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Entry version 150 (11 Dec 2019)
Sequence version 2 (26 Jun 2013)
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Protein
Submitted name:

Uncharacterized protein

Gene

CG8473

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi471 – 478ATPPROSITE-ProRule annotation8
Nucleotide bindingi1281 – 1288ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolaseImported
LigandATP-bindingPROSITE-ProRule annotation, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-1369062 ABC transporters in lipid homeostasis
R-DME-5683826 Surfactant metabolism

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
CBM14 Carbohydrate-Binding Module Family 14

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported (EC:3.6.1.3Imported, EC:3.6.3.-Imported)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CG8473Imported
Synonyms:CG33173Imported, Dmel\CG43672Imported
ORF Names:CG43672Imported, Dmel_CG43672Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0263747 CG43672

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei183 – 204HelicalSequence analysisAdd BLAST22
Transmembranei225 – 247HelicalSequence analysisAdd BLAST23
Transmembranei263 – 286HelicalSequence analysisAdd BLAST24
Transmembranei293 – 310HelicalSequence analysisAdd BLAST18
Transmembranei322 – 340HelicalSequence analysisAdd BLAST19
Transmembranei368 – 391HelicalSequence analysisAdd BLAST24
Transmembranei963 – 982HelicalSequence analysisAdd BLAST20
Transmembranei994 – 1013HelicalSequence analysisAdd BLAST20
Transmembranei1019 – 1038HelicalSequence analysisAdd BLAST20
Transmembranei1045 – 1069HelicalSequence analysisAdd BLAST25
Transmembranei1075 – 1093HelicalSequence analysisAdd BLAST19
Transmembranei1167 – 1188HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q86B52

PRoteomics IDEntifications database

More...
PRIDEi
Q86B52

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0263747 Expressed in 3 organ(s), highest expression level in material anatomical entity

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q86B52 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q86B52, 6 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0302542

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini438 – 668ABC transporterInterPro annotationAdd BLAST231
Domaini1249 – 1479ABC transporterInterPro annotationAdd BLAST231

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili704 – 724Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0059 Eukaryota
COG1131 LUCA
COG4152 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00980000199064

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q86B52

Identification of Orthologs from Complete Genome Data

More...
OMAi
HIDFMVN

Database of Orthologous Groups

More...
OrthoDBi
131191at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR003439 ABC_transporter-like
IPR026082 ABCA
IPR027417 P-loop_NTPase

The PANTHER Classification System

More...
PANTHERi
PTHR19229 PTHR19229, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00005 ABC_tran, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50893 ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q86B52-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASKQRNFTT NVFIPDIRVA FAPNSNAALR RLMGDALGKL SMSEDKIVDF
60 70 80 90 100
ENCNDMRIHA ASEHYLASVC FRNVDESLNG LPTVLNFAII MPSELRNYED
110 120 130 140 150
TWIGDSWKET TTLMDRDVAE EDEFDEDGYT DYMGEGFVPL QYHISMQFLR
160 170 180 190 200
ATASKVEKLP KVVMRRFNEN PNVLLSEGIG TSVVLLILLG FMFPVTILTT
210 220 230 240 250
LIVEERELGQ RYMLKILNAS ATLQMAAWFF NVFTHFLITS LLITILLKIE
260 270 280 290 300
WNGATAAVNK CPWPILLCFL ISYGCSVTSL IILMTSAMRR SRVAMVMAPI
310 320 330 340 350
IWILLALPLL SKKELLSDGP DVFYGFATVL LCNVSFSRGL SKIFYIEDYT
360 370 380 390 400
LGVTIGKYMF YRVSKSDFGI FVPIVCFYVQ TIFCTLLAMI FENNAYFWLA
410 420 430 440 450
IRVKNLLKKY HATRSAVGRL KRQIPEVSFS KTSAEALIEF RGVWQKYSNS
460 470 480 490 500
TYVVQDITLN VYAGEVVALL GHNASGKSTI IKMLYGRTRP KLGEIYLSGF
510 520 530 540 550
NIVTQRKEAL KNSSISMSYK TLFTELVVLD HLVFLSRLRG LSKTEAKLEA
560 570 580 590 600
KALLRYLKLE DWEKTLVNDL TIGQRRVLQF LCAFAGGNQI VILDKPFDGI
610 620 630 640 650
DEQRTSLFYS LILDQKKNRS IFFTSNNQKV ASGIADRIFV LSKGKLQAFG
660 670 680 690 700
TVKKLCRMLN ESYRLIIFGN EKCSFKDVYA FMATFIPEIE MDSILADCAS
710 720 730 740 750
FLVKHKYHTE LINLIENLAR LKNDLNVYSF EIHECSIDDI LASLYTRDKS
760 770 780 790 800
TLEFGQPGLQ TLLASRQQSA KRRFIIPTMY LLEELRQLLI ADTRNWFLPI
810 820 830 840 850
LKLTLPSLVV VWTLSMPYFW HNCRQPGHIT FPMSDHGDGI ILMQKDTLDS
860 870 880 890 900
ELLVASEMYA KVGVTEVDKT VDITTFIYNY EYKNSLLSDA DIMEAVIFSN
910 920 930 940 950
VQIEVLFNTK WPHTAPDSLA QALNSLAVAF IDGDAGIKVE LEVLPFSTIH
960 970 980 990 1000
TLQLHLNIDG YDLIFASCLS FCFCFIWSIP LLHMTLSRDG RYNYVELIAG
1010 1020 1030 1040 1050
MPTIVLIVAF LIYELLVVLL ALFPINIAVI FFHWDLLMDS NIHIYSVYVM
1060 1070 1080 1090 1100
FIIAACVFSL NILITIMPIS DMPFVYLKVL LAYSLGILVY IAVKELRPFT
1110 1120 1130 1140 1150
NPNTAHFLLL DFHPFYALLH NLMRIASISE KIWLCSDRQI YETSVYADQC
1160 1170 1180 1190 1200
NTIPNCCDDD AQEFYHLRYL CCVYLLLVVV WISIFIFLKS HMVKRRPRQP
1210 1220 1230 1240 1250
KYFWDSDPDS KYDQNILHIM EPSELENTWI HEKSRVSTLE RNHIESKALH
1260 1270 1280 1290 1300
VEHLSVFFGL KAAIKHIDFM VNRYQVMSVF GANGTGKSVL LKTILGIYTP
1310 1320 1330 1340 1350
SSGRIISSKT VPFKSKDLDS CHMVGYSAQE FQTMQLMTIL ETWDLILRIR
1360 1370 1380 1390 1400
RSKQISFRAE ATKLCKIFGL YKYRFNSLSI CSQGVLKRLS LGIALMSDAE
1410 1420 1430 1440 1450
LILLDDPFTH LDIVSQRSML HIIHDLRRRG HSIIYTCSDT AYSTPALRMA
1460 1470 1480 1490 1500
TLSYPGIAVI GEREEMQQNY YSSYYMVETR IHLAELGSPI DFDSQSTEAK
1510 1520 1530 1540 1550
EDRAGTTGTL LRHKHQEFSA AFTDSADRWK YLKLCGVIEN VFPHAIIKNV
1560 1570 1580 1590 1600
SFPRVCFWLS SHMYPMSRIV DTLHRNKQDF YSFSVSQPSV NSVFLSIHRQ

KSNKDAFPY
Length:1,609
Mass (Da):184,094
Last modified:June 26, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i03E441FCC6F72047
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014298 Genomic DNA Translation: AAO41659.2

NCBI Reference Sequences

More...
RefSeqi
NP_788912.2, NM_176739.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0310394; FBpp0302542; FBgn0263747

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
318910

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG43672

UCSC genome browser

More...
UCSCi
CG33173-RA d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA Translation: AAO41659.2
RefSeqiNP_788912.2, NM_176739.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ86B52, 6 interactors
STRINGi7227.FBpp0302542

Protein family/group databases

CAZyiCBM14 Carbohydrate-Binding Module Family 14

Proteomic databases

PaxDbiQ86B52
PRIDEiQ86B52

Genome annotation databases

EnsemblMetazoaiFBtr0310394; FBpp0302542; FBgn0263747
GeneIDi318910
KEGGidme:Dmel_CG43672
UCSCiCG33173-RA d. melanogaster

Organism-specific databases

FlyBaseiFBgn0263747 CG43672

Phylogenomic databases

eggNOGiKOG0059 Eukaryota
COG1131 LUCA
COG4152 LUCA
GeneTreeiENSGT00980000199064
InParanoidiQ86B52
OMAiHIDFMVN
OrthoDBi131191at2759

Enzyme and pathway databases

ReactomeiR-DME-1369062 ABC transporters in lipid homeostasis
R-DME-5683826 Surfactant metabolism

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
318910

Gene expression databases

BgeeiFBgn0263747 Expressed in 3 organ(s), highest expression level in material anatomical entity
GenevisibleiQ86B52 DM

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003439 ABC_transporter-like
IPR026082 ABCA
IPR027417 P-loop_NTPase
PANTHERiPTHR19229 PTHR19229, 1 hit
PfamiView protein in Pfam
PF00005 ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS50893 ABC_TRANSPORTER_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ86B52_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q86B52
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 26, 2013
Last modified: December 11, 2019
This is version 150 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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