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Protein

RNA-binding Raly-like protein

Gene

RALYL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • RNA binding Source: UniProtKB

Keywordsi

Molecular functionRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding Raly-like protein
Short name:
hRALYL
Alternative name(s):
Heterogeneous nuclear ribonucleoprotein C-like 3
Short name:
hnRNP core protein C-like 3
Gene namesi
Name:RALYL
Synonyms:HNRPCL3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000184672.11
HGNCiHGNC:27036 RALYL
MIMi614648 gene
neXtProtiNX_Q86SE5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi138046
OpenTargetsiENSG00000184672
PharmGKBiPA162400636

Polymorphism and mutation databases

BioMutaiRALYL
DMDMi158564044

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002995251 – 291RNA-binding Raly-like proteinAdd BLAST291

Proteomic databases

MaxQBiQ86SE5
PaxDbiQ86SE5
PeptideAtlasiQ86SE5
PRIDEiQ86SE5
ProteomicsDBi69574
69575 [Q86SE5-2]

PTM databases

iPTMnetiQ86SE5
PhosphoSitePlusiQ86SE5

Expressioni

Tissue specificityi

Widely expressed, with highest levels in brain.1 Publication

Gene expression databases

BgeeiENSG00000184672 Expressed in 123 organ(s), highest expression level in frontal cortex
CleanExiHS_RALYL
ExpressionAtlasiQ86SE5 baseline and differential
GenevisibleiQ86SE5 HS

Organism-specific databases

HPAiHPA055868
HPA059112

Interactioni

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi126498, 43 interactors
IntActiQ86SE5, 24 interactors
MINTiQ86SE5
STRINGi9606.ENSP00000430128

Structurei

3D structure databases

ProteinModelPortaliQ86SE5
SMRiQ86SE5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 92RRMPROSITE-ProRule annotationAdd BLAST72

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili190 – 249Sequence analysisAdd BLAST60

Sequence similaritiesi

Belongs to the RRM HNRPC family. RALY subfamily.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0118 Eukaryota
COG0724 LUCA
GeneTreeiENSGT00390000006718
HOGENOMiHOG000231958
HOVERGENiHBG002302
InParanoidiQ86SE5
OMAiKPYRPKA
OrthoDBiEOG091G0O1Q
PhylomeDBiQ86SE5
TreeFamiTF330974

Family and domain databases

CDDicd12605 RRM_RALYL, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR017347 hnRNP_C
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR034504 RALYL_RRM
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
PIRSFiPIRSF037992 hnRNP-C_Raly, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q86SE5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTGKTQTSNV TNKNDPKSIN SRVFIGNLNT AIVKKVDIEA IFSKYGKIVG
60 70 80 90 100
CSVHKGYAFV QYMSERHARA AVAGENARVI AGQPLDINMA GEPKPYRPKP
110 120 130 140 150
GNKRPLSALY RLESKEPFLS VGGYVFDYDY YRDDFYNRLF DYHGRVPPPP
160 170 180 190 200
RAVIPLKRPR VAVTTTRRGK GVFSMKGGSR STASGSTGSK LKSDELQTIK
210 220 230 240 250
KELTQIKTKI DSLLGRLEKI EKQQKAEAEA QKKQLEESLV LIQEECVSEI
260 270 280 290
ADHSTEEPAE GGPDADGEEM TDGIEEDFDE DGGHELFLQI K
Length:291
Mass (Da):32,331
Last modified:September 11, 2007 - v2
Checksum:iA07D1D72029B3DC4
GO
Isoform 2 (identifier: Q86SE5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-73: Missing.
     74-86: GENARVIAGQPLD → MTMYKSKRRHQRY

Show »
Length:218
Mass (Da):24,789
Checksum:i09074D847B4693A0
GO
Isoform 3 (identifier: Q86SE5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MSKRRRLKQGEPIM

Note: No experimental confirmation available.
Show »
Length:304
Mass (Da):33,911
Checksum:i3490D51A93F83BF8
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B3KT61B3KT61_HUMAN
RNA-binding Raly-like protein
RALYL
280Annotation score:
E5RJ39E5RJ39_HUMAN
RNA-binding Raly-like protein
RALYL
146Annotation score:
E5RG71E5RG71_HUMAN
RNA-binding Raly-like protein
RALYL
85Annotation score:
E5RIX9E5RIX9_HUMAN
RNA-binding Raly-like protein
RALYL
47Annotation score:

Sequence cautioni

The sequence AAH31090 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti142Y → F in AAO85516 (PubMed:12688537).Curated1
Sequence conflicti142Y → F in AAO85517 (PubMed:12688537).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0277251 – 73Missing in isoform 2. 1 PublicationAdd BLAST73
Alternative sequenceiVSP_0540671M → MSKRRRLKQGEPIM in isoform 3. 1 Publication1
Alternative sequenceiVSP_02772674 – 86GENAR…GQPLD → MTMYKSKRRHQRY in isoform 2. 1 PublicationAdd BLAST13

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF495529 mRNA Translation: AAO85516.1
AF495530 mRNA Translation: AAO85517.1
AK095560 mRNA Translation: BAG53084.1
AK123437 mRNA Translation: BAC85617.1
AC009901 Genomic DNA No translation available.
AC012400 Genomic DNA No translation available.
AC027043 Genomic DNA No translation available.
AC087368 Genomic DNA No translation available.
AC092699 Genomic DNA No translation available.
AC092709 Genomic DNA No translation available.
AC103816 Genomic DNA No translation available.
CH471068 Genomic DNA Translation: EAW87118.1
BC031090 mRNA Translation: AAH31090.1 Different initiation.
CCDSiCCDS55252.1 [Q86SE5-3]
CCDS55253.1 [Q86SE5-1]
CCDS75761.1 [Q86SE5-2]
RefSeqiNP_001093861.1, NM_001100391.1 [Q86SE5-3]
NP_001093862.1, NM_001100392.1 [Q86SE5-1]
NP_001093863.1, NM_001100393.1 [Q86SE5-1]
NP_001274173.1, NM_001287244.1 [Q86SE5-2]
NP_776247.3, NM_173848.5 [Q86SE5-1]
XP_016868548.1, XM_017013059.1
XP_016868549.1, XM_017013060.1
XP_016868550.1, XM_017013061.1
XP_016868551.1, XM_017013062.1
XP_016868552.1, XM_017013063.1
XP_016868553.1, XM_017013064.1
XP_016868554.1, XM_017013065.1
UniGeneiHs.121663

Genome annotation databases

EnsembliENST00000517638; ENSP00000430128; ENSG00000184672 [Q86SE5-3]
ENST00000521268; ENSP00000430367; ENSG00000184672 [Q86SE5-1]
ENST00000521695; ENSP00000428667; ENSG00000184672 [Q86SE5-1]
ENST00000522455; ENSP00000430394; ENSG00000184672 [Q86SE5-1]
ENST00000523850; ENSP00000428807; ENSG00000184672 [Q86SE5-2]
GeneIDi138046
KEGGihsa:138046
UCSCiuc003ycq.5 human [Q86SE5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF495529 mRNA Translation: AAO85516.1
AF495530 mRNA Translation: AAO85517.1
AK095560 mRNA Translation: BAG53084.1
AK123437 mRNA Translation: BAC85617.1
AC009901 Genomic DNA No translation available.
AC012400 Genomic DNA No translation available.
AC027043 Genomic DNA No translation available.
AC087368 Genomic DNA No translation available.
AC092699 Genomic DNA No translation available.
AC092709 Genomic DNA No translation available.
AC103816 Genomic DNA No translation available.
CH471068 Genomic DNA Translation: EAW87118.1
BC031090 mRNA Translation: AAH31090.1 Different initiation.
CCDSiCCDS55252.1 [Q86SE5-3]
CCDS55253.1 [Q86SE5-1]
CCDS75761.1 [Q86SE5-2]
RefSeqiNP_001093861.1, NM_001100391.1 [Q86SE5-3]
NP_001093862.1, NM_001100392.1 [Q86SE5-1]
NP_001093863.1, NM_001100393.1 [Q86SE5-1]
NP_001274173.1, NM_001287244.1 [Q86SE5-2]
NP_776247.3, NM_173848.5 [Q86SE5-1]
XP_016868548.1, XM_017013059.1
XP_016868549.1, XM_017013060.1
XP_016868550.1, XM_017013061.1
XP_016868551.1, XM_017013062.1
XP_016868552.1, XM_017013063.1
XP_016868553.1, XM_017013064.1
XP_016868554.1, XM_017013065.1
UniGeneiHs.121663

3D structure databases

ProteinModelPortaliQ86SE5
SMRiQ86SE5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126498, 43 interactors
IntActiQ86SE5, 24 interactors
MINTiQ86SE5
STRINGi9606.ENSP00000430128

PTM databases

iPTMnetiQ86SE5
PhosphoSitePlusiQ86SE5

Polymorphism and mutation databases

BioMutaiRALYL
DMDMi158564044

Proteomic databases

MaxQBiQ86SE5
PaxDbiQ86SE5
PeptideAtlasiQ86SE5
PRIDEiQ86SE5
ProteomicsDBi69574
69575 [Q86SE5-2]

Protocols and materials databases

DNASUi138046
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000517638; ENSP00000430128; ENSG00000184672 [Q86SE5-3]
ENST00000521268; ENSP00000430367; ENSG00000184672 [Q86SE5-1]
ENST00000521695; ENSP00000428667; ENSG00000184672 [Q86SE5-1]
ENST00000522455; ENSP00000430394; ENSG00000184672 [Q86SE5-1]
ENST00000523850; ENSP00000428807; ENSG00000184672 [Q86SE5-2]
GeneIDi138046
KEGGihsa:138046
UCSCiuc003ycq.5 human [Q86SE5-1]

Organism-specific databases

CTDi138046
DisGeNETi138046
EuPathDBiHostDB:ENSG00000184672.11
GeneCardsiRALYL
HGNCiHGNC:27036 RALYL
HPAiHPA055868
HPA059112
MIMi614648 gene
neXtProtiNX_Q86SE5
OpenTargetsiENSG00000184672
PharmGKBiPA162400636
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0118 Eukaryota
COG0724 LUCA
GeneTreeiENSGT00390000006718
HOGENOMiHOG000231958
HOVERGENiHBG002302
InParanoidiQ86SE5
OMAiKPYRPKA
OrthoDBiEOG091G0O1Q
PhylomeDBiQ86SE5
TreeFamiTF330974

Miscellaneous databases

ChiTaRSiRALYL human
GeneWikiiRALYL
GenomeRNAii138046
PROiPR:Q86SE5
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000184672 Expressed in 123 organ(s), highest expression level in frontal cortex
CleanExiHS_RALYL
ExpressionAtlasiQ86SE5 baseline and differential
GenevisibleiQ86SE5 HS

Family and domain databases

CDDicd12605 RRM_RALYL, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR017347 hnRNP_C
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR034504 RALYL_RRM
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
PIRSFiPIRSF037992 hnRNP-C_Raly, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRALYL_HUMAN
AccessioniPrimary (citable) accession number: Q86SE5
Secondary accession number(s): B3KTH2
, G3V129, Q6ZW87, Q8N1C2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: September 11, 2007
Last modified: November 7, 2018
This is version 137 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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