Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 101 (10 Feb 2021)
Sequence version 2 (04 Jan 2005)
Previous versions | rss
Add a publicationFeedback
Protein

Breast cancer type 2 susceptibility protein homolog

Gene

BRCA2

Organism
Felis catus (Cat) (Felis silvestris catus)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with PALB2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity. In concert with NPM1, regulates centrosome duplication. Interacts with the TREX-2 complex (transcription and export complex 2) subunits PCID2 and SEM1, and is required to prevent R-loop-associated DNA damage and thus transcription-associated genomic instability, independently of its known role in homologous recombination (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processDNA damage, DNA recombination, DNA repair

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Breast cancer type 2 susceptibility protein homolog
Alternative name(s):
Fanconi anemia group D1 protein homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BRCA2
Synonyms:FANCD1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiFelis catus (Cat) (Felis silvestris catus)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9685 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000011712 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002270141 – 3372Breast cancer type 2 susceptibility protein homologAdd BLAST3372

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei435PhosphoserineBy similarity1
Modified residuei483PhosphoserineBy similarity1
Modified residuei1924PhosphoserineBy similarity1
Modified residuei1990PhosphothreonineBy similarity1
Modified residuei2039PhosphoserineBy similarity1
Modified residuei3236Phosphoserine; by CDK1 and CDK2By similarity1
Modified residuei3264PhosphoserineBy similarity1
Modified residuei3331Phosphothreonine; by CHEK1 and CHEK2By similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by ATM upon irradiation-induced DNA damage. Phosphorylation by CHEK1 and CHEK2 regulates interaction with RAD51. Phosphorylation at Ser-3291 by CDK1 and CDK2 is low in S phase when recombination is active, but increases as cells progress towards mitosis; this phosphorylation prevents homologous recombination-dependent repair during S phase and G2 by inhibiting RAD51 binding.By similarity
Ubiquitinated in the absence of DNA damage; this does not lead to proteasomal degradation. In contrast, ubiquitination in response to DNA damage leads to proteasomal degradation.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer and dimer.

Interacts with RAD51; regulates RAD51 recruitment and function at sites of DNA repair.

Interacts with SEM1, WDR16, USP11, DMC1, ROCK2 and NPM1.

Interacts with both nonubiquitinated and monoubiquitinated FANCD2; this complex also includes XRCC3 and phosphorylated FANCG.

Part of a BRCA complex containing BRCA1, BRCA2 and PALB2.

Interacts directly with PALB2 which may serve as a scaffold for a HR complex containing PALB2, BRCA2, RAD51C, RAD51 and XRCC3.

Interacts with BRCA1 only in the presence of PALB2 which serves as the bridging protein.

Interacts with POLH; the interaction is direct.

Interacts with the TREX-2 complex subunits PCID2 and SEM1 (By similarity).

Interacts with HSF2BP and BRME1; the interaction with HSF2BP is direct and allow the formation of a ternary complex. The complex BRME1:HSF2BP:BRCA2 interacts with SPATA22, MEIOB and RAD51 (By similarity).

By similarity

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q864S8, 1 interactor

Molecular INTeraction database

More...
MINTi
Q864S8

STRING: functional protein association networks

More...
STRINGi
9685.ENSFCAP00000019777

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q864S8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati994 – 1028BRCA2 1Add BLAST35
Repeati1208 – 1242BRCA2 2Add BLAST35
Repeati1417 – 1451BRCA2 3Add BLAST35
Repeati1518 – 1552BRCA2 4Add BLAST35
Repeati1663 – 1697BRCA2 5Add BLAST35
Repeati1925 – 1959BRCA2 6Add BLAST35
Repeati1995 – 2029BRCA2 7Add BLAST35

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 40Interaction with PALB2By similarityAdd BLAST40
Regioni630 – 992Interaction with NPM1By similarityAdd BLAST363
Regioni995 – 2026Interaction with RAD51By similarityAdd BLAST1032
Regioni2213 – 2279Interaction with HSF2BPBy similarityAdd BLAST67
Regioni2425 – 2776Interaction with SEM1By similarityAdd BLAST352

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi2626 – 2642Nuclear export signal; masked by interaction with SEM1By similarityAdd BLAST17

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4751, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q864S8

Database of Orthologous Groups

More...
OrthoDBi
257485at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd04493, BRCA2DBD_OB1, 1 hit
cd04495, BRCA2DBD_OB3, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015525, BRCA2
IPR015252, BRCA2_hlx
IPR036315, BRCA2_hlx_sf
IPR015187, BRCA2_OB_1
IPR015188, BRCA2_OB_3
IPR002093, BRCA2_repeat
IPR012340, NA-bd_OB-fold
IPR015205, Tower_dom

The PANTHER Classification System

More...
PANTHERi
PTHR11289, PTHR11289, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09169, BRCA-2_helical, 1 hit
PF09103, BRCA-2_OB1, 1 hit
PF09104, BRCA-2_OB3, 1 hit
PF00634, BRCA2, 7 hits
PF09121, Tower, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF002397, BRCA2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01341, Tower, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50249, SSF50249, 3 hits
SSF81872, SSF81872, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50138, BRCA2_REPEAT, 7 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q864S8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPIGCKERPT FFEIFRTRCN KADLGPISLN WFEELCLEAP PYNSEPTEES
60 70 80 90 100
GYKISYEPNL FKTPQRKPCH QLASTPIIFK EQGLIPPIYQ QSPLKELGKD
110 120 130 140 150
ITNSKHRSCC TMKSKMDQTN DVTSPPLNSC LSESPLLRST HVTPQREKSV
160 170 180 190 200
VCGSLFHTPK LTKGQTPKRI SESLGAEVDP DMSWSSSLAT PPTLSSTVLI
210 220 230 240 250
VRDEEASAAV FPNDTTAIFK SYFCNHDESL KKNDRFIPSG PDSENKSQRE
260 270 280 290 300
AKSQGLGKMV GNSCDKVNSC KDPFGNSTLN VLEDGVRERV ADVSEEDSFP
310 320 330 340 350
LCVPKCKTRN LQKIKTSKTR KNIFNETTDE CKEAKKQMKE NKHSFVSEME
360 370 380 390 400
ANASDPLDSN VTNQKPFGNG SDKISKEVVL SSASESCHLT LSGLNGTHME
410 420 430 440 450
KLPLLCISSC DQNNSEKDLI TTEKECTNFI ILEDSLPQIS GVPKCTEKIL
460 470 480 490 500
NEEIVVNKID EGQCLESHED SILAVKQAVF ETSLIASPLQ GIRKSIFRIR
510 520 530 540 550
ESPEETFSAV FSNNITDPNF KEEHEASESV LEKHSICSQK EDSLSTSSLD
560 570 580 590 600
NGSWPATIKH TSVALKNSGL ISTLKKKTKK FIYVVNDETS YQGLKTQKDQ
610 620 630 640 650
QSGLMNYSAQ FEANVLEGPL TFANADSGLL HSSVKKTCLQ NDSKEPILSL
660 670 680 690 700
TNSFGTLLRK VSNKGSSSPN NKIISQDLDY KEAKIKKEKL QSFISTETNC
710 720 730 740 750
LSSLQEKHCE DDTKSQRVAD RKEEILPAVS QPSVPYSEVE DSGIHFQTLK
760 770 780 790 800
SFSSDPDKSS QLTPHPRDPP SNPVGLSRGR ESYEVSETLK CKNHEAGFEL
810 820 830 840 850
TKTMENSQEI HVLNEHAKKA KLLSTEKYVT EASPSMKVPF NQNAHLTIIQ
860 870 880 890 900
KDQKETTLIS KITMNPNSEE LFPDGDNFVF KITKERNVPV LGSIKELQDS
910 920 930 940 950
DLCCVKEPVL ENSTMVVYTD MDDKQAAKVS ITKGFDSSNI DDLTEKDRNS
960 970 980 990 1000
IKQQLRMTLD QDSKSDITLD SDMKSNGNND YMDNWARLSD PILNHNFGNG
1010 1020 1030 1040 1050
FRTASNKEIK LSEHNIKKSK MLFKDIEERY PTNLACIEIV NTPLESQEKL
1060 1070 1080 1090 1100
SKPHILDPQS INTVSGCVQS SAYVSDSENR HTTPPTLSLK RDFDSNHNLT
1110 1120 1130 1140 1150
PSQKAEITEL STILEESGSQ FEFTQFRKPS HLKQKNPCEM PEKHLTISNT
1160 1170 1180 1190 1200
TPEEQKDGHL RLTINALSIS QGDSSKKFEG IIGGKQKLAC LSKTSCNKSA
1210 1220 1230 1240 1250
SGHLTGKNEV EFRGFYSARG TKLNVCSEAL QKAKKLFSDL ENISEETSVE
1260 1270 1280 1290 1300
VDRSFSSSKC NGSVSMFKKE NCNNEKKLNE KNNKYRLILQ NNIEMTTGIF
1310 1320 1330 1340 1350
VAEDTEGYKR NIENKANKYT DASRNVYNFR EADGSDSSKN DTVYIHKEEN
1360 1370 1380 1390 1400
GLPYIDQHDI DLKLSSQFIK EGNTQIKEGL SDLTCLEVVK AEETLHVNTS
1410 1420 1430 1440 1450
NKEHLTANTM GRITKDFDIF DVSFQTASGK NIRVSRASLN KVTNLLDQKC
1460 1470 1480 1490 1500
TEEELNNFAD SLNSELLSGI DINKADISHH GEMEILKKRQ MKESDLTGTE
1510 1520 1530 1540 1550
NKSLTLQQRP EYEIKKIKEP TILGFHTASG KRIEIAKESL DKVKNLFDEQ
1560 1570 1580 1590 1600
EQDKSEMTNF SHRGTKMSKG REECEGGLRL ACKTIEITPA SKEEEMQKPL
1610 1620 1630 1640 1650
EKNLVSNEIV VVPRLLSDNL YKQTENLKIP NRASLKVKVH ENTGKETAKK
1660 1670 1680 1690 1700
PTTCTNQSTY SATENSALSF YTGHGRKISV SQSSILEVKK WLRGGELDDQ
1710 1720 1730 1740 1750
PEKTVYNISE YLPKSKVDNS GIEPVVRNVG ERENTSVSEI MFTVREADTD
1760 1770 1780 1790 1800
PQSVNEDICV QRLVTNFSCK KENTAIKVTV SDSNNFDSTQ KLNSDSNDAV
1810 1820 1830 1840 1850
PVYTTASSER VLVAHETKVA EGFTENCSMA IKQTTKSKPG KIVAGYRKAP
1860 1870 1880 1890 1900
DDSEDTICPN SLDGAECSSP SHKDFAETQS EQTPQLNQSI SGFKKRSEIP
1910 1920 1930 1940 1950
PHQINLKTSD ICKLSTGKRL QSISYTNACG IFSTASGKCV QVSDAALQKA
1960 1970 1980 1990 2000
RQVFSKVEDS AKQPFSKVSF KHNEDHSDKF TREENTMIHT PQNLLSSAFS
2010 2020 2030 2040 2050
GFSTASGKQV PVSESALCKV KGILEEFDVM RTECGPQRSP TSRQDVSKMP
2060 2070 2080 2090 2100
PPSCVENKTP KHSVNSKLEK AYNKEFKLSS NSKIENGSSE NHSVQVSPYP
2110 2120 2130 2140 2150
SQFKQDKQLI QGNKASLVEN IHLLEKEQAL PKNIKWKLET EAFPNLPLKT
2160 2170 2180 2190 2200
DTAIHSTDSK DPENYFETET VEIAKAFMED GELTDADLLS HARHFLPTCQ
2210 2220 2230 2240 2250
HSEETLVSNS RRGKRRGVLV SVGEPPIKRN LLNEFDRIIK NQEKSLKASK
2260 2270 2280 2290 2300
STPDGIIKDR SLFMHHISLE PVTCGPFSTT KKRQEIQNPN FTAPGQKFLS
2310 2320 2330 2340 2350
KSHFYEHLAL EKSSSNVSIS GQPFCTVPAT RSEKRGHSIT PSKPVKVFVP
2360 2370 2380 2390 2400
PFKTKSRFLQ DEQHISKNTH VEENKQKPNN IDEHSSGDSK NNINNSEIHQ
2410 2420 2430 2440 2450
LNKNNSSQAA TMVFTKCEKE PLDLIASLQN ARDIQDMRIR EKRKQHIFPQ
2460 2470 2480 2490 2500
PGSLFLAKTS TVPRISLRVA VEGRVPSACS HKQLYMYGVS KHCVKINSKN
2510 2520 2530 2540 2550
AESFQFHTQD YFGKEVQWAK EGIQLADGGW LIPSNDGKAG KEEFYRALCD
2560 2570 2580 2590 2600
TPGVDPNLIS RIWVYNHYRW IIWKLAAMEF AFPKEFANRC LSPERVLLQL
2610 2620 2630 2640 2650
KYRYDMEIDR SKRSAIKKIM ERDDTAAKTL VLCISETISS STDLSETSGS
2660 2670 2680 2690 2700
KTSGVGTKNV GIVELTDGWY AIKAQLDPPL LALVKKGRLT VGHKIIIHGA
2710 2720 2730 2740 2750
ELAGSPDACT PLEAPESLIL KISANSTRPA CWYAKLGFFP DPRPFPLPLS
2760 2770 2780 2790 2800
SLFSDGGNVG CVDVVIQRTY PIQWMEKTPS GLCIFRNERE EEREATKYAE
2810 2820 2830 2840 2850
AQQKKLEVLF NKIQAEFEKH DENITKRCVP LRALTRQQVC ALQDGAELYE
2860 2870 2880 2890 2900
AVKNAPDPAS LEAYFSEEQI RALNNHRQML NDKKQAQIQL EFRKAMESAE
2910 2920 2930 2940 2950
QGEQMLPRDV TTVWKMRIIS YGKKEKDSVT LSIWRPSSDL YSLLTEGKRY
2960 2970 2980 2990 3000
RIYHLATSQS KSKSERAHIQ LTATKKTQYQ QLPASDELLF QVYQPREPLY
3010 3020 3030 3040 3050
FNKLLDPDFQ PPCSEVDLIG FVVSVVKKIG FAPLVYLSDE CHNLLAIKVW
3060 3070 3080 3090 3100
TDLNEDIVKP HTLIAASNLQ WRPESKSGIP TLFAGDFSRF SASPKEGHFQ
3110 3120 3130 3140 3150
ETFHKMKNTI ENVETFCNDA ENKLVHILNA NSPKVSTPMK DYASEPHTIQ
3160 3170 3180 3190 3200
TVLGLGNKLS MSSPNSEMNY QSPLSLCKPK AKSVPTPGSA QMTSKSCYKG
3210 3220 3230 3240 3250
ERELDDPKTC KKRKALDFLS RLPLPPPVSP ICTFVSPAAQ KAFQPPRSCG
3260 3270 3280 3290 3300
TKYETPIKKR ELNSPQMTPL KFNDTSLVES DSIADEELAL INTQALLSGL
3310 3320 3330 3340 3350
AGEDQLMSLN DSPRTAPTSS KDYVRPKSYP TAPGIRDCEN PQASTEGGEP
3360 3370
DVQDTDTVKR SSMRLQRRQQ QT
Length:3,372
Mass (Da):377,345
Last modified:January 4, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i37F23DA23CA94665
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB107955 mRNA Translation: BAC75821.2

NCBI Reference Sequences

More...
RefSeqi
NP_001009858.1, NM_001009858.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
493878

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
fca:493878

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB107955 mRNA Translation: BAC75821.2
RefSeqiNP_001009858.1, NM_001009858.1

3D structure databases

SMRiQ864S8
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ864S8, 1 interactor
MINTiQ864S8
STRINGi9685.ENSFCAP00000019777

Genome annotation databases

GeneIDi493878
KEGGifca:493878

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
675

Phylogenomic databases

eggNOGiKOG4751, Eukaryota
InParanoidiQ864S8
OrthoDBi257485at2759

Family and domain databases

CDDicd04493, BRCA2DBD_OB1, 1 hit
cd04495, BRCA2DBD_OB3, 1 hit
InterProiView protein in InterPro
IPR015525, BRCA2
IPR015252, BRCA2_hlx
IPR036315, BRCA2_hlx_sf
IPR015187, BRCA2_OB_1
IPR015188, BRCA2_OB_3
IPR002093, BRCA2_repeat
IPR012340, NA-bd_OB-fold
IPR015205, Tower_dom
PANTHERiPTHR11289, PTHR11289, 1 hit
PfamiView protein in Pfam
PF09169, BRCA-2_helical, 1 hit
PF09103, BRCA-2_OB1, 1 hit
PF09104, BRCA-2_OB3, 1 hit
PF00634, BRCA2, 7 hits
PF09121, Tower, 1 hit
PIRSFiPIRSF002397, BRCA2, 1 hit
SMARTiView protein in SMART
SM01341, Tower, 1 hit
SUPFAMiSSF50249, SSF50249, 3 hits
SSF81872, SSF81872, 1 hit
PROSITEiView protein in PROSITE
PS50138, BRCA2_REPEAT, 7 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBRCA2_FELCA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q864S8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: January 4, 2005
Last modified: February 10, 2021
This is version 101 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again