISPRQNP LVALGAIGEG FHNYHHTFPF DYSASEFGLN FNPTTWFIDF
310 320 330
MCWLGLATDR KRATKPMIEA RKARTGDSSA
Length:330
Mass (Da):37,610
Last modified:December 4, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i50652E942C19DB82
GO
Isoform 2 (identifier: Q86SK9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     190-330: KYYKISVVLM...RKARTGDSSA → NTQHIQKEGR...RALSVSLEVF

Show »
Length:256
Mass (Da):28,983
Checksum:iB8A6129F645C0ADE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti82F → L in BAB14961 (PubMed:14702039).Curated1
Sequence conflicti127W → R in AAP31443 (PubMed:12727354).Curated1
Sequence conflicti127W → R in BAB14961 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_029883190 – 330KYYKI…GDSSA → NTQHIQKEGRALNQEAACEM LREWHQGHILKVTLPGLHIL ALLHTHCNHSEKCCLMLRAL SVSLEVF in isoform 2. 1 PublicationAdd BLAST141

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF389338 mRNA Translation: AAP31443.1
AK024685 mRNA Translation: BAB14961.1
AC073413 Genomic DNA Translation: AAY40977.1
CH471057 Genomic DNA Translation: EAX05903.1
CH471057 Genomic DNA Translation: EAX05904.1
BC137429 mRNA Translation: AAI37430.1
BC137432 mRNA Translation: AAI37433.1
AL831891 mRNA Translation: CAD38567.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34024.1 [Q86SK9-1]
CCDS3595.1 [Q86SK9-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001032671.2, NM_001037582.2 [Q86SK9-1]
NP_079182.2, NM_024906.2 [Q86SK9-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000273908; ENSP00000273908; ENSG00000145284 [Q86SK9-2]
ENST00000319540; ENSP00000316329; ENSG00000145284 [Q86SK9-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
79966

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:79966

UCSC genome browser

More...
UCSCi
uc003hna.3, human [Q86SK9-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF389338 mRNA Translation: AAP31443.1
AK024685 mRNA Translation: BAB14961.1
AC073413 Genomic DNA Translation: AAY40977.1
CH471057 Genomic DNA Translation: EAX05903.1
CH471057 Genomic DNA Translation: EAX05904.1
BC137429 mRNA Translation: AAI37430.1
BC137432 mRNA Translation: AAI37433.1
AL831891 mRNA Translation: CAD38567.1
CCDSiCCDS34024.1 [Q86SK9-1]
CCDS3595.1 [Q86SK9-2]
RefSeqiNP_001032671.2, NM_001037582.2 [Q86SK9-1]
NP_079182.2, NM_024906.2 [Q86SK9-2]

3D structure databases

SMRiQ86SK9
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi123034, 15 interactors
IntActiQ86SK9, 3 interactors
STRINGi9606.ENSP00000316329

Chemistry databases

BindingDBiQ86SK9
ChEMBLiCHEMBL1275210
SwissLipidsiSLP:000001074

PTM databases

iPTMnetiQ86SK9
PhosphoSitePlusiQ86SK9

Genetic variation databases

BioMutaiSCD5
DMDMi162416247

Proteomic databases

EPDiQ86SK9
jPOSTiQ86SK9
MassIVEiQ86SK9
MaxQBiQ86SK9
PaxDbiQ86SK9
PeptideAtlasiQ86SK9
PRIDEiQ86SK9
ProteomicsDBi69599 [Q86SK9-1]
69600 [Q86SK9-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
51995, 100 antibodies

The DNASU plasmid repository

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DNASUi
79966

Genome annotation databases

EnsembliENST00000273908; ENSP00000273908; ENSG00000145284 [Q86SK9-2]
ENST00000319540; ENSP00000316329; ENSG00000145284 [Q86SK9-1]
GeneIDi79966
KEGGihsa:79966
UCSCiuc003hna.3, human [Q86SK9-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
79966
DisGeNETi79966

GeneCards: human genes, protein and diseases

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GeneCardsi
SCD5
HGNCiHGNC:21088, SCD5
HPAiENSG00000145284, Group enriched (adrenal gland, brain, epididymis, ovary)
MIMi608370, gene
neXtProtiNX_Q86SK9
OpenTargetsiENSG00000145284
PharmGKBiPA134934692
VEuPathDBiHostDB:ENSG00000145284.11

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1600, Eukaryota
GeneTreeiENSGT00940000162090
HOGENOMiCLU_027359_0_0_1
InParanoidiQ86SK9
OMAiINSICHA
PhylomeDBiQ86SK9
TreeFamiTF313251

Enzyme and pathway databases

BRENDAi1.14.19.1, 2681
PathwayCommonsiQ86SK9
ReactomeiR-HSA-75105, Fatty acyl-CoA biosynthesis
R-HSA-9619665, EGR2 and SOX10-mediated initiation of Schwann cell myelination

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
79966, 2 hits in 990 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SCD5, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
79966
PharosiQ86SK9, Tchem

Protein Ontology

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PROi
PR:Q86SK9
RNActiQ86SK9, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000145284, Expressed in ventral tegmental area and 235 other tissues
GenevisibleiQ86SK9, HS

Family and domain databases

CDDicd03505, Delta9-FADS-like, 1 hit
InterProiView protein in InterPro
IPR015876, Acyl-CoA_DS
IPR005804, FA_desaturase_dom
IPR001522, FADS-1_CS
PANTHERiPTHR11351, PTHR11351, 1 hit
PfamiView protein in Pfam
PF00487, FA_desaturase, 1 hit
PRINTSiPR00075, FACDDSATRASE
PROSITEiView protein in PROSITE
PS00476, FATTY_ACID_DESATUR_1, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSCD5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86SK9
Secondary accession number(s): B2RPG0
, Q4W5Q5, Q8NDS0, Q9H7D1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: December 4, 2007
Last modified: June 2, 2021
This is version 136 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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