NEK8

Functionⁱ

Required for renal tubular integrity. May regulate local cytoskeletal structure in kidney tubule epithelial cells. May regulate ciliary biogenesis through targeting of proteins to the cilia (By similarity). Plays a role in organogenesis and is involved in the regulation of the Hippo signaling pathway.By similarity1 Publication

Catalytic activityⁱ

ATP + a protein = ADP + a phosphoprotein.

Cofactorⁱ

Mg²⁺By similarity

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	33	ATPPROSITE-ProRule annotation		1
Active siteⁱ	128	Proton acceptorPROSITE-ProRule annotation		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	10 – 18	ATPPROSITE-ProRule annotation		9

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
metal ion binding Source: UniProtKB-KW
protein serine/threonine kinase activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

animal organ morphogenesis
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 23418306
determination of left/right symmetry Source: Ensembl
heart development Source: Ensembl
regulation of hippo signaling
Source: UniProtKB
Inferred from direct assayⁱ
- 23418306

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Serine/threonine-protein kinase, Transferase
Ligand	ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkⁱ	Q86SG6
SIGNORⁱ	Q86SG6

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Serine/threonine-protein kinase Nek8 (EC:2.7.11.1) Alternative name(s): Never in mitosis A-related kinase 8 Short name: NimA-related protein kinase 8 Nima-related protein kinase 12a
Gene namesⁱ	Name:NEK8 Synonyms:JCK, NEK12A
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000160602.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:13387 NEK8
MIMⁱ	609799 gene
neXtProtⁱ	NX_Q86SG6

Keywords - Cellular componentⁱ

Cell projection, Cilium, Cytoplasm, Cytoskeleton

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Nephronophthisis 9 (NPHP9)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAn autosomal recessive disorder resulting in end-stage renal disease. It is a progressive tubulo-interstitial kidney disorder histologically characterized by modifications of the tubules with thickening of the basement membrane, interstitial fibrosis and, in the advanced stages, medullary cysts.

Renal-hepatic-pancreatic dysplasia 2 (RHPD2)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA form of renal-hepatic-pancreatic dysplasia, a disease characterized by cystic malformations of the kidneys, liver, and pancreas. The pathological findings consist of multicystic dysplastic kidneys, dilated and dysgenetic bile ducts, a dysplastic pancreas with dilated ducts, cysts, fibrosis and inflammatory infiltrates.

Keywords - Diseaseⁱ

Ciliopathy, Disease mutation, Nephronophthisis

Organism-specific databases

DisGeNET More...DisGeNETⁱ	284086
MalaCards human disease database More...MalaCardsⁱ	NEK8
MIMⁱ	613824 phenotype 615415 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000160602
Orphanetⁱ	93591 Infantile nephronophthisis 294415 Renal-hepatic-pancreatic dysplasia
PharmGKBⁱ	PA38361

Chemistry databases

ChEMBLⁱ	CHEMBL2417353
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	2123

Polymorphism and mutation databases

BioMutaⁱ	NEK8
DMDMⁱ	34098463

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000086432	1 – 692	Serine/threonine-protein kinase Nek8Add BLAST		692

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	162	Phosphothreonine; by autocatalysisBy similarity		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

PaxDbⁱ	Q86SG6
PeptideAtlas More...PeptideAtlasⁱ	Q86SG6
PRIDEⁱ	Q86SG6
ProteomicsDBⁱ	69588

PTM databases

iPTMnetⁱ	Q86SG6
PhosphoSitePlusⁱ	Q86SG6

Expressionⁱ

Tissue specificityⁱ

Highest expression in thyroid, adrenal gland and skin. Low levels in spleen, colon and uterus. Overexpressed in breast tumors, with highest expression in infiltrating ductal carcinomas and moderate levels in mucinous adenocarcinoma.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000160602
CleanExⁱ	HS_NEK8
ExpressionAtlasⁱ	Q86SG6 baseline and differential
Genevisibleⁱ	Q86SG6 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA040661 HPA040679

HPAⁱ

HPA040661
HPA040679

Interactionⁱ

Subunit structureⁱ

Interacts with PKD2; may regulate PKD2 targeting to the cilium (By similarity). Component of a complex containing at least ANKS6, INVS, NEK8 and NPHP3. ANKS6 may organize complex assembly by linking INVS and NPHP3 to NEK8 and INVS may target the complex to the proximal ciliary axoneme. Interacts with ANKS3 (By similarity).By similarity2 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
ANKS6	Q68DC2	4	EBI-1752987,EBI-7054139
NUDCD2	Q8WVJ2	2	EBI-1752987,EBI-1052153
TCF4	P15884	3	EBI-1752987,EBI-533224
TRIM69	Q86WT6	3	EBI-1752987,EBI-749955

Show more details

Protein-protein interaction databases

BioGridⁱ	129755, 31 interactors
CORUMⁱ	Q86SG6
IntActⁱ	Q86SG6, 38 interactors
STRINGⁱ	9606.ENSP00000268766

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q86SG6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	4 – 258	Protein kinasePROSITE-ProRule annotationAdd BLAST	255
Repeatⁱ	312 – 350	RCC1 1Add BLAST	39
Repeatⁱ	410 – 461	RCC1 2Add BLAST	52
Repeatⁱ	462 – 513	RCC1 3Add BLAST	52
Repeatⁱ	580 – 631	RCC1 4Add BLAST	52
Repeatⁱ	632 – 684	RCC1 5Add BLAST	53

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.Curated

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	KOG0589 Eukaryota ENOG410Y7JF LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118997
HOGENOMⁱ	HOG000006908
HOVERGENⁱ	HBG098799
InParanoidⁱ	Q86SG6
KEGG Orthology (KO) More...KOⁱ	K20877
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0GU4
PhylomeDBⁱ	Q86SG6
TreeFamⁱ	TF106472

Family and domain databases

Gene3Dⁱ	2.130.10.30, 2 hits
InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR009091 RCC1/BLIP-II IPR000408 Reg_chr_condens IPR008271 Ser/Thr_kinase_AS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit PF00415 RCC1, 4 hits
PRINTSⁱ	PR00633 RCCNDNSATION
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF50985 SSF50985, 1 hit SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit PS50012 RCC1_3, 5 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

Q86SG6-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEKYERIRVV GRGAFGIVHL CLRKADQKLV IIKQIPVEQM TKEERQAAQN 
        60         70         80         90        100
ECQVLKLLNH PNVIEYYENF LEDKALMIAM EYAPGGTLAE FIQKRCNSLL 
       110        120        130        140        150
EEETILHFFV QILLALHHVH THLILHRDLK TQNILLDKHR MVVKIGDFGI 
       160        170        180        190        200
SKILSSKSKA YTVVGTPCYI SPELCEGKPY NQKSDIWALG CVLYELASLK 
       210        220        230        240        250
RAFEAANLPA LVLKIMSGTF APISDRYSPE LRQLVLSLLS LEPAQRPPLS 
       260        270        280        290        300
HIMAQPLCIR ALLNLHTDVG SVRMRRAEKS VAPSNTGSRT TSVRCRGIPR 
       310        320        330        340        350
GPVRPAIPPP LSSVYAWGGG LGTPLRLPML NTEVVQVAAG RTQKAGVTRS 
       360        370        380        390        400
GRLILWEAPP LGAGGGSLLP GAVEQPQPQF ISRFLEGQSG VTIKHVACGD 
       410        420        430        440        450
FFTACLTDRG IIMTFGSGSN GCLGHGSLTD ISQPTIVEAL LGYEMVQVAC 
       460        470        480        490        500
GASHVLALST ERELFAWGRG DSGRLGLGTR ESHSCPQQVP MPPGQEAQRV 
       510        520        530        540        550
VCGIDSSMIL TVPGQALACG SNRFNKLGLD HLSLGEEPVP HQQVEEALSF 
       560        570        580        590        600
TLLGSAPLDQ EPLLSIDLGT AHSAAVTASG DCYTFGSNQH GQLGTNTRRG 
       610        620        630        640        650
SRAPCKVQGL EGIKMAMVAC GDAFTVAIGA ESEVYSWGKG ARGRLGRRDE 
       660        670        680        690 
DAGLPRPVQL DETHPYTVTS VSCCHGNTLL AVRSVTDEPV PP

Length:692

Mass (Da):74,806

Last modified:June 1, 2003 - v1

Checksum:ⁱ9E09820DFB3D5CA1

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_065769	330	L → F in NPHP9; a full-length mouse NEK8 construct containing the mutation shows a defect in ciliary localization with no apparent effect on ciliation, mitosis or centriole number. 1 PublicationCorresponds to variant dbSNP:rs199962228Ensembl.	1
Natural variantⁱVAR_065770	425	H → Y in NPHP9; a full-length mouse NEK8 construct containing the mutation shows a defect in ciliary localization with no apparent effect on ciliation, mitosis or centriole number. 1 PublicationCorresponds to variant dbSNP:rs118204032EnsemblClinVar.	1
Natural variantⁱVAR_065771	497	A → P in NPHP9; a full-length mouse NEK8 construct containing the mutation shows a defect in ciliary localization with no apparent effect on ciliation, mitosis or centriole number. 1 PublicationCorresponds to variant dbSNP:rs146326420Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY242354 mRNA Translation: AAO88243.1 AY267371 mRNA Translation: AAP04006.1 AC010761 Genomic DNA No translation available. CH471159 Genomic DNA Translation: EAW51136.1 BC112240 mRNA Translation: AAI12241.1 BC113705 mRNA Translation: AAI13706.1 AL833909 mRNA Translation: CAD38765.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS32597.1
NCBI Reference Sequences More...RefSeqⁱ	NP_835464.1, NM_178170.2
UniGeneⁱ	Hs.448468

Genome annotation databases

Ensemblⁱ	ENST00000268766; ENSP00000268766; ENSG00000160602
GeneIDⁱ	284086
KEGGⁱ	hsa:284086
UCSC genome browser More...UCSCⁱ	uc002hcp.4 human

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q86SG6	UPI000CCC640C		MYOLU		828
UPI0007A6EA3B		MINNA		731
UPI0009486011		FELCA		731
UPI000904BA31		PANPR		717
UPI000C8139D5		LOXAF		717
+163

Protein	Similar proteins		Species	Score	Length
Q86SG6	UPI000CCC640C		MYOLU		828
UPI0007A6EA3B		MINNA		731
UPI0009486011		FELCA		731
UPI000904BA31		PANPR		717
UPI000C8139D5		LOXAF		717
+212

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY242354 mRNA Translation: AAO88243.1 AY267371 mRNA Translation: AAP04006.1 AC010761 Genomic DNA No translation available. CH471159 Genomic DNA Translation: EAW51136.1 BC112240 mRNA Translation: AAI12241.1 BC113705 mRNA Translation: AAI13706.1 AL833909 mRNA Translation: CAD38765.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS32597.1
NCBI Reference Sequences More...RefSeqⁱ	NP_835464.1, NM_178170.2
UniGeneⁱ	Hs.448468

3D structure databases

ProteinModelPortalⁱ	Q86SG6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	129755, 31 interactors
CORUMⁱ	Q86SG6
IntActⁱ	Q86SG6, 38 interactors
STRINGⁱ	9606.ENSP00000268766

Chemistry databases

ChEMBLⁱ	CHEMBL2417353
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	2123

PTM databases

iPTMnetⁱ	Q86SG6
PhosphoSitePlusⁱ	Q86SG6

Polymorphism and mutation databases

BioMutaⁱ	NEK8
DMDMⁱ	34098463

Proteomic databases

PaxDbⁱ	Q86SG6
PeptideAtlas More...PeptideAtlasⁱ	Q86SG6
PRIDEⁱ	Q86SG6
ProteomicsDBⁱ	69588

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	284086
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000268766; ENSP00000268766; ENSG00000160602
GeneIDⁱ	284086
KEGGⁱ	hsa:284086
UCSC genome browser More...UCSCⁱ	uc002hcp.4 human

Organism-specific databases

CTDⁱ	284086
DisGeNET More...DisGeNETⁱ	284086
EuPathDBⁱ	HostDB:ENSG00000160602.13
GeneCardsⁱ	NEK8
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:13387 NEK8
Human Protein Atlas More...HPAⁱ	HPA040661 HPA040679
MalaCards human disease database More...MalaCardsⁱ	NEK8
MIMⁱ	609799 gene 613824 phenotype 615415 phenotype
neXtProtⁱ	NX_Q86SG6
Open Targets More...OpenTargetsⁱ	ENSG00000160602
Orphanetⁱ	93591 Infantile nephronophthisis 294415 Renal-hepatic-pancreatic dysplasia
PharmGKBⁱ	PA38361
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0589 Eukaryota ENOG410Y7JF LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118997
HOGENOMⁱ	HOG000006908
HOVERGENⁱ	HBG098799
InParanoidⁱ	Q86SG6
KEGG Orthology (KO) More...KOⁱ	K20877
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0GU4
PhylomeDBⁱ	Q86SG6
TreeFamⁱ	TF106472

Enzyme and pathway databases

SignaLinkⁱ	Q86SG6
SIGNORⁱ	Q86SG6

Miscellaneous databases

GeneWikiⁱ	NEK8
GenomeRNAiⁱ	284086
Protein Ontology More...PROⁱ	PR:Q86SG6
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000160602
CleanExⁱ	HS_NEK8
ExpressionAtlasⁱ	Q86SG6 baseline and differential
Genevisibleⁱ	Q86SG6 HS

Family and domain databases

Gene3Dⁱ	2.130.10.30, 2 hits
InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR009091 RCC1/BLIP-II IPR000408 Reg_chr_condens IPR008271 Ser/Thr_kinase_AS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit PF00415 RCC1, 4 hits
PRINTSⁱ	PR00633 RCCNDNSATION
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF50985 SSF50985, 1 hit SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit PS50012 RCC1_3, 5 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NEK8_HUMAN
Accessionⁱ	Q86SG6Primary (citable) accession number: Q86SG6 Secondary accession number(s): A6NIC5 , Q14CL7, Q2M1S6, Q8NDH1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 15, 2003
	Last sequence update:	June 1, 2003
	Last modified:	July 18, 2018
	This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human and mouse protein kinases
Human and mouse protein kinases: classification and index
SIMILARITY comments
Index of protein domains and families

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UniProtKB - Q86SG6 (NEK8_HUMAN)

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Serine/threonine-protein kinase Nek8

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Other locations

Cytoskeleton

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ