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UniProtKB - Q869W9 (PKS16_DICDI)
Protein
Probable polyketide synthase 16
Gene
pks16
Organism
Dictyostelium discoideum (Slime mold)
Status
Functioni
Probable polyketide synthase.
By similarityMiscellaneous
Encoded by one of the numerous copies of polyketide synthase genes and clustered as a pair pks16/pks17 in chromosome 2.
Cofactori
pantetheine 4'-phosphateBy similarityNote: Binds 1 phosphopantetheine covalently.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 179 | For beta-ketoacyl synthase activityPROSITE-ProRule annotation | 1 | |
Active sitei | 641 | For acyl/malonyl transferase activityPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- 3-oxoacyl-[acyl-carrier-protein] synthase activity Source: InterPro
- fatty acid synthase activity Source: GO_Central
- oxidoreductase activity Source: InterPro
GO - Biological processi
- fatty acid biosynthetic process Source: GO_Central
- sexual reproduction Source: dictyBase
Keywordsi
Molecular function | Transferase |
Enzyme and pathway databases
Reactomei | R-DDI-163765, ChREBP activates metabolic gene expression R-DDI-199220, Vitamin B5 (pantothenate) metabolism R-DDI-75105, Fatty acyl-CoA biosynthesis |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:pks16 ORF Names:DDB_G0275069 |
Organismi | Dictyostelium discoideum (Slime mold) |
Taxonomic identifieri | 44689 [NCBI] |
Taxonomic lineagei | Eukaryota › Amoebozoa › Evosea › Eumycetozoa › Dictyostelia › Dictyosteliales › Dictyosteliaceae › Dictyostelium |
Proteomesi |
|
Organism-specific databases
dictyBasei | DDB_G0275069, pks16 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000371381 | 1 – 2603 | Probable polyketide synthase 16Add BLAST | 2603 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2543 | O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation | 1 |
Keywords - PTMi
Phosphopantetheine, PhosphoproteinProteomic databases
PaxDbi | Q869W9 |
PRIDEi | Q869W9 |
Expressioni
Inductioni
Up-regulated by P.aeruginosa, PAO1 strain and PA14 strain infection and down-regulated by phagocytic stimuli and growth on bacteria.2 Publications
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2506 – 2583 | CarrierPROSITE-ProRule annotationAdd BLAST | 78 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 160 – 213 | Beta-ketoacyl synthaseAdd BLAST | 54 | |
Regioni | 631 – 664 | Acyl/malonyl transferasesAdd BLAST | 34 | |
Regioni | 1358 – 1407 | DisorderedSequence analysisAdd BLAST | 50 | |
Regioni | 2580 – 2603 | DisorderedSequence analysisAdd BLAST | 24 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1360 – 1407 | Polar residuesSequence analysisAdd BLAST | 48 |
Domaini
Modular protein that is responsible for the completion of one condensation-processing cycle. The beta-ketoacyl synthase region is responsible for the actual condensation reaction while the acyl/malonyl transferase region is responsible for incorporating carboxylic acids units onto an acyl carrier protein (ACP) domain (By similarity).By similarity
Phylogenomic databases
eggNOGi | KOG1202, Eukaryota |
HOGENOMi | CLU_000022_31_5_1 |
InParanoidi | Q869W9 |
OMAi | TFRWEED |
PhylomeDBi | Q869W9 |
Family and domain databases
Gene3Di | 1.10.1200.10, 1 hit 3.10.129.110, 1 hit 3.40.366.10, 1 hit 3.40.47.10, 1 hit |
InterProi | View protein in InterPro IPR001227, Ac_transferase_dom_sf IPR036736, ACP-like_sf IPR014043, Acyl_transferase IPR016035, Acyl_Trfase/lysoPLipase IPR011032, GroES-like_sf IPR018201, Ketoacyl_synth_AS IPR014031, Ketoacyl_synth_C IPR014030, Ketoacyl_synth_N IPR016036, Malonyl_transacylase_ACP-bd IPR036291, NAD(P)-bd_dom_sf IPR032821, PKS_assoc IPR020841, PKS_Beta-ketoAc_synthase_dom IPR020807, PKS_dehydratase IPR042104, PKS_dehydratase_sf IPR020843, PKS_ER IPR013968, PKS_KR IPR009081, PP-bd_ACP IPR029063, SAM-dependent_MTases IPR016039, Thiolase-like |
Pfami | View protein in Pfam PF00698, Acyl_transf_1, 1 hit PF16197, KAsynt_C_assoc, 1 hit PF00109, ketoacyl-synt, 1 hit PF02801, Ketoacyl-synt_C, 1 hit PF08659, KR, 1 hit PF00550, PP-binding, 1 hit PF14765, PS-DH, 1 hit |
SMARTi | View protein in SMART SM00827, PKS_AT, 1 hit SM00829, PKS_ER, 1 hit SM00825, PKS_KS, 1 hit |
SUPFAMi | SSF47336, SSF47336, 1 hit SSF50129, SSF50129, 1 hit SSF51735, SSF51735, 2 hits SSF52151, SSF52151, 1 hit SSF53335, SSF53335, 1 hit SSF53901, SSF53901, 1 hit SSF55048, SSF55048, 1 hit |
PROSITEi | View protein in PROSITE PS00606, B_KETOACYL_SYNTHASE, 1 hit PS50075, CARRIER, 1 hit |
i Sequence
Sequence statusi: Complete.
Q869W9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTFNNIKDEN NDDIAIIGMG FRFPGGGNNP DQFWNQLSNK MDGISKISQE
60 70 80 90 100
KWSRSFYEQK YINNEYGGVL KDEEWKNFDP LFFGISPKEA PTIDPQQRLL
110 120 130 140 150
MTTLWEAFED ANIKPSTLRG SDTAVFIGMM NLDYQRCQFR DISYINPYTV
160 170 180 190 200
TGSAGSFVSN RLSFSFDLRG PSMTLDTACS SSLNAVYLGC QAIATGDSKM
210 220 230 240 250
AIVGGVNGIF DPSISMTFSG LNMLGHKGQC RSFDAGADGY IRSEGGGVCI
260 270 280 290 300
LKKYSDAIKD GDRIYCVIKG GSSNVDGYNA KTNITQPSMK AQGENIEIAL
310 320 330 340 350
KKSGVNPSDI YYIEAHGTGT PVGDPIEIEA ISRIFKDNHT PDAPLYIGSV
360 370 380 390 400
KSNIGHLESA AGIASLIKVA LSLKNRSLVP NIHFEKPNPL IKFEDWNIRV
410 420 430 440 450
VTDEIQFPTN KLINMGINCF GLSGSNCHMI LSEAPINYDE LLKTTNNNST
460 470 480 490 500
SSSSNDDKKE YLIPFSANCN ISLDKYIEKL ISNQSIYKDT ILFKDFVKHQ
510 520 530 540 550
TISKSNLIKR KVITASDWDD FLNKRNETTS TSSLTSTISA PASSTPVIYV
560 570 580 590 600
FTGQGPQWRD MGKALYETES VFKDAIDHCD KLLANYFGYS ILQKLRSLES
610 620 630 640 650
DDSPEIHHPI LAQPSIFLIQ VGLVALYKSF GISPSIVVGH SFGEVSSALF
660 670 680 690 700
SGVISLETAV KIVYYRGLAQ NLTMGTGRLL SIGIGADAYL EKCALLYPEI
710 720 730 740 750
EIACYNDPNS IVITGSEQDL LGAKSTLSAE GVFCAFLGTP CSFHSSKQEM
760 770 780 790 800
IKEKIFKDLS DLPESNVPCV PFFSTITGSQ LSHKGFYNVQ YIYDNLRMPV
810 820 830 840 850
EFTKAISNIF NFIEENESYK NAIFLEIGPH PTLGFYIPKC KPSNSTITSK
860 870 880 890 900
PIIVSPLHKK KEELTQFKLA ISTLYCNGVE IDFASGQQLL PTSSSSGGGD
910 920 930 940 950
ISSFKESTNK LPRYQWDFEE YWDEPNQSKM VKRGPSNNLL GHDQFAGNTL
960 970 980 990 1000
MELFIDINKS AHQYLKGHKI KGKYLFPGSG YIDNILRQFN GQDITIFNLE
1010 1020 1030 1040 1050
FSNPFFLKDG VQHHLQTSIT PTTKGEFKVE FFIKDNRNST KWTKTSNGRI
1060 1070 1080 1090 1100
GLFKHNPKNN KLDIEKLKSQ CSFTTLTKSE VYNKLLLLSL PYGPTFQRVE
1110 1120 1130 1140 1150
SCSIGDGCSF FKLSMSPCSE FDKDFLNPSI IDCAFHGLLV LSEGPQEIVF
1160 1170 1180 1190 1200
DRLQDMKFYS SNVPSTRPQF IYAFAKFDKI VGNSTHGSLD IMLEDGTLLI
1210 1220 1230 1240 1250
SIKNVKCTSL IRLKKQSIKY PSQNVYSHHW QSKDSPLTLI ENQLIEEKSS
1260 1270 1280 1290 1300
ESKINFEKLL NDKLFNDYLI RLLNQSIKSE FIEFDYKTST VDTLEIDSNN
1310 1320 1330 1340 1350
TKLLEKIQSI LKTIDSLDQS IDLASLKQVI IEKSSSFKKE INLIEKSIKR
1360 1370 1380 1390 1400
IVSLLKGGES EHFSPSNPSS PNDTPRYNSN NCSSKSNNTS SGADDDTNNE
1410 1420 1430 1440 1450
ETINQLNNEP FNFSNSQFIS NQNQLISKTI VNSFDRLINS IEIGEKKLIK
1460 1470 1480 1490 1500
IIDLSSIYQN NQLSKLLLLQ LNQLLINLSN NNNIEIEYTI PSNTKNIDSI
1510 1520 1530 1540 1550
KEETKSISNL LNIKYRSFDL QDDLESNGYL NSNYDLIITS LLLVSTNSID
1560 1570 1580 1590 1600
SNEVLSKLYK LLLPKGQLIL MEPPKDVLSF NLLFANDFKQ SLEIKSEQEI
1610 1620 1630 1640 1650
KSLIRYCGFT KIETNNITQD DEEEQQQPPS ILIVQTEKRD IESMSLTFSS
1660 1670 1680 1690 1700
DPESLNSSYS NCIFIVSKEQ KENPTSYIQE YFDITEVFCD NTTIIEAGDS
1710 1720 1730 1740 1750
ELLTKTIESG IGKNDIIFFL VSLEELTIEN YKQVTMQYTL VNQILLRNNL
1760 1770 1780 1790 1800
STRFALLTYD SQNGGKNYLG SSLIGTFRYF LEFPSLNTFS IDVDKDSIDN
1810 1820 1830 1840 1850
LTLFLRLVDL STIGDRETIV RNNKIFVQKI FKEPKLLSPS NNYEKDTNNL
1860 1870 1880 1890 1900
YLNTNSNLDF SFQCKEKLPH GSVEIKVMST GINYKDNLFY RGLLPQEIFT
1910 1920 1930 1940 1950
KGDIYSPPFG LECAGYITRV APSGVTRFKV GDQVVGFASH SLSSLAITHQ
1960 1970 1980 1990 2000
DKIVLKPENI SFNEAAAVCV VYATSYYSIF HIGAFMADKE SILVHSATGG
2010 2020 2030 2040 2050
VGLATLNLLK WKRNQLKKHG NSEISNDASI YATVGSKEKV DYLQEKYGDL
2060 2070 2080 2090 2100
ITAIYNSRDT EYCDEIKQQS AQGGVDLILN TLSGDYLSAN FRSLSQVGRI
2110 2120 2130 2140 2150
MDLSVTQLVE NDSLDFSNFK YHVTYSTIDL ERATTYNSKI VRDILTEVFD
2160 2170 2180 2190 2200
AISDGSLENI PVKVFPATQV KTAIEYINER VHIGKIVVDF ENFEQDILKP
2210 2220 2230 2240 2250
ALQEKENPIQ LNKVKKLEHT CDTLNNTILI TGQTGIAVHI LKWIISGSVL
2260 2270 2280 2290 2300
NSNKSQQQVT DFIILSRSSL KWELENLINQ TKHKYGDRFR FHYKSVNIAD
2310 2320 2330 2340 2350
LNSTRTAIDQ VYSSCKNVSP IKSVLHFATV YEYILPEDIT QTVIDNTHNP
2360 2370 2380 2390 2400
KAVGAINLHN LSIEKDWKLE NFILFSSIGA IIGGSKQCAY SSANLVLDSL
2410 2420 2430 2440 2450
SNYRKSIGLA STSINWGGLD AGGVAATDKS VASFLEGQGI LLVSLSKILG
2460 2470 2480 2490 2500
CLDSVFQPSN SHLSNFMLSS FNIDNLLSSA PQMKRKMGHH LTNYKTSSAS
2510 2520 2530 2540 2550
SDDSLGDSSS TQAKVISTIS ELLSIHPSKL NLDTRLKDYG IDSLLTVQLK
2560 2570 2580 2590 2600
NWIDKEFTKN LFTHLQLSSS SINSIIQRIS SKSTSTSTPN PTNTTKQTAT
TKT
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAFI02000013 Genomic DNA Translation: EAL69815.1 |
RefSeqi | XP_643784.1, XM_638692.1 |
Genome annotation databases
EnsemblProtistsi | EAL69815; EAL69815; DDB_G0275069 |
GeneIDi | 8619829 |
KEGGi | ddi:DDB_G0275069 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAFI02000013 Genomic DNA Translation: EAL69815.1 |
RefSeqi | XP_643784.1, XM_638692.1 |
3D structure databases
SMRi | Q869W9 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 44689.DDB0230068 |
Proteomic databases
PaxDbi | Q869W9 |
PRIDEi | Q869W9 |
Genome annotation databases
EnsemblProtistsi | EAL69815; EAL69815; DDB_G0275069 |
GeneIDi | 8619829 |
KEGGi | ddi:DDB_G0275069 |
Organism-specific databases
dictyBasei | DDB_G0275069, pks16 |
Phylogenomic databases
eggNOGi | KOG1202, Eukaryota |
HOGENOMi | CLU_000022_31_5_1 |
InParanoidi | Q869W9 |
OMAi | TFRWEED |
PhylomeDBi | Q869W9 |
Enzyme and pathway databases
Reactomei | R-DDI-163765, ChREBP activates metabolic gene expression R-DDI-199220, Vitamin B5 (pantothenate) metabolism R-DDI-75105, Fatty acyl-CoA biosynthesis |
Miscellaneous databases
PROi | PR:Q869W9 |
Family and domain databases
Gene3Di | 1.10.1200.10, 1 hit 3.10.129.110, 1 hit 3.40.366.10, 1 hit 3.40.47.10, 1 hit |
InterProi | View protein in InterPro IPR001227, Ac_transferase_dom_sf IPR036736, ACP-like_sf IPR014043, Acyl_transferase IPR016035, Acyl_Trfase/lysoPLipase IPR011032, GroES-like_sf IPR018201, Ketoacyl_synth_AS IPR014031, Ketoacyl_synth_C IPR014030, Ketoacyl_synth_N IPR016036, Malonyl_transacylase_ACP-bd IPR036291, NAD(P)-bd_dom_sf IPR032821, PKS_assoc IPR020841, PKS_Beta-ketoAc_synthase_dom IPR020807, PKS_dehydratase IPR042104, PKS_dehydratase_sf IPR020843, PKS_ER IPR013968, PKS_KR IPR009081, PP-bd_ACP IPR029063, SAM-dependent_MTases IPR016039, Thiolase-like |
Pfami | View protein in Pfam PF00698, Acyl_transf_1, 1 hit PF16197, KAsynt_C_assoc, 1 hit PF00109, ketoacyl-synt, 1 hit PF02801, Ketoacyl-synt_C, 1 hit PF08659, KR, 1 hit PF00550, PP-binding, 1 hit PF14765, PS-DH, 1 hit |
SMARTi | View protein in SMART SM00827, PKS_AT, 1 hit SM00829, PKS_ER, 1 hit SM00825, PKS_KS, 1 hit |
SUPFAMi | SSF47336, SSF47336, 1 hit SSF50129, SSF50129, 1 hit SSF51735, SSF51735, 2 hits SSF52151, SSF52151, 1 hit SSF53335, SSF53335, 1 hit SSF53901, SSF53901, 1 hit SSF55048, SSF55048, 1 hit |
PROSITEi | View protein in PROSITE PS00606, B_KETOACYL_SYNTHASE, 1 hit PS50075, CARRIER, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PKS16_DICDI | |
Accessioni | Q869W9Primary (citable) accession number: Q869W9 Secondary accession number(s): Q554C7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 5, 2009 |
Last sequence update: | June 1, 2003 | |
Last modified: | February 23, 2022 | |
This is version 121 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Dictyostelium discoideum
Dictyostelium discoideum: entries, gene names and cross-references to dictyBase