Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 167 (29 Sep 2021)
Sequence version 1 (01 Jun 2003)
Previous versions | rss
Add a publicationFeedback
Protein

Amphoterin-induced protein 2

Gene

AMIGO2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal transduction through its intracellular domain. May be required for tumorigenesis of a subset of gastric adenocarcinomas.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q86SJ2

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-9013149, RAC1 GTPase cycle
R-HSA-9013423, RAC3 GTPase cycle

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Amphoterin-induced protein 2
Alternative name(s):
AMIGO-2
Alivin-1
Differentially expressed in gastric adenocarcinomas
Short name:
DEGA
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AMIGO2Imported
Synonyms:ALI1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24073, AMIGO2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
615690, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q86SJ2

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000139211

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini40 – 398ExtracellularSequence analysisAdd BLAST359
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei399 – 419HelicalSequence analysisAdd BLAST21
Topological domaini420 – 522CytoplasmicSequence analysisAdd BLAST103

Keywords - Cellular componenti

Cell membrane, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
347902

Open Targets

More...
OpenTargetsi
ENSG00000139211

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142672626

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q86SJ2, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
AMIGO2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
68052338

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 39Sequence analysisAdd BLAST39
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001450940 – 522Amphoterin-induced protein 2Sequence analysisAdd BLAST483

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi41 ↔ 47PROSITE-ProRule annotation
Disulfide bondi45 ↔ 54PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi58N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi104N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi232 ↔ 260PROSITE-ProRule annotation
Disulfide bondi234 ↔ 282PROSITE-ProRule annotation
Glycosylationi281N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi288N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi310 ↔ 363PROSITE-ProRule annotation
Glycosylationi345N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi373N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi381N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi384N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q86SJ2

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q86SJ2

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q86SJ2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q86SJ2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q86SJ2

PeptideAtlas

More...
PeptideAtlasi
Q86SJ2

PRoteomics IDEntifications database

More...
PRIDEi
Q86SJ2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
69596

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1007, 4 N-Linked glycans (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q86SJ2, 9 sites, 4 N-linked glycans (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q86SJ2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q86SJ2

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q86SJ2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highest levels in breast, ovary, cervix, and uterus. Lower levels in lung, colon, and rectum. Differentially expressed in 56% of thyroid, 57% of pancreatic and 45% of stomach cancers.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000139211, Expressed in blood vessel layer and 224 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q86SJ2, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q86SJ2, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000139211, Tissue enhanced (ovary)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds itself as well as AMIGO1 and AMIGO3.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
131497, 22 interactors

Protein interaction database and analysis system

More...
IntActi
Q86SJ2, 6 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000266581

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q86SJ2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini40 – 68LRRNTAdd BLAST29
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati69 – 90LRR 1Add BLAST22
Repeati94 – 115LRR 2Add BLAST22
Repeati118 – 139LRR 3Add BLAST22
Repeati142 – 163LRR 4Add BLAST22
Repeati166 – 187LRR 5Add BLAST22
Repeati193 – 214LRR 6Add BLAST22
Domaini228 – 284LRRCTAdd BLAST57
Domaini289 – 379Ig-like C2-typeSequence analysisAdd BLAST91

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni501 – 522DisorderedSequence analysisAdd BLAST22

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi502 – 522Polar residuesSequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502R009, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183146

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_030478_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q86SJ2

Identification of Orthologs from Complete Genome Data

More...
OMAi
LNQSNAH

Database of Orthologous Groups

More...
OrthoDBi
496131at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q86SJ2

TreeFam database of animal gene trees

More...
TreeFami
TF326838

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 1 hit
3.80.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR031283, AMIGO
IPR031286, AMIGO2
IPR000483, Cys-rich_flank_reg_C
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003599, Ig_sub
IPR013151, Immunoglobulin
IPR001611, Leu-rich_rpt
IPR003591, Leu-rich_rpt_typical-subtyp
IPR032675, LRR_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR24368, PTHR24368, 1 hit
PTHR24368:SF209, PTHR24368:SF209, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00047, ig, 1 hit
PF13855, LRR_8, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00409, IG, 1 hit
SM00369, LRR_TYP, 5 hits
SM00082, LRRCT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726, SSF48726, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50835, IG_LIKE, 1 hit
PS51450, LRR, 7 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q86SJ2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLRVHTLPT LLGAVVRPGC RELLCLLMIT VTVGPGASGV CPTACICATD
60 70 80 90 100
IVSCTNKNLS KVPGNLFRLI KRLDLSYNRI GLLDSEWIPV SFAKLNTLIL
110 120 130 140 150
RHNNITSIST GSFSTTPNLK CLDLSSNKLK TVKNAVFQEL KVLEVLLLYN
160 170 180 190 200
NHISYLDPSA FGGLSQLQKL YLSGNFLTQF PMDLYVGRFK LAELMFLDVS
210 220 230 240 250
YNRIPSMPMH HINLVPGKQL RGIYLHGNPF VCDCSLYSLL VFWYRRHFSS
260 270 280 290 300
VMDFKNDYTC RLWSDSRHSR QVLLLQDSFM NCSDSIINGS FRALGFIHEA
310 320 330 340 350
QVGERLMVHC DSKTGNANTD FIWVGPDNRL LEPDKEMENF YVFHNGSLVI
360 370 380 390 400
ESPRFEDAGV YSCIAMNKQR LLNETVDVTI NVSNFTVSRS HAHEAFNTAF
410 420 430 440 450
TTLAACVASI VLVLLYLYLT PCPCKCKTKR QKNMLHQSNA HSSILSPGPA
460 470 480 490 500
SDASADERKA GAGKRVVFLE PLKDTAAGQN GKVRLFPSEA VIAEGILKST
510 520
RGKSDSDSVN SVFSDTPFVA ST
Length:522
Mass (Da):57,934
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i20A86E3D82C05B9B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY237005 mRNA Translation: AAO48946.1
AB079074 mRNA Translation: BAC81188.1
AB080610 mRNA Translation: BAC81189.1
AY454159 mRNA Translation: AAR83271.1
AL833007 mRNA Translation: CAH56293.1
BC014103 mRNA Translation: AAH14103.2
BC047595 mRNA Translation: AAH47595.1
BC095477 mRNA Translation: AAH95477.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS8751.1

NCBI Reference Sequences

More...
RefSeqi
NP_001137140.1, NM_001143668.1
NP_862830.1, NM_181847.4
XP_005268894.1, XM_005268837.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000266581; ENSP00000266581; ENSG00000139211
ENST00000429635; ENSP00000406020; ENSG00000139211
ENST00000550413; ENSP00000449034; ENSG00000139211

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
347902

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:347902

UCSC genome browser

More...
UCSCi
uc001rpk.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY237005 mRNA Translation: AAO48946.1
AB079074 mRNA Translation: BAC81188.1
AB080610 mRNA Translation: BAC81189.1
AY454159 mRNA Translation: AAR83271.1
AL833007 mRNA Translation: CAH56293.1
BC014103 mRNA Translation: AAH14103.2
BC047595 mRNA Translation: AAH47595.1
BC095477 mRNA Translation: AAH95477.1
CCDSiCCDS8751.1
RefSeqiNP_001137140.1, NM_001143668.1
NP_862830.1, NM_181847.4
XP_005268894.1, XM_005268837.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi131497, 22 interactors
IntActiQ86SJ2, 6 interactors
STRINGi9606.ENSP00000266581

PTM databases

GlyConnecti1007, 4 N-Linked glycans (1 site)
GlyGeniQ86SJ2, 9 sites, 4 N-linked glycans (1 site)
iPTMnetiQ86SJ2
PhosphoSitePlusiQ86SJ2
SwissPalmiQ86SJ2

Genetic variation databases

BioMutaiAMIGO2
DMDMi68052338

Proteomic databases

EPDiQ86SJ2
jPOSTiQ86SJ2
MassIVEiQ86SJ2
MaxQBiQ86SJ2
PaxDbiQ86SJ2
PeptideAtlasiQ86SJ2
PRIDEiQ86SJ2
ProteomicsDBi69596

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
13397, 245 antibodies

The DNASU plasmid repository

More...
DNASUi
347902

Genome annotation databases

EnsembliENST00000266581; ENSP00000266581; ENSG00000139211
ENST00000429635; ENSP00000406020; ENSG00000139211
ENST00000550413; ENSP00000449034; ENSG00000139211
GeneIDi347902
KEGGihsa:347902
UCSCiuc001rpk.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
347902
DisGeNETi347902

GeneCards: human genes, protein and diseases

More...
GeneCardsi
AMIGO2
HGNCiHGNC:24073, AMIGO2
HPAiENSG00000139211, Tissue enhanced (ovary)
MIMi615690, gene
neXtProtiNX_Q86SJ2
OpenTargetsiENSG00000139211
PharmGKBiPA142672626
VEuPathDBiHostDB:ENSG00000139211

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502R009, Eukaryota
GeneTreeiENSGT00950000183146
HOGENOMiCLU_030478_0_0_1
InParanoidiQ86SJ2
OMAiLNQSNAH
OrthoDBi496131at2759
PhylomeDBiQ86SJ2
TreeFamiTF326838

Enzyme and pathway databases

PathwayCommonsiQ86SJ2
ReactomeiR-HSA-9013149, RAC1 GTPase cycle
R-HSA-9013423, RAC3 GTPase cycle

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
347902, 7 hits in 1026 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
347902
PharosiQ86SJ2, Tbio

Protein Ontology

More...
PROi
PR:Q86SJ2
RNActiQ86SJ2, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000139211, Expressed in blood vessel layer and 224 other tissues
ExpressionAtlasiQ86SJ2, baseline and differential
GenevisibleiQ86SJ2, HS

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR031283, AMIGO
IPR031286, AMIGO2
IPR000483, Cys-rich_flank_reg_C
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003599, Ig_sub
IPR013151, Immunoglobulin
IPR001611, Leu-rich_rpt
IPR003591, Leu-rich_rpt_typical-subtyp
IPR032675, LRR_dom_sf
PANTHERiPTHR24368, PTHR24368, 1 hit
PTHR24368:SF209, PTHR24368:SF209, 1 hit
PfamiView protein in Pfam
PF00047, ig, 1 hit
PF13855, LRR_8, 1 hit
SMARTiView protein in SMART
SM00409, IG, 1 hit
SM00369, LRR_TYP, 5 hits
SM00082, LRRCT, 1 hit
SUPFAMiSSF48726, SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835, IG_LIKE, 1 hit
PS51450, LRR, 7 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAMGO2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86SJ2
Secondary accession number(s): Q4VBP6, Q7Z4A0, Q96CN8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: June 1, 2003
Last modified: September 29, 2021
This is version 167 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again