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Protein

Tryptophan--tRNA ligase, mitochondrial

Gene

wars2

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei21ATPBy similarity1
Binding sitei181L-tryptophanBy similarity1
Binding sitei245ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi28 – 31ATPBy similarity4
Nucleotide bindingi193 – 195ATPBy similarity3
Nucleotide bindingi242 – 246ATPBy similarity5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligase, mitochondrial (EC:6.1.1.2)
Alternative name(s):
Tryptophanyl-tRNA synthetase
Short name:
TrpRS
Gene namesi
Name:wars2
Synonyms:mtrpS
ORF Names:DDB_G0274567
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 2, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0274567 mtrpS

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000327720? – 377Tryptophan--tRNA ligase, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

PaxDbiQ86A90

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0231246

Structurei

3D structure databases

ProteinModelPortaliQ86A90
SMRiQ86A90
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi22 – 31"HIGH" region10
Motifi242 – 246"KMSKS" region5

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2713 Eukaryota
COG0180 LUCA
InParanoidiQ86A90
KOiK01867
OMAiQRMTQFK
PhylomeDBiQ86A90

Family and domain databases

CDDicd00806 TrpRS_core, 1 hit
Gene3Di3.40.50.620, 3 hits
HAMAPiMF_00140_B Trp_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR002305 aa-tRNA-synth_Ic
IPR014729 Rossmann-like_a/b/a_fold
IPR002306 Trp-tRNA-ligase
IPR024109 Trp-tRNA-ligase_bac-type
PfamiView protein in Pfam
PF00579 tRNA-synt_1b, 2 hits
PRINTSiPR01039 TRNASYNTHTRP
TIGRFAMsiTIGR00233 trpS, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q86A90-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIDEVNFKD KTKVTVFSGM QPTSSALHLG NYLGAMGNWL KIQDLVTKNN
60 70 80 90 100
KEEEELLNLS ESSSSSSSSQ STKINEKHKL IFSIVDLHSL TSTKSLSPKE
110 120 130 140 150
LQSNTISVAI NYLACGIDPE KVILFNQSMV PAHSELTWIL NCITSFSKLS
160 170 180 190 200
NMIQFKEKTK SSNEASVSNG LLSYPVLMAA DILLYKATHV PVGEDQTQHL
210 220 230 240 250
EFTRDIAQAF HSNFKSKFFP YPSIITSEQS KRIMSLQDGR LKMSKSDPLE
260 270 280 290 300
ISRISLTDTD DQIKLKIKKS KTDTIIGITY DPINRPDISN LLSIASETSG
310 320 330 340 350
IPITDLQSEF KDKSNAIFKE FLSNSIIKNI SPIREKINYY QSNPKLVRDI
360 370
LLQGSEKANK IANKNLNIIK DIVGLYH
Length:377
Mass (Da):42,215
Last modified:June 1, 2003 - v1
Checksum:iA531E956E586AD18
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000012 Genomic DNA Translation: EAL70176.1
RefSeqiXP_643957.1, XM_638865.1

Genome annotation databases

EnsemblProtistsiEAL70176; EAL70176; DDB_G0274567
GeneIDi8619385
KEGGiddi:DDB_G0274567

Similar proteinsi

Entry informationi

Entry nameiSYWM_DICDI
AccessioniPrimary (citable) accession number: Q86A90
Secondary accession number(s): Q555V3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: June 1, 2003
Last modified: March 28, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  3. SIMILARITY comments
    Index of protein domains and families

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