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Entry version 79 (26 Feb 2020)
Sequence version 1 (01 Jun 2003)
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Protein

Nck-associated protein 1 homolog

Gene

napA

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in regulation of actin and microtubule organization. Involved in cell adhesion.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DDI-2029482 Regulation of actin dynamics for phagocytic cup formation
R-DDI-5663213 RHO GTPases Activate WASPs and WAVEs
R-DDI-6798695 Neutrophil degranulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nck-associated protein 1 homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:napA
Synonyms:nap1
ORF Names:DDB_G0274519
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDictyostelium discoideum (Slime mold)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri44689 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaAmoebozoaEvoseaEumycetozoaDictyosteliaDictyostelialesDictyosteliaceaeDictyostelium
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002195 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 2, Unassembled WGS sequence

Organism-specific databases

Dictyostelium discoideum online informatics resource

More...
dictyBasei
DDB_G0274519 napA

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Cells have defects in motility, and various developmental defects, notably in aggregation and adhesion.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003313891 – 1160Nck-associated protein 1 homologAdd BLAST1160

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q869Q3

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of a Scar/WAVE complex containing brk1, scrA, abiA, pirA and napA.

1 Publication

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
44689.DDB0231423

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q869Q3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the HEM-1/HEM-2 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1917 Eukaryota
ENOG410XPQI LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004450_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q869Q3

KEGG Orthology (KO)

More...
KOi
K05750

Identification of Orthologs from Complete Genome Data

More...
OMAi
VGMVMYN

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q869Q3

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019137 Nck-associated_protein-1

The PANTHER Classification System

More...
PANTHERi
PTHR12093 PTHR12093, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09735 Nckap1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q869Q3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAHTNLPEKF QVVIENGENI LQRVYNTYKL FQNNKVKPSF FNDEKISKIL
60 70 80 90 100
KNLIAKYPEL PENNDKSITG FDLLTSRAKQ HLEELEDHYY TITDAYDWKE
110 120 130 140 150
ASFILMQEIS SNTVSINFNN NIQLCSKFLD VLVLYGKINY LVSLIPDKKI
160 170 180 190 200
ITAVYAKLFL YTRSASEPTF SKMGRWINDI EQPFKKIQEE FRVLNDAVGH
210 220 230 240 250
ALSSFELTYA KRRVITQLRK DGALNLILKP EDIARPVQDS YRIELAYAGR
260 270 280 290 300
IQQWILFGYL FAPGTLSTPQ SIELLRFTLS ECFYLSVFKD ISISIHNEFN
310 320 330 340 350
TLFKNYKSKT INLQKQKKII KDAAQASTQE APRKHAERRV YIRQELEAMW
360 370 380 390 400
NLFRDKPCLL APKINVLLAA LSMAKEEIFW YFRHTDVIPP EKVKKFYNKQ
410 420 430 440 450
NEVREKRISS LLSLVDHLVQ LVHTHKKMIQ NYYLEYISGA DILGLQKVIT
460 470 480 490 500
PQLLQNAGSI VTQAVNTIVN ELKSLNANGQ DYSFEGFRAN WMRLGYLLQS
510 520 530 540 550
NSCPLKESES KQITSRLNLI YTHSKNVDCL DQLLDEYGNM TQLWSYKEPL
560 570 580 590 600
FHSFDAAIVD MTCDQPSHSM IYLKLLSQFP NHVANQFYPE EKELIGKECV
610 620 630 640 650
ELANSCLTKI TNRIVSIMAN TIASTFLSDE QQLADVNAAF PLLQKKKDWK
660 670 680 690 700
PPKDFVPPIE PASESQFRNR ANLEQLRSEE KNAFQLCTAL NEFLDITIYD
710 720 730 740 750
HIFVPREFLR EKLGSALKQY MRQSIQPPAP TSSSSQIDIN ITRLSTYESQ
760 770 780 790 800
LRVFIGVLIL VENHVDIDIG DLIRETILTE FYAKALGKSG RVDWFPEGEI
810 820 830 840 850
EMNELTLHSI TSYYVDLVSK KLNTPGVVFS PVKLGFISKA GTPFRAEEHA
860 870 880 890 900
DLTEMRALCD LVGPYGIKVI EREILRFILT TTTSMKEILS LNAANLEEFA
910 920 930 940 950
SNYYKPKAME LLKKFKTTDL DLIVTKSIAI GNALHLRSMI RESMKDVITD
960 970 980 990 1000
NFPYINNAVA NAFDQYNRNT FMFPDFLGVD TLALDSGLNV GIADQYLKVI
1010 1020 1030 1040 1050
LRKVSSEADK RIWELLPVMF SLTFYGNIWK ETQYKATIDA HSNNVHVLSK
1060 1070 1080 1090 1100
TIIDLLIAFG AINSTTGNEA ELFQSFKRFL EISSVNILRM FKGKQGEKFV
1110 1120 1130 1140 1150
PNEIQSVIIF LDKFTQQCPL LSKDSLEQYI PYSLIRNMYK DLYEHKNLQK
1160
QQSETSEQNF
Length:1,160
Mass (Da):133,540
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i89F7D2B447919C0A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAFI02000012 Genomic DNA Translation: EAL70152.1

NCBI Reference Sequences

More...
RefSeqi
XP_644083.1, XM_638991.1

Genome annotation databases

Ensembl protists genome annotation project

More...
EnsemblProtistsi
EAL70152; EAL70152; DDB_G0274519

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8619512

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ddi:DDB_G0274519

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000012 Genomic DNA Translation: EAL70152.1
RefSeqiXP_644083.1, XM_638991.1

3D structure databases

SMRiQ869Q3
ModBaseiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0231423

Proteomic databases

PaxDbiQ869Q3

Genome annotation databases

EnsemblProtistsiEAL70152; EAL70152; DDB_G0274519
GeneIDi8619512
KEGGiddi:DDB_G0274519

Organism-specific databases

dictyBaseiDDB_G0274519 napA

Phylogenomic databases

eggNOGiKOG1917 Eukaryota
ENOG410XPQI LUCA
HOGENOMiCLU_004450_1_0_1
InParanoidiQ869Q3
KOiK05750
OMAiVGMVMYN
PhylomeDBiQ869Q3

Enzyme and pathway databases

ReactomeiR-DDI-2029482 Regulation of actin dynamics for phagocytic cup formation
R-DDI-5663213 RHO GTPases Activate WASPs and WAVEs
R-DDI-6798695 Neutrophil degranulation

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q869Q3

Family and domain databases

InterProiView protein in InterPro
IPR019137 Nck-associated_protein-1
PANTHERiPTHR12093 PTHR12093, 1 hit
PfamiView protein in Pfam
PF09735 Nckap1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNAPA_DICDI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q869Q3
Secondary accession number(s): Q555I6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: June 1, 2003
Last modified: February 26, 2020
This is version 79 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
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