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Entry version 75 (02 Jun 2021)
Sequence version 1 (01 Jun 2003)
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Protein

SPX and EXS domain-containing protein 2

Gene

DDB_G0274481

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SPX and EXS domain-containing protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:DDB_G0274481
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDictyostelium discoideum (Slime mold)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri44689 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAmoebozoaEvoseaEumycetozoaDictyosteliaDictyostelialesDictyosteliaceaeDictyostelium
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002195 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 2, Unassembled WGS sequence

Organism-specific databases

Dictyostelium discoideum online informatics resource

More...
dictyBasei
DDB_G0274481

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei391 – 411HelicalSequence analysisAdd BLAST21
Transmembranei427 – 447HelicalSequence analysisAdd BLAST21
Transmembranei476 – 496HelicalSequence analysisAdd BLAST21
Transmembranei510 – 530HelicalSequence analysisAdd BLAST21
Transmembranei561 – 581HelicalSequence analysisAdd BLAST21
Transmembranei595 – 615HelicalSequence analysisAdd BLAST21
Transmembranei630 – 652HelicalSequence analysisAdd BLAST23
Transmembranei666 – 686HelicalSequence analysisAdd BLAST21
Transmembranei712 – 732HelicalSequence analysisAdd BLAST21
Transmembranei745 – 765HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003308211 – 1053SPX and EXS domain-containing protein 2Add BLAST1053

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q86HQ3

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
44689.DDB0266497

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q86HQ3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 339SPXPROSITE-ProRule annotationAdd BLAST339
Domaini596 – 798EXSPROSITE-ProRule annotationAdd BLAST203

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni54 – 137DisorderedSequence analysisAdd BLAST84
Regioni799 – 871DisorderedSequence analysisAdd BLAST73
Regioni1023 – 1053DisorderedSequence analysisAdd BLAST31

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi54 – 111Polar residuesSequence analysisAdd BLAST58
Compositional biasi112 – 137Acidic residuesSequence analysisAdd BLAST26
Compositional biasi799 – 843Basic and acidic residuesSequence analysisAdd BLAST45
Compositional biasi854 – 871Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi1023 – 1047Polar residuesSequence analysisAdd BLAST25

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1162, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_290612_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q86HQ3

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q86HQ3

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004342, EXS_C
IPR004331, SPX_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03124, EXS, 1 hit
PF03105, SPX, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51380, EXS, 1 hit
PS51382, SPX, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q86HQ3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKFRDYLKDN KVSHWRDKYI DYEYLKNLID NEYINAEILN SAIIDLPLSP
60 70 80 90 100
EEQNNINKNN NNNNNNNNNN NNNNNNNNNI NNNNNNNNTL KDGEQTNSNN
110 120 130 140 150
ISIPNQMAPQ ESSGEDEDDE NENGNGVVGD EDGGDDDEIE MDELVIDDNG
160 170 180 190 200
EIINITATAG SRVKVKKGIN KGVKRLKKIA KNTNNRLSRM VSRSPKNKGL
210 220 230 240 250
GSSSEIEGDE FQLDGGGISS QIEMVASNNI TGATVFVPQE TFQDGFIDQV
260 270 280 290 300
NKVDIFFVDR YRKTKFKCVD LVGMIPFLSD NEQLRTIRNI DYVKQGFHDN
310 320 330 340 350
YHYLESLESY KNLNLDGFYK ILDKYEKINP RIAKECRKYL ENTRLTSTNS
360 370 380 390 400
PVRELSRRIK QIYARYFTGN DIKLANNQIR TNKQVNQFQN YIIGFLIGAS
410 420 430 440 450
AILIAQVIFK FYYYFPDVAD SPKNSPMAWL LFRISSLPII LGTLFALMTK
460 470 480 490 500
LWEKAGINYV FIFELKPDIK RSSSRYLMYG MIFVTMWLVV FNVYVDSISN
510 520 530 540 550
KTGSPETSRY LLLIPLLFIL GSIFFLILPF KVLAHRTRFW VLHKMSKVVQ
560 570 580 590 600
APFVPVRFPD FFMSVQLLCL GEFLFNMQQI VCMFKFNDPL YSPSGVCFKH
610 620 630 640 650
KAVIFPILSV LPFYWRVMQC VRRFWETGQF FPHITSAIRS TFSIVTNILL
660 670 680 690 700
WVANNYGNKE WSWIKILWFI INVVGTVYKL YADFTVDWGL FLNYKTNKQW
710 720 730 740 750
PLREKMVFKR KWVYYVAMSF DTFFRFVWLI VFSIRQGTSY KLDHPLFLFW
760 770 780 790 800
FSLSEIAWAA QFIFFRVESE HVQCADTYSH FKDIPLPFSQ DYKNYMEEKK
810 820 830 840 850
SRYDEKKPHH HHHHDNNNNE TKDGSGGTHH RRNLSNGHHP YDDDDDDESI
860 870 880 890 900
DSDADSKDLN LESNSEFVDD EGYNQRKNSI ISSIKKIAST QELNSMNRIS
910 920 930 940 950
SHPDLYSTMQ RFAGHVPDSN SSMPRMYSHP DFNHPIPRVL TSHVEVNPST
960 970 980 990 1000
LRTVPQHRLN NIPNQRIISH ADINPQHLRV GSPRVEFNST VQQRSPHGEI
1010 1020 1030 1040 1050
QSSMIRNHSR ADLNSSMQRI QSHPELNSSN RNQVDPNSPM NRLITRADLN

KSR
Length:1,053
Mass (Da):122,393
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7109AEEB8696BBE9
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAFI02000012 Genomic DNA Translation: EAL70133.1

NCBI Reference Sequences

More...
RefSeqi
XP_644139.1, XM_639047.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
EAL70133; EAL70133; DDB_G0274481

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8619569

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ddi:DDB_G0274481

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000012 Genomic DNA Translation: EAL70133.1
RefSeqiXP_644139.1, XM_639047.1

3D structure databases

SMRiQ86HQ3
ModBaseiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0266497

Proteomic databases

PaxDbiQ86HQ3

Genome annotation databases

EnsemblProtistsiEAL70133; EAL70133; DDB_G0274481
GeneIDi8619569
KEGGiddi:DDB_G0274481

Organism-specific databases

dictyBaseiDDB_G0274481

Phylogenomic databases

eggNOGiKOG1162, Eukaryota
HOGENOMiCLU_290612_0_0_1
InParanoidiQ86HQ3
PhylomeDBiQ86HQ3

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q86HQ3

Family and domain databases

InterProiView protein in InterPro
IPR004342, EXS_C
IPR004331, SPX_dom
PfamiView protein in Pfam
PF03124, EXS, 1 hit
PF03105, SPX, 2 hits
PROSITEiView protein in PROSITE
PS51380, EXS, 1 hit
PS51382, SPX, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPXS2_DICDI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86HQ3
Secondary accession number(s): Q555D4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: June 1, 2003
Last modified: June 2, 2021
This is version 75 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families
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