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Entry version 140 (17 Jun 2020)
Sequence version 2 (05 Sep 2006)
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Protein

Papilin

Gene

Ppn

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Essential extracellular matrix (ECM) protein that influences cell rearrangements. May act by modulating metalloproteinases action during organogenesis. Able to non-competitively inhibit procollagen N-proteinase, an ADAMTS metalloproteinase.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPS protease database

More...
MEROPSi
I02.955

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Papilin
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ppn
ORF Names:CG33103
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0003137 Ppn

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Basement membrane, Extracellular matrix, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 261 PublicationAdd BLAST26
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000024854427 – 2898PapilinAdd BLAST2872

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi69 ↔ 105By similarity
Disulfide bondi73 ↔ 110By similarity
Disulfide bondi84 ↔ 95By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi258N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi319N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi419N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi462 ↔ 504By similarity
Disulfide bondi473 ↔ 515By similarity
Disulfide bondi477 ↔ 520By similarity
Glycosylationi669N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi889N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi914N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi917N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi950N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1064N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1489N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1612 ↔ 1662By similarity
Disulfide bondi1621 ↔ 1645By similarity
Glycosylationi1623N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1637 ↔ 1658By similarity
Disulfide bondi1671 ↔ 1721By similarity
Disulfide bondi1680 ↔ 1704By similarity
Disulfide bondi1696 ↔ 1717By similarity
Disulfide bondi1730 ↔ 1780By similarity
Disulfide bondi1739 ↔ 1763By similarity
Glycosylationi1750N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1755 ↔ 1776By similarity
Disulfide bondi1790 ↔ 1840By similarity
Disulfide bondi1799 ↔ 1823By similarity
Disulfide bondi1815 ↔ 1836By similarity
Disulfide bondi1849 ↔ 1899By similarity
Disulfide bondi1858 ↔ 1882By similarity
Disulfide bondi1874 ↔ 1895By similarity
Disulfide bondi1922 ↔ 1972By similarity
Disulfide bondi1931 ↔ 1955By similarity
Disulfide bondi1947 ↔ 1968By similarity
Disulfide bondi2001 ↔ 2051By similarity
Disulfide bondi2010 ↔ 2034By similarity
Glycosylationi2020N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2026 ↔ 2047By similarity
Disulfide bondi2071 ↔ 2121By similarity
Disulfide bondi2080 ↔ 2104By similarity
Glycosylationi2083N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2096 ↔ 2117By similarity
Disulfide bondi2128 ↔ 2178By similarity
Disulfide bondi2137 ↔ 2161By similarity
Disulfide bondi2153 ↔ 2174By similarity
Disulfide bondi2194 ↔ 2244By similarity
Disulfide bondi2203 ↔ 2227By similarity
Glycosylationi2205N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2219 ↔ 2240By similarity
Disulfide bondi2253 ↔ 2303By similarity
Disulfide bondi2262 ↔ 2286By similarity
Disulfide bondi2278 ↔ 2299By similarity
Disulfide bondi2318 ↔ 2371By similarity
Disulfide bondi2327 ↔ 2354By similarity
Disulfide bondi2346 ↔ 2367By similarity
Glycosylationi2465N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2543 ↔ 2592By similarity
Glycosylationi2552N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2625N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2640 ↔ 2687By similarity
Disulfide bondi2775 ↔ 2824By similarity
Glycosylationi2784N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2838N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.2 Publications
Sulfated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Proteoglycan, Sulfation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q868Z9

PRoteomics IDEntifications database

More...
PRIDEi
Q868Z9

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q868Z9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

During embryogenesis it first appears in the extracellular matrix during gastrulation and early mesoderm development at sites where basement membranes do not subsequently form. Later, migrating hemocytes prominently produce it together with other ECM components, in basement membranes that underlie epithelia and envelop muscles and emerging organs. At various life stages, it can be synthesized by other cells, such as those of the fat body, and it also occurs in a few, circumscribed regions of relatively amorphous ECM. Isoform E is specifically expressed in ECM of heart and proventriculus. Isoform C is a major component of transitory ECM deposit in the early embryo. Isoform F is a major component of the basement membrane during embryogenesis.2 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed throughout development and is prominent in adult basement membranes. Appears after 4 hours of embryogenesis, peaks at 8-12 hours and remains thereafter.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
FBgn0003137 Expressed in embryonic/larval hemocyte (Drosophila) and 37 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q868Z9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q868Z9 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homooligomer; disulfide-linked.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
68683, 26 interactors

Protein interaction database and analysis system

More...
IntActi
Q868Z9, 4 interactors

STRING: functional protein association networks

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STRINGi
7227.FBpp0291051

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q868Z9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini57 – 111TSP type-1 1PROSITE-ProRule annotationAdd BLAST55
Domaini338 – 397TSP type-1 2PROSITE-ProRule annotationAdd BLAST60
Domaini461 – 521TSP type-1 3PROSITE-ProRule annotationAdd BLAST61
Domaini522 – 575TSP type-1 4PROSITE-ProRule annotationAdd BLAST54
Domaini576 – 633TSP type-1 5PROSITE-ProRule annotationAdd BLAST58
Domaini639 – 694TSP type-1 6PROSITE-ProRule annotationAdd BLAST56
Domaini1612 – 1662BPTI/Kunitz inhibitor 1PROSITE-ProRule annotationAdd BLAST51
Domaini1671 – 1721BPTI/Kunitz inhibitor 2PROSITE-ProRule annotationAdd BLAST51
Domaini1730 – 1780BPTI/Kunitz inhibitor 3PROSITE-ProRule annotationAdd BLAST51
Domaini1790 – 1840BPTI/Kunitz inhibitor 4PROSITE-ProRule annotationAdd BLAST51
Domaini1849 – 1899BPTI/Kunitz inhibitor 5PROSITE-ProRule annotationAdd BLAST51
Domaini1922 – 1972BPTI/Kunitz inhibitor 6PROSITE-ProRule annotationAdd BLAST51
Domaini2001 – 2051BPTI/Kunitz inhibitor 7PROSITE-ProRule annotationAdd BLAST51
Domaini2071 – 2121BPTI/Kunitz inhibitor 8PROSITE-ProRule annotationAdd BLAST51
Domaini2128 – 2178BPTI/Kunitz inhibitor 9PROSITE-ProRule annotationAdd BLAST51
Domaini2194 – 2244BPTI/Kunitz inhibitor 10PROSITE-ProRule annotationAdd BLAST51
Domaini2253 – 2303BPTI/Kunitz inhibitor 11PROSITE-ProRule annotationAdd BLAST51
Domaini2318 – 2371BPTI/Kunitz inhibitor 12PROSITE-ProRule annotationAdd BLAST54
Domaini2452 – 2498WAPPROSITE-ProRule annotationAdd BLAST47
Domaini2523 – 2607Ig-like C2-type 1Add BLAST85
Domaini2617 – 2697Ig-like C2-type 2Add BLAST81
Domaini2749 – 2840Ig-like C2-type 3Add BLAST92
Domaini2847 – 2886PLACPROSITE-ProRule annotationAdd BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi776 – 1232Ser-richAdd BLAST457
Compositional biasi1403 – 1586Cys-richAdd BLAST184

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the papilin family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4295 Eukaryota
KOG4475 Eukaryota
KOG4597 Eukaryota
ENOG410XQNP LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000171211

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q868Z9

KEGG Orthology (KO)

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KOi
K23624

Identification of Orthologs from Complete Genome Data

More...
OMAi
VRISECE

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q868Z9

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00109 KU, 12 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.20.100.10, 5 hits
2.60.40.10, 3 hits
4.10.410.10, 12 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010294 ADAM_spacer1
IPR013273 ADAMTS/ADAMTS-like
IPR036645 Elafin-like_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR002223 Kunitz_BPTI
IPR036880 Kunitz_BPTI_sf
IPR010909 PLAC
IPR020901 Prtase_inh_Kunz-CS
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
IPR008197 WAP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05986 ADAM_spacer1, 1 hit
PF07679 I-set, 1 hit
PF00014 Kunitz_BPTI, 12 hits
PF08686 PLAC, 1 hit
PF00090 TSP_1, 6 hits
PF00095 WAP, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01857 ADAMTSFAMILY
PR00759 BASICPTASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 3 hits
SM00131 KU, 12 hits
SM00209 TSP1, 7 hits
SM00217 WAP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 3 hits
SSF57256 SSF57256, 1 hit
SSF57362 SSF57362, 12 hits
SSF82895 SSF82895, 7 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00280 BPTI_KUNITZ_1, 11 hits
PS50279 BPTI_KUNITZ_2, 12 hits
PS50835 IG_LIKE, 3 hits
PS50900 PLAC, 1 hit
PS50092 TSP1, 5 hits
PS51390 WAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform E (identifier: Q868Z9-1) [UniParc]FASTAAdd to basket
Also known as: Papilin-3

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDLSRRLCST ALVAFIVLAS IHDSQSRFPG LRQKRQYGAN MYLPESSVTP
60 70 80 90 100
GGEGNDPDEW TPWSSPSDCS RTCGGGVSYQ TRECLRRDDR GEAVCSGGSR
110 120 130 140 150
RYFSCNTQDC PEEESDFRAQ QCSRFDRQQF DGVFYEWVPY TNAPNPCELN
160 170 180 190 200
CMPKGERFYY RQREKVVDGT RCNDKDLDVC VNGECMPVGC DMMLGSDAKE
210 220 230 240 250
DKCRKCGGDG STCKTIRNTI TTKDLAPGYN DLLLLPEGAT NIRIEETVPS
260 270 280 290 300
SNYLACRNHS GHYYLNGDWR IDFPRPMFFA NSWWNYQRKP MGFAAPDQLT
310 320 330 340 350
CSGPISESLF IVMLVQEKNI SLDYEYSIPE SLSHSQQDTH TWTHHQFNAC
360 370 380 390 400
SASCGGGSQS RKVTCNNRIT LAEVNPSLCD QKSKPVEEQA CGTEPCAPHW
410 420 430 440 450
VEGEWSKCSK GCGSDGFQNR SITCERISSS GEHTVEEDAV CLKEVGNKPA
460 470 480 490 500
TKQECNRDVK NCPKYHLGPW TPCDKLCGDG KQTRKVTCFI EENGHKRVLP
510 520 530 540 550
EEDCVEEKPE TEKSCLLTPC EGVDWIISQW SGCNACGQNT ETRTAICGNK
560 570 580 590 600
EGKVYPEEFC EPEVPTLSRP CKSPKCEAQW FSSEWSKCSA PCGKGVKSRI
610 620 630 640 650
VICGEFDGKT VTPADDDSKC NKETKPESEQ DCEGEEKVCP GEWFTGPWGK
660 670 680 690 700
CSKPCGGGER VREVLCLSNG TKSVNCDEEK VEPLSEKCNS EACTEDEILP
710 720 730 740 750
LTSTDKPIED DEEDCDEDGI ELISDGLSDD EKSEDVIDLE GTAKTETTPE
760 770 780 790 800
AEDLMQSDSP TPYDEFESTG TTFEGSGYDS ESTTDSGIST EGSGDDEETS
810 820 830 840 850
EASTDLSSST DSGSTSSDST SSDSSSSISS DATSEAPASS VSDSSDSTDA
860 870 880 890 900
STETTGVSDD STDVSSSTEA SASESTDVSG ASDSTGSTNA SDSTPESSTE
910 920 930 940 950
ASSSTDDSTD SSDNSSNVSE SSTEASSSSV SDSNDSSDGS TDGVSSTTEN
960 970 980 990 1000
SSDSTSDATS DSTASSDSTD STSDQTTETT PESSTDSTES STLDASSTTD
1010 1020 1030 1040 1050
ASSTSESSSE SSTDGSSTTS NSASSETTGL SSDGSTTDAT TAASDNTDIT
1060 1070 1080 1090 1100
TDGSTDESTD GSSNASTEGS TEGASEDTTI STESSGSTES TDAIASDGST
1110 1120 1130 1140 1150
TEGSTVEDLS SSTSSDVTSD STITDSSPST EVSGSTDSSS STDGSSTDAS
1160 1170 1180 1190 1200
STEASSTDVT ESTDSTVSGG TSDTTESGPT EESTTEGSTE STTEGSTDST
1210 1220 1230 1240 1250
QSTDLDSTTS DIWSTSDKDD ESESSTPYSF DSEVTKSKPR KCKPKKSTCA
1260 1270 1280 1290 1300
KSEYGCCPDG KSTPKGPFDE GCPIAKTCAD TKYGCCLDGV SPAKGKNNKG
1310 1320 1330 1340 1350
CPKSQCAETL FGCCPDKFTA ADGENDEGCP ETTTVPPTTT TEETQPETTT
1360 1370 1380 1390 1400
EIEGSGQDST TSEPDTKKSC SFSEFGCCPD AETSAKGPDF EGCGLASPVA
1410 1420 1430 1440 1450
KGCAESENGC CPDGQTPASG PNGEGCSGCT RERFGCCPDS QTPAHGPNKE
1460 1470 1480 1490 1500
GCCLDTQFGC CPDNILAARG PNNEGCECHY TPYGCCPDNK SAATGYNQEG
1510 1520 1530 1540 1550
CACETTQYGC CPDKITAAKG PKHEGCPCET TQFGCCPDGL TFAKGPHHHG
1560 1570 1580 1590 1600
CHCTQTEFKC CDDEKTPAKG PNGDGCTCVE SKFGCCPDGV TKATDEKFGG
1610 1620 1630 1640 1650
CENVQEPPQK ACGLPKETGT CNNYSVKYYF DTSYGGCARF WYGGCDGNDN
1660 1670 1680 1690 1700
RFESEAECKD TCQDYTGKHV CLLPKSAGPC TGFTKKWYFD VDRNRCEEFQ
1710 1720 1730 1740 1750
YGGCYGTNNR FDSLEQCQGT CAASENLPTC EQPVESGPCA GNFERWYYDN
1760 1770 1780 1790 1800
ETDICRPFTY GGCKGNKNNY PTEHACNYNC RQPGVLKDRC ALPKQTGDCS
1810 1820 1830 1840 1850
EKLAKWHFSE SEKRCVPFYY SGCGGNKNNF PTLESCEDHC PRQVAKDICE
1860 1870 1880 1890 1900
IPAEVGECAN YVTSWYYDTQ DQACRQFYYG GCGGNENRFP TEESCLARCD
1910 1920 1930 1940 1950
RKPEPTTTTP ATRPQPSRQD VCDEEPAPGE CSTWVLKWHF DRKIGACRQF
1960 1970 1980 1990 2000
YYGNCGGNGN RFETENDCQQ RCLSQEPPAP TPPRAPAPTR QPDPAPTVAQ
2010 2020 2030 2040 2050
CSQPADPGQC DKWALHWNYN ETEGRCQSFY YGGCGGNDNR FATEEECSAR
2060 2070 2080 2090 2100
CSVNIDIRIG ADPVEHDTSK CFLAFEPGNC YNNVTRWFYN SAEGLCDEFV
2110 2120 2130 2140 2150
YTGCGGNANN YATEEECQNE CNDAQTTCAL PPVRGRCSDL SRRWYFDERS
2160 2170 2180 2190 2200
GECHEFEFTG CRGNRNNFVS QSDCLNFCIG EPVVEPSAPT YSVCAEPPEA
2210 2220 2230 2240 2250
GECDNRTTAW FYDSENMACT AFTYTGCGGN GNRFETRDQC ERQCGEFKGV
2260 2270 2280 2290 2300
DVCNEPVTTG PCTDWQTKYY FNTASQACEP FTYGGCDGTG NRFSDLFECQ
2310 2320 2330 2340 2350
TVCLAGREPR VGSAKEICLL PVATGRCNGP SVHERRWYYD DEAGNCVSFI
2360 2370 2380 2390 2400
YAGCSGNQNN FRSFEACTNQ CRPEPNKQDN EIGQNPCDTF DAECQELRCP
2410 2420 2430 2440 2450
YGVRRVAARS QPECTQCICE NPCEGYSCPE GQQCAIDVAS SDDRQFAPVC
2460 2470 2480 2490 2500
RDIYKPGECP ALSANASGCA RECYTDADCR GDNKCCSDGC GQLCVHPARP
2510 2520 2530 2540 2550
TQPPRTQAPV VSYPGDARAA LEPKEAHELD VQTAIGGIAV LRCFATGNPA
2560 2570 2580 2590 2600
PNITWSLKNL VINTNKGRYV LTANGDLTIV QVRQTDDGTY VCVASNGLGE
2610 2620 2630 2640 2650
PVRREVALQV TEPVSQPAYI YGDKNVTQIV ELNRPAVIRC PAGGFPEPHV
2660 2670 2680 2690 2700
SWWRNGQMFG LKNNLMARDY SLVFNSIQLS DLGLYTCEVY NQRRPVSLRV
2710 2720 2730 2740 2750
TLKAVGPVRP LSPEEEQYMQ YVLNPATRPV TQRPSYPYRP TRPAYVPEPT
2760 2770 2780 2790 2800
VNVHAVLALE PKNSYTPGST IVMSCSVQGY PEPNVTWIKD DVPLYNNERV
2810 2820 2830 2840 2850
QITYQPHRLV LSDVTSADSG KYTCRASNAY TYANGEANVS IQSVVPVSPE
2860 2870 2880 2890
CVDNPYFANC KLIVKGRYCS NPYYTQFCCR SCTLAGQVAS PPLHPNAV
Length:2,898
Mass (Da):313,035
Last modified:September 5, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5FFF75A4155D49A4
GO
Isoform F (identifier: Q868Z9-2) [UniParc]FASTAAdd to basket
Also known as: Papilin-2

The sequence of this isoform differs from the canonical sequence as follows:
     2251-2373: DVCNEPVTTG...FEACTNQCRP → A

Show »
Length:2,776
Mass (Da):299,526
Checksum:i51E2F29A2D87748C
GO
Isoform C (identifier: Q868Z9-5) [UniParc]FASTAAdd to basket
Also known as: Papilin-1

The sequence of this isoform differs from the canonical sequence as follows:
     1788-2372: Missing.
     2373-2373: P → A
     2612-2750: Missing.

Show »
Length:2,174
Mass (Da):231,767
Checksum:i5FCA6DB89FDED450
GO
Isoform G (identifier: Q868Z9-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1788-1844: Missing.

Show »
Length:2,841
Mass (Da):306,554
Checksum:i36F93848BD7641E9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti224D → N in AAG37995 (PubMed:11076767).Curated1
Sequence conflicti224D → N in AAO84907 (PubMed:12666201).Curated1
Sequence conflicti224D → N in AAO84908 (PubMed:12666201).Curated1
Sequence conflicti360S → N in AAG37995 (PubMed:11076767).Curated1
Sequence conflicti360S → N in AAO84907 (PubMed:12666201).Curated1
Sequence conflicti360S → N in AAO84908 (PubMed:12666201).Curated1
Sequence conflicti852T → P in AAG37995 (PubMed:11076767).Curated1
Sequence conflicti852T → P in AAO84907 (PubMed:12666201).Curated1
Sequence conflicti852T → P in AAO84908 (PubMed:12666201).Curated1
Sequence conflicti934N → S in AAG37995 (PubMed:11076767).Curated1
Sequence conflicti934N → S in AAO84907 (PubMed:12666201).Curated1
Sequence conflicti934N → S in AAO84908 (PubMed:12666201).Curated1
Sequence conflicti1029G → W in AAG37995 (PubMed:11076767).Curated1
Sequence conflicti1029G → W in AAO84907 (PubMed:12666201).Curated1
Sequence conflicti1029G → W in AAO84908 (PubMed:12666201).Curated1
Sequence conflicti1344T → S in AAG37995 (PubMed:11076767).Curated1
Sequence conflicti1344T → S in AAO84907 (PubMed:12666201).Curated1
Sequence conflicti1344T → S in AAO84908 (PubMed:12666201).Curated1
Sequence conflicti1484G → S in AAG37995 (PubMed:11076767).Curated1
Sequence conflicti1484G → S in AAO84907 (PubMed:12666201).Curated1
Sequence conflicti1484G → S in AAO84908 (PubMed:12666201).Curated1
Sequence conflicti1574D → E in AAG37995 (PubMed:11076767).Curated1
Sequence conflicti1574D → E in AAO84907 (PubMed:12666201).Curated1
Sequence conflicti1574D → E in AAO84908 (PubMed:12666201).Curated1
Sequence conflicti2566K → R in AAG37995 (PubMed:11076767).Curated1
Sequence conflicti2764S → R in AAO84907 (PubMed:12666201).Curated1
Sequence conflicti2764S → R in AAO84908 (PubMed:12666201).Curated1
Sequence conflicti2788I → T in AAG37995 (PubMed:11076767).Curated1
Sequence conflicti2811L → V in AAO84907 (PubMed:12666201).Curated1
Sequence conflicti2811L → V in AAO84908 (PubMed:12666201).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0417511788 – 2372Missing in isoform C. 1 PublicationAdd BLAST585
Alternative sequenceiVSP_0417501788 – 1844Missing in isoform G. CuratedAdd BLAST57
Alternative sequenceiVSP_0203042251 – 2373DVCNE…NQCRP → A in isoform F. 2 PublicationsAdd BLAST123
Alternative sequenceiVSP_0417522373P → A in isoform C. 1 Publication1
Alternative sequenceiVSP_0417532612 – 2750Missing in isoform C. 1 PublicationAdd BLAST139

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF205357 mRNA Translation: AAG37995.1
AF529179 mRNA Translation: AAO84907.1
AF529180 mRNA Translation: AAO84908.1
AE014297 Genomic DNA Translation: AAF56794.4
AE014297 Genomic DNA Translation: AAF56795.4
AE014297 Genomic DNA Translation: ACZ95054.1
AE014297 Genomic DNA Translation: ACZ95055.1
BT011127 mRNA Translation: AAR82794.1

NCBI Reference Sequences

More...
RefSeqi
NP_001163760.1, NM_001170289.2 [Q868Z9-5]
NP_001163761.1, NM_001170290.2 [Q868Z9-6]
NP_788751.2, NM_176574.3 [Q868Z9-2]
NP_788752.2, NM_176575.3 [Q868Z9-1]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0300337; FBpp0289566; FBgn0003137 [Q868Z9-5]
FBtr0301837; FBpp0291051; FBgn0003137 [Q868Z9-1]
FBtr0301838; FBpp0291052; FBgn0003137 [Q868Z9-2]
FBtr0301839; FBpp0291053; FBgn0003137 [Q868Z9-6]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
43872

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG33103

UCSC genome browser

More...
UCSCi
CG33103-RA d. melanogaster [Q868Z9-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF205357 mRNA Translation: AAG37995.1
AF529179 mRNA Translation: AAO84907.1
AF529180 mRNA Translation: AAO84908.1
AE014297 Genomic DNA Translation: AAF56794.4
AE014297 Genomic DNA Translation: AAF56795.4
AE014297 Genomic DNA Translation: ACZ95054.1
AE014297 Genomic DNA Translation: ACZ95055.1
BT011127 mRNA Translation: AAR82794.1
RefSeqiNP_001163760.1, NM_001170289.2 [Q868Z9-5]
NP_001163761.1, NM_001170290.2 [Q868Z9-6]
NP_788751.2, NM_176574.3 [Q868Z9-2]
NP_788752.2, NM_176575.3 [Q868Z9-1]

3D structure databases

SMRiQ868Z9
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi68683, 26 interactors
IntActiQ868Z9, 4 interactors
STRINGi7227.FBpp0291051

Protein family/group databases

MEROPSiI02.955

PTM databases

iPTMnetiQ868Z9

Proteomic databases

PaxDbiQ868Z9
PRIDEiQ868Z9

Genome annotation databases

EnsemblMetazoaiFBtr0300337; FBpp0289566; FBgn0003137 [Q868Z9-5]
FBtr0301837; FBpp0291051; FBgn0003137 [Q868Z9-1]
FBtr0301838; FBpp0291052; FBgn0003137 [Q868Z9-2]
FBtr0301839; FBpp0291053; FBgn0003137 [Q868Z9-6]
GeneIDi43872
KEGGidme:Dmel_CG33103
UCSCiCG33103-RA d. melanogaster [Q868Z9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
43872
FlyBaseiFBgn0003137 Ppn

Phylogenomic databases

eggNOGiKOG4295 Eukaryota
KOG4475 Eukaryota
KOG4597 Eukaryota
ENOG410XQNP LUCA
GeneTreeiENSGT00940000171211
InParanoidiQ868Z9
KOiK23624
OMAiVRISECE
PhylomeDBiQ868Z9

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
43872 0 hits in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
43872

Protein Ontology

More...
PROi
PR:Q868Z9

Gene expression databases

BgeeiFBgn0003137 Expressed in embryonic/larval hemocyte (Drosophila) and 37 other tissues
ExpressionAtlasiQ868Z9 baseline and differential
GenevisibleiQ868Z9 DM

Family and domain databases

CDDicd00109 KU, 12 hits
Gene3Di2.20.100.10, 5 hits
2.60.40.10, 3 hits
4.10.410.10, 12 hits
InterProiView protein in InterPro
IPR010294 ADAM_spacer1
IPR013273 ADAMTS/ADAMTS-like
IPR036645 Elafin-like_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR002223 Kunitz_BPTI
IPR036880 Kunitz_BPTI_sf
IPR010909 PLAC
IPR020901 Prtase_inh_Kunz-CS
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
IPR008197 WAP_dom
PfamiView protein in Pfam
PF05986 ADAM_spacer1, 1 hit
PF07679 I-set, 1 hit
PF00014 Kunitz_BPTI, 12 hits
PF08686 PLAC, 1 hit
PF00090 TSP_1, 6 hits
PF00095 WAP, 1 hit
PRINTSiPR01857 ADAMTSFAMILY
PR00759 BASICPTASE
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 3 hits
SM00131 KU, 12 hits
SM00209 TSP1, 7 hits
SM00217 WAP, 1 hit
SUPFAMiSSF48726 SSF48726, 3 hits
SSF57256 SSF57256, 1 hit
SSF57362 SSF57362, 12 hits
SSF82895 SSF82895, 7 hits
PROSITEiView protein in PROSITE
PS00280 BPTI_KUNITZ_1, 11 hits
PS50279 BPTI_KUNITZ_2, 12 hits
PS50835 IG_LIKE, 3 hits
PS50900 PLAC, 1 hit
PS50092 TSP1, 5 hits
PS51390 WAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPPN_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q868Z9
Secondary accession number(s): E1JJ05
, E1JJ06, Q6NP04, Q7KRX2, Q869A0, Q9GQR0, Q9VAV3, Q9VAV4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: September 5, 2006
Last modified: June 17, 2020
This is version 140 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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