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Protein

Polycomb group RING finger protein 5

Gene

PCGF5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:26151332). Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332). Plays a redundant role with PCGF3 as part of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri18 – 57RING-typePROSITE-ProRule annotation1 PublicationAdd BLAST40

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known

Names & Taxonomyi

Protein namesi
Recommended name:
Polycomb group RING finger protein 5
Alternative name(s):
RING finger protein 159
Gene namesi
Name:PCGF5
Synonyms:RNF159
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000180628.14
HGNCiHGNC:28264 PCGF5
MIMi617407 gene
neXtProtiNX_Q86SE9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000180628
PharmGKBiPA134929149

Polymorphism and mutation databases

BioMutaiPCGF5
DMDMi74750353

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002778681 – 256Polycomb group RING finger protein 5Add BLAST256

Proteomic databases

EPDiQ86SE9
MaxQBiQ86SE9
PaxDbiQ86SE9
PeptideAtlasiQ86SE9
PRIDEiQ86SE9
ProteomicsDBi69577
69578 [Q86SE9-2]

PTM databases

PhosphoSitePlusiQ86SE9

Expressioni

Gene expression databases

BgeeiENSG00000180628 Expressed in 209 organ(s), highest expression level in substantia nigra
CleanExiHS_PCGF5
GenevisibleiQ86SE9 HS

Organism-specific databases

HPAiHPA038349

Interactioni

Subunit structurei

Component of a PRC1-like complex that contains PCGF5, RNF2 and UBE2D3 (PubMed:21282530, PubMed:26151332). Interacts with RNF2; the interaction is direct (PubMed:26151332). Interacts with CBX6, CBX7 and CBX8 (PubMed:21282530). Interacts with AUTS2; the interaction is direct (PubMed:25519132). Identified in a complex that contains AUTS2, PCGF5, CSNK2B and RNF2 (PubMed:25519132).2 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi124057, 44 interactors
DIPiDIP-61356N
IntActiQ86SE9, 48 interactors
MINTiQ86SE9
STRINGi9606.ENSP00000337500

Structurei

Secondary structure

1256
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ86SE9
SMRiQ86SE9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri18 – 57RING-typePROSITE-ProRule annotation1 PublicationAdd BLAST40

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2660 Eukaryota
ENOG410XPCN LUCA
GeneTreeiENSGT00550000074463
HOGENOMiHOG000231946
HOVERGENiHBG052826
InParanoidiQ86SE9
KOiK11489
OMAiGEIMGRD
OrthoDBiEOG091G0EC9
PhylomeDBiQ86SE9
TreeFamiTF324206

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR039642 E3_Ub_ligase/polycomb_RING
IPR032443 RAWUL
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PANTHERiPTHR10825 PTHR10825, 1 hit
PfamiView protein in Pfam
PF16207 RAWUL, 1 hit
SMARTiView protein in SMART
SM00184 RING, 1 hit
PROSITEiView protein in PROSITE
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q86SE9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATQRKHLVK DFNPYITCYI CKGYLIKPTT VTECLHTFCK TCIVQHFEDS
60 70 80 90 100
NDCPRCGNQV HETNPLEMLR LDNTLEEIIF KLVPGLREQE LERESEFWKK
110 120 130 140 150
NKPQENGQDD TSKADKPKVD EEGDENEDDK DYHRSDPQIA ICLDCLRNNG
160 170 180 190 200
QSGDNVVKGL MKKFIRCSTR VTVGTIKKFL SLKLKLPSSY ELDVLCNGEI
210 220 230 240 250
MGKDHTMEFI YMTRWRLRGE NFRCLNCSAS QVCSQDGPLY QSYPMVLQYR

PRIDFG
Length:256
Mass (Da):29,714
Last modified:June 1, 2003 - v1
Checksum:iE5AC78F2A3BBBED5
GO
Isoform 2 (identifier: Q86SE9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     38-49: FCKTCIVQHFED → SAESYWMSTWMS
     50-256: Missing.

Note: No experimental confirmation available.
Show »
Length:49
Mass (Da):5,779
Checksum:i92ED2ED8C317B0BF
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02311838 – 49FCKTC…QHFED → SAESYWMSTWMS in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_02311950 – 256Missing in isoform 2. 1 PublicationAdd BLAST207

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK303014 mRNA Translation: BAH13878.1
AL832003 mRNA Translation: CAD89905.1
AL832496 mRNA Translation: CAD91165.1
CH471066 Genomic DNA Translation: EAW50112.1
CH471066 Genomic DNA Translation: EAW50113.1
BC007377 mRNA Translation: AAH07377.1
BC051845 mRNA Translation: AAH51845.1
CCDSiCCDS7413.1 [Q86SE9-1]
RefSeqiNP_001243478.1, NM_001256549.1 [Q86SE9-1]
NP_001244030.1, NM_001257101.1 [Q86SE9-1]
NP_115749.2, NM_032373.4 [Q86SE9-1]
XP_011538573.1, XM_011540271.2 [Q86SE9-1]
XP_016872265.1, XM_017016776.1 [Q86SE9-1]
UniGeneiHs.500512

Genome annotation databases

EnsembliENST00000336126; ENSP00000337500; ENSG00000180628 [Q86SE9-1]
ENST00000543648; ENSP00000445704; ENSG00000180628 [Q86SE9-1]
ENST00000614189; ENSP00000479492; ENSG00000180628 [Q86SE9-1]
GeneIDi84333
KEGGihsa:84333
UCSCiuc001khh.5 human [Q86SE9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK303014 mRNA Translation: BAH13878.1
AL832003 mRNA Translation: CAD89905.1
AL832496 mRNA Translation: CAD91165.1
CH471066 Genomic DNA Translation: EAW50112.1
CH471066 Genomic DNA Translation: EAW50113.1
BC007377 mRNA Translation: AAH07377.1
BC051845 mRNA Translation: AAH51845.1
CCDSiCCDS7413.1 [Q86SE9-1]
RefSeqiNP_001243478.1, NM_001256549.1 [Q86SE9-1]
NP_001244030.1, NM_001257101.1 [Q86SE9-1]
NP_115749.2, NM_032373.4 [Q86SE9-1]
XP_011538573.1, XM_011540271.2 [Q86SE9-1]
XP_016872265.1, XM_017016776.1 [Q86SE9-1]
UniGeneiHs.500512

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4S3OX-ray2.00C/F1-109[»]
ProteinModelPortaliQ86SE9
SMRiQ86SE9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124057, 44 interactors
DIPiDIP-61356N
IntActiQ86SE9, 48 interactors
MINTiQ86SE9
STRINGi9606.ENSP00000337500

PTM databases

PhosphoSitePlusiQ86SE9

Polymorphism and mutation databases

BioMutaiPCGF5
DMDMi74750353

Proteomic databases

EPDiQ86SE9
MaxQBiQ86SE9
PaxDbiQ86SE9
PeptideAtlasiQ86SE9
PRIDEiQ86SE9
ProteomicsDBi69577
69578 [Q86SE9-2]

Protocols and materials databases

DNASUi84333
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000336126; ENSP00000337500; ENSG00000180628 [Q86SE9-1]
ENST00000543648; ENSP00000445704; ENSG00000180628 [Q86SE9-1]
ENST00000614189; ENSP00000479492; ENSG00000180628 [Q86SE9-1]
GeneIDi84333
KEGGihsa:84333
UCSCiuc001khh.5 human [Q86SE9-1]

Organism-specific databases

CTDi84333
EuPathDBiHostDB:ENSG00000180628.14
GeneCardsiPCGF5
HGNCiHGNC:28264 PCGF5
HPAiHPA038349
MIMi617407 gene
neXtProtiNX_Q86SE9
OpenTargetsiENSG00000180628
PharmGKBiPA134929149
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2660 Eukaryota
ENOG410XPCN LUCA
GeneTreeiENSGT00550000074463
HOGENOMiHOG000231946
HOVERGENiHBG052826
InParanoidiQ86SE9
KOiK11489
OMAiGEIMGRD
OrthoDBiEOG091G0EC9
PhylomeDBiQ86SE9
TreeFamiTF324206

Enzyme and pathway databases

ReactomeiR-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known

Miscellaneous databases

ChiTaRSiPCGF5 human
GeneWikiiPCGF5
GenomeRNAii84333
PROiPR:Q86SE9
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000180628 Expressed in 209 organ(s), highest expression level in substantia nigra
CleanExiHS_PCGF5
GenevisibleiQ86SE9 HS

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR039642 E3_Ub_ligase/polycomb_RING
IPR032443 RAWUL
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
IPR017907 Znf_RING_CS
PANTHERiPTHR10825 PTHR10825, 1 hit
PfamiView protein in Pfam
PF16207 RAWUL, 1 hit
SMARTiView protein in SMART
SM00184 RING, 1 hit
PROSITEiView protein in PROSITE
PS00518 ZF_RING_1, 1 hit
PS50089 ZF_RING_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPCGF5_HUMAN
AccessioniPrimary (citable) accession number: Q86SE9
Secondary accession number(s): B7Z892
, D3DR33, Q6PK47, Q86TD0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: June 1, 2003
Last modified: November 7, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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