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Protein

Proteasome activator complex subunit 2

Gene

PSME2

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome activator complex subunit 2
Alternative name(s):
Proteasome activator 28 subunit beta
Short name:
PA28b
Short name:
PA28beta
Gene namesi
Name:PSME2
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

Keywords - Cellular componenti

Proteasome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001617872 – 239Proteasome activator complex subunit 2Add BLAST238

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei10PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ863Z0
PeptideAtlasiQ863Z0
PRIDEiQ863Z0

Interactioni

Subunit structurei

Heterodimer of PSME1 and PSME2, which forms a hexameric ring.By similarity

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000002190

Structurei

3D structure databases

ProteinModelPortaliQ863Z0
SMRiQ863Z0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PA28 family.Curated

Phylogenomic databases

eggNOGiKOG4470 Eukaryota
ENOG410XQVX LUCA
HOGENOMiHOG000282822
HOVERGENiHBG053745
InParanoidiQ863Z0
KOiK06697

Family and domain databases

Gene3Di1.20.120.180, 1 hit
1.20.5.120, 1 hit
InterProiView protein in InterPro
IPR003186 PA28_C
IPR036997 PA28_C_sf
IPR036996 PA28_N_sf
IPR009077 Proteasome_activ_PA28
IPR003185 Proteasome_activ_PA28_N
IPR036252 Proteasome_activ_sf
PANTHERiPTHR10660 PTHR10660, 1 hit
PfamiView protein in Pfam
PF02251 PA28_alpha, 1 hit
PF02252 PA28_beta, 1 hit
SUPFAMiSSF47216 SSF47216, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

Q863Z0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKPCGVRLS GEARKQVDVF RQNLFQEAEE FLYRFLPQKI IYLSQLLQED
60 70 80 90 100
SLNVTDLTSL RAPLDIPIPD PPPKDDEMET DKQEKKEVPK CGFLPGNEKI
110 120 130 140 150
LALLGLVKPE VWTLKEKCIL VITWIQHLIP KIEDGNDFGV AVQEKVLERV
160 170 180 190 200
NAVKTKVEAF QTTISKYFSE RGDAVAKASK ETHVMDYRAL VHERDEAAHG
210 220 230
ELRAMVLDLR AFYAELYHII SSNLEKIVDP KGEEKPSMY
Length:239
Mass (Da):27,296
Last modified:January 23, 2007 - v3
Checksum:i42569D600F90E963
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1SGM3F1SGM3_PIG
Proteasome activator complex subuni...
PSME2
239Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF527991 mRNA Translation: AAP30879.1
AY317125 Genomic DNA Translation: AAQ83575.1
RefSeqiNP_999444.1, NM_214279.1
UniGeneiSsc.830

Genome annotation databases

GeneIDi397522
KEGGissc:397522

Similar proteinsi

Entry informationi

Entry nameiPSME2_PIG
AccessioniPrimary (citable) accession number: Q863Z0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 9, 2004
Last sequence update: January 23, 2007
Last modified: October 25, 2017
This is version 66 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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