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Protein

Nucleoplasmin-2

Gene

NPM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Core histones chaperone involved in chromatin reprogramming, specially during fertilization and early embryonic development. Probably involved in sperm DNA decondensation during fertilization.1 Publication

GO - Molecular functioni

  • chromatin binding Source: GO_Central
  • enzyme binding Source: Ensembl
  • histone binding Source: GO_Central

GO - Biological processi

  • blastocyst development Source: UniProtKB
  • chromatin remodeling Source: UniProtKB
  • oocyte differentiation Source: UniProtKB
  • positive regulation of catalytic activity Source: Ensembl
  • positive regulation of DNA replication Source: GO_Central
  • positive regulation of meiotic nuclear division Source: UniProtKB
  • protein homooligomerization Source: Ensembl
  • regulation of exit from mitosis Source: UniProtKB
  • single fertilization Source: UniProtKB

Keywordsi

Molecular functionChaperone, Chromatin regulator, Developmental protein
Biological processFertilization

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoplasmin-2
Gene namesi
Name:NPM2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000158806.13
HGNCiHGNC:7930 NPM2
MIMi608073 gene
neXtProtiNX_Q86SE8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi10361
OpenTargetsiENSG00000158806
PharmGKBiPA31732

Polymorphism and mutation databases

BioMutaiNPM2
DMDMi37537936

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002194871 – 214Nucleoplasmin-2Add BLAST214

Proteomic databases

MaxQBiQ86SE8
PaxDbiQ86SE8
PeptideAtlasiQ86SE8
PRIDEiQ86SE8
ProteomicsDBi69576

PTM databases

iPTMnetiQ86SE8
PhosphoSitePlusiQ86SE8

Expressioni

Gene expression databases

BgeeiENSG00000158806 Expressed in 195 organ(s), highest expression level in frontal cortex
CleanExiHS_NPM2
ExpressionAtlasiQ86SE8 baseline and differential
GenevisibleiQ86SE8 HS

Organism-specific databases

HPAiHPA041070

Interactioni

Subunit structurei

Homopentamer, when bound to H2A-H2B dimers only. Homodecamer of two stacked pentamers, when bound to H2A-H2B dimers and H3-H4 tetramers simultaneously.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei57Interaction between pentamers1
Sitei84Interaction between pentamers1

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115641, 9 interactors
IntActiQ86SE8, 7 interactors
STRINGi9606.ENSP00000289820

Structurei

Secondary structure

1214
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ86SE8
SMRiQ86SE8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni129 – 152Acidic tract A2Add BLAST24

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi165 – 180Bipartite nuclear localization signalBy similarityAdd BLAST16

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi129 – 144Poly-GluAdd BLAST16
Compositional biasi177 – 180Poly-Lys4
Compositional biasi182 – 187Poly-Glu6

Domaini

The acidic tract A2 mediates histone binding.1 Publication

Sequence similaritiesi

Belongs to the nucleoplasmin family.Curated

Phylogenomic databases

eggNOGiENOG410IYZ7 Eukaryota
ENOG410XY21 LUCA
GeneTreeiENSGT00440000034554
HOGENOMiHOG000207062
HOVERGENiHBG045601
InParanoidiQ86SE8
KOiK11277
OMAiQEKRTWT
OrthoDBiEOG091G0XZ8
PhylomeDBiQ86SE8
TreeFamiTF327704

Family and domain databases

InterProiView protein in InterPro
IPR004301 Nucleoplasmin
IPR024057 Nucleoplasmin_core_dom
IPR036824 Nucleoplasmin_core_dom_sf
PANTHERiPTHR22747 PTHR22747, 1 hit
PfamiView protein in Pfam
PF03066 Nucleoplasmin, 1 hit
SUPFAMiSSF69203 SSF69203, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86SE8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNLSSASSTE EKAVTTVLWG CELSQERRTW TFRPQLEGKQ SCRLLLHTIC
60 70 80 90 100
LGEKAKEEMH RVEILPPANQ EDKKMQPVTI ASLQASVLPM VSMVGVQLSP
110 120 130 140 150
PVTFQLRAGS GPVFLSGQER YEASDLTWEE EEEEEGEEEE EEEEDDEDED
160 170 180 190 200
ADISLEEQSP VKQVKRLVPQ KQASVAKKKK LEKEEEEIRA SVRDKSPVKK
210
AKATARAKKP GFKK
Length:214
Mass (Da):24,152
Last modified:June 1, 2003 - v1
Checksum:iEAE3BEF1DC8E1CC1
GO
Isoform 2 (identifier: Q86SE8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     123-214: ASDLTWEEEE...ARAKKPGFKK → KKAGKRRRGNKSQR

Note: No experimental confirmation available.
Show »
Length:136
Mass (Da):15,238
Checksum:iCEEABE3645C15B3B
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RFQ8E5RFQ8_HUMAN
Nucleoplasmin-2
NPM2
137Annotation score:
E5RGN1E5RGN1_HUMAN
Nucleoplasmin-2
NPM2
99Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_054261123 – 214ASDLT…PGFKK → KKAGKRRRGNKSQR in isoform 2. 1 PublicationAdd BLAST92

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY262113 mRNA Translation: AAP33134.1
AY262114 mRNA Translation: AAP33135.1
AK094267 mRNA Translation: BAG52852.1
AC091171 Genomic DNA No translation available.
CH471080 Genomic DNA Translation: EAW63731.1
CH471080 Genomic DNA Translation: EAW63732.1
BC068078 mRNA Translation: AAH68078.1
CCDSiCCDS6018.1 [Q86SE8-1]
CCDS75703.1 [Q86SE8-2]
RefSeqiNP_001273609.1, NM_001286680.1 [Q86SE8-1]
NP_001273610.1, NM_001286681.1 [Q86SE8-2]
NP_877724.1, NM_182795.1 [Q86SE8-1]
XP_011542664.1, XM_011544362.2 [Q86SE8-1]
XP_011542665.1, XM_011544363.2 [Q86SE8-1]
XP_016868437.1, XM_017012948.1 [Q86SE8-1]
XP_016868438.1, XM_017012949.1 [Q86SE8-1]
UniGeneiHs.131055

Genome annotation databases

EnsembliENST00000289820; ENSP00000289820; ENSG00000158806 [Q86SE8-1]
ENST00000381530; ENSP00000370941; ENSG00000158806 [Q86SE8-2]
ENST00000397940; ENSP00000381032; ENSG00000158806 [Q86SE8-1]
ENST00000518119; ENSP00000427741; ENSG00000158806 [Q86SE8-1]
ENST00000521157; ENSP00000429413; ENSG00000158806 [Q86SE8-1]
ENST00000615914; ENSP00000481018; ENSG00000158806 [Q86SE8-2]
ENST00000621538; ENSP00000481077; ENSG00000158806 [Q86SE8-1]
GeneIDi10361
KEGGihsa:10361
UCSCiuc003xac.5 human [Q86SE8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY262113 mRNA Translation: AAP33134.1
AY262114 mRNA Translation: AAP33135.1
AK094267 mRNA Translation: BAG52852.1
AC091171 Genomic DNA No translation available.
CH471080 Genomic DNA Translation: EAW63731.1
CH471080 Genomic DNA Translation: EAW63732.1
BC068078 mRNA Translation: AAH68078.1
CCDSiCCDS6018.1 [Q86SE8-1]
CCDS75703.1 [Q86SE8-2]
RefSeqiNP_001273609.1, NM_001286680.1 [Q86SE8-1]
NP_001273610.1, NM_001286681.1 [Q86SE8-2]
NP_877724.1, NM_182795.1 [Q86SE8-1]
XP_011542664.1, XM_011544362.2 [Q86SE8-1]
XP_011542665.1, XM_011544363.2 [Q86SE8-1]
XP_016868437.1, XM_017012948.1 [Q86SE8-1]
XP_016868438.1, XM_017012949.1 [Q86SE8-1]
UniGeneiHs.131055

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3T30X-ray1.90A/B/C/D/E/F/G/H/I/J14-122[»]
ProteinModelPortaliQ86SE8
SMRiQ86SE8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115641, 9 interactors
IntActiQ86SE8, 7 interactors
STRINGi9606.ENSP00000289820

PTM databases

iPTMnetiQ86SE8
PhosphoSitePlusiQ86SE8

Polymorphism and mutation databases

BioMutaiNPM2
DMDMi37537936

Proteomic databases

MaxQBiQ86SE8
PaxDbiQ86SE8
PeptideAtlasiQ86SE8
PRIDEiQ86SE8
ProteomicsDBi69576

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000289820; ENSP00000289820; ENSG00000158806 [Q86SE8-1]
ENST00000381530; ENSP00000370941; ENSG00000158806 [Q86SE8-2]
ENST00000397940; ENSP00000381032; ENSG00000158806 [Q86SE8-1]
ENST00000518119; ENSP00000427741; ENSG00000158806 [Q86SE8-1]
ENST00000521157; ENSP00000429413; ENSG00000158806 [Q86SE8-1]
ENST00000615914; ENSP00000481018; ENSG00000158806 [Q86SE8-2]
ENST00000621538; ENSP00000481077; ENSG00000158806 [Q86SE8-1]
GeneIDi10361
KEGGihsa:10361
UCSCiuc003xac.5 human [Q86SE8-1]

Organism-specific databases

CTDi10361
DisGeNETi10361
EuPathDBiHostDB:ENSG00000158806.13
GeneCardsiNPM2
HGNCiHGNC:7930 NPM2
HPAiHPA041070
MIMi608073 gene
neXtProtiNX_Q86SE8
OpenTargetsiENSG00000158806
PharmGKBiPA31732
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IYZ7 Eukaryota
ENOG410XY21 LUCA
GeneTreeiENSGT00440000034554
HOGENOMiHOG000207062
HOVERGENiHBG045601
InParanoidiQ86SE8
KOiK11277
OMAiQEKRTWT
OrthoDBiEOG091G0XZ8
PhylomeDBiQ86SE8
TreeFamiTF327704

Miscellaneous databases

ChiTaRSiNPM2 human
GenomeRNAii10361
PROiPR:Q86SE8
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000158806 Expressed in 195 organ(s), highest expression level in frontal cortex
CleanExiHS_NPM2
ExpressionAtlasiQ86SE8 baseline and differential
GenevisibleiQ86SE8 HS

Family and domain databases

InterProiView protein in InterPro
IPR004301 Nucleoplasmin
IPR024057 Nucleoplasmin_core_dom
IPR036824 Nucleoplasmin_core_dom_sf
PANTHERiPTHR22747 PTHR22747, 1 hit
PfamiView protein in Pfam
PF03066 Nucleoplasmin, 1 hit
SUPFAMiSSF69203 SSF69203, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNPM2_HUMAN
AccessioniPrimary (citable) accession number: Q86SE8
Secondary accession number(s): B3KSU0, D3DSQ8, Q6NVH6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: June 1, 2003
Last modified: November 7, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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