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Protein

Ankyrin repeat domain-containing protein 23

Gene

ANKRD23

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in the energy metabolism. Could be a molecular link between myofibrillar stretch-induced signaling pathways and muscle gene expression.

GO - Molecular functioni

  • titin binding Source: BHF-UCL

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 23
Alternative name(s):
Diabetes-related ankyrin repeat protein
Muscle ankyrin repeat protein 3
Gene namesi
Name:ANKRD23
Synonyms:DARP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000163126.14
HGNCiHGNC:24470 ANKRD23
MIMi610736 gene
neXtProtiNX_Q86SG2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000163126
PharmGKBiPA134960626

Polymorphism and mutation databases

BioMutaiANKRD23
DMDMi74723447

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002406661 – 305Ankyrin repeat domain-containing protein 23Add BLAST305

Proteomic databases

PaxDbiQ86SG2
PeptideAtlasiQ86SG2
PRIDEiQ86SG2
ProteomicsDBi69580
69581 [Q86SG2-2]

PTM databases

PhosphoSitePlusiQ86SG2

Expressioni

Tissue specificityi

Mainly expressed in heart, skeletal muscle and brown adipose tissues.1 Publication

Gene expression databases

BgeeiENSG00000163126 Expressed in 153 organ(s), highest expression level in muscle of leg
CleanExiHS_ANKRD23
GenevisibleiQ86SG2 HS

Organism-specific databases

HPAiHPA036201

Interactioni

Subunit structurei

Interacts with titin/TTN and MYPN.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi128333, 2 interactors
IntActiQ86SG2, 12 interactors
STRINGi9606.ENSP00000321679

Structurei

3D structure databases

ProteinModelPortaliQ86SG2
SMRiQ86SG2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati143 – 172ANK 1Add BLAST30
Repeati176 – 205ANK 2Add BLAST30
Repeati209 – 238ANK 3Add BLAST30
Repeati242 – 271ANK 4Add BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni178 – 195Interaction with TTN1 PublicationAdd BLAST18

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili41 – 72Sequence analysisAdd BLAST32

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG0504 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00910000144039
HOGENOMiHOG000236321
HOVERGENiHBG071561
InParanoidiQ86SG2
KOiK21438
OMAiNARDKIW
OrthoDBiEOG091G0DCN
PhylomeDBiQ86SG2
TreeFamiTF331650

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR028780 ANKRD23
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
PANTHERiPTHR24176:SF12 PTHR24176:SF12, 1 hit
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF13606 Ank_3, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 4 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 4 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q86SG2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDFISIQQLV SGERVEGKVL GFGHGVPDPG AWPSDWRRGP QEAVAREKLK
60 70 80 90 100
LEEEKKKKLE RFNSTRFNLD NLADLENLVQ RRKKRLRHRV PPRKPEPLVK
110 120 130 140 150
PQSQAQVEPV GLEMFLKAAA ENQEYLIDKY LTDGGDPNAH DKLHRTALHW
160 170 180 190 200
ACLKGHSQLV NKLLVAGATV DARDLLDRTP VFWACRGGHL VILKQLLNQG
210 220 230 240 250
ARVNARDKIG STPLHVAVRT RHPDCLEHLI ECGAHLNAQD KEGDTALHEA
260 270 280 290 300
VRHGSYKAMK LLLLYGAELG VRNAASVTPV QLARDWQRGI REALQAHVAH

PRTRC
Length:305
Mass (Da):34,297
Last modified:June 1, 2003 - v1
Checksum:iA9BB41D0532F932D
GO
Isoform 2 (identifier: Q86SG2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     101-142: Missing.

Note: No experimental confirmation available.
Show »
Length:263
Mass (Da):29,683
Checksum:i6860A432B7513062
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti57K → N in CAC86120 (Ref. 6) Curated1
Sequence conflicti277V → L in BAC03915 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_019424101 – 142Missing in isoform 2. 1 PublicationAdd BLAST42

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF492401 mRNA Translation: AAO24067.1
AY196212 mRNA Translation: AAO40750.1
AK092564 mRNA Translation: BAC03915.1
AC092636 Genomic DNA Translation: AAY14965.1
BC107056 mRNA Translation: AAI07057.1
AJ315766 mRNA Translation: CAC86120.1
CCDSiCCDS2027.1 [Q86SG2-1]
RefSeqiNP_659431.5, NM_144994.7 [Q86SG2-1]
UniGeneiHs.643430

Genome annotation databases

EnsembliENST00000318357; ENSP00000321679; ENSG00000163126 [Q86SG2-1]
ENST00000331001; ENSP00000333108; ENSG00000163126 [Q86SG2-2]
ENST00000418232; ENSP00000398987; ENSG00000163126 [Q86SG2-1]
GeneIDi200539
KEGGihsa:200539
UCSCiuc002sxa.4 human [Q86SG2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiANR23_HUMAN
AccessioniPrimary (citable) accession number: Q86SG2
Secondary accession number(s): Q711K7, Q8NAJ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 1, 2003
Last modified: September 12, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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