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Protein

Chymotrypsin-like elastase family member 1

Gene

CELA1

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Acts upon elastin.By similarity

Catalytic activityi

Hydrolysis of proteins, including elastin. Preferential cleavage: Ala-|-Xaa.

Cofactori

Ca2+By similarityNote: Binds 1 Ca2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei63Charge relay systemBy similarity1
Metal bindingi77CalciumBy similarity1
Metal bindingi82Calcium; via carbonyl oxygenBy similarity1
Metal bindingi87CalciumBy similarity1
Active sitei111Charge relay systemBy similarity1
Active sitei206Charge relay systemBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease, Serine protease
LigandCalcium, Metal-binding

Protein family/group databases

MEROPSiS01.153

Names & Taxonomyi

Protein namesi
Recommended name:
Chymotrypsin-like elastase family member 1 (EC:3.4.21.36)
Alternative name(s):
Elastase-1
Gene namesi
Name:CELA1
Synonyms:ELA1, ELS1
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 8By similarity8
PropeptideiPRO_00000276739 – 18Activation peptide10
ChainiPRO_000002767419 – 258Chymotrypsin-like elastase family member 1Add BLAST240

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi48 ↔ 64PROSITE-ProRule annotation
Glycosylationi79N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi145 ↔ 212PROSITE-ProRule annotation
Disulfide bondi176 ↔ 192PROSITE-ProRule annotation
Disulfide bondi202 ↔ 232PROSITE-ProRule annotation
Glycosylationi233N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ867B0

Interactioni

Protein-protein interaction databases

STRINGi9615.ENSCAFP00000011502

Structurei

3D structure databases

ProteinModelPortaliQ867B0
SMRiQ867B0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 256Peptidase S1PROSITE-ProRule annotationAdd BLAST238

Sequence similaritiesi

Belongs to the peptidase S1 family. Elastase subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
InParanoidiQ867B0

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q867B0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVLYGHSTQ DVPETNARVV GGTEARRNSW PSQISLQYLS GGKWYHTCGG
60 70 80 90 100
TLIRQNWVMT AAHCVDRTMT FRVVIGEHNL SQNDGTEQSA SVQKIVVHPY
110 120 130 140 150
WNSNDVSAGY DIALLRLAQK VTLNSYVQLG VLPQEGAILA NNSPCYITGW
160 170 180 190 200
GLTKTNGQLA QVLQQAYLPT VDYAICSSSS YWGSIVKKSM VCAGGDGIRS
210 220 230 240 250
GCQGDSGGPL HCSVNGKYTV HGVTSFVSSL GCNVSRKPTV FTRVSAYITW

INNVIASN
Length:258
Mass (Da):27,900
Last modified:June 1, 2003 - v1
Checksum:iEA7FF7CB67F1C74F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB100595 mRNA Translation: BAC55894.1
UniGeneiCfa.12

Similar proteinsi

Entry informationi

Entry nameiCELA1_CANLF
AccessioniPrimary (citable) accession number: Q867B0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: June 1, 2003
Last modified: May 10, 2017
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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