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Protein

Microsomal triglyceride transfer protein large subunit

Gene

MTTP

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces. Required for the secretion of plasma lipoproteins that contain apolipoprotein B.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processLipid transport, Transport
LigandLipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Microsomal triglyceride transfer protein large subunit
Gene namesi
Name:MTTP
Synonyms:MTP
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000004159619 – 894Microsomal triglyceride transfer protein large subunitAdd BLAST876

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ865F1
PeptideAtlasiQ865F1
PRIDEiQ865F1

Interactioni

Subunit structurei

Heterodimer; heterodimerizes with the protein disulfide isomerase (P4HB/PDI). Interacts with APOB.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000009789

Structurei

3D structure databases

ProteinModelPortaliQ865F1
SMRiQ865F1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 662VitellogeninPROSITE-ProRule annotationAdd BLAST635

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi888 – 891Poly-Ser4

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4337 Eukaryota
ENOG410YKCW LUCA
HOGENOMiHOG000113688
HOVERGENiHBG006416
InParanoidiQ865F1
KOiK14463

Family and domain databases

Gene3Di1.25.10.20, 1 hit
2.30.230.10, 1 hit
InterProiView protein in InterPro
IPR015819 Lipid_transp_b-sht_shell
IPR001747 Lipid_transpt_N
IPR011030 Lipovitellin_superhlx_dom
IPR039988 MTTP
IPR015816 Vitellinogen_b-sht_N
PANTHERiPTHR13024 PTHR13024, 1 hit
PfamiView protein in Pfam
PF01347 Vitellogenin_N, 1 hit
SMARTiView protein in SMART
SM00638 LPD_N, 1 hit
SUPFAMiSSF48431 SSF48431, 1 hit
SSF56968 SSF56968, 1 hit
PROSITEiView protein in PROSITE
PS51211 VITELLOGENIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q865F1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MILLAVLFLC FISSYSASVK GHTTGLSLNN DRLYKLKYST EVFLDRGKGN
60 70 80 90 100
LQDSVGYQIS SNVDVVLLWR SPDGDDDQLI QITIKDVKVE NVNQQRGEKS
110 120 130 140 150
IFKGKKPPQI IRKENLEALQ RPVLLHLIHG KVKEFYSYQN EPPAIQNLKR
160 170 180 190 200
GLASLFQMQL SSGTTNEVDI SGDCKVTYQA HQDKVTKIKA LDSCTIERSG
210 220 230 240 250
FTTRNQVLGV TSKATSVTTY KIEDSFVVAV LAEEIHALRL NFLQTIAGKI
260 270 280 290 300
VSKQKLELKT TEAGPRLKSG KQVAAIIKAV DSKYTAIPIV GQVFQSECKG
310 320 330 340 350
CSSLSQHWQS VRKHLQPDNL SKTEAVRSFL TFIQHLRTAK KEEILQILKA
360 370 380 390 400
ENKDILPQLV DAVTSAQTPD SLDAILDFLD FKSDSNIILQ ERFLYACGFA
410 420 430 440 450
SHPDEELLRA LISKFKGSFG SNDIRESVMI IIGALVRKLC QNEGCKLKAV
460 470 480 490 500
VDAKKLILGG LERAEKKEDT MMYLLALKNA RLPEGIPLLL KYAEAAEGPI
510 520 530 540 550
SHLAVTTLQR YDAPFITDEV KKTMNRIYHQ TRKVHEKTVR TTAAAVILNN
560 570 580 590 600
NPSYMEVKNI LLSIGELPKE MNKYMLSIVQ DILRFEMPAS KMVRRVLKEM
610 620 630 640 650
VAHNYDRFSK SGSSSAYTGY IERGPHSAST YSLDILYSGS GILRRSNLNI
660 670 680 690 700
FQYVGKTPLH AIQVVIEAQG LEALIAATPD EGEENLDSYA GLSPLLFDVQ
710 720 730 740 750
LRPVTFFNGY SDLMSKMLSA SSDPISVVKG LILLIDHSQE LQLQSGLKAN
760 770 780 790 800
MEVQGGLAID ISGSMEFSLW YRESKTRVKN RVTVVITGDI TVDSSFVKAG
810 820 830 840 850
LEISAETEAG LEFISTVQFS QYPFLVCLQM DRDGIPYRQF ETKYERLSTG
860 870 880 890
RGYVSRKRKE ILVAGSEFPL HQENSEMCKV VFAPEPESSS SGWF
Length:894
Mass (Da):99,771
Last modified:June 1, 2003 - v1
Checksum:iFBC410C925FA8F70
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY217034 mRNA Translation: AAO61497.1
RefSeqiNP_999350.1, NM_214185.1
UniGeneiSsc.17221

Genome annotation databases

GeneIDi397381
KEGGissc:397381

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY217034 mRNA Translation: AAO61497.1
RefSeqiNP_999350.1, NM_214185.1
UniGeneiSsc.17221

3D structure databases

ProteinModelPortaliQ865F1
SMRiQ865F1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000009789

Proteomic databases

PaxDbiQ865F1
PeptideAtlasiQ865F1
PRIDEiQ865F1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi397381
KEGGissc:397381

Organism-specific databases

CTDi4547

Phylogenomic databases

eggNOGiKOG4337 Eukaryota
ENOG410YKCW LUCA
HOGENOMiHOG000113688
HOVERGENiHBG006416
InParanoidiQ865F1
KOiK14463

Family and domain databases

Gene3Di1.25.10.20, 1 hit
2.30.230.10, 1 hit
InterProiView protein in InterPro
IPR015819 Lipid_transp_b-sht_shell
IPR001747 Lipid_transpt_N
IPR011030 Lipovitellin_superhlx_dom
IPR039988 MTTP
IPR015816 Vitellinogen_b-sht_N
PANTHERiPTHR13024 PTHR13024, 1 hit
PfamiView protein in Pfam
PF01347 Vitellogenin_N, 1 hit
SMARTiView protein in SMART
SM00638 LPD_N, 1 hit
SUPFAMiSSF48431 SSF48431, 1 hit
SSF56968 SSF56968, 1 hit
PROSITEiView protein in PROSITE
PS51211 VITELLOGENIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMTP_PIG
AccessioniPrimary (citable) accession number: Q865F1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: June 1, 2003
Last modified: November 7, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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