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Protein

Receptor-type guanylate cyclase gcy-28

Gene

gcy-28

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Guanylate cyclase involved in the production of the second messenger cGMP (PubMed:9188508). Regulates olfactory perception in AWC sensory neurons although may not be involved in the primary sensory transduction steps (PubMed:18817734).2 Publications
Isoforms c: Regulates sensory integration of conflicting sensory cues in AIA interneurons (PubMed:21414922).
Isoform d: Regulates sensory integration of conflicting sensory cues in AIA interneurons (PubMed:21414922).

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei756ATPPROSITE-ProRule annotation1
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi1091Magnesium 1PROSITE-ProRule annotation1
Metal bindingi1091Magnesium 2PROSITE-ProRule annotation1
Metal bindingi1092Magnesium 2; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi1135Magnesium 1PROSITE-ProRule annotation1
Metal bindingi1135Magnesium 2PROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi723 – 731ATPPROSITE-ProRule annotation9

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • GTP binding Source: UniProtKB-KW
  • guanylate cyclase activity Source: WormBase
  • metal ion binding Source: UniProtKB-KW
  • peptide receptor activity Source: GO_Central
  • protein kinase activity Source: InterPro

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLyase, Receptor
Biological processcGMP biosynthesis, Chemotaxis
LigandATP-binding, GTP-binding, Magnesium, Metal-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Receptor-type guanylate cyclase gcy-28Curated (EC:4.6.1.21 Publication)
Alternative name(s):
GCY-X11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:gcy-28Imported
ORF Names:T01A4.1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

WormBase

More...
WormBasei
T01A4.1a ; CE33582 ; WBGene00020131 ; gcy-28
T01A4.1b ; CE25977 ; WBGene00020131 ; gcy-28
T01A4.1c ; CE33583 ; WBGene00020131 ; gcy-28
T01A4.1d ; CE43478 ; WBGene00020131 ; gcy-28

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini19 – 515ExtracellularSequence analysisAdd BLAST497
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei516 – 536HelicalSequence analysisAdd BLAST21
Topological domaini537 – 1276CytoplasmicSequence analysisAdd BLAST740

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1204F → L in ky713; loss of chemotaxis response to butanone. Defect in sensory integration when confronted to two opposing environmental chemicals. 2 Publications1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18Sequence analysisAdd BLAST18
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000043329519 – 1276Receptor-type guanylate cyclase gcy-28Sequence analysisAdd BLAST1258

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi87N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi196N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi338N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi384N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi387N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi414N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi428N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi444N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q86GV3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q86GV3

PeptideAtlas

More...
PeptideAtlasi
Q86GV3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in head neurons, ventral cord and tail neurons, body wall muscle, hypodermis, somatic gonad and intestine (PubMed:16547101). Isoform d is expressed specifically in AIA interneurons (PubMed:21414922).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00020131 Expressed in 5 organ(s), highest expression level in material anatomical entity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
6239.T01A4.1c

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q86GV3

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini717 – 1013Protein kinasePROSITE-ProRule annotationAdd BLAST297
Domaini1086 – 1215Guanylate cyclasePROSITE-ProRule annotationAdd BLAST130

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1017 – 1063Sequence analysisAdd BLAST47

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi33 – 40Poly-ProSequence analysis8

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The protein kinase domain is predicted to be catalytically inactive.PROSITE-ProRule annotation

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1023 Eukaryota
COG2114 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156223

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000293307

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q86GV3

KEGG Orthology (KO)

More...
KOi
K12323

Identification of Orthologs from Complete Genome Data

More...
OMAi
DDHASQI

Database of Orthologous Groups

More...
OrthoDBi
EOG091G02QS

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q86GV3

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.1230, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001054 A/G_cyclase
IPR018297 A/G_cyclase_CS
IPR001828 ANF_lig-bd_rcpt
IPR001170 ANPR/GUC
IPR011009 Kinase-like_dom_sf
IPR029787 Nucleotide_cyclase
IPR028082 Peripla_BP_I
IPR000719 Prot_kinase_dom
IPR001245 Ser-Thr/Tyr_kinase_cat_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01094 ANF_receptor, 1 hit
PF00211 Guanylate_cyc, 1 hit
PF07714 Pkinase_Tyr, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00255 NATPEPTIDER

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00044 CYCc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53822 SSF53822, 1 hit
SSF55073 SSF55073, 1 hit
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00452 GUANYLATE_CYCLASE_1, 1 hit
PS50125 GUANYLATE_CYCLASE_2, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform cImported (identifier: Q86GV3-1) [UniParc]FASTAAdd to basket
Also known as: GCY-X11 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLRWLTLLSC ILLTALHGNI VEDVGAAQQA SYPPPPPPFP FNVIVILPKR
60 70 80 90 100
ESTYDNFGMT LQKAMPVIDI AVQEVIKAKK LPPGWINLTY WDSRLYEDIL
110 120 130 140 150
LAERHATVGV IQAYCEHRLD AILGFADNYG LATVTKVTAG LNGGIPILTT
160 170 180 190 200
SGMPSLLNSK KEYPFLTRMQ GSYRLLADSM YQLIAYHDED SVSKSNSSLN
210 220 230 240 250
YLNLIFFYHD KRRAVNRVIA QDESQETGAT SSHCYFSLYA IKRYFTEKSK
260 270 280 290 300
TFKREWALNT PQFPFDEDLV IERETFKQWL REISLQSNVI ILCASPDTVR
310 320 330 340 350
EIMLAAHDLG MATSGEYVFI NIDVSTGSHA EQPWIRANDT NNEENEKAKE
360 370 380 390 400
AYRALKTISL RRSDLDEYKN FELRVKERAD QKYNYTNITG KDYEMNNFIS
410 420 430 440 450
AFYDAVLLYA IALNETIQSG LDPRNGHNIT SRMWGRTFVG ITGNVSIDHN
460 470 480 490 500
GDRYSDYSLL DLDPVQNRFV EVAYYSGASN QLKTVGQLHW VGGKPPTDLP
510 520 530 540 550
ICGYDKSKCP GYPLHVYLLM GSFLLILVLV GLFIFFWRRY KLEQELAAMS
560 570 580 590 600
WKIRWEELDG EESQKKNEKK KAKKRKNHND YLPESDPLLR STSRSSVNSD
610 620 630 640 650
KFDEDSLIPI RFRLRSSSSG TTRKISAMID RKLSIFTRKK STPPSESQKN
660 670 680 690 700
GGLTPNSLQK AENGDCSPIN EVQFRLPLND RRVSSPSSEA TRKKNSNEED
710 720 730 740 750
PENGAKKSLS LKNRKLSFGM VSFKSGSGGS VETIAQNNTQ IYTKTAIFKG
760 770 780 790 800
VVVAIKKLNI DPKKYPRLDL SRAQLMELKK MKDLQHDHIT RFTGACIDFP
810 820 830 840 850
HYCVVTEYCP KGSLEDILEN EKIELDKLMK YSLLHDLVKG LFFLHNSEIR
860 870 880 890 900
SHGRLKSSNC VVDSRFVLKV TDFGLHRLHC LEEINLEEIG EHAYYKKMLW
910 920 930 940 950
TAPELLRDSN APPMGTQKGD IYSFAIILHE MMFRKGVFAL ENEDLSPNEI
960 970 980 990 1000
VQRVRKPVSE DQEPLRPWVS ETGEGEGDDA LNDTLLSLMV ACWSEDPHER
1010 1020 1030 1040 1050
PEVSSVRKAV RSLNRDNETS NLVDNLLKRM EQYANNLEGL VEERTQEYLA
1060 1070 1080 1090 1100
EKKKVEELLH QLLPPAIADT LIAGRAVQAE SYDCVTIYFS DIVGFTSLSS
1110 1120 1130 1140 1150
QSTPMQVVTL LNDLYLAFDG VVDNFKVYKV ETIGDAYMVV SGLPERRDDH
1160 1170 1180 1190 1200
ANQIAQMSLS LLHKVKNFVI RHRPHEQLKL RIGMHSGSVV AGVVGSKMPR
1210 1220 1230 1240 1250
YCLFGDTVNT SSRMESNGLP LKIHVSQQTY DILMQEAGFK LELRGSVEMK
1260 1270
GKGMQTTYWL RGYKDVEIPD FGEEFA
Length:1,276
Mass (Da):144,989
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4941A68DD206E547
GO
Isoform aImported (identifier: Q86GV3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-233: MLRWLTLLSC...SQETGATSSH → MILSDVLLLS...RGPRNKGRSE
     239-289: YAIKRYFTEK...LREISLQSNV → SAIKNLIMNN...LSEASVMSNL
     510-510: P → PQ
     602-614: Missing.

Show »
Length:1,217
Mass (Da):137,811
Checksum:iC42F108F4C8CE46E
GO
Isoform bImported (identifier: Q86GV3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-627: Missing.
     1220-1264: PLKIHVSQQT...QTTYWLRGYK → RMFWNFSLYK...EGKKMVTEFN
     1265-1276: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:637
Mass (Da):72,480
Checksum:i0981DF05AEB20474
GO
Isoform dImported (identifier: Q86GV3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-287: MLRWLTLLSC...QWLREISLQS → MWINSTRTLI...NYLRASSNMA
     510-510: P → PQ
     602-614: Missing.

Show »
Length:1,238
Mass (Da):140,785
Checksum:iFF731DBFB411D372
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0577101 – 627Missing in isoform b. CuratedAdd BLAST627
Alternative sequenceiVSP_0577111 – 287MLRWL…ISLQS → MWINSTRTLIFNHFVRIVLV LLLSHEVVTKSNRKFEEISV KHPIHLVIPLPDDDDFSDGK NPFLFSSHKVKPLADLALER VYREGILPNNSVNLIYRDSK LSDAIGPNVAVEQLLRKQID CIIGYAYGYALAPVARMSPY WKNGIPIITPIGLTMSLDDK REYQLMTRINSPYKVVSSAV STLFNTYKWKRHIFMFHHAK APSVAVGECFLLMASLQHPL RKVMEMQHNFFTFNEDHGAN ISKAERHNQFRNYLRASSNM A in isoform d. CuratedAdd BLAST287
Alternative sequenceiVSP_0577121 – 233MLRWL…ATSSH → MILSDVLLLSLVISSSSSSS HQHSLLPIDIVVGLPIEEGD RGKNPFLLTLAKSKPVFDVA LQDVYHLRILPYGSLKVTFE NSALSDAVGPQKMIEHYCNK TVDAIMGLPYVYALAPVARI SKFWGQGVPVFTTTALVDEL GDRNEFPLLTRMMGSYKSLG KLVTRIAERFEWQHYFFMFN DEVARGPRNKGRSE in isoform a. CuratedAdd BLAST233
Alternative sequenceiVSP_057713239 – 289YAIKR…LQSNV → SAIKNLIMNNKTSTWNVKMF SEFEADRLQYRALLSEASVM SNL in isoform a. CuratedAdd BLAST51
Alternative sequenceiVSP_057714510P → PQ in isoform a and isoform d. Curated1
Alternative sequenceiVSP_057715602 – 614Missing in isoform a and isoform d. CuratedAdd BLAST13
Alternative sequenceiVSP_0577161220 – 1264PLKIH…LRGYK → RMFWNFSLYKIYKFKVFKNK IELDFLKNEKESIEFEGKKM VTEFN in isoform b. CuratedAdd BLAST45
Alternative sequenceiVSP_0577171265 – 1276Missing in isoform b. CuratedAdd BLAST12

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
FO081694 Genomic DNA Translation: CCD73355.1
FO081694 Genomic DNA Translation: CCD73353.1
FO081694 Genomic DNA Translation: CCD73354.1
FO081694 Genomic DNA Translation: CCD73356.1

NCBI Reference Sequences

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RefSeqi
NP_001021600.1, NM_001026429.2 [Q86GV3-1]
NP_001249628.1, NM_001262699.1 [Q86GV3-4]
NP_491379.3, NM_058978.3 [Q86GV3-2]
NP_491380.1, NM_058979.1 [Q86GV3-3]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Cel.18007

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
T01A4.1a; T01A4.1a; WBGene00020131 [Q86GV3-2]
T01A4.1b; T01A4.1b; WBGene00020131 [Q86GV3-3]
T01A4.1c; T01A4.1c; WBGene00020131 [Q86GV3-1]
T01A4.1d; T01A4.1d; WBGene00020131 [Q86GV3-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
172051

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
cel:CELE_T01A4.1

UCSC genome browser

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UCSCi
T01A4.1c c. elegans

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081694 Genomic DNA Translation: CCD73355.1
FO081694 Genomic DNA Translation: CCD73353.1
FO081694 Genomic DNA Translation: CCD73354.1
FO081694 Genomic DNA Translation: CCD73356.1
RefSeqiNP_001021600.1, NM_001026429.2 [Q86GV3-1]
NP_001249628.1, NM_001262699.1 [Q86GV3-4]
NP_491379.3, NM_058978.3 [Q86GV3-2]
NP_491380.1, NM_058979.1 [Q86GV3-3]
UniGeneiCel.18007

3D structure databases

ProteinModelPortaliQ86GV3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.T01A4.1c

Proteomic databases

EPDiQ86GV3
PaxDbiQ86GV3
PeptideAtlasiQ86GV3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiT01A4.1a; T01A4.1a; WBGene00020131 [Q86GV3-2]
T01A4.1b; T01A4.1b; WBGene00020131 [Q86GV3-3]
T01A4.1c; T01A4.1c; WBGene00020131 [Q86GV3-1]
T01A4.1d; T01A4.1d; WBGene00020131 [Q86GV3-4]
GeneIDi172051
KEGGicel:CELE_T01A4.1
UCSCiT01A4.1c c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
172051
WormBaseiT01A4.1a ; CE33582 ; WBGene00020131 ; gcy-28
T01A4.1b ; CE25977 ; WBGene00020131 ; gcy-28
T01A4.1c ; CE33583 ; WBGene00020131 ; gcy-28
T01A4.1d ; CE43478 ; WBGene00020131 ; gcy-28

Phylogenomic databases

eggNOGiKOG1023 Eukaryota
COG2114 LUCA
GeneTreeiENSGT00940000156223
HOGENOMiHOG000293307
InParanoidiQ86GV3
KOiK12323
OMAiDDHASQI
OrthoDBiEOG091G02QS
PhylomeDBiQ86GV3

Miscellaneous databases

Protein Ontology

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PROi
PR:Q86GV3

Gene expression databases

BgeeiWBGene00020131 Expressed in 5 organ(s), highest expression level in material anatomical entity

Family and domain databases

Gene3Di3.30.70.1230, 1 hit
InterProiView protein in InterPro
IPR001054 A/G_cyclase
IPR018297 A/G_cyclase_CS
IPR001828 ANF_lig-bd_rcpt
IPR001170 ANPR/GUC
IPR011009 Kinase-like_dom_sf
IPR029787 Nucleotide_cyclase
IPR028082 Peripla_BP_I
IPR000719 Prot_kinase_dom
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
PfamiView protein in Pfam
PF01094 ANF_receptor, 1 hit
PF00211 Guanylate_cyc, 1 hit
PF07714 Pkinase_Tyr, 1 hit
PRINTSiPR00255 NATPEPTIDER
SMARTiView protein in SMART
SM00044 CYCc, 1 hit
SUPFAMiSSF53822 SSF53822, 1 hit
SSF55073 SSF55073, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00452 GUANYLATE_CYCLASE_1, 1 hit
PS50125 GUANYLATE_CYCLASE_2, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGCY28_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86GV3
Secondary accession number(s): H2L0J9, Q965F7, Q965F8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 24, 2015
Last sequence update: June 1, 2003
Last modified: December 5, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
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