UniProtKB - Q864S8 (BRCA2_FELCA)
Breast cancer type 2 susceptibility protein homolog
BRCA2
Functioni
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- gamma-tubulin binding Source: UniProtKB
GO - Biological processi
- centrosome duplication Source: UniProtKB
- double-strand break repair Source: UniProtKB
- double-strand break repair via homologous recombination Source: GO_Central
- negative regulation of mammary gland epithelial cell proliferation Source: UniProtKB
- nucleotide-excision repair Source: UniProtKB
- positive regulation of transcription, DNA-templated Source: UniProtKB
- regulation of transcription, DNA-templated Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | DNA damage, DNA recombination, DNA repair |
Names & Taxonomyi
Protein namesi | Recommended name: Breast cancer type 2 susceptibility protein homologAlternative name(s): Fanconi anemia group D1 protein homolog |
Gene namesi | Name:BRCA2 Synonyms:FANCD1 |
Organismi | Felis catus (Cat) (Felis silvestris catus) |
Taxonomic identifieri | 9685 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Feliformia › Felidae › Felinae › Felis |
Proteomesi |
|
Subcellular locationi
Nucleus
- Nucleus By similarity
Cytoskeleton
- centrosome By similarity
Cytoskeleton
- centrosome Source: UniProtKB
Nucleus
- nucleus Source: UniProtKB
Other locations
- BRCA2-MAGE-D1 complex Source: UniProtKB
- protein-containing complex Source: UniProtKB
- secretory granule Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000227014 | 1 – 3372 | Breast cancer type 2 susceptibility protein homologAdd BLAST | 3372 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 435 | PhosphoserineBy similarity | 1 | |
Modified residuei | 483 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1924 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1990 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 2039 | PhosphoserineBy similarity | 1 | |
Modified residuei | 3236 | Phosphoserine; by CDK1 and CDK2By similarity | 1 | |
Modified residuei | 3264 | PhosphoserineBy similarity | 1 | |
Modified residuei | 3331 | Phosphothreonine; by CHEK1 and CHEK2By similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Phosphoprotein, Ubl conjugationInteractioni
Subunit structurei
Monomer and dimer.
Interacts with RAD51; regulates RAD51 recruitment and function at sites of DNA repair.
Interacts with SEM1, WDR16, USP11, DMC1, ROCK2 and NPM1.
Interacts with both nonubiquitinated and monoubiquitinated FANCD2; this complex also includes XRCC3 and phosphorylated FANCG.
Part of a BRCA complex containing BRCA1, BRCA2 and PALB2.
Interacts directly with PALB2 which may serve as a scaffold for a HR complex containing PALB2, BRCA2, RAD51C, RAD51 and XRCC3.
Interacts with BRCA1 only in the presence of PALB2 which serves as the bridging protein.
Interacts with POLH; the interaction is direct.
Interacts with the TREX-2 complex subunits PCID2 and SEM1 (By similarity).
Interacts with HSF2BP and BRME1; the interaction with HSF2BP is direct and allow the formation of a ternary complex. The complex BRME1:HSF2BP:BRCA2 interacts with SPATA22, MEIOB and RAD51 (By similarity).
By similarityGO - Molecular functioni
- gamma-tubulin binding Source: UniProtKB
Protein-protein interaction databases
IntActi | Q864S8, 1 interactor |
MINTi | Q864S8 |
STRINGi | 9685.ENSFCAP00000019777 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 994 – 1028 | BRCA2 1Add BLAST | 35 | |
Repeati | 1208 – 1242 | BRCA2 2Add BLAST | 35 | |
Repeati | 1417 – 1451 | BRCA2 3Add BLAST | 35 | |
Repeati | 1518 – 1552 | BRCA2 4Add BLAST | 35 | |
Repeati | 1663 – 1697 | BRCA2 5Add BLAST | 35 | |
Repeati | 1925 – 1959 | BRCA2 6Add BLAST | 35 | |
Repeati | 1995 – 2029 | BRCA2 7Add BLAST | 35 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 40 | Interaction with PALB2By similarityAdd BLAST | 40 | |
Regioni | 630 – 992 | Interaction with NPM1By similarityAdd BLAST | 363 | |
Regioni | 995 – 2026 | Interaction with RAD51By similarityAdd BLAST | 1032 | |
Regioni | 2213 – 2279 | Interaction with HSF2BPBy similarityAdd BLAST | 67 | |
Regioni | 2425 – 2776 | Interaction with SEM1By similarityAdd BLAST | 352 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 2626 – 2642 | Nuclear export signal; masked by interaction with SEM1By similarityAdd BLAST | 17 |
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG4751, Eukaryota |
InParanoidi | Q864S8 |
OrthoDBi | 257485at2759 |
Family and domain databases
CDDi | cd04493, BRCA2DBD_OB1, 1 hit cd04495, BRCA2DBD_OB3, 1 hit |
InterProi | View protein in InterPro IPR015525, BRCA2 IPR015252, BRCA2_hlx IPR036315, BRCA2_hlx_sf IPR015187, BRCA2_OB_1 IPR015188, BRCA2_OB_3 IPR002093, BRCA2_repeat IPR012340, NA-bd_OB-fold IPR015205, Tower_dom |
PANTHERi | PTHR11289, PTHR11289, 1 hit |
Pfami | View protein in Pfam PF09169, BRCA-2_helical, 1 hit PF09103, BRCA-2_OB1, 1 hit PF09104, BRCA-2_OB3, 1 hit PF00634, BRCA2, 7 hits PF09121, Tower, 1 hit |
PIRSFi | PIRSF002397, BRCA2, 1 hit |
SMARTi | View protein in SMART SM01341, Tower, 1 hit |
SUPFAMi | SSF50249, SSF50249, 3 hits SSF81872, SSF81872, 1 hit |
PROSITEi | View protein in PROSITE PS50138, BRCA2_REPEAT, 7 hits |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MPIGCKERPT FFEIFRTRCN KADLGPISLN WFEELCLEAP PYNSEPTEES
60 70 80 90 100
GYKISYEPNL FKTPQRKPCH QLASTPIIFK EQGLIPPIYQ QSPLKELGKD
110 120 130 140 150
ITNSKHRSCC TMKSKMDQTN DVTSPPLNSC LSESPLLRST HVTPQREKSV
160 170 180 190 200
VCGSLFHTPK LTKGQTPKRI SESLGAEVDP DMSWSSSLAT PPTLSSTVLI
210 220 230 240 250
VRDEEASAAV FPNDTTAIFK SYFCNHDESL KKNDRFIPSG PDSENKSQRE
260 270 280 290 300
AKSQGLGKMV GNSCDKVNSC KDPFGNSTLN VLEDGVRERV ADVSEEDSFP
310 320 330 340 350
LCVPKCKTRN LQKIKTSKTR KNIFNETTDE CKEAKKQMKE NKHSFVSEME
360 370 380 390 400
ANASDPLDSN VTNQKPFGNG SDKISKEVVL SSASESCHLT LSGLNGTHME
410 420 430 440 450
KLPLLCISSC DQNNSEKDLI TTEKECTNFI ILEDSLPQIS GVPKCTEKIL
460 470 480 490 500
NEEIVVNKID EGQCLESHED SILAVKQAVF ETSLIASPLQ GIRKSIFRIR
510 520 530 540 550
ESPEETFSAV FSNNITDPNF KEEHEASESV LEKHSICSQK EDSLSTSSLD
560 570 580 590 600
NGSWPATIKH TSVALKNSGL ISTLKKKTKK FIYVVNDETS YQGLKTQKDQ
610 620 630 640 650
QSGLMNYSAQ FEANVLEGPL TFANADSGLL HSSVKKTCLQ NDSKEPILSL
660 670 680 690 700
TNSFGTLLRK VSNKGSSSPN NKIISQDLDY KEAKIKKEKL QSFISTETNC
710 720 730 740 750
LSSLQEKHCE DDTKSQRVAD RKEEILPAVS QPSVPYSEVE DSGIHFQTLK
760 770 780 790 800
SFSSDPDKSS QLTPHPRDPP SNPVGLSRGR ESYEVSETLK CKNHEAGFEL
810 820 830 840 850
TKTMENSQEI HVLNEHAKKA KLLSTEKYVT EASPSMKVPF NQNAHLTIIQ
860 870 880 890 900
KDQKETTLIS KITMNPNSEE LFPDGDNFVF KITKERNVPV LGSIKELQDS
910 920 930 940 950
DLCCVKEPVL ENSTMVVYTD MDDKQAAKVS ITKGFDSSNI DDLTEKDRNS
960 970 980 990 1000
IKQQLRMTLD QDSKSDITLD SDMKSNGNND YMDNWARLSD PILNHNFGNG
1010 1020 1030 1040 1050
FRTASNKEIK LSEHNIKKSK MLFKDIEERY PTNLACIEIV NTPLESQEKL
1060 1070 1080 1090 1100
SKPHILDPQS INTVSGCVQS SAYVSDSENR HTTPPTLSLK RDFDSNHNLT
1110 1120 1130 1140 1150
PSQKAEITEL STILEESGSQ FEFTQFRKPS HLKQKNPCEM PEKHLTISNT
1160 1170 1180 1190 1200
TPEEQKDGHL RLTINALSIS QGDSSKKFEG IIGGKQKLAC LSKTSCNKSA
1210 1220 1230 1240 1250
SGHLTGKNEV EFRGFYSARG TKLNVCSEAL QKAKKLFSDL ENISEETSVE
1260 1270 1280 1290 1300
VDRSFSSSKC NGSVSMFKKE NCNNEKKLNE KNNKYRLILQ NNIEMTTGIF
1310 1320 1330 1340 1350
VAEDTEGYKR NIENKANKYT DASRNVYNFR EADGSDSSKN DTVYIHKEEN
1360 1370 1380 1390 1400
GLPYIDQHDI DLKLSSQFIK EGNTQIKEGL SDLTCLEVVK AEETLHVNTS
1410 1420 1430 1440 1450
NKEHLTANTM GRITKDFDIF DVSFQTASGK NIRVSRASLN KVTNLLDQKC
1460 1470 1480 1490 1500
TEEELNNFAD SLNSELLSGI DINKADISHH GEMEILKKRQ MKESDLTGTE
1510 1520 1530 1540 1550
NKSLTLQQRP EYEIKKIKEP TILGFHTASG KRIEIAKESL DKVKNLFDEQ
1560 1570 1580 1590 1600
EQDKSEMTNF SHRGTKMSKG REECEGGLRL ACKTIEITPA SKEEEMQKPL
1610 1620 1630 1640 1650
EKNLVSNEIV VVPRLLSDNL YKQTENLKIP NRASLKVKVH ENTGKETAKK
1660 1670 1680 1690 1700
PTTCTNQSTY SATENSALSF YTGHGRKISV SQSSILEVKK WLRGGELDDQ
1710 1720 1730 1740 1750
PEKTVYNISE YLPKSKVDNS GIEPVVRNVG ERENTSVSEI MFTVREADTD
1760 1770 1780 1790 1800
PQSVNEDICV QRLVTNFSCK KENTAIKVTV SDSNNFDSTQ KLNSDSNDAV
1810 1820 1830 1840 1850
PVYTTASSER VLVAHETKVA EGFTENCSMA IKQTTKSKPG KIVAGYRKAP
1860 1870 1880 1890 1900
DDSEDTICPN SLDGAECSSP SHKDFAETQS EQTPQLNQSI SGFKKRSEIP
1910 1920 1930 1940 1950
PHQINLKTSD ICKLSTGKRL QSISYTNACG IFSTASGKCV QVSDAALQKA
1960 1970 1980 1990 2000
RQVFSKVEDS AKQPFSKVSF KHNEDHSDKF TREENTMIHT PQNLLSSAFS
2010 2020 2030 2040 2050
GFSTASGKQV PVSESALCKV KGILEEFDVM RTECGPQRSP TSRQDVSKMP
2060 2070 2080 2090 2100
PPSCVENKTP KHSVNSKLEK AYNKEFKLSS NSKIENGSSE NHSVQVSPYP
2110 2120 2130 2140 2150
SQFKQDKQLI QGNKASLVEN IHLLEKEQAL PKNIKWKLET EAFPNLPLKT
2160 2170 2180 2190 2200
DTAIHSTDSK DPENYFETET VEIAKAFMED GELTDADLLS HARHFLPTCQ
2210 2220 2230 2240 2250
HSEETLVSNS RRGKRRGVLV SVGEPPIKRN LLNEFDRIIK NQEKSLKASK
2260 2270 2280 2290 2300
STPDGIIKDR SLFMHHISLE PVTCGPFSTT KKRQEIQNPN FTAPGQKFLS
2310 2320 2330 2340 2350
KSHFYEHLAL EKSSSNVSIS GQPFCTVPAT RSEKRGHSIT PSKPVKVFVP
2360 2370 2380 2390 2400
PFKTKSRFLQ DEQHISKNTH VEENKQKPNN IDEHSSGDSK NNINNSEIHQ
2410 2420 2430 2440 2450
LNKNNSSQAA TMVFTKCEKE PLDLIASLQN ARDIQDMRIR EKRKQHIFPQ
2460 2470 2480 2490 2500
PGSLFLAKTS TVPRISLRVA VEGRVPSACS HKQLYMYGVS KHCVKINSKN
2510 2520 2530 2540 2550
AESFQFHTQD YFGKEVQWAK EGIQLADGGW LIPSNDGKAG KEEFYRALCD
2560 2570 2580 2590 2600
TPGVDPNLIS RIWVYNHYRW IIWKLAAMEF AFPKEFANRC LSPERVLLQL
2610 2620 2630 2640 2650
KYRYDMEIDR SKRSAIKKIM ERDDTAAKTL VLCISETISS STDLSETSGS
2660 2670 2680 2690 2700
KTSGVGTKNV GIVELTDGWY AIKAQLDPPL LALVKKGRLT VGHKIIIHGA
2710 2720 2730 2740 2750
ELAGSPDACT PLEAPESLIL KISANSTRPA CWYAKLGFFP DPRPFPLPLS
2760 2770 2780 2790 2800
SLFSDGGNVG CVDVVIQRTY PIQWMEKTPS GLCIFRNERE EEREATKYAE
2810 2820 2830 2840 2850
AQQKKLEVLF NKIQAEFEKH DENITKRCVP LRALTRQQVC ALQDGAELYE
2860 2870 2880 2890 2900
AVKNAPDPAS LEAYFSEEQI RALNNHRQML NDKKQAQIQL EFRKAMESAE
2910 2920 2930 2940 2950
QGEQMLPRDV TTVWKMRIIS YGKKEKDSVT LSIWRPSSDL YSLLTEGKRY
2960 2970 2980 2990 3000
RIYHLATSQS KSKSERAHIQ LTATKKTQYQ QLPASDELLF QVYQPREPLY
3010 3020 3030 3040 3050
FNKLLDPDFQ PPCSEVDLIG FVVSVVKKIG FAPLVYLSDE CHNLLAIKVW
3060 3070 3080 3090 3100
TDLNEDIVKP HTLIAASNLQ WRPESKSGIP TLFAGDFSRF SASPKEGHFQ
3110 3120 3130 3140 3150
ETFHKMKNTI ENVETFCNDA ENKLVHILNA NSPKVSTPMK DYASEPHTIQ
3160 3170 3180 3190 3200
TVLGLGNKLS MSSPNSEMNY QSPLSLCKPK AKSVPTPGSA QMTSKSCYKG
3210 3220 3230 3240 3250
ERELDDPKTC KKRKALDFLS RLPLPPPVSP ICTFVSPAAQ KAFQPPRSCG
3260 3270 3280 3290 3300
TKYETPIKKR ELNSPQMTPL KFNDTSLVES DSIADEELAL INTQALLSGL
3310 3320 3330 3340 3350
AGEDQLMSLN DSPRTAPTSS KDYVRPKSYP TAPGIRDCEN PQASTEGGEP
3360 3370
DVQDTDTVKR SSMRLQRRQQ QT
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB107955 mRNA Translation: BAC75821.2 |
RefSeqi | NP_001009858.1, NM_001009858.1 |
Genome annotation databases
GeneIDi | 493878 |
KEGGi | fca:493878 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB107955 mRNA Translation: BAC75821.2 |
RefSeqi | NP_001009858.1, NM_001009858.1 |
3D structure databases
SMRi | Q864S8 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q864S8, 1 interactor |
MINTi | Q864S8 |
STRINGi | 9685.ENSFCAP00000019777 |
Genome annotation databases
GeneIDi | 493878 |
KEGGi | fca:493878 |
Organism-specific databases
CTDi | 675 |
Phylogenomic databases
eggNOGi | KOG4751, Eukaryota |
InParanoidi | Q864S8 |
OrthoDBi | 257485at2759 |
Family and domain databases
CDDi | cd04493, BRCA2DBD_OB1, 1 hit cd04495, BRCA2DBD_OB3, 1 hit |
InterProi | View protein in InterPro IPR015525, BRCA2 IPR015252, BRCA2_hlx IPR036315, BRCA2_hlx_sf IPR015187, BRCA2_OB_1 IPR015188, BRCA2_OB_3 IPR002093, BRCA2_repeat IPR012340, NA-bd_OB-fold IPR015205, Tower_dom |
PANTHERi | PTHR11289, PTHR11289, 1 hit |
Pfami | View protein in Pfam PF09169, BRCA-2_helical, 1 hit PF09103, BRCA-2_OB1, 1 hit PF09104, BRCA-2_OB3, 1 hit PF00634, BRCA2, 7 hits PF09121, Tower, 1 hit |
PIRSFi | PIRSF002397, BRCA2, 1 hit |
SMARTi | View protein in SMART SM01341, Tower, 1 hit |
SUPFAMi | SSF50249, SSF50249, 3 hits SSF81872, SSF81872, 1 hit |
PROSITEi | View protein in PROSITE PS50138, BRCA2_REPEAT, 7 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BRCA2_FELCA | |
Accessioni | Q864S8Primary (citable) accession number: Q864S8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 7, 2006 |
Last sequence update: | January 4, 2005 | |
Last modified: | February 10, 2021 | |
This is version 101 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |