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Protein

Secreted frizzled-related protein 2

Gene

SFRP2

Organism
Canis lupus familiaris (Dog) (Canis familiaris)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 may be important for eye retinal development and for myogenesis.

GO - Molecular functioni

  • fibronectin binding Source: BHF-UCL
  • G-protein coupled receptor activity Source: GO_Central
  • integrin binding Source: BHF-UCL
  • Wnt-activated receptor activity Source: GO_Central
  • Wnt-protein binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Wnt signaling pathway

Protein family/group databases

MEROPSiI93.002

Names & Taxonomyi

Protein namesi
Recommended name:
Secreted frizzled-related protein 2
Short name:
sFRP-2
Gene namesi
Name:SFRP2
OrganismiCanis lupus familiaris (Dog) (Canis familiaris)
Taxonomic identifieri9615 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
Proteomesi
  • UP000002254 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000003254125 – 294Secreted frizzled-related protein 2Add BLAST270

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi39 ↔ 102By similarity
Disulfide bondi49 ↔ 95By similarity
Disulfide bondi86 ↔ 124By similarity
Disulfide bondi113 ↔ 151By similarity
Disulfide bondi117 ↔ 141By similarity
Disulfide bondi171 ↔ 244By similarity
Disulfide bondi174 ↔ 246By similarity
Disulfide bondi189 ↔ 294By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ863H1

Expressioni

Inductioni

Up-regulated in mammary gland tumors.

Interactioni

GO - Molecular functioni

  • fibronectin binding Source: BHF-UCL
  • integrin binding Source: BHF-UCL
  • Wnt-protein binding Source: GO_Central

Protein-protein interaction databases

CORUMiQ863H1
STRINGi9615.ENSCAFP00000012270

Structurei

3D structure databases

ProteinModelPortaliQ863H1
SMRiQ863H1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 154FZPROSITE-ProRule annotationAdd BLAST121
Domaini171 – 294NTRPROSITE-ProRule annotationAdd BLAST124

Domaini

The FZ domain is involved in binding with Wnt ligands.By similarity

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3577 Eukaryota
ENOG410XRC8 LUCA
HOVERGENiHBG052928
InParanoidiQ863H1
KOiK02176

Family and domain databases

Gene3Di1.10.2000.10, 1 hit
InterProiView protein in InterPro
IPR015526 Frizzled/SFRP
IPR020067 Frizzled_dom
IPR036790 Frizzled_dom_sf
IPR001134 Netrin_domain
IPR018933 Netrin_module_non-TIMP
IPR026558 SFRP2
IPR008993 TIMP-like_OB-fold
PANTHERiPTHR11309 PTHR11309, 1 hit
PTHR11309:SF45 PTHR11309:SF45, 1 hit
PfamiView protein in Pfam
PF01392 Fz, 1 hit
PF01759 NTR, 1 hit
SMARTiView protein in SMART
SM00643 C345C, 1 hit
SM00063 FRI, 1 hit
SUPFAMiSSF50242 SSF50242, 1 hit
SSF63501 SSF63501, 1 hit
PROSITEiView protein in PROSITE
PS50038 FZ, 1 hit
PS50189 NTR, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q863H1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRGPGSLLL LVLASHCCLG SARGLFFGQP DFSYKRSNCK PIPANLQLCH
60 70 80 90 100
GIEYQNMRLP NLLGHETMKE VLEQAGAWIP LVMKQCHPDT KKFLCSLFAP
110 120 130 140 150
VCLDDLDETI QPCHSLCVQV KDRCAPVMSA FGFPWPDMLE CDRFPQDNDL
160 170 180 190 200
CIPLASSDHL LPATEEAPKV CEACKNKNED DNDIMETLCK NDFALKIKVK
210 220 230 240 250
EITYINRDTK IILETKSKTI YKLNGVSERD LKKSVLWLKD SLQCTCEEMN
260 270 280 290
DINAPYLVMG QKLGGELVIT SVKRWQKGQR EFKRISRSIR KLQC
Length:294
Mass (Da):33,340
Last modified:June 1, 2003 - v1
Checksum:i79C1FF3882CBE1B1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ560716 mRNA Translation: CAD90762.1
RefSeqiNP_001002987.1, NM_001002987.2
UniGeneiCfa.1200

Genome annotation databases

GeneIDi475471
KEGGicfa:475471

Similar proteinsi

Entry informationi

Entry nameiSFRP2_CANLF
AccessioniPrimary (citable) accession number: Q863H1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: June 1, 2003
Last modified: June 20, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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