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Protein

Galactoside 2-alpha-L-fucosyltransferase 1

Gene

FUT1

Organism
Saimiri boliviensis boliviensis (Bolivian squirrel monkey)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Gal-beta-) called the H antigen which is an essential substrate for the final step in the soluble A and B antigen synthesis pathway.By similarity

Catalytic activityi

GDP-beta-L-fucose + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-R = GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-R.By similarity

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

UniPathwayi
UPA00378

Protein family/group databases

CAZyiGT11 Glycosyltransferase Family 11

Names & Taxonomyi

Protein namesi
Recommended name:
Galactoside 2-alpha-L-fucosyltransferase 1 (EC:2.4.1.344By similarity)
Alternative name(s):
Alpha(1,2)FT 1
Fucosyltransferase 1
GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1
Gene namesi
Name:FUT1
OrganismiSaimiri boliviensis boliviensis (Bolivian squirrel monkey)
Taxonomic identifieri39432 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniPlatyrrhiniCebidaeSaimiriinaeSaimiri
Proteomesi
  • UP000233220 Componenti: Whole Genome Shotgun Assembly

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 8CytoplasmicSequence analysis8
Transmembranei9 – 25Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST17
Topological domaini26 – 366LumenalSequence analysisAdd BLAST341

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001491041 – 366Galactoside 2-alpha-L-fucosyltransferase 1Add BLAST366

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi66N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi302N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi328N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ866F0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 11 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG004338

Family and domain databases

InterProiView protein in InterPro
IPR002516 Glyco_trans_11
PANTHERiPTHR11927 PTHR11927, 1 hit
PfamiView protein in Pfam
PF01531 Glyco_transf_11, 1 hit

Sequencei

Sequence statusi: Complete.

Q866F0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWPRSHRHLC LAFLLVCVLS AISFLIHFHQ DSIRHGLGLS VLCPDRRLVT
60 70 80 90 100
PAVAIFCLPG TPMSPNTSSS CPQHPASLSG TWTIYPDGRF GNQMGQYATL
110 120 130 140 150
LALAQLNGRR AFILPAMHAA LAPVFRITLP VLAPEVDSRT PWQELRLHDW
160 170 180 190 200
MSEEYADLGD PFLKLSGFPC SWTFFHHLRE QIRSEFTLHD HLREEAQSVL
210 220 230 240 250
RRLRLGRSGA RPRTFVGVHV RRGDYLQVMP QRWKGVVANS AYLREAMDWF
260 270 280 290 300
RARHEAPVFV VTSNGMEWCR ENIDASKGDV MFAGDGQEAS PWKDFALLTQ
310 320 330 340 350
CNHTIMTIGT FGFWAAYLAG GDTVYLANFT LPDSEFLKIF KPEAAFLPEW
360
VGINADLSPL WPLAEP
Length:366
Mass (Da):41,316
Last modified:June 1, 2003 - v1
Checksum:i6AF854B0F03067EA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY219618 Genomic DNA Translation: AAO43060.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY219618 Genomic DNA Translation: AAO43060.1

3D structure databases

ProteinModelPortaliQ866F0
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGT11 Glycosyltransferase Family 11

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG004338

Enzyme and pathway databases

UniPathwayi
UPA00378

Family and domain databases

InterProiView protein in InterPro
IPR002516 Glyco_trans_11
PANTHERiPTHR11927 PTHR11927, 1 hit
PfamiView protein in Pfam
PF01531 Glyco_transf_11, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFUT1_SAIBB
AccessioniPrimary (citable) accession number: Q866F0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: June 1, 2003
Last modified: May 23, 2018
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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