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Entry version 154 (18 Sep 2019)
Sequence version 1 (01 Jun 2003)
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Protein
Submitted name:

High voltage activated calcium channel alpha-1 subunit

Gene

unc-2

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • voltage-gated calcium channel activity Source: WormBase

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalcium channelUniRule annotation, Ion channel, Voltage-gated channelUniRule annotation
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
High voltage activated calcium channel alpha-1 subunitImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:unc-2Imported
ORF Names:CELE_T02C5.5Imported, T02C5.5Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCaenorhabditis elegansImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri6239 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditinaRhabditomorphaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001940 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

WormBase

More...
WormBasei
T02C5.5b ; CE34980 ; WBGene00006742 ; unc-2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei107 – 127HelicalSequence analysisAdd BLAST21
Transmembranei149 – 169HelicalSequence analysisAdd BLAST21
Transmembranei181 – 198HelicalSequence analysisAdd BLAST18
Transmembranei248 – 270HelicalSequence analysisAdd BLAST23
Transmembranei331 – 352HelicalSequence analysisAdd BLAST22
Transmembranei364 – 386HelicalSequence analysisAdd BLAST23
Transmembranei524 – 545HelicalSequence analysisAdd BLAST22
Transmembranei557 – 576HelicalSequence analysisAdd BLAST20
Transmembranei649 – 671HelicalSequence analysisAdd BLAST23
Transmembranei728 – 750HelicalSequence analysisAdd BLAST23
Transmembranei989 – 1011HelicalSequence analysisAdd BLAST23
Transmembranei1102 – 1128HelicalSequence analysisAdd BLAST27
Transmembranei1184 – 1202HelicalSequence analysisAdd BLAST19
Transmembranei1214 – 1237HelicalSequence analysisAdd BLAST24
Transmembranei1249 – 1270HelicalSequence analysisAdd BLAST22
Transmembranei1306 – 1333HelicalSequence analysisAdd BLAST28
Transmembranei1399 – 1422HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
WBGene00006742 Expressed in 4 organ(s), highest expression level in multi-cellular organism

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1438 – 1473EF-handInterPro annotationAdd BLAST36

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni455 – 484DisorderedSequence analysisAdd BLAST30
Regioni1606 – 1662DisorderedSequence analysisAdd BLAST57
Regioni1713 – 1874DisorderedSequence analysisAdd BLAST162
Regioni1895 – 2027DisorderedSequence analysisAdd BLAST133

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili394 – 414Sequence analysisAdd BLAST21
Coiled coili755 – 785Sequence analysisAdd BLAST31

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi467 – 484AcidicSequence analysisAdd BLAST18
Compositional biasi1608 – 1662PolarSequence analysisAdd BLAST55
Compositional biasi1726 – 1742PolarSequence analysisAdd BLAST17
Compositional biasi1783 – 1798PolyampholyteSequence analysisAdd BLAST16
Compositional biasi1799 – 1815PolarSequence analysisAdd BLAST17
Compositional biasi1826 – 1843PolarSequence analysisAdd BLAST18
Compositional biasi1845 – 1864PolyampholyteSequence analysisAdd BLAST20
Compositional biasi1895 – 1919PolarSequence analysisAdd BLAST25
Compositional biasi1926 – 1966PolarSequence analysisAdd BLAST41

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410INF8 Eukaryota
COG1226 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000170242

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231529

Database of Orthologous Groups

More...
OrthoDBi
172471at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.120.350, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002048 EF_hand_dom
IPR031649 GPHH_dom
IPR005821 Ion_trans_dom
IPR014873 VDCC_a1su_IQ
IPR002077 VDCCAlpha1
IPR027359 Volt_channel_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08763 Ca_chan_IQ, 1 hit
PF16905 GPHH, 1 hit
PF00520 Ion_trans, 4 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00167 CACHANNEL

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01062 Ca_chan_IQ, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50222 EF_HAND_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 15 potential isoforms that are computationally mapped.Show allAlign All

Q86G45-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIPIAASEII PSPIHPRKIS INDRLFEIRT PRPGEMIKEA VQMAVWPALP
60 70 80 90 100
RLAAEEARRE QKAESGTFVR KTTLSSNAPV KEKGPSSLFI FAEDNIIRRN
110 120 130 140 150
AKAIIEWGPF EYFILLTIIG NCVVLSMEQH LPKNDKKALS EWLERTEPYF
160 170 180 190 200
MGIFCLECVL KVIAFGFALH KGSYLRSGWN IMDFIVVVSG VVTMLPFSPA
210 220 230 240 250
TQTANQPVDS VDLRTLRAVR VLRPLKLVSG IPSLQVVLKS ILCAMAPLLQ
260 270 280 290 300
IGLLVLFAII IFAIIGLEFY SGAFHSACYN ERGEIENVSE RPMPCTNKTS
310 320 330 340 350
PMGVYNCDVK GTTCLQKWIG PNYGITSFDN IGFAMITVFQ CITMEGWTTV
360 370 380 390 400
MYYTNDSLGS TYNWAYFIPL IVLGSFFMLN LVLGVLSGEF AKERERVENR
410 420 430 440 450
REFLKLRRQQ QIERELNGYL EWILTAEEVI LKEDRTTEEE KAAIMEARRR
460 470 480 490 500
AANKKLKQAS KQQSTETEED FEEDEDEMEE EYVDEGGTVE DEFAERKKRG
510 520 530 540 550
CCHSVGKFIK QLRIQIRIMV KTQIFYWSVI TLVFLNTCCV ASEHYGQPQW
560 570 580 590 600
FTDFLKYAEF VFLGIFVVEM LLKLFAMGSR TYFASKFNRF DCVVIVGSAA
610 620 630 640 650
EVIWAEVYGG SFGISVMRAL RLLRIFKLTS YWVSLRNLVR SLMNSMRSII
660 670 680 690 700
SLLFLLFLFI LIFALLGMQL FGGRFNFPTM HPYTHFDTFP VALITVFQIL
710 720 730 740 750
TGEDWNEVMY LAIESQGGIY SGGWPYSIYF IVLVLFGNYT LLNVFLAIAV
760 770 780 790 800
DNLANAQELT AAEEADEKAN EIEEESEELD EQYQEGDHCT IDMEGKTAGD
810 820 830 840 850
MCAVARAMDD LDEECEEEES PFGGPKPMVP YSSMFFLSPT NPFRVLIHSI
860 870 880 890 900
VCTKYFEMMV MTVICLSSVS LAAEDPVDEE NPRNKVLQYM DYCFTGVFAC
910 920 930 940 950
EMLLKLIDQG ILLHPGSYCR DFWNILDGIV VTCALFAFGF AGTEGSAGKN
960 970 980 990 1000
LNTIKSLRVL RVLRPLKTIK RIPKLKAVFD CVVNSLKNVF NILIVYFLFQ
1010 1020 1030 1040 1050
FIFAVIAVQL FNGKFFFCTD KNRKFANTCH GQFFVYDNQN DPPRVEQREW
1060 1070 1080 1090 1100
RLRPFNYDNT INAMLTLFVV TTGEGWPGIR QNSMDTTFED QGPSPFFRVE
1110 1120 1130 1140 1150
VALFYVMFFI VFPFFFVNIF VALIIITFQE QGEAELSEGD LDKNQKQCID
1160 1170 1180 1190 1200
FALNARPRSL FMPEDKNSTK YRIWRLVTSP PFEYFIMTMI CCNTLILMMK
1210 1220 1230 1240 1250
YYNNPLFYEE ILRLFNTALT AVFTVESILK ILAFGVRNYF RDGWNRFDFV
1260 1270 1280 1290 1300
TVVGSITDAL VTEFGGHFVS LGFLRLFRAA RLIRLLQQGY TIRILLWTFV
1310 1320 1330 1340 1350
QSFKALPYVC LLIGMLFFIY AIVGMQVFGN IWLNAATEIN RHNNFQSFFN
1360 1370 1380 1390 1400
AVILLFRCAT GEGWQDIMMA AVQGKDCARA GSAEINFEKG QTCGSNVSYA
1410 1420 1430 1440 1450
YFTSFVFLSS FLMLNLFVAV IMDNFDYLTR DSSILGPHHL DEFIRVWADY
1460 1470 1480 1490 1500
DPAATGRIHY SEMYEMLRIM APPVGFGKKC PYRLAYKHLI RMNMPVAEDG
1510 1520 1530 1540 1550
TVHFTTTLFA LIRESLSIKM RPVEEMDEAD EELRLTLKKI WPLKAKKNMV
1560 1570 1580 1590 1600
DLVVPPNHEL CFQKLTVGKI YAGLLILENY RARKSGTEVG GQGLFGGGLR
1610 1620 1630 1640 1650
SLVAAAKAAE SQHSSHTPQP PEETTPIIPQ HAQQFSAAPT MSAQGSLQQM
1660 1670 1680 1690 1700
QGTSSGGGQR PYSLFNSFVD TIKSGKQDGD VTDVQYQSVD QQHEKMNSTG
1710 1720 1730 1740 1750
RRLSDMFSKI RRGTSADHNP HQTEHLLAQD NRSPSSPRYR SMARASPPSP
1760 1770 1780 1790 1800
AERYGHPPRY RTESPPSSRS EYQMSIRDPI IRRNRYNTME HSRSSHDPQY
1810 1820 1830 1840 1850
HQDQQQQQQP HHQQHSQHLQ HSHHKTYQNH NQYSRSPIYS DDSSVAESYR
1860 1870 1880 1890 1900
REREFRRYQD STPQDVSEDD DPMPTAVRAR RLPLISTMPT HYESAYQPSS
1910 1920 1930 1940 1950
YNQHLNDSYG LGTGYQRDYH TSHSHSHHPT SQQQQHQPMY STSPLISPRS
1960 1970 1980 1990 2000
SHSYYTPRSS QYYEIPSPSP DIYPSYRGSA SPRRYPTSTV VVAPDREGSS
2010 2020
ARVIQAQPGS IPLSDSETED DPRWAIV
Length:2,027
Mass (Da):231,454
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFB79822A0FBDD297
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 15 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G4SFC3G4SFC3_CAEEL
EF-hand domain-containing protein
unc-2 CELE_T02C5.5, T02C5.5
2,087Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q8MPY5Q8MPY5_CAEEL
EF-hand domain-containing protein
unc-2 CELE_T02C5.5, T02C5.5
1,911Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G5EFB0G5EFB0_CAEEL
EF-hand domain-containing protein
unc-2 CELE_T02C5.5, T02C5.5
1,523Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1N7SYV5A0A1N7SYV5_CAEEL
EF-hand domain-containing protein
unc-2 CELE_T02C5.5, T02C5.5
2,000Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1N7SYU0A0A1N7SYU0_CAEEL
EF-hand domain-containing protein
unc-2 CELE_T02C5.5, T02C5.5
2,065Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1N7SYT8A0A1N7SYT8_CAEEL
EF-hand domain-containing protein
unc-2 CELE_T02C5.5, T02C5.5
2,049Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1N7SYV7A0A1N7SYV7_CAEEL
EF-hand domain-containing protein
unc-2 CELE_T02C5.5, T02C5.5
2,067Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1N7SYT1A0A1N7SYT1_CAEEL
EF-hand domain-containing protein
unc-2 CELE_T02C5.5, T02C5.5
2,002Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1N7SYU4A0A1N7SYU4_CAEEL
EF-hand domain-containing protein
unc-2 CELE_T02C5.5, T02C5.5
2,047Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1N7SYU6A0A1N7SYU6_CAEEL
EF-hand domain-containing protein
unc-2 CELE_T02C5.5, T02C5.5
1,984Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY264781 mRNA Translation: AAP13107.1
BX284606 Genomic DNA Translation: CCD74385.1

NCBI Reference Sequences

More...
RefSeqi
NP_741732.2, NM_171638.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
T02C5.5b.1; T02C5.5b.1; WBGene00006742

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
180570

UCSC genome browser

More...
UCSCi
T02C5.5d.3 c. elegans

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY264781 mRNA Translation: AAP13107.1
BX284606 Genomic DNA Translation: CCD74385.1
RefSeqiNP_741732.2, NM_171638.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiT02C5.5b.1; T02C5.5b.1; WBGene00006742
GeneIDi180570
UCSCiT02C5.5d.3 c. elegans

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
180570
WormBaseiT02C5.5b ; CE34980 ; WBGene00006742 ; unc-2

Phylogenomic databases

eggNOGiENOG410INF8 Eukaryota
COG1226 LUCA
GeneTreeiENSGT00940000170242
HOGENOMiHOG000231529
OrthoDBi172471at2759

Gene expression databases

BgeeiWBGene00006742 Expressed in 4 organ(s), highest expression level in multi-cellular organism

Family and domain databases

Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR002048 EF_hand_dom
IPR031649 GPHH_dom
IPR005821 Ion_trans_dom
IPR014873 VDCC_a1su_IQ
IPR002077 VDCCAlpha1
IPR027359 Volt_channel_dom_sf
PfamiView protein in Pfam
PF08763 Ca_chan_IQ, 1 hit
PF16905 GPHH, 1 hit
PF00520 Ion_trans, 4 hits
PRINTSiPR00167 CACHANNEL
SMARTiView protein in SMART
SM01062 Ca_chan_IQ, 1 hit
PROSITEiView protein in PROSITE
PS50222 EF_HAND_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ86G45_CAEEL
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86G45
Secondary accession number(s): Q8MPY6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: September 18, 2019
This is version 154 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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