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Entry version 151 (11 Dec 2019)
Sequence version 1 (01 Jun 2003)
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Protein

[F-actin]-monooxygenase Mical

Gene

Mical

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin. Acts by modifying actin subunits at 'Met-44' and 'Met-47' through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament disassembly and prevent repolymerization. Plays a key role in semaphorin-plexin repulsive axon guidance and cell morphological changes, probably via its ability to modify and regulate actin.3 Publications

Caution

The reaction mechanism is subject to discussion. Some work suggest MICAL enzymes directly oxidize actin methionine residues to produce methionine-(R)-S-oxide. Other publications suggest that the enzyme functions as a NADPH oxidase producing H2O2 (EC 1.6.3.1) and that it is the produced H2O2 that is responsible for the methionine-(R)-S-oxide production.By similarity2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

FAD2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei138FADBy similarity1
Binding sitei224FAD; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei334FADBy similarity1
Binding sitei434FADBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi1074Zinc 1By similarity1
Metal bindingi1077Zinc 1By similarity1
Metal bindingi1095Zinc 1; via pros nitrogenBy similarity1
Metal bindingi1098Zinc 1By similarity1
Metal bindingi1101Zinc 2By similarity1
Metal bindingi1104Zinc 2By similarity1
Metal bindingi1126Zinc 2By similarity1
Metal bindingi1129Zinc 2; via pros nitrogenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi157 – 159FADBy similarity3
Nucleotide bindingi164 – 166FADBy similarity3

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding, Monooxygenase, Oxidoreductase
LigandFAD, Flavoprotein, Metal-binding, NADP, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
[F-actin]-monooxygenase Mical (EC:1.14.13.2251 Publication)
Alternative name(s):
Molecule interacting with CasL protein homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Mical
ORF Names:CG33208
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0053208 Mical

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Defects in motor neuron guidance, myofilament organization and bristle formation. Surviving adult flies show abnormally shaped bristle cell processes that are variously straight, thick, bent, twisted and/or had abnormal 'club-like' or blunt tips.2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi134 – 139GAGPCG → WAWPCW: Abolishes Monooxygenase activity and impairs axon guidance functions. 1 Publication6

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004163071 – 4723[F-actin]-monooxygenase MicalAdd BLAST4723

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1049Phosphothreonine1 Publication1
Modified residuei1194Phosphoserine1 Publication1
Modified residuei1199Phosphoserine1 Publication1
Modified residuei1212Phosphoserine1 Publication1
Modified residuei4349Phosphoserine1 Publication1
Modified residuei4353Phosphoserine1 Publication1
Modified residuei4426Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q86BA1

PRoteomics IDEntifications database

More...
PRIDEi
Q86BA1

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q86BA1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Present in neuronal cell bodies, along axons, and in growth cones. Appears in the nervous system at stage 13 and labels motor and CNS projections, and at later embryonic stages, it is present on axons that make up all motor axon pathways: the intersegmental nerve (ISN), the intersegmental nerves b and d (ISNb and ISNd), and the segmental nerves a and c (SNa and SNc). Also present in segment boundaries at the position of muscle attachment sites and at low levels in the lateral cluster of chordotonal organs (at protein level). Localizes to growing bristle tips in close proximity to the bristle cell membrane and at sites of bristle branching and actin localization. Localizes to growth cones.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

During early development (stages 7-8), expressed in the ventral neurogenic region and in many nonneuronal tissues (including developing mesoderm, cells surrounding the cephalic furrow and amnioproctodeal invagination, and in gut primordia). This nonneuronal expression is also seen later in embryonic development (stages 11-17), where it is expressed within the anterior and posterior midgut primordia, the visceral musculature, and weakly in somatic musculature. During axonal pathfinding (stage 13 onward), expressed within the developing brain and ventral nerve cord in most, if not all, CNS neurons. Not highly expressed in peripheral sensory neurons.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Directly regulated by Sox14 during pruning.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0053208 Expressed in 33 organ(s), highest expression level in larva

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q86BA1 differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q86BA1 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with plexA.

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
66380, 12 interactors

Database of interacting proteins

More...
DIPi
DIP-61753N

Protein interaction database and analysis system

More...
IntActi
Q86BA1, 23 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0297564

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q86BA1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini562 – 669Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST108
Domaini1072 – 1136LIM zinc-bindingPROSITE-ProRule annotationAdd BLAST65
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1297 – 1320LRR 1Add BLAST24
Repeati1579 – 1601LRR 2Add BLAST23
Repeati1730 – 1754LRR 3Add BLAST25
Repeati1931 – 1956LRR 4Add BLAST26
Repeati2548 – 2574LRR 5Add BLAST27
Repeati2680 – 2704LRR 6Add BLAST25
Repeati2934 – 2957LRR 7Add BLAST24
Repeati3545 – 3568LRR 8Add BLAST24
Repeati3642 – 3665LRR 9Add BLAST24
Domaini4550 – 4705bMERBPROSITE-ProRule annotationAdd BLAST156
Repeati4646 – 4668LRR 10Add BLAST23

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 520Monooxygenase domainAdd BLAST520

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi4 – 41Gln-richAdd BLAST38

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Mical family.Curated

Keywords - Domaini

Leucine-rich repeat, LIM domain, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1700 Eukaryota
COG5069 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q86BA1

KEGG Orthology (KO)

More...
KOi
K19947

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR022735 bMERB_dom
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR036188 FAD/NAD-bd_sf
IPR001781 Znf_LIM

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00307 CH, 1 hit
PF12130 DUF3585, 1 hit
PF00412 LIM, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00132 LIM, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47576 SSF47576, 1 hit
SSF51905 SSF51905, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51848 BMERB, 1 hit
PS50021 CH, 1 hit
PS50023 LIM_DOMAIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform C (identifier: Q86BA1-1) [UniParc]FASTAAdd to basket
Also known as: D, F, G, H

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSRQHQRHHQ QHHHLPPHQQ PQQQMPQQQQ QLTAQQQQQQ QLLMAEHAAA
60 70 80 90 100
AEAAELFDLL CVATTMRQIL ALHRAMCEAV GLRPSPLNDF YPRLKAKVRS
110 120 130 140 150
WKAQALWKKF DARAAHRVYG KGAACTGTRV LVIGAGPCGL RTAIEAQLLG
160 170 180 190 200
AKVVVLEKRD RITRNNVLHL WPFVITDLRN LGAKKFYGKF CAGSIDHISI
210 220 230 240 250
RQLQCMLLKV ALLLGVEIHE GVSFDHAVEP SGDGGGWRAA VTPADHPVSH
260 270 280 290 300
YEFDVLIGAD GKRNMLDFRR KEFRGKLAIA ITANFINKKT EAEAKVEEIS
310 320 330 340 350
GVAFIFNQAF FKELYGKTGI DLENIVYYKD ETHYFVMTAK KHSLIDKGVI
360 370 380 390 400
IEDMADPGEL LAPANVDTQK LHDYAREAAE FSTQYQMPNL EFAVNHYGKP
410 420 430 440 450
DVAMFDFTSM FAAEMSCRVI VRKGARLMQC LVGDSLLEPF WPTGSGCARG
460 470 480 490 500
FLSSMDAAYA IKLWSNPQNS TLGVLAQRES IYRLLNQTTP DTLQRDISAY
510 520 530 540 550
TVDPATRYPN LNRESVNSWQ VKHLVDTDDP SILEQTFMDT HALQTPHLDT
560 570 580 590 600
PGRRKRRSGD LLPQGATLLR WISAQLHSYQ FIPELKEASD VFRNGRVLCA
610 620 630 640 650
LINRYRPDLI DYAATKDMSP VECNELSFAV LERELHIDRV MSAKQSLDLT
660 670 680 690 700
ELESRIWLNY LDQICDLFRG EIPHIKHPKM DFSDLRQKYR INHTHAQPDF
710 720 730 740 750
SKLLATKPKA KSPMQDAVDI PTTVQRRSVL EEERAKRQRR HEQLLNIGGG
760 770 780 790 800
AAGAAAGVAG SGTGTTTQGQ NDTPRRSKKR RQVDKTANIE ERQQRLQEIE
810 820 830 840 850
ENRQERMSKR RQQRYHQTQN FYKSLQLLQA GKLLREGGEA GVAEDGTPFE
860 870 880 890 900
DYSIFLYRQQ APVFNDRVKD LERKLLFPDR ERGDIPSALP RTADEQFSDR
910 920 930 940 950
IKNMEQRMTG RGGLGGDKKP KDLMRAIGKI DSNDWNVREI EKKIELSKKT
960 970 980 990 1000
EIHGPKGREK VPKWSKEQFQ ARQHKMSKPQ RQDSREAEKF KDIDQTIRNL
1010 1020 1030 1040 1050
DKQLKEGHNL DVGERGRNKV ASIAGQFGKK DEANSDEKNA GSSNATTNTN
1060 1070 1080 1090 1100
NTVIPKSSSK VALAFKKQAA SEKCRFCKQT VYLMEKTTVE GLVLHRNCLK
1110 1120 1130 1140 1150
CHHCHTNLRL GGYAFDRDDP QGRFYCTQHF RLPPKPLPQR TNKARKSAAA
1160 1170 1180 1190 1200
QPASPAVPPT AGSVPTAAAT SEHMDTTPPR DQVDLLETSR ANASADAMSD
1210 1220 1230 1240 1250
DEANVIDEHE WSGRNFLPES NNDSQSELSS SDESDTESDS EMFEEADDSP
1260 1270 1280 1290 1300
FGAQTLQLAS DWIGKQYCED SDDSDDFYDS SEGIADDGKD DTEGEEFKKA
1310 1320 1330 1340 1350
RELRRQEVRL QPLPANLPTD TETEKLKLNV DNKENMADRS SLKSGNSFES
1360 1370 1380 1390 1400
ARSQPSTPLS TPTRVEMEQL ERNAPRKFSS EIEAISEKLY HMNNMVKMNK
1410 1420 1430 1440 1450
DLEVLAKENL VKSDILRKLT LKEKWLAENA AIAAGQKVTP TPSATAPGLQ
1460 1470 1480 1490 1500
PKSKFDEKFE KVVSPPQPVV EPKPKPVIDF NLDELKPRKP NFEERPKEQL
1510 1520 1530 1540 1550
PRPESLKKPP QQKPKGSSTN VSRSNSLKSN ASNGSPKVKK APISNNSKMQ
1560 1570 1580 1590 1600
IEGILGTLRK IQSQNSSDQD EDMDVDEDVE RKPNKELNSK LKEIQASSFA
1610 1620 1630 1640 1650
GTMDHIKSQL TMPTVSAQAP PSMDLSKYFP NQKQEKSSTS STNKNQVTLK
1660 1670 1680 1690 1700
DVNLAKYFPS SPAPQRRTVE TVADRLKKSQ TEAALAKTKL LEDQANNQAE
1710 1720 1730 1740 1750
KTKKEVEKEG ESKKITKKVA DSKAVPPKRQ ASLDTFSLRE HQMDGALDLT
1760 1770 1780 1790 1800
KKKGPTKASA GVKKPAKSGS TTSVTKATAT SKGKTIKIVK KIVPKGTKAK
1810 1820 1830 1840 1850
KAAEAAQESA VVEAPPEKKP PKDEAERILD EILGDGEYRS PSSEYQRLFQ
1860 1870 1880 1890 1900
DEKSPSDLSD NIDRILEESG LDVELGLPKR SSKKLVKTKS LGEGDFDMKP
1910 1920 1930 1940 1950
SKERLTGVQN ILKRFESMSS VTSQNSDEQA AFKLRRMEST TSNLSSLTRS
1960 1970 1980 1990 2000
RESLVSVSDS MSDLEKTMDY LRNEWRNEAT NFLQKKRDKF YAKKEEQEKE
2010 2020 2030 2040 2050
SKILAKPDPL DNLPVQYRDS KLAKFFGLAA SKSPENRKSP IKKKKSPSKT
2060 2070 2080 2090 2100
PKVTKANNSL EELAKISNVR QTKKAQPKTL KPVEVKPLKP ASPVPDDFEI
2110 2120 2130 2140 2150
LDLLEKATEA KELERSKTKS PAVESISQTP KEAIVEISLP VEDIKNLPKT
2160 2170 2180 2190 2200
GCDKSSNSSR RGSQSSLIMS RRHSEISLNE KLNQDALAAL NQIEKEREAE
2210 2220 2230 2240 2250
QVDELFQSMV EEMEQEPQPT AIVEPPEEDI DADSLCTTIS KSPSAQPVTV
2260 2270 2280 2290 2300
VKRGSSEDQS IEKLFSHFSD EMLVNVEFDS NDELVGITPR ATLVSRNTED
2310 2320 2330 2340 2350
RDYLDKLESL ERDEETFQPV VGEKFIQENV QDEVDGLHFP SRPQRRPKSS
2360 2370 2380 2390 2400
SSSSEPSLPV APQRLKKKLS KLDPEDMPPS VQDLLQQVYQ KNIQPELVEV
2410 2420 2430 2440 2450
IPVEGKQTLR FPSMLAEEDV DEVDHSKEGI KKIETAPEEV RKVTEPEDVA
2460 2470 2480 2490 2500
RVIPSPIKPS ISQSNSLKSE NSSGSSLVEI PKIITPPKSS SKENSSDWDM
2510 2520 2530 2540 2550
EKLPASPMPR RRLLPNQTPY KAPSVASKES SLEWDMEKLP NSPMLPRRNK
2560 2570 2580 2590 2600
MRAISPSTNP VQLLNNLPSD VDDEAAQRRL IEDFEQERRQ ALIKRDENFE
2610 2620 2630 2640 2650
AIAAEQRRRD SLQSSSNSSS KRSLPPPTPP MMASRRGTTQ DTNRTQDTAS
2660 2670 2680 2690 2700
RHEGTPPMFK KLDVDGSGTS MDSTSCSTRR SSFAFIELQD NKPVIVPMPK
2710 2720 2730 2740 2750
KLKLPKPEPP RFVPEPVATD EPVPEVFQGR AWPKTQLEGE VDLGDSDNED
2760 2770 2780 2790 2800
ETEKLKKQLP EYARSDSPPS AAFKNRKWPD GKTVFDKRAE SLEEEDIFEG
2810 2820 2830 2840 2850
LLSPRKRGSQ RFMDKPRSQS PQPFKPLANS SRKSSKSFSD LKKGPSLQSL
2860 2870 2880 2890 2900
SAQSSQDTDT LSTTTTVATA RPASYANYED PMDASTQALL DRSKRLHNRK
2910 2920 2930 2940 2950
RDFVNERVVE RNPYMRDVLR STDRRDYDDV DEDLTSYRPR HYASSTLNRF
2960 2970 2980 2990 3000
PNTTIRKSNN YDYLSPSSDY LSRRSYIPSA SATSSYYPST TRSSHLSDLF
3010 3020 3030 3040 3050
RRRSPASGTV SALSGYGNKE SCIGLALDRV GHLIESKCTW VRSTKVQTES
3060 3070 3080 3090 3100
ESTSPDEVEL NSATEISTDS EFDNDEIIRQ APKIFIDDTH LRKPTKVQIK
3110 3120 3130 3140 3150
STMIGPNAAS AGLHQKQLAA REKGGSYLQK YQPQPPLPQF KPLVQVDPTL
3160 3170 3180 3190 3200
LIGSQRAPLQ NPRPGDYLLN KTASTEGIAS KKSLELKKRY LLGEPANGNK
3210 3220 3230 3240 3250
IQKSGSTSVL DSRIRSFQSN ISECQKLLNP SSDISAGMRT FLDRTKLGEG
3260 3270 3280 3290 3300
SQTTPGQTNE LIRSATSNVI NDLRVELRIQ KTGSSHSTDN EKENVFVNCK
3310 3320 3330 3340 3350
NELNKGMEYT DAVNATLLDQ LARKSSPTTP TNKTVVEVID LVTPEKPIDI
3360 3370 3380 3390 3400
IDLTALETPK KQLVDGSAMD VDERLTPDSN KISELQQEVK EEPKPDVSRD
3410 3420 3430 3440 3450
VKECIPDILG HIKEGTGSKE PGGEDQQSLL EQSDEEKRDS PEKDVAEHEL
3460 3470 3480 3490 3500
YEPDSVQIQV PNIPWEKSKP EVMSTTGSSG SICSSSDSSS IEDIQHYILE
3510 3520 3530 3540 3550
STTSPDTQTV GGKHNVPRLE VHDTSGALMQ VDSLMIVNGK YIGDPEDVKF
3560 3570 3580 3590 3600
LDMPANVIVP PAPALKTNEL DMEDDQEAEA EPVTATPEPV ECTVIEAERR
3610 3620 3630 3640 3650
VTAPPPLPEM GPPKLKFDSK NENKIESLKN LPLIVESNVE HSQAVKPITL
3660 3670 3680 3690 3700
NLSNLARTPD TPTTPTAHDS DKTPTGEILS RGSDSETEHT GTGQVLTETE
3710 3720 3730 3740 3750
LSDWTADDCI SENFVDLEFA LNSNKGTIKR RKDRRRSGAS KLPSGNEVIH
3760 3770 3780 3790 3800
ELARQAPVVQ MDGILSAIDI DDIEFMDTGS EGSCAEAYSA TNTALIQNRG
3810 3820 3830 3840 3850
YMEYIEAEPK KTTRKAAPPS SYPGNLPPLM TKRDEKLGVD YIEQGAYIMH
3860 3870 3880 3890 3900
DDAKTPVNEV APAMTQSLTD SITLNELDDD SMIISQTQPT TTEESEALTV
3910 3920 3930 3940 3950
VTSPLDTSSP RVLDQFASML AAGKGDSTPS SSEQQPKTST VTSSSTGPNS
3960 3970 3980 3990 4000
STTGNVSKEP QEEDLQIQFE YVRALQQRIS QISTQRRKSS KGEAPNLQLN
4010 4020 4030 4040 4050
SSAPVIESAE DPAKPAEEPL VSMRPRTTSI SGKVPEIPTL SSKLEEITKE
4060 4070 4080 4090 4100
RTKQKDLIHD LVMDKLQSKK QLNAEKRLHR SRQRSLLTSG YASGSSLSPT
4110 4120 4130 4140 4150
PKLAAACSPQ DSNCSSQAHY HASTAEEAPK PPAERPLQKS ATSTYVSPYR
4160 4170 4180 4190 4200
TVQAPTRSAD LYKPRPFSEH IDSNALAGYK LGKTASFNGG KLGDFAKPIA
4210 4220 4230 4240 4250
PARVNRGGGV ATADIANISA STENLRSEAR ARARLKSNTE LGLSPEEKMQ
4260 4270 4280 4290 4300
LIRSRLHYDQ NRSLKPKQLE EMPSGDLAAR ARKMSASKSV NDLAYMVGQQ
4310 4320 4330 4340 4350
QQQQVEKDAV LQAKAADFTS DPNLASGGQE KAGKTKSGRR PKDPERRKSL
4360 4370 4380 4390 4400
IQSLSSFFQK GSGSAASSSK EQGGAVAAVH SEQSERPGTS SSGTPTISDA
4410 4420 4430 4440 4450
AGGGGGGGGV FSRFRISPKS KEKSKSCFDL RNFGFGDKDM LVCNAASPAG
4460 4470 4480 4490 4500
ATSASQKNHS QEYLNTTNNS RYRKQTNTAK PKPESFSSSS PQLYIHKPHH
4510 4520 4530 4540 4550
LAAAHPSALD DQTPPPIPPL PLNYQRSDDE SYANETREHK KQRAISKASR
4560 4570 4580 4590 4600
QAELKRLRIA QEIQREQEEI EVQLKDLEAR GVLIEKALRG EAQNIENLDA
4610 4620 4630 4640 4650
TKDNDEKLLK ELLEIWRNIT ALKKRDEELT IRQQELQLEY RHAQLKEELN
4660 4670 4680 4690 4700
LRLSCNKLDK SSADVAAEGA ILNEMLEIVA KRAALRPTAS QLDLTAAGSA
4710 4720
STSAEATGIK LTGQPHDHEE SII
Length:4,723
Mass (Da):525,047
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC96ECC28393C7E9F
GO
Isoform E (identifier: Q86BA1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     790-1057: Missing.
     1325-3045: Missing.

Show »
Length:2,734
Mass (Da):301,484
Checksum:i432E00F0E9C0D670
GO
Isoform B (identifier: Q86BA1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1325-3045: Missing.

Show »
Length:3,002
Mass (Da):332,502
Checksum:i8C754C12F57E0337
GO
Isoform I (identifier: Q86BA1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     770-789: QNDTPRRSKKRRQVDKTANI → LLKITILHHSLMENKFRSGC
     790-4723: Missing.

Show »
Length:789
Mass (Da):88,863
Checksum:i8811003C38C53118
GO
Isoform A (identifier: Q86BA1-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     790-810: EERQQRLQEIEENRQERMSKR → VSKCWHYFISWIGSYANVQKV
     811-4723: Missing.

Show »
Length:810
Mass (Da):91,432
Checksum:i7BF01EA391A543DB
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4K6N6A0A0B4K6N6_DROME
Molecule interacting with CasL, iso...
Mical CG11685, CG11687, CG18484, CG18667, CG18668
3,029Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4K6D5A0A0B4K6D5_DROME
Molecule interacting with CasL, iso...
Mical CG11685, CG11687, CG18484, CG18667, CG18668
4,743Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4K703A0A0B4K703_DROME
Molecule interacting with CasL, iso...
Mical CG11685, CG11687, CG18484, CG18667, CG18668
4,732Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A126GUS4A0A126GUS4_DROME
Molecule interacting with CasL, iso...
Mical CG11685, CG11687, CG18484, CG18667, CG18668
4,689Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A126GUS6A0A126GUS6_DROME
Molecule interacting with CasL, iso...
Mical CG11685, CG11687, CG18484, CG18667, CG18668
2,991Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti518S → N in AEA30989 (Ref. 5) Curated1
Sequence conflicti770Q → L in AEA30989 (Ref. 5) Curated1
Sequence conflicti815Y → C in AAM55243 (PubMed:12110185).Curated1
Sequence conflicti815Y → C in AAM55244 (PubMed:12110185).Curated1
Sequence conflicti1083L → P in AAM55244 (PubMed:12110185).Curated1
Sequence conflicti1124F → L in AAM55244 (PubMed:12110185).Curated1
Sequence conflicti1187E → Q in AAM55244 (PubMed:12110185).Curated1
Sequence conflicti1283 – 1285Missing in AAM55244 (PubMed:12110185).Curated3
Sequence conflicti1339R → G in AAM55244 (PubMed:12110185).Curated1
Sequence conflicti1373N → D in AAM55244 (PubMed:12110185).Curated1
Sequence conflicti1414D → G in AAM55244 (PubMed:12110185).Curated1
Sequence conflicti1543I → V in AAM55244 (PubMed:12110185).Curated1
Sequence conflicti1556G → D in AAM55244 (PubMed:12110185).Curated1
Sequence conflicti1782K → E in AAM55244 (PubMed:12110185).Curated1
Sequence conflicti1870G → E in AAM55244 (PubMed:12110185).Curated1
Sequence conflicti1931A → G in AAM55244 (PubMed:12110185).Curated1
Sequence conflicti2001S → A in AAM55244 (PubMed:12110185).Curated1
Sequence conflicti2366K → E in AAM55244 (PubMed:12110185).Curated1
Sequence conflicti2485T → A in AAM55244 (PubMed:12110185).Curated1
Sequence conflicti2500M → R in AAM55244 (PubMed:12110185).Curated1
Sequence conflicti2802L → P in AAM55244 (PubMed:12110185).Curated1
Sequence conflicti3022C → CVIS in AAM55244 (PubMed:12110185).Curated1
Sequence conflicti3138P → S in AAM55242 (PubMed:12110185).Curated1
Sequence conflicti3138P → S in AAM55243 (PubMed:12110185).Curated1
Sequence conflicti3141K → R in AAM55244 (PubMed:12110185).Curated1
Sequence conflicti3185E → G in AAM55244 (PubMed:12110185).Curated1
Sequence conflicti3199N → D in AAM55242 (PubMed:12110185).Curated1
Sequence conflicti3199N → D in AAM55243 (PubMed:12110185).Curated1
Sequence conflicti3283G → D in AAM55242 (PubMed:12110185).Curated1
Sequence conflicti3283G → D in AAM55243 (PubMed:12110185).Curated1
Sequence conflicti3789S → P in AAM55242 (PubMed:12110185).Curated1
Sequence conflicti3789S → P in AAM55243 (PubMed:12110185).Curated1
Sequence conflicti3789S → P in AAM55244 (PubMed:12110185).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_042612770 – 789QNDTP…KTANI → LLKITILHHSLMENKFRSGC in isoform I. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_042613790 – 4723Missing in isoform I. 1 PublicationAdd BLAST3934
Alternative sequenceiVSP_042614790 – 1057Missing in isoform E. 1 PublicationAdd BLAST268
Alternative sequenceiVSP_042615790 – 810EERQQ…RMSKR → VSKCWHYFISWIGSYANVQK V in isoform A. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_042616811 – 4723Missing in isoform A. 1 PublicationAdd BLAST3913
Alternative sequenceiVSP_0426171325 – 3045Missing in isoform E and isoform B. 1 PublicationAdd BLAST1721

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF520713 mRNA Translation: AAM55242.1
AF520714 mRNA Translation: AAM55243.1
AF520715 mRNA Translation: AAM55244.1
AE014297 Genomic DNA Translation: AAF54478.2
AE014297 Genomic DNA Translation: AAO41531.1
AE014297 Genomic DNA Translation: AAO41532.1
AE014297 Genomic DNA Translation: AAO41533.1
AE014297 Genomic DNA Translation: AAO41534.1
AE014297 Genomic DNA Translation: AAO41535.1
AE014297 Genomic DNA Translation: AAO41536.1
AE014297 Genomic DNA Translation: AAO41537.1
AE014297 Genomic DNA Translation: ACL83491.1
AY118290 mRNA Translation: AAM48319.1
BT126186 mRNA Translation: AEA30989.1

NCBI Reference Sequences

More...
RefSeqi
NP_001138032.1, NM_001144560.3 [Q86BA1-4]
NP_788620.1, NM_176443.2 [Q86BA1-2]
NP_788621.1, NM_176444.2 [Q86BA1-3]
NP_788622.1, NM_176445.2 [Q86BA1-1]
NP_788623.1, NM_176446.2 [Q86BA1-1]
NP_788624.1, NM_176447.2 [Q86BA1-1]
NP_788625.1, NM_176448.2 [Q86BA1-1]
NP_788626.2, NM_176449.3
NP_788627.1, NM_176450.1 [Q86BA1-5]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0082206; FBpp0081684; FBgn0053208 [Q86BA1-5]
FBtr0082207; FBpp0081685; FBgn0053208 [Q86BA1-3]
FBtr0082208; FBpp0081686; FBgn0053208 [Q86BA1-2]
FBtr0082209; FBpp0081687; FBgn0053208 [Q86BA1-1]
FBtr0082210; FBpp0081688; FBgn0053208 [Q86BA1-1]
FBtr0082212; FBpp0081690; FBgn0053208 [Q86BA1-1]
FBtr0082213; FBpp0081691; FBgn0053208 [Q86BA1-1]
FBtr0273185; FBpp0271693; FBgn0053208 [Q86BA1-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
41225

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG33208

UCSC genome browser

More...
UCSCi
CG33208-RA d. melanogaster
CG33208-RB d. melanogaster
CG33208-RC d. melanogaster [Q86BA1-1]
CG33208-RE d. melanogaster

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF520713 mRNA Translation: AAM55242.1
AF520714 mRNA Translation: AAM55243.1
AF520715 mRNA Translation: AAM55244.1
AE014297 Genomic DNA Translation: AAF54478.2
AE014297 Genomic DNA Translation: AAO41531.1
AE014297 Genomic DNA Translation: AAO41532.1
AE014297 Genomic DNA Translation: AAO41533.1
AE014297 Genomic DNA Translation: AAO41534.1
AE014297 Genomic DNA Translation: AAO41535.1
AE014297 Genomic DNA Translation: AAO41536.1
AE014297 Genomic DNA Translation: AAO41537.1
AE014297 Genomic DNA Translation: ACL83491.1
AY118290 mRNA Translation: AAM48319.1
BT126186 mRNA Translation: AEA30989.1
RefSeqiNP_001138032.1, NM_001144560.3 [Q86BA1-4]
NP_788620.1, NM_176443.2 [Q86BA1-2]
NP_788621.1, NM_176444.2 [Q86BA1-3]
NP_788622.1, NM_176445.2 [Q86BA1-1]
NP_788623.1, NM_176446.2 [Q86BA1-1]
NP_788624.1, NM_176447.2 [Q86BA1-1]
NP_788625.1, NM_176448.2 [Q86BA1-1]
NP_788626.2, NM_176449.3
NP_788627.1, NM_176450.1 [Q86BA1-5]

3D structure databases

SMRiQ86BA1
ModBaseiSearch...

Protein-protein interaction databases

BioGridi66380, 12 interactors
DIPiDIP-61753N
IntActiQ86BA1, 23 interactors
STRINGi7227.FBpp0297564

PTM databases

iPTMnetiQ86BA1

Proteomic databases

PaxDbiQ86BA1
PRIDEiQ86BA1

Genome annotation databases

EnsemblMetazoaiFBtr0082206; FBpp0081684; FBgn0053208 [Q86BA1-5]
FBtr0082207; FBpp0081685; FBgn0053208 [Q86BA1-3]
FBtr0082208; FBpp0081686; FBgn0053208 [Q86BA1-2]
FBtr0082209; FBpp0081687; FBgn0053208 [Q86BA1-1]
FBtr0082210; FBpp0081688; FBgn0053208 [Q86BA1-1]
FBtr0082212; FBpp0081690; FBgn0053208 [Q86BA1-1]
FBtr0082213; FBpp0081691; FBgn0053208 [Q86BA1-1]
FBtr0273185; FBpp0271693; FBgn0053208 [Q86BA1-4]
GeneIDi41225
KEGGidme:Dmel_CG33208
UCSCiCG33208-RA d. melanogaster
CG33208-RB d. melanogaster
CG33208-RC d. melanogaster [Q86BA1-1]
CG33208-RE d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
41225
FlyBaseiFBgn0053208 Mical

Phylogenomic databases

eggNOGiKOG1700 Eukaryota
COG5069 LUCA
InParanoidiQ86BA1
KOiK19947

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Mical fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
41225

Protein Ontology

More...
PROi
PR:Q86BA1

Gene expression databases

BgeeiFBgn0053208 Expressed in 33 organ(s), highest expression level in larva
ExpressionAtlasiQ86BA1 differential
GenevisibleiQ86BA1 DM

Family and domain databases

Gene3Di1.10.418.10, 1 hit
InterProiView protein in InterPro
IPR022735 bMERB_dom
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR036188 FAD/NAD-bd_sf
IPR001781 Znf_LIM
PfamiView protein in Pfam
PF00307 CH, 1 hit
PF12130 DUF3585, 1 hit
PF00412 LIM, 1 hit
SMARTiView protein in SMART
SM00132 LIM, 1 hit
SUPFAMiSSF47576 SSF47576, 1 hit
SSF51905 SSF51905, 1 hit
PROSITEiView protein in PROSITE
PS51848 BMERB, 1 hit
PS50021 CH, 1 hit
PS50023 LIM_DOMAIN_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMICAL_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86BA1
Secondary accession number(s): B7Z0U5
, F2FB99, Q86BA2, Q86BA3, Q8MTA1, Q8MUJ8, Q8MUJ9, Q8MUK0, Q9VH41
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: June 1, 2003
Last modified: December 11, 2019
This is version 151 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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