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Entry version 56 (12 Aug 2020)
Sequence version 1 (01 Jun 2003)
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Protein
Submitted name:

Reverse transcriptase

Gene
N/A
Organism
Anopheles gambiae (African malaria mosquito)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionNucleotidyltransferase, RNA-directed DNA polymeraseImported, Transferase

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Reverse transcriptaseImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiAnopheles gambiae (African malaria mosquito)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7165 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraNematoceraCulicoideaCulicidaeAnophelinaeAnopheles

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini480 – 757Reverse transcriptaseInterPro annotationAdd BLAST278

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1062 – 1173DisorderedSequence analysisAdd BLAST112

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili317 – 337Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1083 – 1110PolyampholyteSequence analysisAdd BLAST28

Keywords - Domaini

Coiled coilSequence analysis

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.60.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR043502, DNA/RNA_pol_sf
IPR036691, Endo/exonu/phosph_ase_sf
IPR005135, Endo/exonuclease/phosphatase
IPR000477, RT_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14529, Exo_endo_phos_2, 1 hit
PF00078, RVT_1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56219, SSF56219, 1 hit
SSF56672, SSF56672, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50878, RT_POL, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q868T0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MCGLRWTSSH RAHELRTSGF AFNLKVMQIN VDHCQAGQDL ALQAAREHRA
60 70 80 90 100
DVLLLSDIYR PPANNGRWAY DAAKSVAVVA TSSYPIQRVL RSAVPGIVAA
110 120 130 140 150
QIGGIVFISC YARPRRPEED YEGFLAAVQL EASTHSQVVI DGDFNAWHTE
160 170 180 190 200
WGSARNSQRG EDLLQLIQSV QLQVINSGNE PTFIGRGAAT SSVIDVCFAT
210 220 230 240 250
PSIARPETWE VHEFARSDHQ LITYSVGEAE QQSRGLSTGG PSAGRQRVIC
260 270 280 290 300
AGRRWITTQF HVDSFRSALE DVNFAEQATT HAGLVDAMVD ACDIVMQRAP
310 320 330 340 350
NVLQHQHRDV YWWAPVIEEL RNECIAARER MRLTTDLQER SLAAAEHRTA
360 370 380 390 400
KTRLEKAIKV GKRAEFAKLI DIAEENELGV GYQVVLSHLR GSRVPPETDP
410 420 430 440 450
VELGRIVTDL FPTHPPVYWP ETDDVDSGAS DFDRVTPEEL QEIAAHMAIR
460 470 480 490 500
KAPGLDGIPN AAVKVAIEKY PGVFCRVYQD CLNTGTFPQQ WKRQRLVLLP
510 520 530 540 550
KPGKAPGESS SYRPLCMLDA LGKVLERLIL NRHLEDPDSP QLSDAQYGFR
560 570 580 590 600
RGRSTISAIQ SLVDAGKASR SFGQTNNRDK RCLMVVALDV RNAFNTASWQ
610 620 630 640 650
SIANALREKG VPSGLLRILQ SYFTDRELIF NTSEGPVVRC VSAGVPQGSI
660 670 680 690 700
LGPTLWNVMY DGVLRIPLPD EAKVIGYADD LVVLAPGRTP EESAAVAEAA
710 720 730 740 750
VSAVDQWMQQ HHLELAPAKT EMTIISSLKH PPSHISIDVR GTAVPYSRSI
760 770 780 790 800
KHLGVLVHDH LSWIPHVTAV TQRAVQIAQA VGRLMPNHRG PKMSKSRLLA
810 820 830 840 850
AVADSVMRYA APVWHEALNT RECRRLLERV QRKSAIAVAR TFRTVRYETA
860 870 880 890 900
VLLAGLLPIC RAICEDTRVH SRRGTAAGAQ LRKEERETTI AEWQATWDSD
910 920 930 940 950
AAGHQASGYV RWAHRLIPDI GAWQSRKHGE VNFHLSQIIS GHGFFRKYLA
960 970 980 990 1000
DMKFTSSPDC PNCPGVRESA EHAMFACLRF AEVRERLMDG VNPDTLLTHM
1010 1020 1030 1040 1050
LQSQQNWSNV CEAAKQITTI LQREWDDFRT SLFEQGVLAD NAQLRNADVL
1060 1070 1080 1090 1100
RQERLRRYNE TRNAARRAAT QQRQAERLPP PPPSPRTERR REVNRLAVAR
1110 1120 1130 1140 1150
LRERQRAARA EMHGAYQPAP SNDSDDDDDD VENRQATNAA STSEAARTAA
1160 1170
EESRVGLTEA EAAAAVEAEL SSR
Length:1,173
Mass (Da):130,443
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i42BC78E1A6206328
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB090812 Genomic DNA Translation: BAC57900.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB090812 Genomic DNA Translation: BAC57900.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Family and domain databases

Gene3Di3.60.10.10, 1 hit
InterProiView protein in InterPro
IPR043502, DNA/RNA_pol_sf
IPR036691, Endo/exonu/phosph_ase_sf
IPR005135, Endo/exonuclease/phosphatase
IPR000477, RT_dom
PfamiView protein in Pfam
PF14529, Exo_endo_phos_2, 1 hit
PF00078, RVT_1, 1 hit
SUPFAMiSSF56219, SSF56219, 1 hit
SSF56672, SSF56672, 1 hit
PROSITEiView protein in PROSITE
PS50878, RT_POL, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ868T0_ANOGA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q868T0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: August 12, 2020
This is version 56 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Transposable elementARBA annotation
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