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Entry version 161 (29 Sep 2021)
Sequence version 1 (01 Jun 2003)
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Protein

Modifier of mdg4

Gene

mod(mdg4)

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the gypsy chromatin insulator complex which is required for the function of the gypsy chromatin insulator and other endogenous chromatin insulators. Chromatin insulators are regulatory elements which establish independent domains of transcriptional activity within eukaryotic genomes. Insulators have two defining properties; they can block the communication between an enhancer and a promoter when placed between them and can also buffer transgenes from position effect variegation (PEV). Insulators are proposed to structure the chromatin fiber into independent domains of differing transcriptional potential by promoting the formation of distinct chromatin loops. This chromatin looping may involve the formation of insulator bodies, where homotypic interactions between individual subunits of the insulator complex could promote the clustering of widely spaced insulators at the nuclear periphery. Within the gypsy insulator complex, this protein may control the nature of the repressive effect of su(Hw): in the absence of mod(mdg4) protein, su(Hw) exerts a bidirectional silencing effect, whereas in the presence of mod(mdg4), the silencing effect is unidirectional. Isoform H is specifically required to maintain the pairing of achiasmate homologs in male meiosis I which is mediated by the rDNA repeats on the achiasmate X-Y bivalents. Isoform H also plays a role in apoptotic regulatory pathways.

12 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri452 – 512FLYWCH-typeAdd BLAST61

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator
Biological processApoptosis, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q86B87

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Modifier of mdg4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mod(mdg4)Imported
Synonyms:bpd, doomImported, E(var)3-93DImported
ORF Names:CG32491Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0002781, mod(mdg4)

Eukaryotic Pathogen, Vector and Host Database Resources

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VEuPathDBi
VectorBase:FBgn0002781

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi33D → N in allele mod(mdg4)351; embryonic lethal; when associated with S-92. 1
Mutagenesisi92G → S in allele mod(mdg4)351; embryonic lethal; when associated with N-33. 1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000965051 – 610Modifier of mdg4Add BLAST610

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei230Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q86B87

PeptideAtlas

More...
PeptideAtlasi
Q86B87

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q86B87

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed both maternally and zygotically. Zygotic expression is high in pupae and adult females but low in other stages of development.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0002781, Expressed in embryo and 59 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q86B87, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q86B87, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Can self-associate (PubMed:11350941, PubMed:11416154).

Interacts with Chi (PubMed:11416154).

Interacts with Top2 (PubMed:21304601). Isoform mod2.2:

Component of the gypsy chromatin insulator complex, composed of Cp190, mod(mdg4) and su(Hw) (PubMed:7664338, PubMed:11350941, PubMed:11416154, PubMed:15574329). The gypsy chromatin insulator complex interacts with Topors via mod(mdg4) and su(Hw) (PubMed:16209949). Isoform mod2.2 interacts with Trl/GAGA and interaction with this protein may bypass the repressive effects of the su(Hw) insulator (PubMed:15465920).

7 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
72097, 78 interactors

Protein interaction database and analysis system

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IntActi
Q86B87, 32 interactors

Molecular INTeraction database

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MINTi
Q86B87

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0083463

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q86B87

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini32 – 98BTBPROSITE-ProRule annotationAdd BLAST67

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 308Interaction with ChiAdd BLAST308
Regioni1 – 160Self-associationAdd BLAST160
Regioni115 – 156DisorderedSequence analysisAdd BLAST42
Regioni219 – 259DisorderedSequence analysisAdd BLAST41
Regioni311 – 339DisorderedSequence analysisAdd BLAST29
Regioni386 – 432DisorderedSequence analysisAdd BLAST47
Regioni551 – 610Interaction with su(Hw)Add BLAST60
Regioni567 – 595DisorderedSequence analysisAdd BLAST29

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi134 – 153Polar residuesSequence analysisAdd BLAST20
Compositional biasi314 – 329Basic and acidic residuesSequence analysisAdd BLAST16
Compositional biasi386 – 409Polar residuesSequence analysisAdd BLAST24
Compositional biasi577 – 595Basic and acidic residuesSequence analysisAdd BLAST19

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Homotypic interactions mediated by the BTB (POZ) domain of this protein may promote the clustering of distant insulator complexes into nuclear insulator bodies.

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri452 – 512FLYWCH-typeAdd BLAST61

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG502S6BI, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_1514257_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q86B87

Identification of Orthologs from Complete Genome Data

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OMAi
RYDESYF

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.30.710.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000210, BTB/POZ_dom
IPR011333, SKP1/BTB/POZ_sf
IPR007588, Znf_FLYWCH

Pfam protein domain database

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Pfami
View protein in Pfam
PF00651, BTB, 1 hit
PF04500, FLYWCH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00225, BTB, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF54695, SSF54695, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50097, BTB, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (31+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 31 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 31 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform mod2.2 (identifier: Q86B87-1) [UniParc]FASTAAdd to basket
Also known as: 67.21 Publication, E(VAR)3-93D

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MADDEQFSLC WNNFNTNLSA GFHESLCRGD LVDVSLAAEG QIVKAHRLVL
60 70 80 90 100
SVCSPFFRKM FTQMPSNTHA IVFLNNVSHS ALKDLIQFMY CGEVNVKQDA
110 120 130 140 150
LPAFISTAES LQIKGLTDND PAPQPPQESS PPPAAPHVQQ QQIPAQRVQR
160 170 180 190 200
QQPRASARYK IETVDDGLGD EKQSTTQIVI QTTAAPQATI VQQQQPQQAA
210 220 230 240 250
QQIQSQQLQT GTTTTATLVS TNKRSAQRSS LTPASSSAGV KRSKTSTSAN
260 270 280 290 300
VMDPLDSTTE TGATTTAQLV PQQITVQTSV VSAAEAKLHQ QSPQQVRQEE
310 320 330 340 350
AEYIDLPMEL PTKSEPDYSE DHGDAAGDAE GTYVEDDTYG DMRYDDSYFT
360 370 380 390 400
ENEDAGNQTA ANTSGGGVTA TTSKAVVKQQ SQNYSESSFV DTSGDQGNTE
410 420 430 440 450
AQAATSASAT KIPPRKRGRP KTKVEDQTPK PKLLEKLQAA TLNEEASEPA
460 470 480 490 500
VYASTTKGGV KLIFNGHLFK FSFRKADYSV FQCCYREHGE ECKVRVVCDQ
510 520 530 540 550
KRVFPYEGEH VHFMQASDKS CLPSQFMPGE SGVISSLSPS KELLMKNTTK
560 570 580 590 600
LEEADDKEDE DFEEFEIQEI DEIELDEPEK TPAKEEEVDP NDFREKIKRR
610
LQKALQNKKK
Note: C-terminal exons are translated from the opposite DNA strand. This may be due to a trans-splicing event.
Length:610
Mass (Da):67,171
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i79CC78E52D2ADAF5
GO
Isoform 53.11 Publication (identifier: Q86B87-16) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     403-610: AATSASATKI...LQKALQNKKK → GDATQFFFTK...KDRGRASQRM

Note: C-terminal exons are translated from the opposite DNA strand. This may be due to a trans-splicing event.Curated
Show »
Length:486
Mass (Da):53,163
Checksum:iFDBF392D523625B0
GO
Isoform 53.6 (identifier: Q86B87-28) [UniParc]FASTAAdd to basket
Also known as: X

The sequence of this isoform differs from the canonical sequence as follows:
     404-610: ATSASATKIP...LQKALQNKKK → CYQLVPNRRG...RCRKRPGDRK

Note: C-terminal exons are translated from the opposite DNA strand. This may be due to a trans-splicing event.Curated
Show »
Length:490
Mass (Da):53,598
Checksum:iA11F19784919ECA9
GO
Isoform 54.7 (identifier: Q86B87-23) [UniParc]FASTAAdd to basket
Also known as: Y

The sequence of this isoform differs from the canonical sequence as follows:
     403-610: AATSASATKI...LQKALQNKKK → EQEDDFKLHL...SALSGLHNHP

Note: C-terminal exons are translated from the opposite DNA strand. This may be due to a trans-splicing event.Curated
Show »
Length:500
Mass (Da):54,767
Checksum:i3553C45452B1D106
GO
Isoform 55.61 Publication (identifier: Q86B87-13) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     403-610: AATSASATKI...LQKALQNKKK → GHLSTLRHLP...HNHPPKKRRL

Note: C-terminal exons are translated from the opposite DNA strand. This may be due to a trans-splicing event.Curated
Show »
Length:505
Mass (Da):55,639
Checksum:i151D67B2D5AF4B09
GO
Isoform 59.0 (identifier: Q86B87-25) [UniParc]FASTAAdd to basket
Also known as: Z

The sequence of this isoform differs from the canonical sequence as follows:
     403-610: AATSASATKI...LQKALQNKKK → VTQHVRNCGP...EGNPDHLPKM

Note: C-terminal exons are translated from the opposite DNA strand. This may be due to a trans-splicing event.Curated
Show »
Length:526
Mass (Da):57,477
Checksum:i1370A094F8362FE2
GO
Isoform 62.31 Publication (identifier: Q86B87-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     403-610: AATSASATKI...LQKALQNKKK → ESSVAIYSAT...GGTRVVSRRK

Note: C-terminal exons are translated from the opposite DNA strand. This may be due to a trans-splicing event.Curated
Show »
Length:567
Mass (Da):62,299
Checksum:i3ED3199914164550
GO
Isoform A1 Publication (identifier: Q86B87-17) [UniParc]FASTAAdd to basket
Also known as: 54.21 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     403-610: AATSASATKI...LQKALQNKKK → EKQFEYVVSQ...QYMKLQLNNV

Show »
Length:485
Mass (Da):53,387
Checksum:iAA9826AB6148038F
GO
Isoform AA (identifier: Q86B87-29) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     403-610: AATSASATKI...LQKALQNKKK → VLTYDDRGKL...CPPRPHKEDY

Show »
Length:488
Mass (Da):53,509
Checksum:i4E94A618509F8E0A
GO
Isoform AC (identifier: Q86B87-30) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     404-610: ATSASATKIP...LQKALQNKKK → FHIDFADSKK...IKSKLRNQDF

Show »
Length:540
Mass (Da):59,341
Checksum:i639CD4CC356093A4
GO
Isoform AB (identifier: Q86B87-31) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     403-610: AATSASATKI...LQKALQNKKK → GVIQSLKALF...DLLDEFPELQ

Show »
Length:506
Mass (Da):55,208
Checksum:iD23436303F3941D2
GO
Isoform B (identifier: Q86B87-27) [UniParc]FASTAAdd to basket
Also known as: 54.6

The sequence of this isoform differs from the canonical sequence as follows:
     403-610: AATSASATKI...LQKALQNKKK → VTFDVLTDPI...YAVSGVHNHP

Show »
Length:498
Mass (Da):54,592
Checksum:i54808234E545F377
GO
Isoform C2 Publications (identifier: Q86B87-9) [UniParc]FASTAAdd to basket
Also known as: 58.01 Publication, 31 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     403-610: AATSASATKI...LQKALQNKKK → DGPSKDTAIP...LKLMPIKEGK

Show »
Length:534
Mass (Da):58,074
Checksum:iB2111920052F391A
GO
Isoform D (identifier: Q86B87-24) [UniParc]FASTAAdd to basket
Also known as: 57.4

The sequence of this isoform differs from the canonical sequence as follows:
     403-610: AATSASATKI...LQKALQNKKK → EFDYGHGQYR...PQSMAHMFDM

Show »
Length:520
Mass (Da):57,399
Checksum:iC7B5007F97844321
GO
Isoform E1 Publication (identifier: Q86B87-2) [UniParc]FASTAAdd to basket
Also known as: 65.01 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     403-610: AATSASATKI...LQKALQNKKK → VKIKMEPSPT...HGAVFISKDY

Show »
Length:603
Mass (Da):64,967
Checksum:iA887D5F7B595684C
GO
Isoform F1 Publication (identifier: Q86B87-8) [UniParc]FASTAAdd to basket
Also known as: 58.61 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     403-610: AATSASATKI...LQKALQNKKK → VVLANDEVPN...EELNELTHDV

Show »
Length:536
Mass (Da):58,617
Checksum:i0CB2EA5DAA49D51F
GO
Isoform G1 Publication (identifier: Q86B87-15) [UniParc]FASTAAdd to basket
Also known as: 54.21 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     403-610: AATSASATKI...LQKALQNKKK → ELAVFGTGQR...REKALSLDAS

Show »
Length:497
Mass (Da):54,270
Checksum:i9FAB36A15DD9D08C
GO
Isoform H2 Publications (identifier: Q86B87-10) [UniParc]FASTAAdd to basket
Also known as: 56.31 Publication, Doom, MNM

The sequence of this isoform differs from the canonical sequence as follows:
     403-610: AATSASATKI...LQKALQNKKK → DLGELNPSNL...VAISGVHNHL

Show »
Length:514
Mass (Da):56,411
Checksum:i022205D469E30597
GO
Isoform I1 Publication (identifier: Q86B87-6) [UniParc]FASTAAdd to basket
Also known as: 59.11 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     403-610: AATSASATKI...LQKALQNKKK → VCDDLDDMKG...LSIEDLNNLQ

Show »
Length:541
Mass (Da):59,087
Checksum:iD7DD3B7CF114FFD2
GO
Isoform J1 Publication (identifier: Q86B87-19) [UniParc]FASTAAdd to basket
Also known as: 51.41 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     403-610: AATSASATKI...LQKALQNKKK → GSVAYYSYIT...KCGQHNHPPY

Show »
Length:473
Mass (Da):51,380
Checksum:i266F2F799B396F7C
GO
Isoform K1 Publication (identifier: Q86B87-11) [UniParc]FASTAAdd to basket
Also known as: 55.71 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     403-610: AATSASATKI...LQKALQNKKK → GQFIGDIPRG...MPKDAFYPQY

Show »
Length:510
Mass (Da):55,771
Checksum:i98A0D72C25E352D9
GO
Isoform L1 Publication (identifier: Q86B87-18) [UniParc]FASTAAdd to basket
Also known as: 52.21 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     404-610: ATSASATKIP...LQKALQNKKK → KDQNKGVLLK...EHAQHCLQCY

Show »
Length:476
Mass (Da):52,255
Checksum:iB185798E8C0D9179
GO
Isoform M1 Publication (identifier: Q86B87-14) [UniParc]FASTAAdd to basket
Also known as: 55.31 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     403-610: AATSASATKI...LQKALQNKKK → DRKRYSKKFL...SLKMPWVFTD

Show »
Length:503
Mass (Da):55,331
Checksum:iCDB2A54ABD6E6FD4
GO
Isoform N1 Publication (identifier: Q86B87-3) [UniParc]FASTAAdd to basket
Also known as: 64.21 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     403-610: AATSASATKI...LQKALQNKKK → DTEISFIRSQ...HRSLLKSEHP

Show »
Length:580
Mass (Da):64,190
Checksum:iED213DBC04CDCE9C
GO
Isoform O1 Publication (identifier: Q86B87-5) [UniParc]FASTAAdd to basket
Also known as: 60.11 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     403-610: AATSASATKI...LQKALQNKKK → EDELVFIESP...MHASMMLMHE

Show »
Length:545
Mass (Da):60,168
Checksum:iCACC30E1C0C6BF3E
GO
Isoform P1 Publication (identifier: Q86B87-7) [UniParc]FASTAAdd to basket
Also known as: 58.6

The sequence of this isoform differs from the canonical sequence as follows:
     404-610: ATSASATKIP...LQKALQNKKK → KFDYQISVDV...AATSAPATTT

Show »
Length:539
Mass (Da):58,790
Checksum:iB72215EDC9459174
GO
Isoform Q1 Publication (identifier: Q86B87-21) [UniParc]FASTAAdd to basket
Also known as: 46.31 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     403-610: AATSASATKI...LQKALQNKKK → GCDGLQGSCRDRGGQKLTGANHQMHLRA

Show »
Length:430
Mass (Da):46,366
Checksum:iD5C44FD56D3A84BA
GO
Isoform R1 Publication (identifier: Q86B87-20) [UniParc]FASTAAdd to basket
Also known as: 52.01 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     403-610: AATSASATKI...LQKALQNKKK → GTSHLATFSC...RLKYAKHSHL

Show »
Length:475
Mass (Da):52,074
Checksum:i5F85B8A076A397A4
GO
Isoform S1 Publication (identifier: Q86B87-12) [UniParc]FASTAAdd to basket
Also known as: 55.11 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     403-610: AATSASATKI...LQKALQNKKK → GLIFKAARHI...CEPCFEELHS

Show »
Length:506
Mass (Da):55,261
Checksum:i03003F412683D702
GO
Isoform mod1.8 (identifier: Q86B87-26) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     459-610: GVKLIFNGHL...LQKALQNKKK → DPTRPQLWSS...ILPTQTFVFC

Show »
Length:613
Mass (Da):66,799
Checksum:i85E0A9750C2A3AE2
GO
Isoform mod1.9 (identifier: Q86B87-22) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     360-449: Missing.

Show »
Length:520
Mass (Da):57,814
Checksum:iEBC834C8A8EB3DB8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4K6B8A0A0B4K6B8_DROME
Modifier of mdg4, isoform AE
mod(mdg4) BcDNA:GH07769, BcDNA:SD03001, bpd, CG15500, CG15501
479Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0B4K7A6A0A0B4K7A6_DROME
Modifier of mdg4, isoform AD
mod(mdg4) BcDNA:GH07769, BcDNA:SD03001, bpd, CG15500, CG15501
510Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA82990 differs from that shown. Intron retention.Curated
The sequence AAL29128 differs from that shown. Intron retention.Curated
The sequence AAN13870 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti151 – 152QQ → HE in AAA82988 (PubMed:7664338).Curated2
Sequence conflicti151 – 152QQ → HE in AAA82989 (PubMed:7664338).Curated2
Sequence conflicti151 – 152QQ → HE in AAA82990 (PubMed:7664338).Curated2
Sequence conflicti151 – 152QQ → HE in AAC17459 (PubMed:9111355).Curated2
Sequence conflicti466G → V in AAL33875 (PubMed:11604507).Curated1
Sequence conflicti507E → K in CAA53216 (PubMed:8248257).Curated1
Sequence conflicti507E → K in CAB85487 (PubMed:10790390).Curated1
Isoform C2 Publications (identifier: Q86B87-9)
Sequence conflicti422V → A in CAA53215 (PubMed:8248257).Curated1
Isoform H2 Publications (identifier: Q86B87-10)
Sequence conflicti447D → A in CAB85478 (PubMed:10790390).Curated1
Isoform 54.7 (identifier: Q86B87-23)
Sequence conflicti458N → D in CAC51489 (PubMed:11493677).Curated1
Isoform L1 Publication (identifier: Q86B87-18)
Sequence conflicti469A → T in CAC51387 (PubMed:11493677).Curated1
Isoform K1 Publication (identifier: Q86B87-11)
Sequence conflicti484A → P in CAB85477 (PubMed:10790390).Curated1
Isoform F1 Publication (identifier: Q86B87-8)
Sequence conflicti521S → T in CAB85480 (PubMed:10790390).Curated1
Isoform O1 Publication (identifier: Q86B87-5)
Sequence conflicti543M → I in CAB85483 (PubMed:10790390).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_010283360 – 449Missing in isoform mod1.9. 1 PublicationAdd BLAST90
Alternative sequenceiVSP_050724403 – 610AATSA…QNKKK → GDATQFFFTKGQRESVKLNY CGHSYVKFMENGRGTKWICA TRSTTKCRARIRTTKNNYLE VLYASHNHGFPPQKKDRGRA SQRM in isoform 53.1. 1 PublicationAdd BLAST208
Alternative sequenceiVSP_010287403 – 610AATSA…QNKKK → EQEDDFKLHLPLLVTRRKKT PGGSRKQSFDHLEVSFTRSN RGNNLLTIDGKPFTLNRRIK DVCYWECVKLRCKYIKCSAR VVTKSNRISALSGLHNHP in isoform 54.7. 1 PublicationAdd BLAST208
Alternative sequenceiVSP_050725403 – 610AATSA…QNKKK → GHLSTLRHLPVEAIFDADGK QMDFIPNIRVIRSQRKTIKL MFKKYAYSKTNEHDTTTYWH CRSRRNGRPACKARFSTKKL KNGSYKVYLTQPEHNHPPKK RRL in isoform 55.6. 2 PublicationsAdd BLAST208
Alternative sequenceiVSP_010288403 – 610AATSA…QNKKK → VTQHVRNCGPQMFLISRKGG TLLTINNFVYRSNLKFFGKS NNILYWECVQNRSVKCRSRL KTIGDDLYVTNDVHNHMGDN KRIEAAKAAGMLIHKKLSSL TAADKIQGSWKMDTEGNPDH LPKM in isoform 59.0. 1 PublicationAdd BLAST208
Alternative sequenceiVSP_050701403 – 610AATSA…QNKKK → ESSVAIYSATSRGRMQLIYG GQPFIFEKTLKLSSGEEKRF WRCNQWWNQKCRSRVFTIND VVCPLNRFHTHEEIVRRKKR VRRVPPVETIAKVVATTPRH PQHQQTTQQQQEIQLTSDAI AGAILDDESPATIDVSELGM HLKYEEIVADVTGIVGGTRV VSRRK in isoform 62.3. 1 PublicationAdd BLAST208
Alternative sequenceiVSP_050713403 – 610AATSA…QNKKK → EKQFEYVVSQKGHVLLLHKK FPFIREKCINGKTYWRCTQY TTKTKCHGRLHVLNGKIVHI KTHNHSPLDQERKQYMKLQL NNV in isoform A. 1 PublicationAdd BLAST208
Alternative sequenceiVSP_034704403 – 610AATSA…QNKKK → VLTYDDRGKLVHEGFTFSCY SRNPGKCLAFWRCSMYKKMH CTSALTTHIKSIKSIRGFHN HKPPERLKTFVPRVLDCPPR PHKEDY in isoform AA. 1 PublicationAdd BLAST208
Alternative sequenceiVSP_034705403 – 610AATSA…QNKKK → GVIQSLKALFEGKTTGASIQ YTTTQRGRVMLVYEGYRYVV NRQSLKNVFWRCSRYVKHSC RATLVTSKVQEVTLRIAGTP HTHAPEVSSMDLTTDLLDEF PELQ in isoform AB. CuratedAdd BLAST208
Alternative sequenceiVSP_010284403 – 610AATSA…QNKKK → VTFDVLTDPIVKPDQHQLMK RVRLSKSMEGVHYVRTPAGN VVLHCGEHRYLRNAAYKDKV YWKCSKWRKQCRSRVITHIL PNGQSRYAVSGVHNHP in isoform B. 1 PublicationAdd BLAST208
Alternative sequenceiVSP_050714403 – 610AATSA…QNKKK → DGPSKDTAIPKPAEHPRKPV TDSVQKSPRDADAIPLFDGS RVFVSKVALAKAYIPMPMIY TCRVMDLVIGKDKLVRIAQH EETTDKDLIQDIITHVCKVF ALRGNQLTPSAVQEFIDHKL STLKLMPIKEGK in isoform C. 2 PublicationsAdd BLAST208
Alternative sequenceiVSP_010285403 – 610AATSA…QNKKK → EFDYGHGQYRGNNPQIQFSV SKRGGQLLWLDGMKFFRNNI NRTNLYWRCHWYYRHTKCPV LICMSKTNSNDFRQIHDHCH IRPKRKENSGTGDGPKIRTP VVSNVRSLPQSMAHMFDM in isoform D. 1 PublicationAdd BLAST208
Alternative sequenceiVSP_050699403 – 610AATSA…QNKKK → VKIKMEPSPTPGHSSDAAVA ALAVTYLSDEESFRKPFTLP KLLDGKFYKNIQPNQKTPGA IQATCTTCHGLISGTTKSTG NFLSHIKRRHKELLPLCQLY CQAKANGTVPAVKSSPPNPN HVLTSATPTPAMEMMTQVAQ MPPTAAYATGPTHLGMPVTV PVPVSMSLAMPISLPHVQTP QMMALMQQHQAHGAVFISKD Y in isoform E. 2 PublicationsAdd BLAST208
Alternative sequenceiVSP_050704403 – 610AATSA…QNKKK → VVLANDEVPNPEDVLVFFTQ SLRGRPAIMANGIRFLIMSE NKKKILWRCSSMATKKLKCP ARITMLKETPPKFIINKAEH LHAELKRNKYSSSKAQTLRD PHQMATKLDCEMEGAGGVSF DLHEEELNELTHDV in isoform F. 1 PublicationAdd BLAST208
Alternative sequenceiVSP_050715403 – 610AATSA…QNKKK → ELAVFGTGQRGRTVLLFQNE KFVKNRCSASRTYWICSKKD VTVCRARVVTAVDKNSQERI IKCTYEHDHSRKFPSNNVNL PVLIKREKALSLDAS in isoform G. 1 PublicationAdd BLAST208
Alternative sequenceiVSP_050716403 – 610AATSA…QNKKK → DLGELNPSNLADFGNESFLP KTKGKRPQNVRCGLAPDQKC VRTLDDWDRIRYDRTRSGDV LVYDGYRYDRRANYNDIIYW GCAKKRLSCNVYMITHKNKP TYVAISGVHNHL in isoform H. 2 PublicationsAdd BLAST208
Alternative sequenceiVSP_050703403 – 610AATSA…QNKKK → VCDDLDDMKGAIKHSLLTFI RGQRGCKLLAFNGHNYVRNR RSNLKTYWICSKKGSTKCNA RVVTNVVEGVHKIVLESCHH TCLNTERKKRLSVTNVVGKA RSKSEKSVSTGFIKEEGDED LTLELRTLNLSIEDLNNLQ in isoform I. 1 PublicationAdd BLAST208
Alternative sequenceiVSP_050717403 – 610AATSA…QNKKK → GSVAYYSYITGFRGSRKLKI GEFSFTRNKTSGLKTYWSCA RAGVHKCKARVVTAQDHDVT IKCGQHNHPPY in isoform J. 1 PublicationAdd BLAST208
Alternative sequenceiVSP_050718403 – 610AATSA…QNKKK → GQFIGDIPRGQWIDKHEYFF LKNQKQGFNLVFNGYMYKKE ASFRATVNWICSDGNGKRLN ENKCSARAITKFDGGIKLGK NAHNHPPRFLGGKVPAKLMP KDAFYPQY in isoform K. 1 PublicationAdd BLAST208
Alternative sequenceiVSP_050720403 – 610AATSA…QNKKK → DRKRYSKKFLNFDGPAEFSL AAHRRPRLIIANKHFIVHRI LGKDNLIGSWRCMYHHKGCK ARATTFMVDSEVKYRSTCSS HNHKNVRSQQQSLKMPWVFT D in isoform M. 1 PublicationAdd BLAST208
Alternative sequenceiVSP_050700403 – 610AATSA…QNKKK → DTEISFIRSQKKNAQLVFRN YIYNKKLTQANGQTTWRCAD VLKLRCKAVVITRDGHFIDA RRQHNHESHASRIGQRQLYK VEQELEEYIEICTSNPKISQ YLGSSNIIVTAKDGKDCKLF LPAAEATEIEMQALVDAAEE ELDEEERHAEERIRDRQRVG RWRTEEAKHRSLLKSEHP in isoform N. 1 PublicationAdd BLAST208
Alternative sequenceiVSP_050702403 – 610AATSA…QNKKK → EDELVFIESPWSTPCLVLNG YMYNCHSRKSNKQYWRCHNY SKKAHEMRCRSRCVLENGRL KSVTGGLHNHQPHTEKIDKI IQRNKMAAIGTGRKLSRTHS FTQLQLQEQKQEFIDEHQLT SDAATLQLTDQELMHASMML MHE in isoform O. 1 PublicationAdd BLAST208
Alternative sequenceiVSP_050721403 – 610AATSA…QNKKK → GCDGLQGSCRDRGGQKLTGA NHQMHLRA in isoform Q. 1 PublicationAdd BLAST208
Alternative sequenceiVSP_050722403 – 610AATSA…QNKKK → GTSHLATFSCTRKKKRKLVI DRHEFVMDRKLKSSINWRCA RYRSSNCKVRATTHVQKNGL EVYRLKYAKHSHL in isoform R. 1 PublicationAdd BLAST208
Alternative sequenceiVSP_050723403 – 610AATSA…QNKKK → GLIFKAARHIAPIQKVRQVR DDKFLATIIKLEPAGRLNLK NPDNIIRTSSNEHNFVYVGL PRMKGKCVNCLKKNRTGLRR INTLCNTCPGSNWMCEPCFE ELHS in isoform S. 1 PublicationAdd BLAST208
Alternative sequenceiVSP_010286404 – 610ATSAS…QNKKK → CYQLVPNRRGGKNLIFQGHM YSVERKYRNSINWVCSKNSN SVLRCPARCVTNPESGNGIK LSHRRHNHPADAFKPHKRCR KRPGDRK in isoform 53.6. 2 PublicationsAdd BLAST207
Alternative sequenceiVSP_034706404 – 610ATSAS…QNKKK → FHIDFADSKKNGGKLLVING FRFFRNKKRGHLQYWKCRNY YKERCPAIAIHDESTLILRL CHQHQHTESNDIEIKPLPGS ETKLAESAEDEAQAEPEAEL DNETDPDTNHEPARVPPLIM EPPPLLEIKSKLRNQDF in isoform AC. CuratedAdd BLAST207
Alternative sequenceiVSP_050719404 – 610ATSAS…QNKKK → KDQNKGVLLKRTAQGEFLVV NGKSYKKTRAMQYRTYFHCL TRNCPTYYVLVELSRRPRLT RHHEHAQHCLQCY in isoform L. 1 PublicationAdd BLAST207
Alternative sequenceiVSP_050705404 – 610ATSAS…QNKKK → KFDYQISVDVGEATMQLANA SSAGVVNSNSPFFIVSKYGT KQIMLKQHTFNRHICRDDVT YWRCSQFAVLRCRARLKTKL DTLTILNSEHNHEVITKARK YGSLKRQRAEAEAAARAERR QDPLETAATSAPATTT in isoform P. 3 PublicationsAdd BLAST207
Alternative sequenceiVSP_010289459 – 610GVKLI…QNKKK → DPTRPQLWSSDVPDQPQATL LTINNFVYRANLKFFGKSNN ILYWECVKTDRLSAAVALKT IGDDLYVTNGSYSAVSKCKG HLMASFHLQMCTITWATTSV LRRPRRLDADPQEVEFPHSR RQNPGFLENGHRGQPRPSAQ DVAASILPTQTFVFC in isoform mod1.8. 1 PublicationAdd BLAST152

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X75498 Genomic DNA Translation: CAA53215.1
X75499 mRNA Translation: CAA53216.1
U30905 mRNA Translation: AAA82988.1
U30913 mRNA Translation: AAA82989.1
U30914 mRNA Translation: AAA82990.1 Sequence problems.
U62802 mRNA Translation: AAC17459.1
AJ277174 mRNA Translation: CAB85469.1
AJ277175 mRNA Translation: CAB85470.1
AJ277176 mRNA Translation: CAB85471.1
AJ277177 mRNA Translation: CAB85472.1
AJ277178 mRNA Translation: CAB85473.1
AJ277179 mRNA Translation: CAB85474.1
AJ277180 mRNA Translation: CAB85475.1
AJ277181 mRNA Translation: CAB85476.1
AJ277182 mRNA Translation: CAB85477.1
AJ277183 mRNA Translation: CAB85478.1
AJ277184 mRNA Translation: CAB85479.1
AJ277185 mRNA Translation: CAB85480.1
AJ277186 mRNA Translation: CAB85481.1
AJ277187 mRNA Translation: CAB85482.1
AJ277188 mRNA Translation: CAB85483.1
AJ277189 mRNA Translation: CAB85484.1
AJ277190 mRNA Translation: CAB85485.1
AJ277191 mRNA Translation: CAB85486.1
AJ277192 mRNA Translation: CAB85487.1
AJ277193 mRNA Translation: CAB85488.1
AJ277194 mRNA Translation: CAB85489.1
AJ320161 mRNA Translation: CAC51387.1
AJ320162 mRNA Translation: CAC51487.1
AJ320163 mRNA Translation: CAC51488.1
AJ320164 mRNA Translation: CAC51489.1
AJ320165 mRNA Translation: CAC51388.1
AE014297 Genomic DNA Translation: AAF55882.2
AE014297 Genomic DNA Translation: AAF55883.2
AE014297 Genomic DNA Translation: AAF55884.1
AE014297 Genomic DNA Translation: AAF55885.2
AE014297 Genomic DNA Translation: AAF55888.1
AE014297 Genomic DNA Translation: AAN13862.1
AE014297 Genomic DNA Translation: AAN13863.1
AE014297 Genomic DNA Translation: AAN13864.1
AE014297 Genomic DNA Translation: AAN13865.1
AE014297 Genomic DNA Translation: AAN13866.1
AE014297 Genomic DNA Translation: AAN13867.1
AE014297 Genomic DNA Translation: AAN13868.1
AE014297 Genomic DNA Translation: AAN13869.1
AE014297 Genomic DNA Translation: AAN13870.1 Different initiation.
AE014297 Genomic DNA Translation: AAN13871.1
AE014297 Genomic DNA Translation: AAN13872.1
AE014297 Genomic DNA Translation: AAN13873.1
AE014297 Genomic DNA Translation: AAN13874.1
AE014297 Genomic DNA Translation: AAN13875.1
AE014297 Genomic DNA Translation: AAO41581.1
AE014297 Genomic DNA Translation: AAO41582.1
AE014297 Genomic DNA Translation: AAO41583.1
AE014297 Genomic DNA Translation: ABW08718.1
AE014297 Genomic DNA Translation: ABW08719.1
AE014297 Genomic DNA Translation: ABW08720.1
AY061580 mRNA Translation: AAL29128.1 Sequence problems.
BT003484 mRNA Translation: AAO39487.1
BT003579 mRNA Translation: AAO39583.1
BT029698 mRNA Translation: ABL75755.1
AF214648 Genomic DNA Translation: AAL33873.1
AF214649 Genomic DNA Translation: AAL33874.1
AF214650 Genomic DNA Translation: AAL33875.1

NCBI Reference Sequences

More...
RefSeqi
NP_001097856.1, NM_001104386.2 [Q86B87-29]
NP_001097857.1, NM_001104387.2 [Q86B87-31]
NP_001097858.1, NM_001104388.2 [Q86B87-30]
NP_524936.2, NM_080197.3 [Q86B87-8]
NP_732619.1, NM_163877.2 [Q86B87-20]
NP_732620.1, NM_163878.2 [Q86B87-17]
NP_732621.1, NM_163879.2 [Q86B87-24]
NP_732622.1, NM_163880.2 [Q86B87-15]
NP_732623.2, NM_163881.2
NP_732624.1, NM_163882.2 [Q86B87-10]
NP_732625.1, NM_163883.2 [Q86B87-27]
NP_732626.1, NM_163884.2 [Q86B87-6]
NP_732627.1, NM_163885.2 [Q86B87-19]
NP_732628.1, NM_163886.2 [Q86B87-7]
NP_732629.1, NM_163887.2 [Q86B87-18]
NP_732630.1, NM_163888.2 [Q86B87-11]
NP_732631.1, NM_163889.2 [Q86B87-14]
NP_732632.1, NM_163890.2 [Q86B87-2]
NP_732633.1, NM_163891.2 [Q86B87-9]
NP_732634.1, NM_163892.2 [Q86B87-12]
NP_732635.1, NM_163893.2 [Q86B87-5]
NP_732636.1, NM_163894.2 [Q86B87-3]
NP_788698.1, NM_176521.1 [Q86B87-1]
NP_788699.1, NM_176522.1 [Q86B87-25]
NP_788700.1, NM_176523.1 [Q86B87-23]
NP_788701.1, NM_176524.1 [Q86B87-28]
NP_788702.1, NM_176525.1 [Q86B87-13]
NP_788703.1, NM_176526.1 [Q86B87-4]
NP_788704.1, NM_176527.1 [Q86B87-16]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0084060; FBpp0083459; FBgn0002781 [Q86B87-17]
FBtr0084061; FBpp0083460; FBgn0002781 [Q86B87-27]
FBtr0084062; FBpp0083461; FBgn0002781 [Q86B87-9]
FBtr0084063; FBpp0083462; FBgn0002781 [Q86B87-24]
FBtr0084064; FBpp0083463; FBgn0002781 [Q86B87-2]
FBtr0084065; FBpp0083464; FBgn0002781 [Q86B87-8]
FBtr0084066; FBpp0083465; FBgn0002781 [Q86B87-15]
FBtr0084067; FBpp0083466; FBgn0002781 [Q86B87-10]
FBtr0084068; FBpp0083467; FBgn0002781 [Q86B87-6]
FBtr0084069; FBpp0083468; FBgn0002781 [Q86B87-19]
FBtr0084070; FBpp0083469; FBgn0002781 [Q86B87-11]
FBtr0084071; FBpp0083470; FBgn0002781 [Q86B87-18]
FBtr0084072; FBpp0083471; FBgn0002781 [Q86B87-14]
FBtr0084073; FBpp0083472; FBgn0002781 [Q86B87-3]
FBtr0084074; FBpp0083473; FBgn0002781 [Q86B87-5]
FBtr0084075; FBpp0083474; FBgn0002781 [Q86B87-7]
FBtr0084077; FBpp0083476; FBgn0002781 [Q86B87-20]
FBtr0084078; FBpp0083477; FBgn0002781 [Q86B87-12]
FBtr0084079; FBpp0083478; FBgn0002781 [Q86B87-1]
FBtr0084080; FBpp0083479; FBgn0002781 [Q86B87-16]
FBtr0084081; FBpp0083480; FBgn0002781 [Q86B87-4]
FBtr0084082; FBpp0083481; FBgn0002781 [Q86B87-13]
FBtr0084083; FBpp0083482; FBgn0002781 [Q86B87-28]
FBtr0084084; FBpp0083483; FBgn0002781 [Q86B87-23]
FBtr0084085; FBpp0083484; FBgn0002781 [Q86B87-25]
FBtr0114359; FBpp0112908; FBgn0002781 [Q86B87-29]
FBtr0114360; FBpp0112909; FBgn0002781 [Q86B87-31]
FBtr0114361; FBpp0112910; FBgn0002781 [Q86B87-30]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
49228

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG32491

UCSC genome browser

More...
UCSCi
CG32491-RAA, d. melanogaster
CG32491-RAB, d. melanogaster
CG32491-RAC, d. melanogaster

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75498 Genomic DNA Translation: CAA53215.1
X75499 mRNA Translation: CAA53216.1
U30905 mRNA Translation: AAA82988.1
U30913 mRNA Translation: AAA82989.1
U30914 mRNA Translation: AAA82990.1 Sequence problems.
U62802 mRNA Translation: AAC17459.1
AJ277174 mRNA Translation: CAB85469.1
AJ277175 mRNA Translation: CAB85470.1
AJ277176 mRNA Translation: CAB85471.1
AJ277177 mRNA Translation: CAB85472.1
AJ277178 mRNA Translation: CAB85473.1
AJ277179 mRNA Translation: CAB85474.1
AJ277180 mRNA Translation: CAB85475.1
AJ277181 mRNA Translation: CAB85476.1
AJ277182 mRNA Translation: CAB85477.1
AJ277183 mRNA Translation: CAB85478.1
AJ277184 mRNA Translation: CAB85479.1
AJ277185 mRNA Translation: CAB85480.1
AJ277186 mRNA Translation: CAB85481.1
AJ277187 mRNA Translation: CAB85482.1
AJ277188 mRNA Translation: CAB85483.1
AJ277189 mRNA Translation: CAB85484.1
AJ277190 mRNA Translation: CAB85485.1
AJ277191 mRNA Translation: CAB85486.1
AJ277192 mRNA Translation: CAB85487.1
AJ277193 mRNA Translation: CAB85488.1
AJ277194 mRNA Translation: CAB85489.1
AJ320161 mRNA Translation: CAC51387.1
AJ320162 mRNA Translation: CAC51487.1
AJ320163 mRNA Translation: CAC51488.1
AJ320164 mRNA Translation: CAC51489.1
AJ320165 mRNA Translation: CAC51388.1
AE014297 Genomic DNA Translation: AAF55882.2
AE014297 Genomic DNA Translation: AAF55883.2
AE014297 Genomic DNA Translation: AAF55884.1
AE014297 Genomic DNA Translation: AAF55885.2
AE014297 Genomic DNA Translation: AAF55888.1
AE014297 Genomic DNA Translation: AAN13862.1
AE014297 Genomic DNA Translation: AAN13863.1
AE014297 Genomic DNA Translation: AAN13864.1
AE014297 Genomic DNA Translation: AAN13865.1
AE014297 Genomic DNA Translation: AAN13866.1
AE014297 Genomic DNA Translation: AAN13867.1
AE014297 Genomic DNA Translation: AAN13868.1
AE014297 Genomic DNA Translation: AAN13869.1
AE014297 Genomic DNA Translation: AAN13870.1 Different initiation.
AE014297 Genomic DNA Translation: AAN13871.1
AE014297 Genomic DNA Translation: AAN13872.1
AE014297 Genomic DNA Translation: AAN13873.1
AE014297 Genomic DNA Translation: AAN13874.1
AE014297 Genomic DNA Translation: AAN13875.1
AE014297 Genomic DNA Translation: AAO41581.1
AE014297 Genomic DNA Translation: AAO41582.1
AE014297 Genomic DNA Translation: AAO41583.1
AE014297 Genomic DNA Translation: ABW08718.1
AE014297 Genomic DNA Translation: ABW08719.1
AE014297 Genomic DNA Translation: ABW08720.1
AY061580 mRNA Translation: AAL29128.1 Sequence problems.
BT003484 mRNA Translation: AAO39487.1
BT003579 mRNA Translation: AAO39583.1
BT029698 mRNA Translation: ABL75755.1
AF214648 Genomic DNA Translation: AAL33873.1
AF214649 Genomic DNA Translation: AAL33874.1
AF214650 Genomic DNA Translation: AAL33875.1
RefSeqiNP_001097856.1, NM_001104386.2 [Q86B87-29]
NP_001097857.1, NM_001104387.2 [Q86B87-31]
NP_001097858.1, NM_001104388.2 [Q86B87-30]
NP_524936.2, NM_080197.3 [Q86B87-8]
NP_732619.1, NM_163877.2 [Q86B87-20]
NP_732620.1, NM_163878.2 [Q86B87-17]
NP_732621.1, NM_163879.2 [Q86B87-24]
NP_732622.1, NM_163880.2 [Q86B87-15]
NP_732623.2, NM_163881.2
NP_732624.1, NM_163882.2 [Q86B87-10]
NP_732625.1, NM_163883.2 [Q86B87-27]
NP_732626.1, NM_163884.2 [Q86B87-6]
NP_732627.1, NM_163885.2 [Q86B87-19]
NP_732628.1, NM_163886.2 [Q86B87-7]
NP_732629.1, NM_163887.2 [Q86B87-18]
NP_732630.1, NM_163888.2 [Q86B87-11]
NP_732631.1, NM_163889.2 [Q86B87-14]
NP_732632.1, NM_163890.2 [Q86B87-2]
NP_732633.1, NM_163891.2 [Q86B87-9]
NP_732634.1, NM_163892.2 [Q86B87-12]
NP_732635.1, NM_163893.2 [Q86B87-5]
NP_732636.1, NM_163894.2 [Q86B87-3]
NP_788698.1, NM_176521.1 [Q86B87-1]
NP_788699.1, NM_176522.1 [Q86B87-25]
NP_788700.1, NM_176523.1 [Q86B87-23]
NP_788701.1, NM_176524.1 [Q86B87-28]
NP_788702.1, NM_176525.1 [Q86B87-13]
NP_788703.1, NM_176526.1 [Q86B87-4]
NP_788704.1, NM_176527.1 [Q86B87-16]

3D structure databases

SMRiQ86B87
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi72097, 78 interactors
IntActiQ86B87, 32 interactors
MINTiQ86B87
STRINGi7227.FBpp0083463

PTM databases

iPTMnetiQ86B87

Proteomic databases

PaxDbiQ86B87
PeptideAtlasiQ86B87

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
49228

Genome annotation databases

EnsemblMetazoaiFBtr0084060; FBpp0083459; FBgn0002781 [Q86B87-17]
FBtr0084061; FBpp0083460; FBgn0002781 [Q86B87-27]
FBtr0084062; FBpp0083461; FBgn0002781 [Q86B87-9]
FBtr0084063; FBpp0083462; FBgn0002781 [Q86B87-24]
FBtr0084064; FBpp0083463; FBgn0002781 [Q86B87-2]
FBtr0084065; FBpp0083464; FBgn0002781 [Q86B87-8]
FBtr0084066; FBpp0083465; FBgn0002781 [Q86B87-15]
FBtr0084067; FBpp0083466; FBgn0002781 [Q86B87-10]
FBtr0084068; FBpp0083467; FBgn0002781 [Q86B87-6]
FBtr0084069; FBpp0083468; FBgn0002781 [Q86B87-19]
FBtr0084070; FBpp0083469; FBgn0002781 [Q86B87-11]
FBtr0084071; FBpp0083470; FBgn0002781 [Q86B87-18]
FBtr0084072; FBpp0083471; FBgn0002781 [Q86B87-14]
FBtr0084073; FBpp0083472; FBgn0002781 [Q86B87-3]
FBtr0084074; FBpp0083473; FBgn0002781 [Q86B87-5]
FBtr0084075; FBpp0083474; FBgn0002781 [Q86B87-7]
FBtr0084077; FBpp0083476; FBgn0002781 [Q86B87-20]
FBtr0084078; FBpp0083477; FBgn0002781 [Q86B87-12]
FBtr0084079; FBpp0083478; FBgn0002781 [Q86B87-1]
FBtr0084080; FBpp0083479; FBgn0002781 [Q86B87-16]
FBtr0084081; FBpp0083480; FBgn0002781 [Q86B87-4]
FBtr0084082; FBpp0083481; FBgn0002781 [Q86B87-13]
FBtr0084083; FBpp0083482; FBgn0002781 [Q86B87-28]
FBtr0084084; FBpp0083483; FBgn0002781 [Q86B87-23]
FBtr0084085; FBpp0083484; FBgn0002781 [Q86B87-25]
FBtr0114359; FBpp0112908; FBgn0002781 [Q86B87-29]
FBtr0114360; FBpp0112909; FBgn0002781 [Q86B87-31]
FBtr0114361; FBpp0112910; FBgn0002781 [Q86B87-30]
GeneIDi49228
KEGGidme:Dmel_CG32491
UCSCiCG32491-RAA, d. melanogaster
CG32491-RAB, d. melanogaster
CG32491-RAC, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
49228
FlyBaseiFBgn0002781, mod(mdg4)
VEuPathDBiVectorBase:FBgn0002781

Phylogenomic databases

eggNOGiENOG502S6BI, Eukaryota
HOGENOMiCLU_1514257_0_0_1
InParanoidiQ86B87
OMAiRYDESYF

Enzyme and pathway databases

SignaLinkiQ86B87

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
49228, 2 hits in 3 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
mod(mdg4), fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
49228

Protein Ontology

More...
PROi
PR:Q86B87

Gene expression databases

BgeeiFBgn0002781, Expressed in embryo and 59 other tissues
ExpressionAtlasiQ86B87, baseline and differential
GenevisibleiQ86B87, DM

Family and domain databases

Gene3Di3.30.710.10, 1 hit
InterProiView protein in InterPro
IPR000210, BTB/POZ_dom
IPR011333, SKP1/BTB/POZ_sf
IPR007588, Znf_FLYWCH
PfamiView protein in Pfam
PF00651, BTB, 1 hit
PF04500, FLYWCH, 1 hit
SMARTiView protein in SMART
SM00225, BTB, 1 hit
SUPFAMiSSF54695, SSF54695, 1 hit
PROSITEiView protein in PROSITE
PS50097, BTB, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMMD4_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86B87
Secondary accession number(s): A1A725
, A8JR64, A8JR66, P91932, Q24099, Q24100, Q24101, Q24482, Q24483, Q86B84, Q86B85, Q86B86, Q8IN28, Q8IN29, Q8IN30, Q8IN31, Q8IN32, Q8IN33, Q8IN34, Q8WTI9, Q8WTJ0, Q8WTJ1, Q95R78, Q95ZF4, Q95ZF5, Q95ZF6, Q95ZF7, Q95ZF8, Q9N6U6, Q9N6U7, Q9N6U8, Q9N6U9, Q9N6V0, Q9N6V1, Q9N6V2, Q9N6V3, Q9N6V4, Q9N6V5, Q9N6V6, Q9N6V7, Q9N6V8, Q9N6V9, Q9N6W0, Q9N6W1, Q9N6W2, Q9N6W3, Q9N6W4, Q9N6W5, Q9VDA9, Q9VDB2, Q9VDB3, Q9VDB4, Q9VDB5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: June 1, 2003
Last modified: September 29, 2021
This is version 161 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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