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Entry version 109 (29 Sep 2021)
Sequence version 1 (01 Jun 2003)
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Protein

Cullin-associated NEDD8-dissociated protein 1

Gene

cand1

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor (By similarity).

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DDI-6798695, Neutrophil degranulation
R-DDI-8951664, Neddylation
R-DDI-917937, Iron uptake and transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cullin-associated NEDD8-dissociated protein 1
Alternative name(s):
Cullin-associated and neddylation-dissociated protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:cand1
ORF Names:DDB_G0274167
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDictyostelium discoideum (Slime mold)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri44689 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAmoebozoaEvoseaEumycetozoaDictyosteliaDictyostelialesDictyosteliaceaeDictyostelium
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002195 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 2, Unassembled WGS sequence

Organism-specific databases

Dictyostelium discoideum online informatics resource

More...
dictyBasei
DDB_G0274167, cand1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003279141 – 1238Cullin-associated NEDD8-dissociated protein 1Add BLAST1238

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q86KD1

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
44689.DDB0234116

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q86KD1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati41 – 78HEAT 1Add BLAST38
Repeati126 – 167HEAT 2Add BLAST42
Repeati171 – 208HEAT 3Add BLAST38
Repeati210 – 247HEAT 4Add BLAST38
Repeati251 – 292HEAT 5Add BLAST42
Repeati382 – 419HEAT 6Add BLAST38
Repeati432 – 469HEAT 7Add BLAST38
Repeati603 – 641HEAT 8Add BLAST39
Repeati646 – 683HEAT 9Add BLAST38
Repeati688 – 725HEAT 10Add BLAST38
Repeati853 – 890HEAT 11Add BLAST38
Repeati933 – 966HEAT 12Add BLAST34
Repeati967 – 1004HEAT 13Add BLAST38
Repeati1008 – 1045HEAT 14Add BLAST38

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni315 – 354DisorderedSequence analysisAdd BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi317 – 354Acidic residuesSequence analysisAdd BLAST38

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CAND family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1824, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_007157_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q86KD1

Identification of Orthologs from Complete Genome Data

More...
OMAi
QNLAIKC

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q86KD1

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024, ARM-type_fold
IPR039852, CAND1/CAND2
IPR013932, TATA-bd_TIP120
IPR034085, TOG

The PANTHER Classification System

More...
PANTHERi
PTHR12696, PTHR12696, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08623, TIP120, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01349, TOG, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q86KD1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSFFLGQILE KMGSIDKDIR FMATHDLANE LEKDTFKMDP TYENKIVTKL
60 70 80 90 100
LALTADSANN VQENVVKCLG LLIKRVKDSQ ATEIIDTLSK NILEESNKEE
110 120 130 140 150
LVEISGIGLK TIITNLPSEG SSISTLVIKN LVPKLLIGID SEKLKDKNEI
160 170 180 190 200
KMSCLDILND LLQKYGSFMI GDLENIQKVV LPKLNATRPA IRKRAILCLA
210 220 230 240 250
NIAFPSPDNL FNSLLDYIIK SIEEAKKPDH ISTLIQAIGA ICKSSGYRLG
260 270 280 290 300
KYLPKVMPHV LNYCDNNKFE QNDELRENCL LCFEAIIEKC QKDVTPYIGE
310 320 330 340 350
IITLCTKYIK FDPNYSDDGE GEEDGDEEEE EMETSGDNDE EQEEEEEEED
360 370 380 390 400
LSDDDDISWK IRRSSCKTLC AIISTRPELL VELYQKVAPV LYNRFKEREE
410 420 430 440 450
NVRLDIFTTF VLLLKQLNKK LANPQAKEVL KQQVPKLVQS ISKSLIDKSI
460 470 480 490 500
RTRVGAIALL KELVMIIPGS LTGQVSQIVN GINLSLSEKN TNSNLKIEAL
510 520 530 540 550
VLLKLLLINE PAQSFQSHIT SLSTHIVKCI NDSYYRIASE ALRVCQEFVI
560 570 580 590 600
VFNKIRSSTD CKPIISNLFA ANFVQLKAQD IDQEVKEAAI SSIGTIITLF
610 620 630 640 650
GNEIQSELQP CLSILLERLD NELTRVVTVK VLSRIINSSI NIDLSSILPS
660 670 680 690 700
AIKLLSTFLR KNNRVLKQSS LIALNDIVKV CPNLLPSSLL TGILTEMATL
710 720 730 740 750
INESDLQITH LAFVFIQNLL KNYSEKHQAA TLVNEKCIPP TLALLKSSLL
760 770 780 790 800
QGVALESLLS LFATIVQLDE PGMKYEQLLT LLFNTAADIK QPVTRQSFHS
810 820 830 840 850
ISQCIAVITV NTTPALRKQT IHNLICNLSS VNEPLVLLSL SCLGEIGRRI
860 870 880 890 900
DIHENENLQE SVYKTFEANN EEIKQVAALC LGDIAVCSLQ SYLPFILEQI
910 920 930 940 950
KNQPKKQYLL LHTLRETIVK LSHTDEGIKT IHPFLQSILP LLFDNCVNEE
960 970 980 990 1000
EGTRNIVAEC LGKLSMIEPN EIIPKLVEKI KSPSPLERST IVTSIKFSIM
1010 1020 1030 1040 1050
ENKEVVDQYL APNISQFLSL LHDGDLIVRR SALLSLNYIA HNKPNLIRND
1060 1070 1080 1090 1100
LSVYLPILYN NAKIKPELIR EVDLGPFKHK VDDGIEIRKT AFECMYTLLD
1110 1120 1130 1140 1150
TSIDKIDVAP FIVSLCDGLK DTQYDIKLLC HLMIIRLANS NGAALLENIT
1160 1170 1180 1190 1200
LLLEPLRVIL MTKVNETAVK QQIERNEECI RSALRAVASI SRIPNSDSIV
1210 1220 1230
KFEEFVKNTI RTTPLAAQFN SILSEDTMSN QDSMDTSN
Length:1,238
Mass (Da):138,935
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD2D5FC36F1ACD212
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAFI02000012 Genomic DNA Translation: EAL69976.1

NCBI Reference Sequences

More...
RefSeqi
XP_644297.1, XM_639205.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
EAL69976; EAL69976; DDB_G0274167

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8619725

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ddi:DDB_G0274167

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000012 Genomic DNA Translation: EAL69976.1
RefSeqiXP_644297.1, XM_639205.1

3D structure databases

SMRiQ86KD1
ModBaseiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0234116

Proteomic databases

PaxDbiQ86KD1

Genome annotation databases

EnsemblProtistsiEAL69976; EAL69976; DDB_G0274167
GeneIDi8619725
KEGGiddi:DDB_G0274167

Organism-specific databases

dictyBaseiDDB_G0274167, cand1

Phylogenomic databases

eggNOGiKOG1824, Eukaryota
HOGENOMiCLU_007157_0_0_1
InParanoidiQ86KD1
OMAiQNLAIKC
PhylomeDBiQ86KD1

Enzyme and pathway databases

ReactomeiR-DDI-6798695, Neutrophil degranulation
R-DDI-8951664, Neddylation
R-DDI-917937, Iron uptake and transport

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q86KD1

Family and domain databases

InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR039852, CAND1/CAND2
IPR013932, TATA-bd_TIP120
IPR034085, TOG
PANTHERiPTHR12696, PTHR12696, 1 hit
PfamiView protein in Pfam
PF08623, TIP120, 1 hit
SMARTiView protein in SMART
SM01349, TOG, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCAND1_DICDI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86KD1
Secondary accession number(s): Q554M6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: June 1, 2003
Last modified: September 29, 2021
This is version 109 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families
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