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UniProtKB - Q86PC9 (TULP_DROME)

Entry version 143 (07 Apr 2021)
Sequence version 1 (01 Jun 2003)
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Protein

Protein king tubby

Gene

ktub

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions in regulating protein trafficking, retinal maintenance and lipid storage (PubMed:23228091, PubMed:23355467, PubMed:24068974, PubMed:26723017). Protects photoreceptor cells R1 to R6 against light-induced retinal degeneration by stimulating norpA-mediated endocytosis of the rhodopsin ninaE (Rh1) (PubMed:23228091). In the auditory receptor neurons, functions as a cilia trafficking regulator of various transient receptor potential (TRP) channel components including iav and nompC (PubMed:24068974, PubMed:26723017). Likely to deliver pre-ciliary vesicles containing membrane proteins such as iav and nompC to the intraflagellar transport complex (IFT) at the cilia base (PubMed:24068974, PubMed:26723017). Plays a role in the inhibition of fat storage (PubMed:23355467).4 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandLipid-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-DME-5610787, Hedgehog 'off' state

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein king tubby1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ktub
Synonyms:Tulp
ORF Names:CG9398
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...FlyBasei		FBgn0015721, ktub

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Viable and fertile however flies display a decreased climbing index and extracellular sound-evoked potentials are completely abolished (PubMed:24068974). This hearing defect is likely due to the abnormal localization of the two transient receptor potential channels iav and nompC, as well as eys within the cilia (PubMed:24068974). There is no localization of iav to the proximal cilia, and nompc which is typically found in the distal cilia, is localized to the proximal cilia (PubMed:24068974). Also eys displays a much broader expression pattern (PubMed:24068974). RNAi-mediated knockdown in the fat body of larvae fed a high sugar diet, results in an increase in body weight, an increase in triglyceride accumulation and a decrease in hemolymph glucose levels (PubMed:23355467).2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi24 – 26QKR → AAA in Muta; reduced iav expression in the cilia but is not required for lav or nompC localization in the cilia. 1 Publication3
Mutagenesisi292 – 294KLR → ALA in Mutb; reduced iav expression in the cilia but is not required for lav or nompC localization in the cilia. Decrease in extracellular sound-evoked potentials. Sounds-evoked potentials, and localization of ktub, iav and nompC is partially restored in a ktub and INPP5E double mutant background. 2 Publications3

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004008381 – 460Protein king tubbyAdd BLAST460

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei153Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q86PC9

PRoteomics IDEntifications database

More...PRIDEi		Q86PC9

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q86PC9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in sensory neurons which have a ciliary structure such as the chordotonal neurons, Orco-expressing olfactory receptor neurons, labellar gustatory receptor neurons and in the femoral chordotonal organ (at protein level) (PubMed:24068974, PubMed:26723017). In the chordotonal neurons of the Johnston's organ expressed in the proximal to distal cilia, with lower levels of expression in the distal portion (at protein level) (PubMed:24068974). Also detected in the salivary glands and antenna (at protein level) (PubMed:24068974). Expressed in photoreceptor cells (at protein level) (PubMed:23228091). At stage 9 expression is detected in a subset of neuroblasts (PubMed:12204260). By stage 12 expression is found in both the CNS and PNS (PubMed:12204260). In late-stage embryos, expression persists in the CNS and PNS with more abundant expression in the antennal-maxillary sensory neurons and in bilateral groups of cells in the brain (PubMed:12204260).4 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Most abundant at 2-8 hours of embryonic development.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		FBgn0015721, Expressed in embryo and 47 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q86PC9, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		63037, 20 interactors

Protein interaction database and analysis system

More...IntActi		Q86PC9, 14 interactors

STRING: functional protein association networks

More...STRINGi		7227.FBpp0088961

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q86PC9

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C-terminus is important for mediating light-induced rhodopsin endocytosis.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TUB family.Sequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2502, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000170687

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_028236_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q86PC9

Identification of Orthologs from Complete Genome Data

More...OMAi		YKCRIAR

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q86PC9

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.20.90.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR025659, Tubby-like_C
IPR000007, Tubby_C
IPR018066, Tubby_C_CS

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01167, Tub, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01573, SUPERTUBBY

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54518, SSF54518, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01200, TUB_1, 1 hit
PS01201, TUB_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform B1 Publication (identifier: Q86PC9-1) [UniParc]FASTAAdd to basket
Also known as: TULP-L1 Publication

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSGINSRNQK MEQQRQLMEA YIRQKRASPG MVQASDLQIN RPMSGMRSNS 
        60         70         80         90        100
RELHAYDGPM QFISSPQNPD QILTNGSPGG INPVAMNTSR NHSNNMRSLS 
       110        120        130        140        150
TINQEADLIE EISSHELEDE ESSPVTVIEQ HQQSASHSAN STQSQKPRAR 
       160        170        180        190        200
QHSFSDNLDE DDYTNRNVAG AAPVRPAGMA SSPYKDATLD GSSNGTGNGT 
       210        220        230        240        250
GGESEGDVIG NIDQFVMQPA PQGVLYKCRI TRDRKGMDRG LFPIYYLHLE 
       260        270        280        290        300
RDYGKKIFLL GGRKRKKSKT SNYIVSCDPT DLSRNADGFC GKLRSNVFGT 
       310        320        330        340        350
SFTVFDNGNK ESTESPRLDL AVIIYDTNIL GFKGPRNMTV ILPGMTEDDQ 
       360        370        380        390        400
RVKISSADPK QQGILDLWKM KNMDNIVELH NKTPVWNDET QSYVLNFHGR 
       410        420        430        440        450
VTQASVKNFQ LVHDSDPEYI VMQFGRTSED VFTMDYRYPL CAMQAFAIAL 
       460
SSFDGKIACE
Length:460
Mass (Da):51,281
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i01CEEDD2F90A50E5
GO
Isoform A1 Publication (identifier: Q86PC9-2) [UniParc]FASTAAdd to basket
Also known as: TULP-S1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-17: Missing.

Show »
Length:443
Mass (Da):49,251
Checksum:iF0D86B4A8692EEE2
GO
Isoform CImported (identifier: Q86PC9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     105-105: E → EGKWSYTPRK

Show »
Length:469
Mass (Da):52,386
Checksum:iF1C867485186215C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti3G → A in AAM91018 (PubMed:12204260).Curated1
Sequence conflicti182S → P in AAM91018 (PubMed:12204260).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0400281 – 17Missing in isoform A. 2 PublicationsAdd BLAST17
Alternative sequenceiVSP_058159105E → EGKWSYTPRK in isoform C. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF527823 mRNA Translation: AAM91018.1
AE013599 Genomic DNA Translation: AAF46675.2
AE013599 Genomic DNA Translation: AAS64753.1
AY060625 mRNA Translation: AAL28173.1
BT003201 mRNA Translation: AAO24956.1

NCBI Reference Sequences

More...RefSeqi		NP_611549.2, NM_137705.3 [Q86PC9-3]
NP_995911.1, NM_206189.2 [Q86PC9-1]

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		FBtr0089600; FBpp0088961; FBgn0015721 [Q86PC9-1]
FBtr0342842; FBpp0309666; FBgn0015721 [Q86PC9-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		37400

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dme:Dmel_CG9398

UCSC genome browser

More...UCSCi		CG9398-RA, d. melanogaster
CG9398-RB, d. melanogaster [Q86PC9-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF527823 mRNA Translation: AAM91018.1
AE013599 Genomic DNA Translation: AAF46675.2
AE013599 Genomic DNA Translation: AAS64753.1
AY060625 mRNA Translation: AAL28173.1
BT003201 mRNA Translation: AAO24956.1
RefSeqiNP_611549.2, NM_137705.3 [Q86PC9-3]
NP_995911.1, NM_206189.2 [Q86PC9-1]

3D structure databases

SMRiQ86PC9
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi63037, 20 interactors
IntActiQ86PC9, 14 interactors
STRINGi7227.FBpp0088961

PTM databases

iPTMnetiQ86PC9

Proteomic databases

PaxDbiQ86PC9
PRIDEiQ86PC9

Genome annotation databases

EnsemblMetazoaiFBtr0089600; FBpp0088961; FBgn0015721 [Q86PC9-1]
FBtr0342842; FBpp0309666; FBgn0015721 [Q86PC9-3]
GeneIDi37400
KEGGidme:Dmel_CG9398
UCSCiCG9398-RA, d. melanogaster
CG9398-RB, d. melanogaster [Q86PC9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		37400
FlyBaseiFBgn0015721, ktub

Phylogenomic databases

eggNOGiKOG2502, Eukaryota
GeneTreeiENSGT00940000170687
HOGENOMiCLU_028236_1_1_1
InParanoidiQ86PC9
OMAiYKCRIAR
PhylomeDBiQ86PC9

Enzyme and pathway databases

ReactomeiR-DME-5610787, Hedgehog 'off' state

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		37400, 0 hits in 3 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ktub, fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		37400

Protein Ontology

More...PROi		PR:Q86PC9

Gene expression databases

BgeeiFBgn0015721, Expressed in embryo and 47 other tissues
GenevisibleiQ86PC9, DM

Family and domain databases

Gene3Di3.20.90.10, 1 hit
InterProiView protein in InterPro
IPR025659, Tubby-like_C
IPR000007, Tubby_C
IPR018066, Tubby_C_CS
PfamiView protein in Pfam
PF01167, Tub, 1 hit
PRINTSiPR01573, SUPERTUBBY
SUPFAMiSSF54518, SSF54518, 1 hit
PROSITEiView protein in PROSITE
PS01200, TUB_1, 1 hit
PS01201, TUB_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTULP_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86PC9
Secondary accession number(s): Q8MUB4, Q9W2L5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: June 1, 2003
Last modified: April 7, 2021
This is version 143 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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