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Entry version 131 (31 Jul 2019)
Sequence version 1 (01 Jun 2003)
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Protein

Cytochrome c oxidase subunit 2

Gene

COX2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.UniRule annotationSAAS annotation

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Cu cationUniRule annotationNote: Binds a copper A center.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processElectron transport, Respiratory chainUniRule annotationSAAS annotation, Transport
LigandCopperUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2UniRule annotationSAAS annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:COX2Imported
Synonyms:COIIImported, coxIIImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates if the gene coding for the protein originates from the hydrogenosome, the mitochondrion, the nucleomorph, different plastids or a plasmid. The absence of this section means that the gene is located in one of the main chromosomal element(s).<p><a href='/help/encoded_on' target='_top'>More...</a></p>Encoded oniMitochondrionImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei27 – 46HelicalSequence analysisAdd BLAST20
Transmembranei66 – 85HelicalSequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotationSAAS annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 91COX2_TMInterPro annotationAdd BLAST91
Domaini92 – 225COX2_CUAInterPro annotationAdd BLAST134

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cytochrome c oxidase subunit 2 family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4767 Eukaryota
COG1622 LUCA

Family and domain databases

Conserved Domains Database

More...
CDDi
cd13912 CcO_II_C, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.287.90, 1 hit
2.60.40.420, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002429 CcO_II-like_C
IPR034210 CcO_II_C
IPR001505 Copper_CuA
IPR008972 Cupredoxin
IPR014222 Cyt_c_oxidase_su2
IPR011759 Cyt_c_oxidase_su2_TM_dom
IPR036257 Cyt_c_oxidase_su2_TM_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00116 COX2, 1 hit
PF02790 COX2_TM, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49503 SSF49503, 1 hit
SSF81464 SSF81464, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR02866 CoxB, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00078 COX2, 1 hit
PS50857 COX2_CUA, 1 hit
PS50999 COX2_TM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q85KS0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAHAAQVGLQ DATSPIMEEL ITFHDHTLMI IFLICFLVLY ALFLTLTTKL
60 70 80 90 100
TNTNISDAQE METVWTILPA IILVLIALPS LRILYMTDEV NDPSLTIKSI
110 120 130 140 150
GHQWYWTYEY TDYGGLIFNS YMLPPLFLEP GDLRLLDVDN RVVLPIEAPI
160 170 180 190 200
RMMITSQDVL HSWAVPTLGL KTDAIPGRLN QTTFTATRPG VYYGQCSEIC
210 220
GANHSFMPIV LELIPLKIFE MGPVFTL
Length:227
Mass (Da):25,595
Last modified:June 1, 2003 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4A8A8B5E9EBD6FF6
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY195788 Genomic DNA Translation: AAO88842.1
DQ112911 Genomic DNA Translation: AAZ02714.1
DQ112916 Genomic DNA Translation: AAZ02779.1
DQ112924 Genomic DNA Translation: AAZ02883.1
EU597525 Genomic DNA Translation: ACB48576.1
EU597549 Genomic DNA Translation: ACB48888.1
FJ544231 Genomic DNA Translation: ACK76882.1
FJ544233 Genomic DNA Translation: ACK76908.1
FJ544238 Genomic DNA Translation: ACK76973.1
FJ544239 Genomic DNA Translation: ACK76986.1
FJ544240 Genomic DNA Translation: ACK76999.1
FJ544241 Genomic DNA Translation: ACK77012.1
FJ544242 Genomic DNA Translation: ACK77025.1
FJ383501 Genomic DNA Translation: ACM73642.1
FJ383502 Genomic DNA Translation: ACM73655.1
FJ748717 Genomic DNA Translation: ACN37288.1
GQ859272 Genomic DNA Translation: ACV69860.1
GQ895161 Genomic DNA Translation: ACV92447.1
GQ895169 Genomic DNA Translation: ACV92551.1
GU371930 Genomic DNA Translation: ADB07277.1
HM998901 Genomic DNA Translation: ADL14818.1
HM771192 Genomic DNA Translation: ADL15858.1
HM771193 Genomic DNA Translation: ADL15871.1
HM771194 Genomic DNA Translation: ADL15884.1
HM771195 Genomic DNA Translation: ADL15897.1
HM771208 Genomic DNA Translation: ADL16066.1
HQ412622 Genomic DNA Translation: ADO79250.1
JN966735 Genomic DNA Translation: AET11532.1
JX289131 Genomic DNA Translation: AFP96448.1
JX669233 Genomic DNA Translation: AFV54745.1
KC505106 Genomic DNA Translation: AGI50049.1
KC887476 Genomic DNA Translation: AGS47484.1
KC887477 Genomic DNA Translation: AGS47497.1
KC887491 Genomic DNA Translation: AGS47679.1
KC887496 Genomic DNA Translation: AGS47744.1
KF451014 Genomic DNA Translation: AGZ66818.1
KF451027 Genomic DNA Translation: AGZ66987.1
KF451032 Genomic DNA Translation: AGZ67052.1
KF451177 Genomic DNA Translation: AGZ68937.1
KF451589 Genomic DNA Translation: AGZ74293.1
KJ446268 Genomic DNA Translation: AHX49541.1
KJ446750 Genomic DNA Translation: AHX55807.1
KJ446751 Genomic DNA Translation: AHX55820.1
KJ446752 Genomic DNA Translation: AHX55833.1
KJ185995 Genomic DNA Translation: AID15347.1
KP317070 Genomic DNA Translation: AJT36517.1
KP240909 Genomic DNA Translation: ALD88135.1
KT587480 Genomic DNA Translation: AMZ82036.1
KT587579 Genomic DNA Translation: AMZ83323.1
KT587580 Genomic DNA Translation: AMZ83336.1
KT725959 Genomic DNA Translation: ANA93270.1
KT726028 Genomic DNA Translation: ANA94167.1
KY595565 Genomic DNA Translation: ARD71972.1
KY645566 Genomic DNA Translation: ASR13138.1
KY645578 Genomic DNA Translation: ASR13294.1
KY645582 Genomic DNA Translation: ASR13346.1
KY797229 Genomic DNA Translation: AUG83116.1
MH981875 Genomic DNA Translation: AZJ14348.1
AP008512 Genomic DNA Translation: BAE10642.1
AP008594 Genomic DNA Translation: BAE11710.1
AP008654 Genomic DNA Translation: BAE12490.1
AP008665 Genomic DNA Translation: BAE12633.1
AP008848 Genomic DNA Translation: BAE15012.1
AP008917 Genomic DNA Translation: BAE15909.1
AP010740 Genomic DNA Translation: BAG15423.1
AP009471 Genomic DNA Translation: BAG39386.1
AP011018 Genomic DNA Translation: BAH16012.1
AP013265 Genomic DNA Translation: BAN81237.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY195788 Genomic DNA Translation: AAO88842.1
DQ112911 Genomic DNA Translation: AAZ02714.1
DQ112916 Genomic DNA Translation: AAZ02779.1
DQ112924 Genomic DNA Translation: AAZ02883.1
EU597525 Genomic DNA Translation: ACB48576.1
EU597549 Genomic DNA Translation: ACB48888.1
FJ544231 Genomic DNA Translation: ACK76882.1
FJ544233 Genomic DNA Translation: ACK76908.1
FJ544238 Genomic DNA Translation: ACK76973.1
FJ544239 Genomic DNA Translation: ACK76986.1
FJ544240 Genomic DNA Translation: ACK76999.1
FJ544241 Genomic DNA Translation: ACK77012.1
FJ544242 Genomic DNA Translation: ACK77025.1
FJ383501 Genomic DNA Translation: ACM73642.1
FJ383502 Genomic DNA Translation: ACM73655.1
FJ748717 Genomic DNA Translation: ACN37288.1
GQ859272 Genomic DNA Translation: ACV69860.1
GQ895161 Genomic DNA Translation: ACV92447.1
GQ895169 Genomic DNA Translation: ACV92551.1
GU371930 Genomic DNA Translation: ADB07277.1
HM998901 Genomic DNA Translation: ADL14818.1
HM771192 Genomic DNA Translation: ADL15858.1
HM771193 Genomic DNA Translation: ADL15871.1
HM771194 Genomic DNA Translation: ADL15884.1
HM771195 Genomic DNA Translation: ADL15897.1
HM771208 Genomic DNA Translation: ADL16066.1
HQ412622 Genomic DNA Translation: ADO79250.1
JN966735 Genomic DNA Translation: AET11532.1
JX289131 Genomic DNA Translation: AFP96448.1
JX669233 Genomic DNA Translation: AFV54745.1
KC505106 Genomic DNA Translation: AGI50049.1
KC887476 Genomic DNA Translation: AGS47484.1
KC887477 Genomic DNA Translation: AGS47497.1
KC887491 Genomic DNA Translation: AGS47679.1
KC887496 Genomic DNA Translation: AGS47744.1
KF451014 Genomic DNA Translation: AGZ66818.1
KF451027 Genomic DNA Translation: AGZ66987.1
KF451032 Genomic DNA Translation: AGZ67052.1
KF451177 Genomic DNA Translation: AGZ68937.1
KF451589 Genomic DNA Translation: AGZ74293.1
KJ446268 Genomic DNA Translation: AHX49541.1
KJ446750 Genomic DNA Translation: AHX55807.1
KJ446751 Genomic DNA Translation: AHX55820.1
KJ446752 Genomic DNA Translation: AHX55833.1
KJ185995 Genomic DNA Translation: AID15347.1
KP317070 Genomic DNA Translation: AJT36517.1
KP240909 Genomic DNA Translation: ALD88135.1
KT587480 Genomic DNA Translation: AMZ82036.1
KT587579 Genomic DNA Translation: AMZ83323.1
KT587580 Genomic DNA Translation: AMZ83336.1
KT725959 Genomic DNA Translation: ANA93270.1
KT726028 Genomic DNA Translation: ANA94167.1
KY595565 Genomic DNA Translation: ARD71972.1
KY645566 Genomic DNA Translation: ASR13138.1
KY645578 Genomic DNA Translation: ASR13294.1
KY645582 Genomic DNA Translation: ASR13346.1
KY797229 Genomic DNA Translation: AUG83116.1
MH981875 Genomic DNA Translation: AZJ14348.1
AP008512 Genomic DNA Translation: BAE10642.1
AP008594 Genomic DNA Translation: BAE11710.1
AP008654 Genomic DNA Translation: BAE12490.1
AP008665 Genomic DNA Translation: BAE12633.1
AP008848 Genomic DNA Translation: BAE15012.1
AP008917 Genomic DNA Translation: BAE15909.1
AP010740 Genomic DNA Translation: BAG15423.1
AP009471 Genomic DNA Translation: BAG39386.1
AP011018 Genomic DNA Translation: BAH16012.1
AP013265 Genomic DNA Translation: BAN81237.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG4767 Eukaryota
COG1622 LUCA

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MT-CO2 human

Family and domain databases

CDDicd13912 CcO_II_C, 1 hit
Gene3Di1.10.287.90, 1 hit
2.60.40.420, 1 hit
InterProiView protein in InterPro
IPR002429 CcO_II-like_C
IPR034210 CcO_II_C
IPR001505 Copper_CuA
IPR008972 Cupredoxin
IPR014222 Cyt_c_oxidase_su2
IPR011759 Cyt_c_oxidase_su2_TM_dom
IPR036257 Cyt_c_oxidase_su2_TM_sf
PfamiView protein in Pfam
PF00116 COX2, 1 hit
PF02790 COX2_TM, 1 hit
SUPFAMiSSF49503 SSF49503, 1 hit
SSF81464 SSF81464, 1 hit
TIGRFAMsiTIGR02866 CoxB, 1 hit
PROSITEiView protein in PROSITE
PS00078 COX2, 1 hit
PS50857 COX2_CUA, 1 hit
PS50999 COX2_TM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ85KS0_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q85KS0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2003
Last sequence update: June 1, 2003
Last modified: July 31, 2019
This is version 131 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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